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CN103735906A - Chinese herb preparation for treating dry bronchiectasis and preparation method thereof - Google Patents

Chinese herb preparation for treating dry bronchiectasis and preparation method thereof Download PDF

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CN103735906A
CN103735906A CN201310749410.1A CN201310749410A CN103735906A CN 103735906 A CN103735906 A CN 103735906A CN 201310749410 A CN201310749410 A CN 201310749410A CN 103735906 A CN103735906 A CN 103735906A
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radix
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semen
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不公告发明人
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Qingdao Hengbo Instrument Co Ltd
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Qingdao Hengbo Instrument Co Ltd
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Abstract

The invention discloses a Chinese herb preparation for treating dry bronchiectasis. The Chinese herb preparation comprises the following raw materials in parts by weight: 10 to 20 parts of scutellaria baicalensis, 10 to 20 parts of bamboo shavings, 10 to 20 parts of radix rubiae, 10 to 20 parts of rhizoma bletillae, 10 to 20 parts of the root bark of white mulberry, 10 to 20 parts of the root bark of the peony tree, 10 to 20 parts of fructus forsythiae, 10 to 20 parts of houttuynia cordata, 10 to 20 parts of rhizoma phragmitis, 10 to 20 parts of almond, 10 to 20 parts of semen lepidii, 10 to 20 parts of platycodon grandiflorum, 10 to 20 parts of raw liquorice, 10 to 20 parts of polygonatum, 10 to 20 parts of dogwood, 10 to 20 parts of pericarpium trichosanthis, 10 to 20 parts of melon kernels, 10 to 20 parts of jasmine, 10 to 20 parts of indigo naturalis, 10 to 20 parts of adenophora stricta, 10 to 20 parts of cortex lycii radicis, 10 to 20 parts of angelica sinensis, 10 to 20 parts of radix ophiopogonis and 10 to 20 parts of pseudo-ginseng. The hemostasis effect is obvious, the proliferation and migration of vascular smooth muscle cell can be inhibited, the vascular endothelial cell function can be protected, the infiltration of inflammatory cell on the blood vessel wall can be inhibited, and the expression of inflammatory cell factory and growth factor can be inhibited, and an effect of inhibiting the reconstruction of vasa publica can be realized to some extent.

Description

A kind of Chinese medicine preparation for the treatment of dry bronchiectasis and preparation method thereof
Technical field
The present invention relates to contain the medicinal preparation that derives from plant, animal or mineral component, particularly a kind of Chinese medicine preparation for the treatment of dry bronchiectasis and preparation method thereof.
Background technology
Bronchiectasic Etiological is Bronchi-pulmonary tissue infection and bronchial obstruction.Dry bronchiectasis clinical manifestation be mainly a large amount of hemoptysis, repeatedly hemoptysis, chronic cough, cough a large amount of purulent sputums.Primary disease majority is acquired, is more common in child and youth.Mostly be secondary to after acute and chronic respiratory tract infection and bronchial obstruction, patient has the medical histories such as young measles, pertussis or bronchopneumonia more.
This disease some patients were, repeatedly to spit blood as unique symptom, without symptoms such as coughing, vomica, is called " dry bronchiectasis " at ordinary times clinically, and its bronchiectasis multidigit is in the good position of drain.Recurrent pulmonary infection is characterized in that pneumonia protracted course of disease occur same lung section repeatedly.Due to often being spread by upper respiratory tract infection, there is the symptoms such as heating, cough aggravation, amount of expectoration increase, uncomfortable in chest, chest pain downwards.
Bronchiectasis sign: early stage or dry bronchiectasis can be without abnormal physical signs of lung; the heavy or secondary infection of pathological changes often audible and pectus, back is fixed and the lasting thick moist sound of limitation; audible and wheezing sound sometimes, part chronic patients is with drumstick finger (toe).While there is the complication such as emphysema, pulmonary heart disease, there is corresponding sign.
Bronchi-pulmonary tissue infection and block common virus and antibacterial infects and makes that bronchial tube transmucosal is congested, edema, block of secretion makes tube chamber narrow and small, causes inadequate drainage and increases the weight of to infect, and both influence each other, and impel bronchiectasic generation and development.Child's pertussis, measles, bronchopneumonia are the modal reasons of bronchiectasis due to Bronchi-pulmonary tissue infection.Because child's bronchus tube chamber is thin, tube wall is weak, easily blocks, and repeated infection destroys each layer tissue of bronchial wall, makes elasticity attenuation, or lung fibrosis around bronchioles, and tractive tube wall causes bronchus distortion expansion.Fibrous tissue tractive after the chronic infection of lung tissue or tuberculose focus healing, also can form bronchiectasis.In addition, tumor, foreign body suck or the lymph node of the outer enlargement of pipe is oppressed, and also can cause far-end Bronchi-pulmonary tissue infection and cause bronchiectasis.
Bronchiectasis can betide any age, but take teenager as common.Most patients once had measles, pertussis or bronchopneumonia protracted course of disease medical history children in year, and some bronchiectasis patients may be with chronic sinusitis or familial immunity defect medical history.
Bronchiectasic symptom: typical symptom is chronic cough, a large amount of purulent sputum and repeatedly spits blood.1, chronic cough, a large amount of purulent sputum, relevant with Body Position Change, this is because bronchiectasis position secretions stores up, while changing position, secretions stimulates bronchial mucosa to cause cough and expectoration.Being everlasting, rise morning or lie in bed night cough, expectoration amount while rotating position increase.While infecting acute attack, yellow green purulent sputum showed increased, can reach hundreds of milliliters every day, and as expectorant frowziness, prompting is associated with anaerobic infection.Sputum collecting standing rear feature that occurs layering in vial during infection: upper strata is foam, lower outstanding purulence composition, middle level is muddy mucus, lower floor is slough precipitate.The commonly encountered diseases substance that causes infection is Pseudomonas aeruginosa, staphylococcus aureus, hemophilus influenza, streptococcus pneumoniae and moraxelle catarrhalis.2, repeatedly spit blood.50%~70% patient has the spitting of blood of varying degree, spitting of blood varying degree, and spitting of blood amount and coincident with severity degree of condition, extent of disease are sometimes inconsistent.Some patients were, repeatedly to spit blood as unique symptom, without symptoms such as coughing, vomica, is called " dry bronchiectasis " at ordinary times clinically, and its bronchiectasis multidigit is in the good position of drain.3, recurrent pulmonary infection is characterized in that pneumonia protracted course of disease occur same lung section repeatedly.Due to often being spread by upper respiratory tract infection, there is the symptoms such as heating, cough aggravation, amount of expectoration increase, uncomfortable in chest, chest pain downwards.4, chronic infection poisoning symptom repeatedly secondary infection can have whole body poisoning symptom, as heating, weak, loss of appetite, become thin, anemia etc., can there is tachypnea and cyanosis in severe patient.Serious symptom bronchiectasis patient is due to bronchus around lung tissue suppurative inflammation and lung fibrosis widely, can concurrent obstructive emphysema, pulmonary heart disease, then there is corresponding symptom.
Generally speaking, bronchiectasis is that the destructiveness on dissecting changes, is irreversible, so the target of Drug therapy is the progress of controlling symptom and delaying disease.Bronchiectasis is secondary to other diseases conventionally, so reply protopathy is treated in time, the sinusitis being combined etc. should thoroughly be treated., should strengthen Supporting Therapy, reasonable arrangement rest according to the state of an illness herein, should avoid suffering from cold, advice smoking cessation, preventing respiratory tract infection.
Infection control is the primary treatment measure of bronchiectasis acute infection period.According to the state of an illness, with reference to antibacterial culturing and drug sensitivity test result, select antibacterials, expectorant cultivation results out before or expectorant cultivate when negative, antibiotic can be selected following empirical scheme.Light disease person can select oral ampicillin or amoxicillin 0.5g, every day 4 times, or first and second in generation cephalosporin; While there is charrin disease, can select oral quinolones; Patient with severe symptoms, often needs combined with intravenous medication.If any anaerobe mixed infection, add with metronidazole (metronidazole) or tinidazole.Repeatedly show effect acute lower respiratory infection or massive hemoptysis, extent of disease is confined to a side lung, is no more than 2 lobes of the lung, and wayward through Drug therapy, systemic conditions is good, can make lung section or pulmonary lobectomy according to extent of disease.As lighter in pathological changes, and symptom is not obvious, or pathological changes more extensively involves bilateral pulmonary, or with serious Respiratory Function Impairments person, unsuitable operative treatment.
Summary of the invention
Technical problem to be solved by this invention is, for this patient recurrent cough, expectoration, spitting of blood, patient's work capacity and quality of life have been had a strong impact on, present western medical treatment, great majority are selected antibiotic therapy or the excision pathological changes lobe of the lung, and price comparison is expensive, and effect is also not obvious, easily initiation secondary infection is returned patient and is brought very large financial burden, to physical function, brings certain side effect; For Chinese traditional treatment, there is no this disease of specific specialized Drug therapy, and drug effect is slow, formula compatibility is bad, unstable again.Anastalsis of the present invention is obvious; suppress vascular smooth muscle cell proliferation and migration, protection blood vessel inner skin cell function, inflammation-inhibiting cell in the infiltration of blood vessel wall and the expression of inflammation-inhibiting cytokine and somatomedin; therefore have certain effect to suppressing pulmonary vascular reconstruct, may delay the process of Complicated with Pulmonary arterial hypertension, pulmonary heart disease.Chinese medicine preparation of the present invention is to a large amount of hemoptysis of bronchiectasis patient, and expectoration symptom has significant remissive treatment effect, can improve patient's quality of life.
