CN111135235A

CN111135235A - A composition for preventing and relieving acute alcoholism or alcoholic intoxication

Info

Publication number: CN111135235A
Application number: CN201910103453.XA
Authority: CN
Inventors: 颜明
Original assignee: Nanjing Sato Health Technology Co ltd
Current assignee: Nanjing Sato Health Technology Co ltd
Priority date: 2019-02-01
Filing date: 2019-02-01
Publication date: 2020-05-12

Abstract

A composition for preventing and relieving acute alcoholism or alcoholic intoxication is prepared from leaves of Ampelopsis Michx of Vitaceae, digestant, interior warming agent and heat-clearing agent, or their effective components. The composition can accelerate oxidation and metabolism of ethanol, prevent and relieve acute alcoholism or drunkenness to central nervous system, liver, cardiovascular and cerebrovascular, etc., rapidly improve headache, dizziness, debilitation, emesis, accelerated heartbeat, stomach ache, inattention, etc., so that the user can be awake rapidly after intoxication, and avoid serious harm of alcohol to body.

Description

A composition for preventing and relieving acute alcoholism or alcoholic intoxication

Technical Field

The invention relates to a composition for preventing and relieving acute alcoholism or drunkenness, in particular to a composition for preventing and relieving bad body senses such as headache, dizziness, hypodynamia, vomit, accelerated heartbeat, stomachache, inattention and the like caused by excessive drinking.

Background

The wine is a common beverage, and people often have drunk symptoms such as dizziness, vomit, inattention, hypomnesis, emotional instability and the like when drinking excessive wine at one time. If people drink wine for a long time, the visceral dysfunction can be caused, and then the visceral lesion can occur. The development of effective anti-alcoholism medicines has important significance in reducing or eliminating the harm of alcohol to human bodies and preventing and treating alcohol-related diseases.

Acute Alcoholism (AAI) is a pathological process of damage to the central nervous system, liver, cardiovascular and cerebrovascular systems, etc. caused by a large amount of alcohol intake in a short period of time. Acute alcoholism is extremely dangerous, and even serious patients are life-threatening, so that effective treatment measures are actively taken, and important clinical significance is achieved for preventing complications. Naloxone is the most commonly used medicament for treating acute alcoholism in clinic, has an action mechanism of a specific opioid receptor antagonist, has the effect of reversing opioid, increases cerebral blood flow, promotes the awakening of patients and recovers the central nervous function. Naloxone administration to patients with acute alcoholism usually requires intravenous drip administration, thus greatly limiting its range of use. Nalmefene is an opioid receptor antagonist with high selectivity and specificity, can block central nerves, circulatory systems and other symptoms caused by opioid peptides, and is also used for treating acute alcoholism and is also administered by intravenous injection due to the advantages of safe action, small side effect, quick response, long maintenance time and the like. Although the western medicine injections can protect the cerebral nerves of patients suffering from acute alcoholism and have the effects of promoting wakefulness and relieving respiratory depression, acute severe alcoholism has a plurality of complications such as upper gastrointestinal hemorrhage, hypoglycemia, electrolyte disorder, acute pancreatitis, disulfiram-like reaction and the like, and naloxone and nalmefene cannot directly improve the toxic and stimulating effects of alcohol on other main organs of the body such as the stomach, the liver and the kidney. Therefore, in the actual use process, the pharmaceutical composition is often combined with drugs with the effects of protecting the liver and the gastric mucosa, for example, the pharmaceutical composition can effectively and thoroughly protect the gastric mucosa and prevent upper gastrointestinal hemorrhage by combining with a proton pump inhibitor, and the respiratory and circulatory disturbance of severe patients can be rapidly improved by combining with reduced glutathione; the combination of the aceglutamide or the citicoline can improve the coma condition more obviously.