For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation for the treatment of dry bronchiectasis, in described preparation, the parts by weight of various crude drug are: 10~20 parts of Radix Scutellariaes, 10~20 parts of Caulis Bambusae In Taenia, 10~20 parts, Radix Rubiae, 10~20 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10~20 parts of Cortex Mori, 10~20 parts of Cortex Moutans, 10~20 parts of Fructus Forsythiaes, 10~20 parts of Herba Houttuyniae, 10~20 parts of Rhizoma Phragmitiss, 10~20 parts, Semen Armeniacae Amarum, 10~20 parts of Semen Lepidii (Semen Descurainiae)s, 10~20 parts of Radix Platycodoniss, 10~20 parts of Radix Glycyrrhizae, 10~20 parts of Rhizoma Polygonatis, 10~20 parts of Fructus Corni, 10~20 parts of the fruit-rinds of Chinese trichosanthes, 10~20 parts of Semen Benincasaes, 10~20 parts of Fructus Gardeniaes, 10~20 parts of Indigo Naturaliss, 10~20 parts of Radix Adenophorae (Radix Glehniae), 10~20 parts of Cortex Lycii, 10~20 parts of Radix Angelicae Sinensis, 10~20 parts of Radix Ophiopogonis, 10~20 parts of Radix Notoginseng.
The Chinese medicine preparation of described treatment dry bronchiectasis, described in it, in preparation, the parts by weight of various crude drug can be: 10~15 parts of Radix Scutellariaes, 10~15 parts of Caulis Bambusae In Taenia, 10~15 parts, Radix Rubiae, 10~15 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10~15 parts of Cortex Mori, 10~15 parts of Cortex Moutans, 10~15 parts of Fructus Forsythiaes, 10~15 parts of Herba Houttuyniae, 10~15 parts of Rhizoma Phragmitiss, 10~15 parts, Semen Armeniacae Amarum, 10~15 parts of Semen Lepidii (Semen Descurainiae)s, 10~15 parts of Radix Platycodoniss, 10~20 parts of Radix Glycyrrhizae, 10~20 parts of Rhizoma Polygonatis, 10~20 parts of Fructus Corni, 10~20 parts of the fruit-rinds of Chinese trichosanthes, 10~20 parts of Semen Benincasaes, 10~20 parts of Fructus Gardeniaes, 10~20 parts of Indigo Naturaliss, 10~20 parts of Radix Adenophorae (Radix Glehniae), 10~20 parts of Cortex Lycii, 10~20 parts of Radix Angelicae Sinensis, 10~20 parts of Radix Ophiopogonis, 10~20 parts of Radix Notoginseng.
The Chinese medicine preparation of described treatment dry bronchiectasis, described in it, in preparation, the parts by weight of various crude drug can also be: 10~20 parts of Radix Scutellariaes, 10~20 parts of Caulis Bambusae In Taenia, 10~20 parts, Radix Rubiae, 10~20 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10~20 parts of Cortex Mori, 10~20 parts of Cortex Moutans, 10~20 parts of Fructus Forsythiaes, 10~20 parts of Herba Houttuyniae, 10~20 parts of Rhizoma Phragmitiss, 10~20 parts, Semen Armeniacae Amarum, 10~20 parts of Semen Lepidii (Semen Descurainiae)s, 10~20 parts of Radix Platycodoniss, 10~15 parts of Radix Glycyrrhizae, 10~15 parts of Rhizoma Polygonatis, 10~15 parts of Fructus Corni, 10~15 parts of the fruit-rinds of Chinese trichosanthes, 10~15 parts of Semen Benincasaes, 10~15 parts of Fructus Gardeniaes, 10~15 parts of Indigo Naturaliss, 10~15 parts of Radix Adenophorae (Radix Glehniae), 10~15 parts of Cortex Lycii, 10~15 parts of Radix Angelicae Sinensis, 10~15 parts of Radix Ophiopogonis, 10~15 parts of Radix Notoginseng.
For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine preparation of dry bronchiectasis, and the oral solutions preparation method of described Chinese medicine preparation comprises the following steps:
A. described crude drug is put into pulverizer grinding and sieving,
B. particulate matter remaining after sieving is put into ethanol heating and refluxing extraction 2 times;
C. get again the medicinal residues after above-mentioned ethanol extraction, add water heating and refluxing extraction 2 times;
D. above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol adds dextrin and is in harmonious proportion; Canned.
In described step a, described crude drug can be put into after pulverizer is pulverized and cross 120 order dusting covers, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 30%, collects by the raw material fine powder of 120 mesh sieves standby.
In described step b, particulate matter remaining after sieving can be put into ethanol heating and refluxing extraction 2 times, each 1~2 hour, 2 extracting solution be merged standing.
In described step c, the medicinal residues that above-mentioned ethanol extraction can be crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1~2 hour, 2 extracting solution are merged standing.
In described steps d, above-mentioned two kinds of extracting solution can be merged, reclaim after ethanol decompression and put into concentrator when concentrated, the concentrated solution that while being concentrated into 90 ℃, relative density is 1.05, set to 0~5 ℃ of deepfreezes 24 hours; Cold preservation liquid is added to 0.3% filter aid kieselguhr, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, adds dextrin and is in harmonious proportion, and bottles canned.
For solving the problems of the technologies described above, the present invention provides a kind of preparation method for the treatment of the Chinese medicine preparation of dry bronchiectasis again, the preparation process of the pill of described Chinese medicine preparation is: all raw materials are put into 10 times of amount ethanol, heating and refluxing extraction 2 times, each 1~2 hour, 2 extracting solution are merged standing; The medicinal residues of the component raw medicinal material of more above-mentioned ethanol extraction being crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1~2 hour, 2 extracting solution are merged standing; Above-mentioned two kinds of extracting solution are merged, and it is concentrated that recovery ethanol is put into concentrator, and dry rear powdered, then adds Mel, is twisted into pill.
The Chinese medicine preparation of described treatment dry bronchiectasis, the dosage form for the treatment of the Chinese medicine preparation of dry bronchiectasis described in it can be: sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral solutions, suck agent, granule, electuary, pill, powder, sublimed preparation, solution, injection, plaster or spray.
The present invention is directed to this patient recurrent cough, expectoration, spitting of blood, patient's work capacity and the problem of quality of life have been had a strong impact on, to bronchiectasis patient expectoration, hemoptysis symptom has significant therapeutic effect, anastalsis is obvious, be a kind of effectively inexpensive preparation, can improve patient's quality of life.Anastalsis of the present invention is obvious; suppress vascular smooth muscle cell proliferation and migration, protection blood vessel inner skin cell function, inflammation-inhibiting cell in the infiltration of blood vessel wall and the expression of inflammation-inhibiting cytokine and somatomedin; therefore have certain effect to suppressing pulmonary vascular reconstruct, may delay the process of Complicated with Pulmonary arterial hypertension, pulmonary heart disease.The present invention adopts the Chinese crude drug of different properties, has carried out science compatibility, can reach desirable therapeutic effect, and safety, without any side effects, easy to use, after curing, be difficult for recurrence, and cheap, easy to use, can create good social value and economic interests.
The specific embodiment
Bronchiectasis patient be take and repeatedly spat blood as cardinal symptom, and the symptom such as seldom cough at ordinary times, vomica, is called " dry bronchiectasis " clinically, and its bronchiectasis multidigit is in the good position of drain.Recurrent pulmonary infection, is characterized in that pneumonia protracted course of disease occur same lung section repeatedly.Due to often being spread by upper respiratory tract infection, there is the symptoms such as heating, cough aggravation, amount of expectoration increase, uncomfortable in chest, chest pain downwards.Bronchiectasis is many because with the passing of time being invaded by exogenous pathogen does not heal, and pathogen is stayed in lung, and strongly fragrant heat-transformation of a specified duration, decocts body fluid in lung, causes body fluid deficiency liquid consumption, course of disease delay, and prolonged illness impairment of YIN, hyperactivity of fire caused by deficiency of YIN, the lung network of burning, forcing blood is excessive and cause.
This disease, from the beginning of just containing the domination of pathogen, take phlegm-heat obstructing in the lung as common, and the burning hot heresy pulmonary branches venation of burning, is its hemorrhage Etiological, and treatment often should lung heat clearing pathogenic fire purging, and dispersing and lowering lung-QI is joined the method for cooling blood for hemostasis.Sick body void person for a long time consumes impairment of QI blood, and with deficiency in origin and excess in superficiality, hyperactivity of fire caused by deficiency of YIN is many, is also no lack of the deficiency of vital energy simultaneously and loses solid or the stagnant card of the venation stasis of blood, conventional suppressing the hyperactive liver pathogenic fire reducing, nourishing YIN and clearing away heat, nourishing qi to stop, the method for the peaceful network of invigorating blood circulation.Bronchiectasis belongs to the categories such as Chinese medicine " cough ", " hemoptysis ", " lung abscess ".
Bronchiectasis (being called for short an expansion) is common chronic bronchial disease, refer to that diameter is greater than the medium sized proximal bronchus of 2mm because muscle and the Elastic tissue of tube wall are destroyed the abnormal expansion causing, cardinal symptom is chronic cough, cough a large amount of purulent sputums and (or) repeatedly spit blood, patient has the medical histories such as young measles, pertussis or bronchopneumonia more.Lung being a delicate viscus, preferring moisture to dryness, bronchiectasis is many because with the passing of time being invaded by exogenous pathogen does not heal, and pathogen is amassed in lung, and strongly fragrant heat-transformation of a specified duration, decocts body fluid in lung, causes body fluid deficiency liquid consumption, hyperactivity of fire caused by deficiency of YIN, the lung network of burning, forcing blood is excessive and cause.When exopathogen is violated lung, lung loses Xuan Fasu and falls, and regulating fluid apssage is unfavorable, and gas is cloth Tianjin not, raw in phlegm-damp, on note in lung, i.e. " the spleen being the source of producing phlegm, the lung being the utensil for storing phlegm ", spleen is source of generating QI and blood, and the pivot of rising and falling of QI is liked dry evil wet, pneumonopathy and spleen, illness of child viscera affecting mother one, dysfunction of the spleen in transportation, the defeated cloth imbalance of body fluid, raw in phlegm-damp, or the pungent savoury of surfeit, interior-heat is decocted bright body fluid, and poly-liquid is expectorant, stagnation of phlegm-damp in middle-JIAO, of a specified duration Yu Huare, the expectorant hot smoking lung network that burns, the absurd row of forcing blood and cause primary disease.