Naloxone is often combined with traditional Chinese medicines clinically, for example, a Xingnaojing injection which is improved from traditional Chinese medicine formula Angong bezoar pills, and the main components of the injection comprise musk, borneol, gardenia, radix curcumae and other traditional Chinese medicine components, and the injection has the effects of clearing away heat and toxic materials, cooling blood, activating blood circulation, inducing resuscitation, refreshing brain and the like. The combination of the Xingnaojing and the naloxone for treating acute severe alcoholism can promote consciousness restoration, shorten coma time, reduce clinical complications and obtain good clinical effect. Qingkailing, pulse activating, salvia miltiorrhiza, ginseng and wheat, compound musk and other traditional Chinese medicine injection are also commonly used for treating acute alcoholism by combined administration. However, the above drugs are mostly used by injection, and need to be diagnosed by a clinician for reasonable administration, which is very inconvenient for most drunkenness people to use, at present, there are many anti-hangover products prepared by using natural plant extracts, such as pueraria lobata, hovenia dulcis thunb, curcumin and the like, which are commonly used for preparing anti-hangover formulas, and ampelopsis grossedentata rich in dihydromyricetin is also reported to have a good anti-drunkenness effect. For example, CN102846771B discloses a composition with anti-hangover and liver-protecting effects, which is composed of pueraria flower, hovenia dulcis thunb, dandelion, licorice, dark plum, alanine, and glutamine in proportion. CN102578352A discloses a chewing gum capable of increasing the alcohol content and rapidly sobering up, protecting liver and nourishing stomach, which is characterized in that the effective components of VC, VB6, alcohol dehydrogenase, acetaldehyde dehydrogenase, red wine polyphenol, dihydromyricetin, hawthorn, mulberry, lemon extract essence and other medicines in the chewing gum are slowly released in a chewing mode and absorbed by the oral cavity of a human body, so that the effects of increasing the alcohol content, rapidly sobering up, protecting liver and nourishing stomach are achieved.

However, these existing products still have certain defects in the actual using process, for example, some products have the effect of preventing drunkenness only when being taken before drinking, and the taking time after drunkenness is longer, such as half an hour to 1 hour or even several hours at the fastest speed, so as to start to take effect, and the phenomenon of 'head up' after drunkenness cannot be well played. In practical use, dihydromyricetin, curcumin and the like are not easy to absorb in vivo due to poor water solubility, and are limited in practical use. The tolerance to ethanol varies greatly from person to person because ethanol contained in wine is absorbed and enzymatically oxidized to acetaldehyde in the body after drinking. Acetaldehyde is decomposed by acetaldehyde dehydrogenase to become acetic acid. Acetic acid is not harmful to the human body and then is decomposed into carbon dioxide and water. Ethanol and acetaldehyde are the most harmful to the human body. Alcohol dehydrogenase and acetaldehyde dehydrogenase are present in the liver of a human body, and generally, the body weight of the human body contains the alcohol dehydrogenase in substantially equal amounts. However, the number of people lacking acetaldehyde dehydrogenase is large. Due to the lack of acetaldehyde dehydrogenase, acetaldehyde can not be completely decomposed into acetic acid, but acetaldehyde is continuously remained in the body, so that drunkenness symptoms such as nausea, vomiting, coma and the like are generated after people drink the alcohol. Therefore, the person who is under the reasonable standard for alcohol capacity due to poor drinking is a person who is deficient or completely deficient in acetaldehyde dehydrogenase. For people who drink well, if drinking too much or too fast, the decomposition capability of acetaldehyde dehydrogenase is exceeded, and intoxication may also occur. There are three pathways for the catabolism of ethanol in the human body: liver, skin and respiratory system; approximately 95% of these enzymes pass through the liver and are primarily referred to as P450 (monooxygenase) for oxidative metabolism. Alcohol dehydrogenase and acetaldehyde dehydrogenase are proteins, and direct oral administration is ineffective, while taking a common Chinese herbal medicine preparation and acting on the liver after absorption to achieve the effect of enhancing the liver anti-alcoholism function requires a long time. The wine contains not only ethanol but also a certain amount of fusel oil, and the ethanol can be metabolized by enzymes in the body, but the fusel is generally slowly metabolized or difficult to metabolize, and sometimes the wine still feels headache and feels nausea and lassitude after one or two days after drinking, which is caused by a small amount of fusel contained in the wine, so that the harm is larger. And the metabolism of ethanol alone is not comprehensive enough. Therefore, the prior art still lacks a pure natural oral composition which has definite effect and can quickly relieve the bad body senses of headache, dizziness, hypodynamia, vomit, accelerated heartbeat, stomachache and the like after being drunk.

Technical content

The inventor of the invention carries out intensive research on a large number of medicines through diligent effort and creative work, and finds that the combination of the leaves of Ampelopsis (Ampelopsis Michx.) plants, the digestion-promoting medicines, the interior-warming medicines and the heat-clearing medicines can obviously improve the speed and the effective rate of relieving alcoholism, and can quickly relieve bad body senses such as headache, dizziness, hypodynamia, vomit, accelerated heartbeat, stomachache and the like after drunkenness within 10-15 minutes after taking. The following invention is thus provided:

most heat-clearing herbs are cold and cool in nature, but a few are even and cool, bitter, sweet, pungent or salty in flavor; it enters lung, stomach, heart, liver and large intestine meridians, and can clear heat, purge fire, cool blood, remove heat toxin, relieve deficiency heat, dry dampness, remove dampness, nourish yin, release exterior, and is mainly indicated for interior heat syndrome with exterior pathogen removed and no interior stagnation, such as exogenous febrile disease with high fever, dysentery with heat, carbuncle, swelling, sore and ulcer, yin injury with internal heat, damp-heat dysentery with diarrhea, warm-toxicity macula, carbuncle, swelling, sore toxin, yin deficiency with tidal fever, etc. The interior-warming herbs are warm in nature, have the actions of warming middle energizer to dispel cold, tonifying fire and strengthening yang, and are indicated for the syndrome of interior cold. The two medicines have opposite effects, and are generally applied less simultaneously in the traditional anti-alcoholism composition, but the applicant has found in clinical practice that the 2 kinds of medicines are used together, and are matched with the leaves of the Ampelopsis (Ampelopsis Michx.) plant of the family Vitaceae, and the digestant has unexpected curative effect.

One aspect of the present invention relates to a composition comprising: the leaf, digestant, interior-warming and heat-clearing herbs of Ampelopsis genus (Ampelopsis Michx) of Vitaceae family, or their extracts or effective components.

The composition is applied to the preparation of medicines, health-care foods and foods for preventing and relieving acute alcoholism or drunkenness, wherein the symptoms of acute alcoholism or drunkenness comprise: headache, dizziness, hypodynamia, vomiting, accelerated heartbeat, stomachache, inattention and other symptoms; the symptoms begin to improve within 10-15 minutes after the composition is administered.

The Ampelopsis plant of Vitaceae is Ampelopsis grossedentata (A. megalophylla Diels et. Gilg), Ampelopsis grossedentata (hand. Mazz.) W.T.Wang, Ampelopsis grossedentata [ A.sincia (Miq.) W.T.Wang ], Ampelopsis grossedentata [ A.sincisvar.hancei (pl.) W.T.Wan, Ampelopsis heterophylla [ A.humulifolia.var.Heterophylla (Thunb.) K.Koch ], Ampelopsis trisplifaensis [ A.delavayana pl. ] or Myrgle ampelopsis grossedentata [ A.breviedaphala-var.kularensis Red. ]; the digestant is hawthorn or dark plum; the interior warming medicine is cinnamon, cassia twig, dried ginger, common fennel, clove, pepper or piper longi; the heat-clearing medicine is fructus Gardeniae, Gypsum Fibrosum, herba Taraxaci, herba Lobeliae chinensis, herba Houttuyniae, rhizoma Smilacis Glabrae, herba Hedyotidis Diffusae, Trichosanthis radix or semen Cassiae.

Preferably, the raw materials of the composition comprise: ampelopsis grossedentata leaf or Ampelopsis grossedentata leaf, fructus crataegi or mume fructus, cortex Cinnamomi or fructus Piperis, and fructus Gardeniae or herba Taraxaci; more preferably, the raw materials of the composition comprise: ampelopsis grossedentata leaf, hawthorn, cinnamon and gardenia.