Expectorant is the product of bronchitis, closely related with Chinese medicine " lung-heat ", and thinks that the expectorant source of primary disease mainly contains four ends: dysfunction of the spleen in transportation, and raw in phlegm-damp; Hyperactivity of fire caused by deficiency of YIN, Tianjin refining expectorant burns; Pathogenic fire derived from stagnation of liver-QI, strongly fragrant in phlegm-fire; Element body is not enough, being invaded by exogenous pathogen.The common machine that stays the stasis of blood in expand developing, various middle because burning hot expectorant is empty, cause burn lung network or disorder of QI movement, the deficiency of vital energy lose take the photograph all can the hyperamization stasis of blood disease, as vomit the thick expectorant of a large amount of Huangs, its taste is stench, take that get up morning or when night is sleeping as many, uncomfortable in chest, spitting of blood color is dim red, or bloody sputum, or squamous and dry skin, or cyanosis of the lips and nails, dim complexion, there is ecchymosis on red tongue or limit, and at the bottom of tongue, vein is tortuous etc.
Lung governing regulation of water passages, if insufficiency of lung-QI, the miopragia of regulating fluid apssage.Water liquid stops gathering in lung system, with abnormal rising of lung-QI, and occurs expectoration; Heresy is stopped up in lung.Strongly fragrant and heat-transformation, stops up in expectorant heat, and refining liquid is expectorant, and expectorant yellow skin is thick; If injury of blood vessel of the lung by heat, network blood trouble is overflow, and can cause spitting of blood; Outside blood oozing from the body openings or subcuta neous tissue arteries and veins, form blood stasis.Insufficiency of lung-QI, declares respectful not normal persistent cough, and gas not cloth Jin Zejin is polymerized to expectorant; Deficiency of lung-YIN, lung loses to moisten supports the few expectorant of dry cough, body fluid deficiency hyperactivity of fire and network wound spitting of blood ".If disease further develops, or illness of child viscera affecting mother one and lung spleen be with sick, or the kidney usually involved in chronic disease and deficiency of both the lung and kidney all can make the symptom of coughing, spit, spitting blood increase the weight of.Because of lung, this is tender dirty again, and innate deficiency is subject to exopathogen invasion and attack further.Exopathogen is violated lung often can lure bronchiectasis acute attack into, wherein especially with wind heat, wind and cold, that lung is violated in wind-dryness is the most common.
Radix Platycodonis: bitter in the mouth; Pungent; Property is put down.Lung qi dispersing, eliminate the phlegm, sore-throat relieving, evacuation of pus, sharp the five internal organs, fill blood, mend five kinds of over strain, foster the spirit of nobility.Cough with copious phlegm, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, uroschesis.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.Radix Platycodonis is China tradition parts of generic medicinal plants, and the functions such as effect has lung qi dispersing, eliminates the phlegm, sore-throat relieving, evacuation of pus, cure mainly the symptoms such as cough with copious phlegm, laryngopharynx swelling and pain.Medicine-food two-purpose, demand is larger.< < property of medicine opinion > >: control the inferior dysentery, removing blood stasis, removes pneumatosis, removing food stagnancy is poly-, sputum, main lung-heat tachypnea is coughed contrary, except cold type of pain in abdomen, main attacked by pestiferous factors and pediatric epilepsy scared.< < Japan hanako materia medica > >: lower all gas, stop cramp caused by acute vomiting and diarrhea, trusted subordinate's distending pain, mends five kinds of over strain, foster the spirit of nobility, evil removing is warded off temperature, tonify deficiency expectorant, broken lump in the abdomen, the evacuation of pus of nourishing blood, mends internal hemorrhage due to trauma and sore throat.
Semen Armeniacae Amarum: hardship, tepor; The bitter warm lung qi dispersing of Semen pruni armeniacae, loosening bowel to relieve constipation, is only suitable for the trouble of the excess syndromes such as ailment said due to cold or exposure, dryness of the intestine.All the moon loses, stagnated fire person, and unsuitable single medicinal material is for oral administration for a long time.As the disease taboo single medicinal materials such as pulmonary tuberculosis, bronchitis, chronic enteritis, dry cough without phlegm take for a long time.There is the effects such as lung moistening, cough-relieving, laxation, the diseases such as dry cough without phlegm, chronic cough of deficiency lung are had to certain mitigation.The nutritional labelings such as Semen pruni armeniacae rich in proteins, fat, saccharide, carotene, vitamin B group, vitamin C, Citrin and calcium, phosphorus, ferrum.Wherein the content of carotene is only second to Fructus Mangifera Indicae in fruit, and people are called anticancer fruit by Semen pruni armeniacae.Semen pruni armeniacae contains abundant fatty oil, has the effect that reduces cholesterol, and therefore, Semen pruni armeniacae has good effect to control cardiovascular system diseases; Chinese medicine theory thinks, Semen pruni armeniacae has the effect of promoting the production of body fluid to quench thirst, lung moistening Dingchuan, is usually used in the dryness of the lung patient's health care and the treatment such as breath with cough.
Cortex Mori is the root bark of moraceae plants Mulberry Moms alba L..Main product in Anhui, the ground such as Henan, Zhejiang, Jiangsu, Hunan.Effect: eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.For lung-heat cough with asthma, the edema of the face, the diseases such as dysuria.< < property of medicine opinion > >: make, flat.Can control lung qi dyspnea with fullness of the chest, aqueous vapor edema, main wound is exhausted, dredging water passages, the aqueous vapor that disappears, the headache of asthenia exopathogenic heat, interior tonifying for the deficiency.< < Japan hanako materia medica > >: temperature, in tune, the therapeutic method to keep the adverse QI flowing downwards.Expectorant is quenched the thirst, sharp intestine and small intestine, and appetizing, lower food, kills abdomen and hides worm, and only cholera is vomited and diarrhoea.
Radix Scutellariae has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibacterial not worse than Rhizoma Coptidis, and does not develop immunity to drugs.We are used in fungal culture miscellaneous bacteria and infect special severity by the strong feature of broad-spectrum antibacterial action, fine by Radix Scutellariae extracting solution effect.< < Bencao Jingshu > >: Radix Scutellariae, its property is respectful clearly, so evil removing: so bitter in the mouth dampness; So YIN-cold victory heat, therefore main all heat.All hot persons, pathogenic heat with all over heat also, jaundice, intestinal be out-of-the-way, let out dysentery, the disease of all damp and hot victory also, is analysed it, all diseases are from recover.Bitter cold can be except damp and hot, thus small intestinal profit and water from by, source is clearly flowed also clean.The blood person of closing, excess-heat is at blood system, and amenorrhea is made us obstructed in instant heating human blood chamber, damp and hot solution, Ying Qi is clearly and voluntarily also.Malignant boil cellulitis erosion person, heat in blood is stayed knot, and is that carbuncle stain is also rotten: acute scleritis person, fire of moxibustion blood trouble also, removing heat from blood heat extraction, spontaneous recovery also.Radix Scutellariae has antiallergic action and antiinflammatory action: the contained baicalin of Radix Scutellariae and baicalin can obviously suppress the anaphylaxis contractile response that sensitized guinea pig rat small intestine in vitro and isolated tracheal produce antigen, to the passive general allergy of Cavia porcellus and mice and Cavia porcellus passivity skin allergic reaction, baicalin and baicalin also have inhibitory action.Radix Scutellariae has refrigeration function, most evidences, and the active ingredient baicaligenin of Radix Scutellariae has refrigeration function.Radix Scutellariae has Detoxication, and baicalin has obvious Detoxication, and this may be that baicalin decomposites glucuronic acid due under the effect at 13-glucuronidase, and due to being combined with multiple poisonous substance.10 milligrams of LD50 that can improve strychnine of baicalin reach 2.5 times, and the hepatic glycogen content of carbon tetrachloride poisoning mice is increased.
Radix Glycyrrhizae sweet in the mouth, property is flat, nontoxic.Function cures mainly: treating disorders in five ZANG-organs six internal organs cold and heat pathogen, and hard muscles and bones, longue meat, times strength, removing toxic substances, clothes are made light of one's life by commiting suicide and are prolonged life for a long time.Raw by pathogenic fire purging heat, the ripe use exterior cold of fall apart, goes pharyngalgia, except pathogenic heat, delays healthy energy, yin nourishing blood, tonifying the spleen and stomach, lung moistening.Radix Glycyrrhizae property is flat, and sweet in the mouth, returns 12 warps.Have removing toxic substances, eliminate the phlegm, pain relieving, spasmolytic be so that the pharmacological action such as anticancer.In the traditional Chinese medical science, Radix Glycyrrhizae invigorating the spleen and replenishing QI, relieving cough and moistening lung, emergency removing toxic substances, mediation hundred medicines.Clinical practice divides " raw using " and " processed with honey " not.Raw with curing mainly laryngopharynx swelling and pain, cellulitis skin infection, gastrointestinal ulceration and solution poison of drug, alimentary toxicosis etc.; Processed with honey cures mainly spleen and stomach function and goes down, and large loose stool is thin, weak heating and cough, cardiopalmus etc.Can coordinating the actions of various ingredients in a prescription.