The pharmaceutical composition of any one of the present invention comprises the following raw material medicines by weight: 50-150 parts of Ampelopsis grossedentata leaf or Ampelopsis grossedentata leaf, 50-150 parts of hawthorn or dark plum fruit, 5-30 parts of cinnamon or pepper, and 10-70 parts of gardenia or dandelion; preferably, 70-130 parts of Ampelopsis grossedentata leaf or Ampelopsis grossedentata leaf, 70-130 parts of hawthorn or dark plum, 10-25 parts of cinnamon or pepper, and 20-60 parts of cape jasmine or dandelion; more preferably, 90-110 parts of Ampelopsis grossedentata leaf or Ampelopsis grossedentata leaf, 90-110 parts of hawthorn or dark plum, 15-20 parts of cinnamon or pepper, and 30-50 parts of cape jasmine or dandelion.

The pharmaceutical composition of the invention can also be prepared by directly crushing the raw materials.

The raw material medicaments in the pharmaceutical composition can be replaced by corresponding extracts or effective components. For example, the composition adopts the following extracts in weight ratio as raw materials: 50-150 parts of ampelopsis grossedentata leaf ethanol extract, 50-150 parts of hawthorn ethanol extract, 5-30 parts of cinnamon ethanol extract and 10-70 parts of gardenia ethanol extract; preferably, the content of the ampelopsis grossedentata leaf ethanol extract is 70-130 parts, the content of the hawthorn ethanol extract is 70-130 parts, the content of the cinnamon ethanol extract is 10-25 parts, and the content of the gardenia ethanol extract is 20-60 parts; more preferably, 90-110 parts of ampelopsis grossedentata leaf ethanol extract, 90-110 parts of hawthorn ethanol extract, 15-20 parts of cinnamon ethanol extract and 30-50 parts of gardenia ethanol extract; most preferably, 100 parts of ampelopsis grossedentata leaf ethanol extract, 100 parts of hawthorn ethanol extract, 18 parts of cinnamon ethanol extract and 40 parts of gardenia ethanol extract.

Preferably, the total flavone content in the ampelopsis grossedentata leaf ethanol extract is not less than 30%, the total flavone content in the hawthorn ethanol extract is not less than 30%, the cinnamaldehyde content in the cinnamon ethanol extract is not less than 10%, and the geniposide content in the gardenia ethanol extract is not less than 30%; preferably, the total flavone content in the ampelopsis grossedentata leaf ethanol extract is not less than 50%, the total flavone content in the hawthorn ethanol extract is not less than 50%, the cinnamaldehyde content in the cinnamon ethanol extract is not less than 20%, and the geniposide content in the gardenia ethanol extract is not less than 50%. The above extracts or effective components can be prepared by the existing preparation process in the prior art, and also can be incorporated into the technical scheme of the invention, and the above extracts and monomers can also be purchased from commercial products.

For example, the Ampelopsis grossedentata ethanol extract, the Crataegus pinnatifida ethanol extract, the Cinnamomum cassia ethanol extract, the Gardenia jasminoides Ellis extract, the Scutellaria baicalensis extract, and the Taraxacum officinale extract can be prepared by respectively extracting with 30-90% ethanol, vacuum concentrating at 40-80 deg.C, drying at low temperature, and mixing at a certain proportion; or extracting with 30-90% alcohol respectively, separating with macroporous resin, vacuum concentrating at 40-80 deg.C, drying at low temperature, and mixing at a certain proportion.

The invention also provides a pharmaceutical preparation, which is any pharmaceutically acceptable dosage form prepared from the pharmaceutical composition and pharmaceutically acceptable auxiliary materials. The preparation can be conventional oral preparations such as common tablets, sustained-release tablets, orally disintegrating tablets, buccal tablets, granules, hard or soft capsules, solutions and the like.

The composition can also be widely used in medicines, health products and health foods.

The composition of the present invention contains an effective amount of the composition as an active ingredient and is formulated into various oral preparations. When formulated, the formulation may be carried out using conventional fillers, extenders, binders, wetting agents, disintegrants, diluents such as surfactants, or excipients. Solid preparations for oral administration include, for example, tablets, pills, powders, granules and capsules, and are prepared by mixing with one or more excipients such as starch, calcium carbonate, sucrose, lactose and gelatin and the composition of the present invention. In addition to simple excipients, lubricants such as magnesium stearate and talc may also be used. As liquid preparations for oral administration, suspensions, solutions for internal administration, emulsions and syrups should also be mentioned.