Fructus Corni, cures mainly pathogen cold and heat under the heart, and warming middle-JIAO, by cold warm numbness, goes three worms, the merit that for a long time clothes have been made light of one's life by commiting suicide reinforcing YIN-essence benefit essence, settling five organs, logical nine orifices, stopped dribbling urination; Take for a long time improving eyesight, brute force all the year round.Fructus Corni, has another name called Fructus Corni, medicine Fructus Jujubae, real Fructus Jujubae, Fructus Corni, meat Fructus Jujubae etc., is the conventional rare Chinese medicine of China, and applicating history is long.It is gentle with its benefit power, tonifying YANG and do not help fire, YIN nourishing and oiliness diaphragm, convergence and do not stay the evil special efficacy that waits by successive dynasties use that medical science is liked.Zhang Zhongjing be take Fructus Corni and has been formulated " JINGUI SHENQI WAN " as monarch.According to chemical analysis, Fructus Corni contains the effective ingredient such as cornin, tartaric acid, gallic acid, malic acid, resin, tannin and multivitamin that physiologically active is stronger, having and strengthen immunity, antiinflammatory, the pharmacological action such as antibacterial, is Herba indigoferae Pseudotinctoriae conventional in tcm clinical practice.
Rhizoma Polygonati is used as medicine with rhizome.There is boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney benefiting functions.Be used for the treatment of weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, the interior-heat disease such as quench one's thirst.Very effective in cure for diabetes.Stir-baked RHIZOMA POLYGONATI with yellow rice wine claims again to process Rhizoma Polygonati.For steaming rear section with adjuvants such as wine and Semen sojae atricolors, clean Rhizoma Polygonati dries the person of being used as medicine.Have the merit of the meridians of escaping concurrently.Rhizoma Polygonati has blood pressure lowering, blood sugar lowering, and blood fat reducing, atherosclerosis, slow down aging and the effect such as antibacterial, polygonatum polysaccharide has Immunestimulatory effect.For lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, and the chronic cough chronic cough of YIN-deficiency of the lung and kidney etc.For weakness of the spleen and stomach.Both tonifying spleen-yin, strengthening the spleen gas again, for deficiency of kidney essence, obtain dizzy, soreness of the waist and knees, early whitening of beard and hair and quenching one's thirst etc.Rhizoma Polygonati strengthening bone and muscle, beneficial marrow, bleaches and sends out; The cough expectorant being suitable for due to lack of lung-YIN is few, dry cough without phlegm, the diseases such as hemoptysis.
Caulis Bambusae In Taenia, latin name Caulis Bambusae in Taeniam, cold nature, sweet in the mouth.Function cures mainly:
Removing heat-phlegm, relieves restlessness and prevents vomiting.For phlegm-heat cough, gallbladder fire, hold expectorant, dysphoria with smothery sensation vomiting, palpitation with fear insomnia, wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement under the arm.Pharmacological action: for cough due to lung-heat, expectorant Huang and febrile disease are irritated, palpitation with fear.Being slightly cold property of Caulis Bambusae In Taenia sweet in the mouth profit, is apt to removing heat-phlegm and relieving restlessness.Control phlegm-heat obstructing in the lung, the yellow thick person that coughs up phlegm, multiplex fresh goods, matches with Radix Scutellariae, Fructus Trichosanthis, Bulbus Fritillariae Uninbracteatae etc., to strengthen the merit of removing heat from the lung and dissipating phlegm.The positive > > of < < book on Chinese herbal medicine: control consumptive lung disease saliva expectorant, hematuria, married woman's heat in blood collapses pouring, fetal movement, and children's wind-heat epilepsy, mental disorder is breathed with cough, and little hydro-thermal is puckery.
Radix Rubiae: Latin formal name used at school: Rubia cordifolia L. is the root and rhizome of Maguireothamnus speciosus Radix Rubiae.It is cold in nature, bitter in the mouth, enter the heart, Liver Channel, there is the effect of promoting the circulation of blood hemostasis, dredge the meridian passage, eliminating phlegm and stopping cough, be usually used in treating haematemesis, epistaxis, hematuria, have blood in stool, the disease such as metrorrhagia, amenorrhea, rheumatic arthralgia, traumatic injury, the stasis of blood stagnantly swell and ache, jaundice, chronic tracheitis.The effect that has cooling blood for hemostasis, blood circulation promoting and blood stasis dispelling.Cure mainly the diseases such as heat in blood spitting of blood, postpartum stagnation stomachache, traumatic injury, rheumatic arthralgia.The sad lung of the < < property of medicine opinion > main six types of severe debility disease of > sweet in the mouth, spits blood and rushes down blood; The sub-> > of < < solar corona sour in the mouth stops serious epistaxis, leukorrhagia, and puerperal blood faints, breast knot, menstruation is more than, hemorrhoidal hamorrhage hemorrhoid complicated by anal fistula, evacuation of pus, controls furuncle, lets out essence, hematuria, flutters damage blood stasis, all gets its removing heat from blood promoting the circulation of blood, the merit ear of clearing up internal heat by using drugs of bitter in taste and cold in nature." (< < Bencao Jingshu > >)
Pseudobulbus Bletillae (Rhizoma Bletillae) is bitter, sweet, puckery, is slightly cold.Return lung, liver, stomach warp.Function cures mainly astringing to arrest bleeding, detumescence and promoting granulation.For hemoptysis, spit blood, traumatic hemorrhage, sore swollen toxin, chapped skin; Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.< < Sheng Nong's herbal classic > >: " main carbuncle, malignant boil, lose cellulitis, the dead flesh of impairment of YIN, pathogen in stomach "; < < Compendium of Materia Medica) > >: " abnormal smells from the patient (root) is bitter, flat, nontoxic.
Cortex Moutan: Cortex Moutan, Chinese medicine name.For the dry root bark of ranunculaceae peony.Originate in the ground such as Anhui, Shandong.Excavate root autumn, remove radicula, strip root bark, dry.Raw using or stir-fry use.< < Compendium of Materia Medica > >: " nourishing YIN to lower pathogenic fire is separated speckle poison, throat, diuresis stasis.Descendant specially controls fire mutually with yellow tiller, does not know that the merit of Cortex Moutan more wins also.Red colored person's profit, the person of spending in vain mends, and people also seldom realizes, and should distinguish it." modern study, contained paeonol and glucosides constituents in addition thereof all have antiinflammatory action; The methanolic extract of Cortex Moutan has inhibition Platelet; Paeonol has the effects such as the central inhibitory actions such as calmness, cooling, antipyretic, analgesia, spasmolytic and atherosclerosis, diuresis, antiulcer.
Herba Houttuyniae cold nature, bitter in the mouth.Return lung meridian, bladder, large intestine channel.Heat-clearing and toxic substances removing; Removing pus and relieving carbuncle; Inducing diuresis for treating stranguria syndrome.Cure mainly: the main lung abscess vomiting pus of pyretic stranguria; Expectorant dyspnea of heat type is coughed; Larynx; Hematodiarrhoea; Carbuncle sore tumefacting virus; Pyretic stranguria.< < detailed outline > >: the malicious carbuncle that dispels the heat, skin ulcer hemorrhoid proctoptosis , Duan Malaria disease, separates Nao poison.> > is wanted in the bun of < < medical center: row water, assault fortified position, and go miasma, expelling summer-heat.Treat snakeworm poison, control beriberi, the carbuncle of bursting, blood stasis removing blood.The fresh juice of Herba Houttuyniae has inhibitory action to staphylococcus aureus, after heating, effect weakens. and in vitro tests proves, Herba Houttuyniae decoct to multiple gram-positive bacteria and negative bacteria as staphylococcus aureus, Staphylococcus albus, Hemolytic streptococcus, Diplococcus pneumoniae, micrococcus catarrhalis, diphtheria corynebacterium, Bacillus proteus, will is congratulated, Amur, Fu Shi and bacterium sonnei, bacillus enteritidiss etc. all have inhibitory action in various degree. and Herba Houttuyniae ether extract has obvious inhibitory action to tubercule bacillus in vitro. in Herba Houttuyniae, extract a kind of grease obtaining, various microorganisms (especially to Molds and yeasts) are all had to inhibitory action, to Hemolytic streptococcus, staphylococcus aureus, hemophilus influenza, micrococcus catarrhalis, streptococcus pneumoniae has obvious inhibitory action, escherichia coli, dysentery bacterium, Bacillus typhi are also had to inhibitory action.
Rhizoma Phragmitis is sweet, cold.Gui Jing: return lung meridian, stomach warp.Function: clearing away heat and promoting production of body fluid, relieving restlessness, preventing or arresting vomiting, diuresis.Cure mainly: for calentura excessive thirst, gastropyretic vomiting, cough due to lung-heat, lung abscess vomiting pus, the puckery pain of pyretic stranguria.Cough due to lung-heat, lung abscess vomiting pus.This product enters the kind clear lung-heat thoroughly of lung meridian, with controlling cough due to lung-heat, often joins Radix Scutellariae, Bulbus Fritillariae Thunbergii, Fructus Trichosanthis etc. medicinal.If control cough due to pathogenic wind-heat, can join Folium Mori, Flos Chrysanthemi, Semen Armeniacae Amarum etc. medicinal, as SANGJU YIN (< < Wenbing Tiaobian, Detailed Analysis of Epidemic Warm Diseases > >).If control lung abscess vomiting pus, the use such as polygamy Semen Coicis, Semen Benincasae, as weijing decoction (< < prescriptions worth thousand gold > >).
Semen Lepidii (Semen Descurainiae) another name: fourth is gone through, suitable greatly, large chamber; Latin literary fame: the annual or biennial herb of Lepidium apetalum Willd., nature and flavor: pungent; Bitter; Cold.Function: eliminating the pathogens from the lung sending down the abnormal ascending QI; Eliminating phlegm and relieving asthma; Inducing diuresis to remove edema; Let out by heresy.China is distributed more widely.Gui Jing: lung meridian; Heart channel; Liver Channel; Stomach warp; Urinary bladder channel.Function cures mainly: warming the lung eliminating phlegm promoting the circulation of QI, resolving mass and removing the obstruction of the collateral pain relieving.For cold-phlegm, breath with cough, distending pain in the chest and hypochondrium, the stagnant meridians of expectorant, joint numbness, pain, phlegm-damp oozing in the body, carbuncle of yin nature toxic swelling.Control lung and stop up cough pus and blood, breathe heavily cough and doss: 125 grams of sweet Semen Lepidii (frying order every paper purple).For end, often take 10 grams, one, water, decocts to six minutes decoction being taken warmly while being regardless of.(< < Shi Yi De Xiao Fang, Effective Formulae Handed Down for Generations > > Semen Lepidii is loose).< < herbal classic > >: main lump in the abdomen stagnation of QI, diet cold and heat, broken hard by heresy, tonneau water channel.
The fruit-rind of Chinese trichosanthes enters lung, stomach, large intestine three warps." moistening the lung and resolving phlegm, promoting the circulation of QI the chest stuffiness relieving.Control phlegm-heat cough, pharyngalgia, chest pain, spits blood, and epistaxis, quenches one's thirst, constipation, carbuncle pyogenic infections from tumour or sore.< < book on Chinese herbal medicine is just read > >: " lung heat clearing." < < Records of Tradition Chinese and Western Medicine in Combination > >: " lung heat clearing, astringes the lung, relieve coughing, Dingchuan." < < decoction pieces is newly joined > >: " the chest stuffiness relieving numbness, heat-transformation expectorant, promoting the production of body fluid for nourishing the lung.″
Semen Benincasae sweet in the mouth, flat, lung moistening, reduces phlegm, eliminating carbuncle, diuretic.Control phlegm-heat cough, lung abscess, acute appendicitis, gonorrhea, edema, beriberi, hemorrhoid, nasal surface wine drum.< < Japan hanako materia medica > >: peeling skin wind stripping casting skin, profit skin.< < detailed outline > >: control acute appendicitis.Control cough with slight fever, stuffy sensation with restlessness, squamous and dry skin on the chest is to be lung abscess: Rhizoma Phragmitis (cut, two liters, boil and get five liters and go dregs with water two bucket), half liter of Semen Coicis, 30 pieces, Semen Persicae, half liter of melon lobe (current multiplex Semen Benincasae).Upper four tastes fritter, and in interior reed juice, boil and get two liters, take one liter, when telling as pus.(< < Medical Treasures of the Golden Chamber > > a thousand pieces of gold weijing decoction).
Fructus Forsythiae is bitter, is slightly cold.Return lung, the heart, small intestine meridian.Function is heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.For carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease is from the beginning of, warm joining the army, high hot excessive thirst, coma is sent out speckle, pyretic stranguria urine retention.The medicinal part of Fructus Forsythiae is mainly fruit.Its shell, i.e. " sticking up " in " a kind of reed mentioned in ancient books sticks up detoxifying pills ".Contain forsythol, coumarin, oleanolic acid, Saponin, Citrin etc.There is the effects such as heat clearing away, removing toxic substances, eliminating stagnation evacuation of pus.Cure mainly warm, skin infection, scrofula, erysipelas, class's rash, influenza, with fruit, be decocted in water for oral dose, or add in prescription.Be usually used in anemopyretic cold.Nature,taste and action: Chinese medicine bitter in the mouth, cold nature.Heat-clearing and toxic substances removing, mass dissipating and swelling eliminating.Mongolian medicine bitter in the mouth, cool in nature." association day " clearly, antidiarrheal.Cure mainly: Chinese medicine is controlled calentura from the beginning of, anemopyretic cold, heating is vexed, laryngopharynx swelling and pain, macule, erysipelas, scrofula, carbuncle pyogenic infections from tumour or sore, acute nephritis, pyretic stranguria.The mongolian medicine subcutaneous ulcer of harnessing the Yellow River, intestinal twinge, " association day " disease, intestinal heat.Sheng Nong's herbal classic > >: main cold and heat, Mus flaccidity, scrofula, carbuncle, malignant boil, goiter, stagnation of pathogenic heat, diseases due to noxious agents produced by various parasites.
Fructus Gardeniae is Chinese medicine, belongs to the 1st batch of medicine-food two-purpose resource that Ministry of Public Health is promulgated, has the effects such as hepatoprotective, function of gallbladder promoting, blood pressure lowering, calmness, hemostasis, detumescence, is usually used in treating the diseases such as icterohepatitis, bruise, hypertension, diabetes at tcm clinical practice.Cure mainly calentura vexed; Liver-fire conjunctival congestion; Headache; Jaundice due to damp-heat; Stranguria; Dysentery hematuria; Aphtha of the mouth and tongue; Sore swollen toxin; Sprain and swell and ache.This product has very large curative effect to conjunctival congestion and swelling pain.These product rush down clearly three warmers pathogenic heat, and the conjunctival congestion and swelling pain of attacking on can treating the liver gallbladder burning hot, often joins Radix Et Rhizoma Rhei use, as Fructus Gardeniae soup < < Shengji Zonglu > >.
Indigo Naturalis: taste cold in nature becomes, and returns Liver Channel.There is heat-clearing and toxic substances removing, blood cooling and ecchymoses removing, the effect of pathogenic fire purging arresting convulsion.For maculae caused by violent heat pathogen, heat in blood is told nosebleed, chest pain hemoptysis, aphtha, mumps, sore throat, pediatric epilepsy scared.Bacteriostasis: couroupitine A is tested through antifungal, active component for antidermatosis fungus, it is 5 μ g/ml that microsporum canis, disconnected tineatonsurans, microsporon gypseum, purple tinea bacterium, trichophyton gypseum, red mentagrophytes, acrothesium floccosum etc. are all had to stronger inhibitory action, its minimal inhibitory concentration., < < Bencao Jingshu > >: " Indigo Naturalis; removing toxic substances heat extraction; Gu its chief; more ancient prescription has and be used for all blood disorder persons, make non-blood system excess-heat, and diease occurrence is in yin asthenia generating intrinsic heat; YANG unable to attach to somewhere; fire of moxibustion, because of scorching in void, sent out as telling to be defeated in battle and coughed up the cards such as saliva, non-suitable with it.Blood must be trembled with fear solidifying, and solidifying cold and heat are handed over and done, and chest and diaphragm or pain, more increase its disease.
Radix Adenophorae (Radix Glehniae) clearing away heat and nourishing YIN, nourishing the lung to arrest cough.Cure mainly tracheitis, pertussis, cough due to lung-heat, coughs up phlegm yellow thick.Radix Adenophorae (Radix Glehniae) has the merit of Yin-nourishing and body fluid promoting, clearing away heat and cooling blood, Combined with Radiotherapy chemotherapy is for tumor patient, especially to patients with advanced cancer blood depletion cloudy lose, the pulmonary carcinoma of deficiency of lung-YIN, the postoperative deficiency of both QI and YIN of digestive tract tumor or the dry person of the withered liquid in Tianjin that causes because of radiotherapy impairment of YIN, there is good curative effect.According to ancient literature, record, forefathers' Radix Adenophorae (Radix Glehniae) used, is Radix Adenophorae.To the Qing Dynasty be loaded with Radix Adenophorae (Radix Glehniae) Fen Nan, north two kinds.It is generally acknowledged that two medicine effects are similar, all belong to yin-nourishing drug, there is nourishing YIN and clearing away lung-heat, the effect of reinforcing stomach reg fluid.So Radix Adenophorae claims again large Radix Adenophorae (Radix Glehniae), RADIX ADENOPHORAE, and its shape is thick, and matter is more loose, and effect is poor, and speciality, in entering " lung ", is partial to lung heat clearing away, sputum eliminating cough-relieving; Radix Glehniae, claims again RADIX GLEHNIAE, slice ginseng, and its shape is elongated, the hard density of matter, and effect is better, and speciality is in entering " stomach ", and relatively YIN nourishing and the production of body fluid promoting is quenched the thirst, and saying is different.Modern study Radix Glehniae, containing alkaloid, volatilization wet goods, has the effects such as the body temperature of reduction, analgesia, heart tonifying; Radix Glehniae, containing flavone, Saponin etc., has and eliminates the phlegm, resists the effects such as true stone, heart tonifying.The Radix Adenophorae replenishing YIN and removing heat moistening the lung and resolving phlegm treatment deficiency of YIN chronic cough consumptive disease expectorant blood cough caused by dryness expectorant of coughing is few; Deficiency-heat sore throat (nourishing the lung to arrest cough).Radix Glehniae deficiency of stomach-YIN deficiency of body fluid dry throat and mouth (nourishing the stomach to promote the production of body fluid).The present invention's Radix Adenophorae (Radix Glehniae) used, all guide Radix Adenophorae (Radix Glehniae).
Cortex Lycii is cold in nature, sweet in the mouth.Removing heat from blood is except steaming, lung heat clearing pathogenic fire reducing.For deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, cough due to lung-heat, spitting of blood, epistaxis.< < does not record > >: " main air is wet, lower breast side of body gas, exopathogenic heat headache, mends internal injury great Lao suctions of hissing, hard muscle, reinforcing YIN-essence, sharp intestine and small intestine, summer-heat resists cold.″
Radix Angelicae Sinensis, its sweet in the mouth and weighing, therefore specially can enrich blood, its gas is light and pungent, thus again can promoting the circulation of blood, invigorating middle warmer has, in row, has benefit, really the gas medicine in blood, the also panacea in blood.About mending to mend of assistant, thus can support nutrition blood, QI invigorating spermatogenesis, settling five organs, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable.Assistant logical to attack, therefore the pain relieving constipation of dispelling, relieving rigidity of muscles and joints, controls contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, assistant is with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can fall apart greatly, and show not hold back person, and help with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, thus want its quiet person when keeping away it, the sliding benefaction of property, stool is not consolidated person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.