The term "health and functional food" used throughout the specification of the present invention means a food to which the composition of the present invention is added to a general food to improve its function. The composition of the present invention may be added to ordinary foods, or may be prepared in the form of capsules, powders, suspensions, etc. Ingestion of such health and functional foods containing the composition of the present invention provides health benefits and has the advantage of not exhibiting side effects caused by long-term use of the drugs because food materials are used as raw materials rather than conventional drugs.

The compositions of the present invention may also be used as food additives, and these compositions may be added separately or may be used together with other foods or food components, or may be suitably used based on other conventional methods. The blending amount of the effective ingredients can be appropriately determined depending on the purpose of use (preventive, health or therapeutic treatment). Generally, in the production of food or beverage using the mixed composition of the present invention, these derivatives may be added in an amount of 0.0001 to 10% by weight, and preferably 1 to 5% by weight, relative to the total weight of the raw materials. However, when a long-term intake is conducted for health purposes and hygiene or for health control, the amount of the composition of the present invention may be adjusted to be lower than the range. Furthermore, when it is used as a pharmaceutical composition, the health food of the present invention preferably contains the composition of the present invention within the range of the measured toxicity.

The above-mentioned food is not particularly limited in kind, and may be candies, chewing gums, various beverages, teas, drinks and multivitamin products. In particular, as examples of health foods containing the composition of the present invention, health foods and particularly flavored products such as candies, teas, jellies and beverages containing the composition of the present invention as a main ingredient should also be mentioned.

In the compositions of the present application, the following combinations of ingredients have the most significant effect: 100 parts of ampelopsis grossedentata leaves, 100 parts of hawthorn, 18 parts of cinnamon and 40 parts of gardenia. Or 100 parts of ampelopsis grossedentata leaf ethanol extract, 100 parts of hawthorn ethanol extract, 18 parts of cinnamon ethanol extract and 40 parts of gardenia ethanol extract. More preferably, the ethanol extract is prepared by respectively extracting with 60% ethanol, vacuum concentrating at 60 deg.C, drying at low temperature, and mixing at a certain proportion; or extracting with 60% ethanol respectively, separating with macroporous resin, vacuum concentrating at 60 deg.C, drying at low temperature, mixing at a certain proportion,

the Ampelopsis grossedentata leaves are new resource food (bulletin number: No. 16 in 2013) approved by the Ministry of health of China, contain a large amount of flavonoids, and have special effects on relieving alcoholism, preventing alcoholic liver and fatty liver and protecting liver. Cinnamon integrates edible and medicinal functions, has the effects of warming stomach, relieving diarrhea, stimulating the menstrual flow, expelling cold and dampness, promoting urination, reducing blood pressure, controlling blood sugar balance and the like, and also has certain functions of refreshing and relieving alcoholism. "Haw, a mountain fruit" is recorded in "follow-up family diet notation" of Qing-Wang Meng Ying. Bei Dai, also known as Biao Tuo, commonly known as hong Guo. Sour, sweet and warm. Activating spleen-qi, promoting digestion, removing blood stasis, resolving hard mass, relieving flatulence, relieving alcoholic intoxication, eliminating phlegm, removing malnutritional stagnation, and stopping dysentery. Gardenia has the effects of purging fire, relieving restlessness, clearing heat, promoting urination, cooling blood and removing toxicity, and has obvious effects on protecting liver and benefiting gallbladder.

Advantageous effects

The composition can accelerate the oxidation and metabolism of ethanol, prevent and relieve the damage of acute alcoholism or drunkenness to a central nervous system, a liver, a heart and cerebral vessels and the like, and can quickly improve symptoms such as headache, dizziness, hypodynamia, vomiting, accelerated heartbeat, stomachache, inattention and the like caused by the reasons; the composition can also effectively treat acute alcoholism, prevent chronic alcoholism and reduce the damage of alcohol to liver cells. The composition of the invention is composed of natural plant active ingredients, does not contain any chemical synthetic substance, has no obvious adverse reaction and toxic and side effect after long-term use, and is safe to use. The composition has low cost and convenient administration, is a necessary product for parties, remuneration and interstellar wine bureau, and can be taken before, during and after drinking.