Radix Ophiopogonis, sweet, micro-hardship, was slightly cold.GUIXIN, lung, stomach warp.[function with cure mainly] YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation.Be the liliaceous plant tuber of Radix Ophiopogonis Radix Ophiopogonis, clinical staple has the heart and does not go dividing of the heart, go saying of the heart to see the earliest TAO Hong-Jing < < Mingyi Bielu > >, call Radix Ophiopogonis if do not gone the heart to make one nervous.Then the opposition person of physicians from a family for generations family is numerous, and as Wu brings up, logical every with indicating and do not remove the heart Radix Ophiopogonis, meaning intentionally can enter the heart by the heart Radix Ophiopogonis, directly clear away heart-fire through heat.The author thinks like the necessity without arguement, because the custom of medication is all over China different, can do as the Romans do while in Rome, and needn't make excessive demands.As wish enters heart heat clearing away with it, available stir and mix with CINNABARIS it, be called occasion Radix Ophiopogonis.
Radix Notoginseng, Latin formal name used at school: Panax Notoginseng (Burk.) F.H.Chen.Have another name called Radix Notoginseng, return Liver Channel; Stomach warp; Heart channel; Lung meridian; Large intestine channel.Function: hemostasis; Loose blood; Analgesic therapy.Cure mainly: fall and flutter congestive edema, thoracic obstruction angor, lump in the abdomen; Blood stasis amenorrhea; Dysmenorrhea; The cloudy stomachache of the stasis of blood in puerperal; Sore, carbuncle and painful swelling.The famous pharmacy man Li Shizhen (1518-1593 A.D.) of the Ming Dynasty is called " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) ".Radix Notoginseng is a jewel in Chinese crude drug, in the pharmacy works < < of Qing Dynasty A Supplement to the Compendium of Materia Medica > >, record: " ginseng qi-tonifying first; Radix Notoginseng enriches blood first; taste with and merit also etc.; therefore claim Panax pseudoginseng, be the most precious person in Chinese medicine.Radix Notoginseng has anti-liver injury effect.It is active that PNS can significantly reduce CC14 hepatic injury mice serum ALT.The Liver Damage in Rats that methanolic extract causes CC14, D mono-galactosamine, can significantly reduce AST and lactic acid dehydrogenase (LDH) activity in rat blood serum, and hepatocellular degeneration necrosis is alleviated.Radix Notoginseng also has effect of anti hepatic fibrosis, to the hepatic injury of N-nitrosodimethylamine poisoning rat, with Radix Notoginseng powder, treats 4 weeks, and hepatocellular degeneration necrosis is alleviated, and between hepatocyte, collagen fiber reduce, and its anastalsis is strong.
The preparation method of oral solutions of the present invention: by all raw material Radix Scutellariae 1500g, Caulis Bambusae In Taenia 1500g, Radix Rubiae 1500g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1500g, Cortex Mori 1500g, Cortex Moutan 1500g, Fructus Forsythiae 1500g, Herba Houttuyniae 1500g, Rhizoma Phragmitis 1500g, Semen Armeniacae Amarum 1500g, Semen Lepidii (Semen Descurainiae) 1500g, Radix Platycodonis 1500g, Radix Glycyrrhizae 1500g, Rhizoma Polygonati 1500g, Fructus Corni 1500g, fruit-rind of Chinese trichosanthes 1500g, Semen Benincasae 1500g, Fructus Gardeniae 1500g, Indigo Naturalis 1500g, Radix Adenophorae (Radix Glehniae) 1500g, Cortex Lycii 1500g, Radix Angelicae Sinensis 1500g, Radix Ophiopogonis 1500g, Radix Notoginseng 1500g, put into 10 times of amount ethanol, heating and refluxing extraction 2 times, each 1~2 hour, 2 extracting solution are merged standing, the medicinal residues of the component raw medicinal material of more above-mentioned ethanol extraction being crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1~2 hour, 2 extracting solution are merged standing, above-mentioned two kinds of extracting solution are mixed, reclaim after ethanol decompression and put into concentrator when concentrated, the concentrated solution that while being concentrated into 90 ℃, relative density is 1.05, set to 0~5 ℃ of deepfreezes 24 hours, cold preservation liquid is added to 0.3% filter aid kieselguhr, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, then adds dextrin and is in harmonious proportion, and ultraviolet sterilization bottling is canned.
Process for producing granula of the present invention is: get raw material Radix Scutellariae 1200g, Caulis Bambusae In Taenia 1200g, Radix Rubiae 1300g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1300g, Cortex Mori 1400g, Cortex Moutan 1200g, Fructus Forsythiae 1300g, Herba Houttuyniae 1300g, Rhizoma Phragmitis 1200g, Semen Armeniacae Amarum 1100g, Semen Lepidii (Semen Descurainiae) 1300g, Radix Platycodonis 1300g, Radix Glycyrrhizae 1200g, Rhizoma Polygonati 1300g, Fructus Corni 1300g, fruit-rind of Chinese trichosanthes 1300g, Semen Benincasae 1300g, Fructus Gardeniae 1400g, Indigo Naturalis 1200g, Radix Adenophorae (Radix Glehniae) 1300g, Cortex Lycii 1300g, Radix Angelicae Sinensis 1300g, Radix Ophiopogonis 1400g, Radix Notoginseng 1400g, get in the water that described crude drug adds 5-10 doubly to measure and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, through the molecular weight that dams, be the ultrafiltration post ultrafiltration of 5000-10000 again, 1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, heating is concentrated into paste, stand for standby use, becoming component 1 soaks, heat is extracted 2 times, become paste, for component 1, the medicinal residues that water extraction is crossed are put into 10 times of amount ethanol, heating and refluxing extraction 2 times, each extraction time is 1~2 hour, 100-120 order filters, through the molecular weight that dams, be the ultrafiltration post ultrafiltration of 5000-10000 again, 1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, heating is concentrated into paste, stand for standby use, becomes component 2, above-mentioned two kinds of component pastes are condensed into pasty state, add after Mel or dextrin are in harmonious proportion and put into granulator, after granulating, with ultraviolet disinfection, then pack.
The preparation method of pill of the present invention is: get raw material Radix Scutellariae 1400g, Caulis Bambusae In Taenia 1200g, Radix Rubiae 1300g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1400g, Cortex Mori 1400g, Cortex Moutan 1200g, Fructus Forsythiae 1300g, Herba Houttuyniae 1200g, Rhizoma Phragmitis 1200g, Semen Armeniacae Amarum 1100g, Semen Lepidii (Semen Descurainiae) 1300g, Radix Platycodonis 1300g, Radix Glycyrrhizae 1300g, Rhizoma Polygonati 1300g, Fructus Corni 1300g, fruit-rind of Chinese trichosanthes 1300g, Semen Benincasae 1300g, Fructus Gardeniae 1400g, Indigo Naturalis 1200g, Radix Adenophorae (Radix Glehniae) 1300g, Cortex Lycii 1400g, Radix Angelicae Sinensis 1300g, Radix Ophiopogonis 1200g, Radix Notoginseng 1400g, drop into pulverizer and be ground into fine powder, granularity is 100~120 orders, sieve, unsifted coarse granule adds 20 liters, water and soaks 45 minutes, and heated and boiled 35 minutes, filters filtrate for later use, filtering residue adds water and heats for the second time, boils 35 minutes, filters filtrate for later use, filtering residue adds water again, and heated and boiled is 45 minutes for the third time, filters, three filtrates are combined, and heating is concentrated into pasty state, put into after 80 ℃ of oven dry of baking oven cooling, and the fine powder sieving, add Mel mediation and be twisted into pill.
Pharmacology's toxicity test
1. irritation test
Get rabbit and shave hair, with pill of the present invention, induce and excite contact test, viewing test rabbit after 24 hours and 48 hours, all loseing skin has the phenomenons such as erythema and edema, with negative control group zero difference.Result shows, this patch is bordering on zero to dermoreaction intensity, without skin allergic reaction.
2. endo-medicine cumulative toxicity test report
Test method: select 20 healthy mices, female, male each 10, it is first phase that dosage designs every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD50,0.50LD50, and the LD50 female, male mice of this sample is 5000m part/k part BW (five dosage be 500,750,1100,1700,2500m part/k part BW).Within every 5 days, weigh once, adjust dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose, to tested material after 20 days, female, buck all occurs without death condition.
3. acute toxicity test
Give white mouse oral administration medicine supplying with 300 times of the clinical consumption per day of this product endo-medicine, observe 5.The all animals of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.White mouse damaged skin is carried out to irritation test, there are no irritative response and other untoward reaction.
Toxicity test proves, the not toxic effect of said preparation and untoward reaction, and clinical practice is safe and reliable.
Clinical trial:
Hemoptysis is middle common complication a kind of of dry bronchiectasis, easily outbreak repeatedly.Hemoptysis, as treatment not in time, is easily died because being choked to death.My section accepts hemoptysis patient 80 examples in recent years altogether for medical treatment, and the hemoptysis prescription of the present invention of take is main formula, with the dialectical method treatment of Chinese medicine, receives good therapeutic effect.
1, source of data
80 routine patients are inpatient, the oldest person 67 years old, reckling 21 years old, 32 years old mean age, hospital stays is the shortest 15 days, the longest 60 days, average 30 days, 80 routine patients were all through chest x-ray photo, bronchofiberscope, Bronchography or spiral CT inspection each and every laboratory examination are clarified a diagnosis, the course of disease has: bronchiectasis 50 examples, pulmonary tuberculosis 16 examples, pulmonary carcinoma 14 examples.
1.1 Therapeutic Method
Chinese medicine preparation of the present invention, side uses: Radix Scutellariae 12g, Caulis Bambusae In Taenia 12g, Radix Rubiae 13g, Pseudobulbus Bletillae (Rhizoma Bletillae) 13g, Cortex Mori 14g, Cortex Moutan 12g, Fructus Forsythiae 13g, Herba Houttuyniae 13g, Rhizoma Phragmitis 12g, Semen Armeniacae Amarum 11g, Semen Lepidii (Semen Descurainiae) 13g, Radix Platycodonis 13g, Radix Glycyrrhizae 12g, Rhizoma Polygonati 13g, Fructus Corni 13g, fruit-rind of Chinese trichosanthes 13g, Semen Benincasae 13g, Fructus Gardeniae 14g, Indigo Naturalis 12g, Radix Adenophorae (Radix Glehniae) 13g, Cortex Lycii 13g, Radix Angelicae Sinensis 14g, Radix Ophiopogonis 14g, Radix Notoginseng 14g.Every day, potion, was decocted in water for oral dose, or made oral liquid according to embodiment 1.
Syndrome Differentiation of Traditional Chinese Medicine medicine plus-minus; Typing standard by spitting of blood in the anxious card of national traditional Chinese medical science blood disorder is divided into following three types.
Lung-heat is stopped up Sheng type: control with clearing heat and moistening lung, peaceful network hemostasis, with we, add Folium Mori, Bulbus Fritillariae Uninbracteatae etc.
Deficiency of YIN lung-heat type: control with nourishing YIN and moistening the lung, cooling blood for hemostasis, with we add Bulbus Lilii, the Radix Rehmanniae, Radix Paeoniae, Radix Ophiopogonis, etc.
Liver-fire attacking lung type: control with clearing liver-fire and purging lung and network hemostasis, rather add Radix Bupleuri, the Radix Paeoniae Alba etc. with we.
The application of Western medicine: slight hemoptysis person does not add Western medicine, moderate hemoptysis person adds use etamsylate, and it is oral that severe hemoptysis person adds use pituitrin and YUNNAN BAIYAO or Radix Notoginseng powder.All cases all adds uses antibiotic therapy.
2, curative effect judging standard
By the efficacy determination of spitting blood in the emergency treatment of national traditional Chinese medical science blood disorder: recovery from illness, within one week, internal hemorrhage stops, and in two weeks, nothing is hemorrhage again.The hemorrhage cardinal symptom of following disappears substantially.
Effective: one week internal hemorrhage basic controlling, accidental sputum mixed with blood.The hemorrhage cardinal symptom of following disappears substantially.
Effective: within one week, internal hemorrhage amount reduces.The hemorrhage cardinal symptom of following makes moderate progress.
Invalid: hemoptysis is after treatment in 1 week, hemorrhage without taking a turn for the better, and even increases the weight of.Hemorrhage simultaneous phenomenon is without improving or increasing the weight of.
Therapeutic effect in Table 1, table 2
Table 1 is the curative effect statistics of hemoptysis pair in various degree
Figure BDA0000450558360000121
Figure BDA0000450558360000131
The curative effect statistics of table 2 pair different pattern of syndrome hemoptysis
Figure BDA0000450558360000132
3, hemostasis situation: bronchiectasis 50 examples, amount of bleeding is that slight to heavy, degree, generally only gives the present invention and various diagnosis and prescription, every day potion.A few patients adds uses etamsylate.Bleeding stopping period is the shortest 3 days, the longest 10 days, average 5 days.While in hospital is without sending out tendency again.
The routine amount of bleeding of pulmonary tuberculosis 16 is the slight severe that arrives, and still take the present invention as main formula, and according to its differentiation of symptoms and signs for classification of syndrome plus-minus.Only there are indivedual patients to add with Radix Notoginseng powder or YUNNAN BAIYAO oral.Bleeding stopping period is the shortest 4 days, the longest 14 days, average 6 days.
Pulmonary carcinoma 14 examples, and great majority are gerontal patient, hemoptysis amount not etc., not take slight or moderate as many.To patient slight or moderate hemoptysis, take the present invention as main formula, and differentiation of symptoms and signs for classification of syndrome plus-minus.Alignment degree bleeder and time are longer, except decoction of the present invention, add with Radix Notoginseng powder or YUNNAN BAIYAO oral.Severe hemoptysis person, except above-mentioned treatment, also gives etamsylate, pituitrin.Bleeding stopping period is the shortest 5 days, the longest 20 days, average 10 days.
80 routine patients after classification therapy of the present invention, recovery from illness 25 examples, effective 35 examples, effective 8 examples, invalid 7 examples, total effective rate 91.25%.
4, the improvement situation of symptom: the simultaneous phenomenon of hemoptysis has heating, giddy, cough, expectoration, chest pain etc.The simultaneous phenomenon for the treatment of one week internal hemorrhage of effective patient substantially improves or disappears.Invalid patient is because the state of an illness is heavy, hemoptysis amount is many, and simultaneous phenomenon fails to improve.
5, the recovery situation of protopathy: 50 routine bronchiectasic patients, be mostly between twenty and fifty, after treatment, the state of an illness of protopathy is controlled rapidly, stopped bleeding, cough, expectoration, the disease such as uncomfortable in chest disappear substantially.It is young that lunger is mostly, and mostly be rural patient, and after the present invention and the treatment of anti-scabies, hemoptysis stops within a few days, and tuberculosis poisoning symptom also improves gradually and fully recovers.Patients with lung cancer mostly is advanced age, and the state of an illness is heavier, and ordinary circumstance is poor, still needs and give supporting treatment and anticancer therapy after the present invention and symptomatic treatment, and this class patient, only obtains short term effect, and prognosis is poor.
6, efficacy analysis: it is main formula that my section adopts the present invention, adds the method for taste by Syndrome Differentiation of Traditional Chinese Medicine, treatment 80 routine hemoptysis patients, total effective rate is 85%.These patients are only limited to bronchiectasis, pulmonary tuberculosis, three sick kinds of pulmonary carcinoma.Therapeutic effect is from table 1 demonstration, and three sick kinds are all effective, effective, illustrate that our treatment target has universality.We to light, moderate Bleeding is close, even add with western medicine result also poor to severe bleeding.Recovery from illness case is few, and this is relevant with protopathy character.Syndrome Types of TCM is treated, various effect is close, without significant difference.From table 2 statistics, the effect of lung-heat Kui Sheng type is slightly more quite a lot of than other amphitypy.These three kinds of protopathy have hidden danger, and as easily outbreak repeatedly of bronchiectasis, pulmonary tuberculosis needs the treatment of Long-term Anti scabies, and pulmonary carcinoma is non-operative treatment patient, there is no the method for radical cure.Even so, the short term effect of this law is reasonable.Effect to the anxious card of traditional Chinese medical herbal treatment is worth developing popularization.Patient to some serious symptom hemoptysis, adds and uses Western medicine hemorrhage, and this can not negate the anastalsis of Chinese medicine.
Except adhering to traditional Chinese medical science tradition method for the treatment of, differentiation of symptoms and signs for classification of syndrome medication is to improving patient's body condition, and it is very useful eliminating symptom.
Anastalsis of the present invention is obvious; suppress vascular smooth muscle cell proliferation and migration, protection blood vessel inner skin cell function, inflammation-inhibiting cell in the infiltration of blood vessel wall and the expression of inflammation-inhibiting cytokine and somatomedin; therefore have certain effect to suppressing pulmonary vascular reconstruct, may delay the process of Complicated with Pulmonary arterial hypertension, pulmonary heart disease.Chinese medicine preparation of the present invention is to a large amount of hemoptysis of bronchiectasis patient, and expectoration symptom has significant remissive treatment effect, can improve patient's quality of life.
Specific embodiment 1: pay certain, man, 45 years old, main suit when medical in 2008: as a child must cross bronchopneumonia.The head of a family is attention not, and touching difficulty heals, the rear easily pulmonary infection of growing up, and easy catching a cold, weak, body is thin, and liver-fire is vigorous, and buccal is crimson.Cause repeatedly hemoptysis is in hospital 3 times.Diagnosis: stop up and contain for lung-heat.Dysfunction of the spleen in transportation, raw in phlegm-damp; Hyperactivity of fire caused by deficiency of YIN, Tianjin refining expectorant burns; Pathogenic fire derived from stagnation of liver-QI, strongly fragrant in phlegm-fire; Element body is not enough, being invaded by exogenous pathogen.Use following Drug therapy:
Side uses: Radix Scutellariae 13g, Caulis Bambusae In Taenia 12g, Radix Rubiae 13g, Pseudobulbus Bletillae (Rhizoma Bletillae) 13g, Cortex Mori 12g, Cortex Moutan 12g, Fructus Forsythiae 13g, Herba Houttuyniae 13g, Rhizoma Phragmitis 12g, Semen Armeniacae Amarum 11g, Semen Lepidii (Semen Descurainiae) 14g, Radix Platycodonis 13g, Radix Glycyrrhizae 12g, Rhizoma Polygonati 13g, Fructus Corni 14g, fruit-rind of Chinese trichosanthes 13g, Semen Benincasae 12g, Fructus Gardeniae 14g, Indigo Naturalis 12g, Radix Adenophorae (Radix Glehniae) 13g, Cortex Lycii 13g, Radix Angelicae Sinensis 14g, Radix Ophiopogonis 13g, Radix Notoginseng 14g.Every day, potion, was decocted in water for oral dose, or according to embodiment 1, made oral liquid and take.
Treatment January, the state of an illness is controlled rapidly, stopped bleeding, and cough, expectoration, the disease such as uncomfortable in chest disappear substantially.Liver-fire is calmed down, and face starts ruddy, uses we to continue one month, and hemoptysis recurs never again, body weight gain, and expectorant is also few, suppresses bacillus pyocyaneus and is attached to respiratory mucosa.Suppress vascular smooth muscle cell proliferation and migration, protection blood vessel inner skin cell function, inflammation-inhibiting cell in the infiltration of blood vessel wall and the expression of inflammation-inhibiting cytokine and somatomedin, therefore have certain effect to suppressing pulmonary vascular reconstruct.Take medicine 30 weeks, expectoration phenomenon disappears, and follows up a case by regular visits to 3 years without recurrence.