Detailed Description

Ampelopsis grossedentata leaf, Hawthorn, cinnamon, and cape jasmine were purchased from Nanjing Miichong drugstore.

Pulverizing the above materials respectively, and sieving with 80 mesh sieve.

Example 1

Respectively soaking the powder of Ampelopsis grossedentata leaf, hawthorn, cinnamon and gardenia in 60% ethanol at room temperature for 2 hours; extracting with reflux method (at 65 deg.C for 2 times, 4 hr each time, the first material-liquid ratio is 1: 10, and the second material-liquid ratio is 1: 6); carrying out vacuum filtration; mixing filtrates, vacuum concentrating, drying at low temperature, and making into extract with relative density of 1.08-1.10(60 deg.C).

Example 2

Taking the extract of example 1, and extracting according to the weight ratio of the ampelopsis grossedentata leaf: and (3) hawthorn extract: cinnamon extract: gardenia extract 100: 100: 18: 40, taking 100g of the mixture, 150g of starch, 12g of 10% starch slurry, 12g of dry starch and 1.5g of magnesium stearate, and preparing 300 tablets by a conventional tablet preparation method.

Example 3

Taking the extract of example 1, and extracting according to the weight ratio of the ampelopsis grossedentata leaf: cinnamon extract: gardenia extract 100: 18: 40, taking 100g of the mixture, 150g of starch, 12g of 10% starch slurry, 12g of dry starch and 1.5g of magnesium stearate, and preparing 300 tablets by a conventional tablet preparation method.

Example 4

Taking the extract of example 1, and extracting according to the weight ratio of the ampelopsis grossedentata leaf: and (3) hawthorn extract: cinnamon extract-100: 100: 18, taking 100g of the mixture, 150g of starch, 12g of 10% starch slurry, 12g of dry starch and 1.5g of magnesium stearate, and preparing 300 tablets by a conventional tablet preparation method.

Experimental example 1 toxicological test

The mixed extract of example 2 is administered to mice at 2500mg/kg daily by intragastric administration, and no obvious toxic symptoms or death is observed after one week of observation, which indicates that the pharmaceutical composition of the present invention has little acute toxicity when administered orally.

The mixed extract in the example 2 is administrated to rats by intragastric administration for 30 days and 90 days at 500mg/kg, 1000 mg/kg and 2000mg/kg daily, the diet, the body weight, the hematuria and the liver and kidney functions of the rats after long-term administration are not obviously changed, and the mixed extract has no obvious toxicity on pathological histological observation of 18 important organs and tissues of experimental animals, such as heart, brain, liver, kidney and the like.

4 normal people voluntarily take 1.5g or 3g of the mixed extract of the example 2 every day, and after one week, compared with the prior and the post-taking, the blood sugar, the blood fat and the blood pressure have no obvious change, and the blood routine and the urine routine have no obvious change.

Experimental example 2 animal experiments

Acute poisoning test of mice caused by ethanol

(1) The method comprises the following steps: 50 Kunming mice are taken, male and female halves are divided into 5 groups randomly, namely a blank control group and an ethanol model group, the composition of the invention is low (0.5g/kg), medium (2.5g/kg) and high dose group (5.0g/kg), and each group comprises 10 animals. The administration groups respectively irrigate different doses of the mixed extract liquid medicine of the invention 2, and irrigate equal-volume physiological saline of 20mL/kg for the blank control group and the model group. After 30min, the rest components are respectively gazed with 65 percent (13g/kg) of ethanol 20mL/kg except that the blank control group is given equal volume of distilled water. The number of deaths and survivals for each group of animals over 24h were then recorded.

(2) As a result: the blank control group of 10 mice was not infused with ethanol and none of the animals died. Most of 10 animals in the model group died within 18 hours after intragastric administration of 65% (13g/kg) ethanol, and the death rate reaches 80%, which is acute toxic reaction and death reaction of mice caused by ethanol. The mortality rates of 10 animals in the low-dosage group and the medium-dosage group are respectively 50% and 30%; in the high dose group, 1 animal died, with a mortality rate of 10%. The composition can reduce the death rate of mice caused by alcohol poisoning and has a protective effect on acute alcoholism.