Specific embodiment 2: together certain, female, 33 years old, every annual meeting was in hospital several times because of spitting of blood repeatedly, easy catching a cold has heating, the amount of vomicaing showed increased and is in hospital, goes various big hospital to treat.Bed throughout the year.Patient recurrent cough, expectoration, spitting of blood, had a strong impact on patient's work capacity and quality of life.Be diagnosed as: liver-fire attacking lung type, declare respectful not normal persistent cough, gas not cloth Jin Zejin is polymerized to expectorant; Deficiency of lung-YIN, lung loses to moisten supports the few expectorant of dry cough, body fluid deficiency hyperactivity of fire and network wound spitting of blood.The empty loss of body, dysfunction of the spleen in transportation, raw in phlegm-damp; Hyperactivity of fire caused by deficiency of YIN, Tianjin refining expectorant burns; Pathogenic fire derived from stagnation of liver-QI, strongly fragrant in phlegm-fire; Element body is not enough, being invaded by exogenous pathogen.Use following Drug therapy.
Side uses: Radix Scutellariae 13g, Caulis Bambusae In Taenia 14g, Radix Rubiae 13g, Pseudobulbus Bletillae (Rhizoma Bletillae) 14g, Cortex Mori 13g, Cortex Moutan 12g, Fructus Forsythiae 13g, Herba Houttuyniae 13g, Rhizoma Phragmitis 12g, Semen Armeniacae Amarum 11g, Semen Lepidii (Semen Descurainiae) 14g, Radix Platycodonis 13g, Radix Glycyrrhizae 12g, Rhizoma Polygonati 13g, Fructus Corni 14g, fruit-rind of Chinese trichosanthes 14g, Semen Benincasae 13g, Fructus Gardeniae 14g, Indigo Naturalis 13g, Radix Adenophorae (Radix Glehniae) 13g, Cortex Lycii 13g, Radix Angelicae Sinensis 14g, Radix Ophiopogonis 13g, Radix Notoginseng 14g, the course for the treatment of, 40 weeks.Make oral liquid or pill, every day three times, each 2 balls.
Treatment January, hemoptysis is controlled rapidly, stopped bleeding, and cough, expectoration, the disease such as uncomfortable in chest disappear substantially.Face starts ruddy, uses we to continue one month, and hemoptysis recurs never again expectoration phenomenon and obviously reduces, and hemoptysis phenomenon is stopped.Position chanP obviously just has productive cough to go out.Body weight gain, immunity improves, no longer easy to catch cold.Hemoptysis no longer occurs.Can be engaged in simple work.Do not need bed.Take medicine 40 weeks, expectoration phenomenon disappears, and health starts health.Follow up a case by regular visits to and without hemoptysis, be in hospital for 3 years.

Claims (10)

1. a Chinese medicine preparation for the treatment of dry bronchiectasis, it is characterized in that, in described preparation, the parts by weight of various crude drug comprise: 10~20 parts of Radix Scutellariaes, 10~20 parts of Caulis Bambusae In Taenia, 10~20 parts, Radix Rubiae, 10~20 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10~20 parts of Cortex Mori, 10~20 parts of Cortex Moutans, 10~20 parts of Fructus Forsythiaes, 10~20 parts of Herba Houttuyniae, 10~20 parts of Rhizoma Phragmitiss, 10~20 parts, Semen Armeniacae Amarum, 10~20 parts of Semen Lepidii (Semen Descurainiae)s, 10~20 parts of Radix Platycodoniss, 10~20 parts of Radix Glycyrrhizae, 10~20 parts of Rhizoma Polygonatis, 10~20 parts of Fructus Corni, 10~20 parts of the fruit-rinds of Chinese trichosanthes, 10~20 parts of Semen Benincasaes, 10~20 parts of Fructus Gardeniaes, 10~20 parts of Indigo Naturaliss, 10~20 parts of Radix Adenophorae (Radix Glehniae), 10~20 parts of Cortex Lycii, 10~20 parts of Radix Angelicae Sinensis, 10~20 parts of Radix Ophiopogonis, 10~20 parts of Radix Notoginseng.
2. treat according to claim 1 the Chinese medicine preparation of dry bronchiectasis, it is characterized in that, in described preparation, the parts by weight of various crude drug are: 10~15 parts of Radix Scutellariaes, 10~15 parts of Caulis Bambusae In Taenia, 10~15 parts, Radix Rubiae, 10~15 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10~15 parts of Cortex Mori, 10~15 parts of Cortex Moutans, 10~15 parts of Fructus Forsythiaes, 10~15 parts of Herba Houttuyniae, 10~15 parts of Rhizoma Phragmitiss, 10~15 parts, Semen Armeniacae Amarum, 10~15 parts of Semen Lepidii (Semen Descurainiae)s, 10~15 parts of Radix Platycodoniss, 10~20 parts of Radix Glycyrrhizae, 10~20 parts of Rhizoma Polygonatis, 10~20 parts of Fructus Corni, 10~20 parts of the fruit-rinds of Chinese trichosanthes, 10~20 parts of Semen Benincasaes, 10~20 parts of Fructus Gardeniaes, 10~20 parts of Indigo Naturaliss, 10~20 parts of Radix Adenophorae (Radix Glehniae), 10~20 parts of Cortex Lycii, 10~20 parts of Radix Angelicae Sinensis, 10~20 parts of Radix Ophiopogonis, 10~20 parts of Radix Notoginseng.
3. treat according to claim 1 the Chinese medicine preparation of dry bronchiectasis, it is characterized in that, in described preparation, the parts by weight of various crude drug are: 10~20 parts of Radix Scutellariaes, 10~20 parts of Caulis Bambusae In Taenia, 10~20 parts, Radix Rubiae, 10~20 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10~20 parts of Cortex Mori, 10~20 parts of Cortex Moutans, 10~20 parts of Fructus Forsythiaes, 10~20 parts of Herba Houttuyniae, 10~20 parts of Rhizoma Phragmitiss, 10~20 parts, Semen Armeniacae Amarum, 10~20 parts of Semen Lepidii (Semen Descurainiae)s, 10~20 parts of Radix Platycodoniss, 10~15 parts of Radix Glycyrrhizae, 10~15 parts of Rhizoma Polygonatis, 10~15 parts of Fructus Corni, 10~15 parts of the fruit-rinds of Chinese trichosanthes, 10~15 parts of Semen Benincasaes, 10~15 parts of Fructus Gardeniaes, 10~15 parts of Indigo Naturaliss, 10~15 parts of Radix Adenophorae (Radix Glehniae), 10~15 parts of Cortex Lycii, 10~15 parts of Radix Angelicae Sinensis, 10~15 parts of Radix Ophiopogonis, 10~15 parts of Radix Notoginseng.
4. as described in any one in claim 1~3, treat a preparation method for the Chinese medicine preparation of dry bronchiectasis, it is characterized in that, the oral solutions preparation method of described Chinese medicine preparation comprises the following steps:
A. described crude drug is put into pulverizer grinding and sieving,
B. particulate matter remaining after sieving is put into ethanol heating and refluxing extraction 2 times;
C. get again the medicinal residues after above-mentioned ethanol extraction, add water heating and refluxing extraction 2 times;
D. above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol adds dextrin and is in harmonious proportion; Canned.
5. the preparation method of oral solutions according to claim 4, it is characterized in that, in described step a, described crude drug is put into after pulverizer is pulverized and crossed 120 order dusting covers, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 30%, collects by the raw material fine powder of 120 mesh sieves standby.
6. the preparation method of oral solutions according to claim 4, is characterized in that, in described step b, particulate matter remaining after sieving is put into ethanol heating and refluxing extraction 2 times, each 1~2 hour, 2 extracting solution is merged standing.
7. the preparation method of oral solutions according to claim 4, is characterized in that, in described step c, the medicinal residues that above-mentioned ethanol extraction is crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1~2 hour, 2 extracting solution is merged standing.
8. the preparation method of oral solutions according to claim 4, is characterized in that, in described steps d, above-mentioned two kinds of extracting solution are merged, reclaim after ethanol decompression and put into concentrator when concentrated, the concentrated solution that while being concentrated into 90 ℃, relative density is 1.05, set to 0~5 ℃ of deepfreezes 24 hours; Cold preservation liquid is added to 0.3% filter aid kieselguhr, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, adds dextrin and is in harmonious proportion, and bottles canned.
9. state the preparation method that dryness is treated bronchiectasic Chinese medicine preparation as any one in claim 1~3 for one kind, it is characterized in that, the preparation process of the pill of described Chinese medicine preparation is: all raw materials are put into 10 times of amount ethanol, heating and refluxing extraction 2 times, each 1~2 hour, 2 extracting solution are merged standing; The medicinal residues of the component raw medicinal material of more above-mentioned ethanol extraction being crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1~2 hour, 2 extracting solution are merged standing; Above-mentioned two kinds of extracting solution are merged, and it is concentrated that recovery ethanol is put into concentrator, and dry rear powdered, then adds Mel, is twisted into pill.
10. according to the Chinese medicine preparation for the treatment of dry bronchiectasis described in any one in claim 1~9, it is characterized in that, the dosage form of the Chinese medicine preparation of described treatment dry bronchiectasis is: sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral solutions, suck agent, granule, electuary, pill, powder, sublimed preparation, solution, injection, plaster or spray.
CN201310749410.1A 2013-12-31 2013-12-31 Chinese herb preparation for treating dry bronchiectasis and preparation method thereof Pending CN103735906A (en)

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CN104383368A (en) * 2014-12-07 2015-03-04 唐云峰 Traditional Chinese medicine composition for treating bronchiectasia
CN104606551A (en) * 2015-02-04 2015-05-13 王银法 Traditional Chinese medicine for treating bronchiectasis

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CN101780238A (en) * 2010-04-20 2010-07-21 泰一和浦(北京)中医药研究院有限公司 Traditional Chinese medicine composition for treating asthma and preparation method thereof
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CN1175440A (en) * 1997-07-10 1998-03-11 迟经惠 Pill for cough, asthma and lung carbuncle
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* Cited by examiner, † Cited by third party
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CN104383368A (en) * 2014-12-07 2015-03-04 唐云峰 Traditional Chinese medicine composition for treating bronchiectasia
CN104606551A (en) * 2015-02-04 2015-05-13 王银法 Traditional Chinese medicine for treating bronchiectasis

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Application publication date: 20140423