Experimental example 3 summary of clinical trial data

60 healthy volunteers were selected, age 28-58. 10 volunteers were randomly selected as 1 group and divided into 6 groups.

The drunkenness prevention experiment:

the first group of volunteers took 3 tablets of the tablet of example 2 before drinking wine, and then took 100ml of red star 43 degree aged Erguotou per person, 10 persons did not have symptoms such as dizziness, vomiting, stomachache and the like.

The second group of volunteers took 3 tablets of example 3 before drinking wine, and then took 100ml of red star 43 degree aged Erguotou per person, 6 of 10 persons showed symptoms of dizziness.

The third group of volunteers took 3 tablets of example 3 before drinking wine, and then took 100ml of red star 43 degree aged Erguotou per person, and 5 out of 10 persons showed symptoms of dizziness.

An anti-alcohol experiment:

each of the four groups of volunteers took 100ml of red star 43 degree aged Erguotou, 8 of 10 people showed dizziness, of which 3 felt burning pain in the stomach, and after taking 3 tablets of the tablet of example 2, the latter was asked again after 15 minutes, 7 people all had no discomfort, 1 person had dizziness and was good, and the stomach was still slightly uncomfortable.

Each of the fifth group of volunteers took 100ml of red star 43 degree aged Erguotou, 9 of 10 people showed symptoms of dizziness, 2 of which felt burning pain in the stomach, and after taking 3 tablets of the tablet of example 2, the latter was asked again after 15 minutes, 3 people did not feel dizzy, 1 person did not feel uncomfortable in the stomach, and 5 other people showed no relief in symptoms.

Each of the sixth group of volunteers took 100ml of red star 43 degree aged Erguotou, 8 of 10 people showed symptoms of dizziness, 4 of them felt burning pain in the stomach, after taking 3 tablets of the tablet of example 2, the latter was asked again after 15 minutes, 2 people did not feel dizzy in the head, 2 people did not feel uncomfortable in the stomach, and 4 other people showed no relief in symptoms.

Typical cases are as follows:

1. zhangzhi, male, 54 years old, dizziness and stomachache after drinking 2 two white spirits at one time at ordinary times. After the composition is taken, 5 two white spirits are drunk at one time, the head is still clear, and discomfort of the stomach is avoided.

2. Some Guo, male, 36 years old, sells and mostly drinks at ordinary times, and after drunk, the drunkenness-relieving products such as Haiwang Jinzun and Jiuqian cup are taken, but the drunkenness symptom cannot be relieved. After one-time drunk, after the composition is taken, the feelings of dizziness, vomiting and liver area swelling are relieved within about 10 minutes, the head is recovered to be clear, the vomiting is disappeared, and the liver area is comfortable.

While specific embodiments of the invention have been described in detail, it will be appreciated by those skilled in the art that various modifications and alternatives to those details could be developed in light of the overall teachings of the disclosure, and that such modifications are intended to be within the scope of the invention. The full scope of the invention encompasses all claims and their equivalents.

Claims

1. A composition characterized by: the raw material medicaments of the composition comprise: leaf of Ampelopsis plant (Ampelopsis Michx.) of Vitaceae, digestant, interior-warming and heat-clearing herbs.

2. The composition of claim 1, wherein: the Ampelopsis plant of Vitaceae is Ampelopsis grossedentata (A. megalophylla Diels et. Gilg), Ampelopsis grossedentata (hand. Mazz.) W.T.Wang, Ampelopsis grossedentata [ A.sincia (Miq.) W.T.Wang ], Ampelopsis grossedentata [ A.sincisvar.hancei (pl.) W.T.Wan, Ampelopsis heterophylla [ A.humulifolia.var.Heterophylla (Thunb.) K.Koch ], Ampelopsis trisplifaensis [ A.delavayana pl. ] or Myrgle ampelopsis grossedentata [ A.breviedaphala-var.kularensis Red. ]; the digestant is hawthorn or dark plum; the interior warming medicine is cinnamon, cassia twig, dried ginger, common fennel, clove, pepper or piper longi; the heat-clearing medicine is fructus Gardeniae, Gypsum Fibrosum, herba Taraxaci, herba Lobeliae chinensis, herba Houttuyniae, rhizoma Smilacis Glabrae, herba Hedyotidis Diffusae, Trichosanthis radix or semen Cassiae.

3. The pharmaceutical composition of claim 1, wherein: the raw materials of the composition comprise: folium Ampelopsis Megalophyllae or Ampelopsis grossedentata, fructus crataegi or mume fructus, cortex Cinnamomi or fructus Piperis, and fructus Gardeniae or herba Taraxaci.

4. The pharmaceutical composition of claim 1, wherein: the raw materials of the composition comprise: ampelopsis grossedentata leaf, hawthorn, cinnamon and gardenia.

5. The pharmaceutical composition of claim 3, wherein: the composition comprises the following raw material medicines in parts by weight: 50-150 parts of Ampelopsis grossedentata leaf or Ampelopsis grossedentata leaf, 50-150 parts of hawthorn or dark plum fruit, 5-30 parts of cinnamon or pepper, and 10-70 parts of gardenia or dandelion; preferably, 70-130 parts of Ampelopsis grossedentata leaf or Ampelopsis grossedentata leaf, 70-130 parts of hawthorn or dark plum, 10-25 parts of cinnamon or pepper, and 20-60 parts of cape jasmine or dandelion; more preferably, 90-110 parts of Ampelopsis grossedentata leaf or Ampelopsis grossedentata leaf, 90-110 parts of hawthorn or dark plum, 15-20 parts of cinnamon or pepper, and 30-50 parts of gardenia or dandelion; most preferably, 100 parts of ampelopsis grossedentata leaves, 100 parts of hawthorn, 18 parts of cinnamon and 40 parts of gardenia.

6. The composition of claim 4, wherein: the composition adopts the following extracts in weight ratio as raw materials: 50-150 parts of ampelopsis grossedentata leaf ethanol extract, 50-150 parts of hawthorn ethanol extract, 5-30 parts of cinnamon ethanol extract and 10-70 parts of gardenia ethanol extract; preferably, the content of the ampelopsis grossedentata leaf ethanol extract is 70-130 parts, the content of the hawthorn ethanol extract is 70-130 parts, the content of the cinnamon ethanol extract is 10-25 parts, and the content of the gardenia ethanol extract is 20-60 parts; more preferably, 90-110 parts of ampelopsis grossedentata leaf ethanol extract, 90-110 parts of hawthorn ethanol extract, 15-20 parts of cinnamon ethanol extract and 30-50 parts of gardenia ethanol extract; most preferably, 100 parts of ampelopsis grossedentata leaf ethanol extract, 100 parts of hawthorn ethanol extract, 18 parts of cinnamon ethanol extract and 40 parts of gardenia ethanol extract.

7. The composition of claim 6, wherein: the total flavone content in the ampelopsis grossedentata leaf ethanol extract is not less than 30 percent, the total flavone content in the hawthorn ethanol extract is not less than 30 percent, the cinnamaldehyde content in the cinnamon ethanol extract is not less than 10 percent, and the geniposide content in the gardenia ethanol extract is not less than 30 percent; preferably, the total flavone content in the ampelopsis grossedentata leaf ethanol extract is not less than 50%, the total flavone content in the hawthorn ethanol extract is not less than 50%, the cinnamaldehyde content in the cinnamon ethanol extract is not less than 20%, and the geniposide content in the gardenia ethanol extract is not less than 50%.

8. Use of the composition of any one of claims 1 to 7 for the preparation of a medicament, health food, food for preventing and alleviating acute alcoholism or intoxication.

9. The use of claim 8, wherein the symptoms of acute alcoholism or intoxication comprise: headache, dizziness, hypodynamia, vomiting, accelerated heartbeat, stomachache, inattention and the like.

10. The use according to claim 9, wherein the symptoms begin to improve within 10 to 15 minutes after the composition is administered.