CN104840934A - Traditional Chinese medicine composition for preventing and treating piglet diarrhea and preparation method of traditional Chinese medicine composition - Google Patents

Abstract

A traditional Chinese medicine composition for preventing and treating piglet diarrhea, belonging to the field of veterinary drug preparation, comprising the following traditional Chinese medicinal ingredients in parts by weight: 8-12 parts of Pulsatilla pulsatillae, 1-3 parts of Codonopsis pilosula, 1-3 parts of Radix Paeoniae Rubra, and 1-3 parts of Atractylodes macrocephala , 1 to 3 parts of dried ginger, 1 to 3 parts of tangerine peel, 1 to 3 parts of Phellodendron cortex, and 1 to 3 parts of licorice. The invention is made of pure Chinese herbal medicinal materials, has wide sources, low cost, high cure rate, no drug residue, no toxic and side effects, especially the same decoction and extraction, which maintains the traditional Chinese medicine technology and is easier to absorb. It has obvious functions of clearing away heat and detoxifying, drying dampness and stopping dysentery, warming and tonifying the stomach and intestines, and regulating body functions. It can effectively treat various types of diarrhea and shorten the recovery period. Easy to use. Clinical trials have proved that the cure rate is over 85%, and it has a unique curative effect.

Description

A traditional Chinese medicine combination for preventing and treating piglet diarrhea and its preparation method

technical field

The invention belongs to the field of veterinary drug preparation, and in particular relates to a traditional Chinese medicine combination for preventing and treating piglet diarrhea and a preparation method.

Background technique

Piglet diarrhea is a typical multifactorial disease under intensive pig production conditions. It is one of the most serious piglet disease groups and an important cause of piglet death. According to reports, piglets below 30kg have an annual average incidence of 46.5% and a mortality rate of 10.3%. Piglet diarrhea ranks first in the hazards of the pig industry. The mortality rate of piglets in my country is generally 15-20%, and the average number of sows is 11-25%. More than 80% of dead piglets died of dysentery.

Weaning piglet diarrhea accounts for a large proportion of piglet diarrhea, and the incidence rate is very high, and it can be popular all year round. There are many reasons for its pathogenesis and are very complicated, but it is mainly caused by stress response. Early weaning of piglets refers to the production process of early weaning of piglets after 8 weeks of age to 3 to 5 weeks of age. Foreign countries have gradually promoted the application of early isolation weaning (SEW) since the 1960s. From the late 1970s and early 1980s in China, some large-scale pig farms began to study and apply this production process. By the late 1980s and early 1990s, the method of weaning piglets at the age of 3 to 4 weeks had been basically implemented in general farms. However, while early weaning shows great potential in terms of production, it is accompanied by stress due to early weaning, resulting in early weaning syndrome. Clinically, it is manifested as a series of clinical symptoms such as loss of appetite, increased desire to drink, growth retardation, hair burns, diarrhea, and edema within 5 days of weaning. Among them, diarrhea is the most common and serious phenomenon.

The causes of piglet diarrhea are complex and can be roughly divided into the following aspects:

1) Self-developmental dysplasia leads to incomplete development of digestive function and digestive organs, which affects the normal absorption of nutrients of piglets, resulting in developmental obstruction; early weaning, weak immunity, weak immune response to pathogen invasion, unable to produce positive immune response, and a large number of piglets Exogenous anti-nutritional factors such as globulin, β-polyglobulin, and protein-carbohydrate complexes are the main antigenic substances that cause abnormal immune responses in the gastrointestinal tract of piglets; gastric acid deficiency can also lead to a large number of pathogenic bacteria, causing digestion Malabsorption, diarrhea and other diseases; in addition, the low activity of digestive enzymes in the digestive tract will also affect the digestion and absorption of feed.

2) Infection by exogenous pathogenic microorganisms, including bacteria such as Escherichia coli, Salmonella, spirochetes, etc. Viruses include piglet diarrhea virus, infectious gastroenteritis, rotavirus, etc.

Chinese veterinarians believe that there are many reasons for diarrhea in piglets, but the most important ones are poor feeding management, changeable climate, exposure to exogenous pathogens, injury from diet, deficiency of viscera and dysfunction of viscera and other factors. The external cause of piglet diarrhea is most obviously related to dampness; the internal cause is related to the spleen and stomach. Because the spleen likes dryness and dislikes dampness, it is mainly used for the transportation and transformation of food and water, so the temper should be raised; the stomach is full of pulses, likes moistening and hates dryness, and it is mainly rotten, so the stomach qi should be lowered. "The function. Any exogenous evil or internal injury factors that affect the function of the spleen and stomach can cause disorders of transport and chemistry, weakness of rottenness, poor appetite, inability to distinguish between clear and turbid, conduction failure, and diarrhea. Due to physical deficiency or prolonged illness, kidney yang is damaged, and fatal fire is insufficient without the yang energy of the spleen and earth, which can aggravate the condition.

Contents of the invention

The invention provides a combination of traditional Chinese medicines for preventing and treating piglet diarrhea and a preparation method. The invention treats piglet diarrhea based on syndrome differentiation and treatment based on the theory of traditional Chinese veterinary medicine, and screens the compatibility of the prescription, which has a significant effect on the prevention and treatment of piglet diarrhea, and is non-toxic. side effect.

The present invention is achieved through the following technical solutions:

A traditional Chinese medicine composition for preventing and treating diarrhea in piglets, comprising the following traditional Chinese medicine ingredients in parts by weight: 8-12 parts of Pulsatilla pulsatillae, 1-3 parts of Codonopsis pilosula, 1-3 parts of red peony root, 1-3 parts of Atractylodes macrocephala, and 1-3 parts of dried ginger 3 parts, 1 to 3 parts of tangerine peel, 1 to 3 parts of Cortex Phellodendri, and 1 to 3 parts of licorice. The whole prescription has the effects of clearing heat and detoxifying, invigorating the spleen and nourishing the stomach, strengthening the body and eliminating pathogenic factors, drying dampness and stopping dysentery.

A preparation method of a traditional Chinese medicine composition for preventing and treating diarrhea in piglets, comprising 8 to 12 parts of Pulsatilla grandis, 1 to 3 parts of Codonopsis pilosula, 1 to 3 parts of red peony root, 1 to 3 parts of Atractylodes macrocephala, and 1 to 3 parts of dried ginger . : sucrose powder (weight ratio) 1:1 ratio, add sucrose powder into the extract, stir evenly, add dregs powder according to the dryness and wetness, stir evenly (based on the principle of hand kneading), and then dry to prepare granules over 8 ~20-mesh sieve, then packed separately.

The method of using the combined medicine is to add 20-60 grams of the composition per kilogram of feed, and feed it mixedly, and a course of treatment is 3-5 days.

The prevention and treatment of piglet diarrhea by Chinese herbal medicine has shown a good momentum. Chinese herbal medicine can not only prevent and treat piglet diarrhea, but also solve the problem of drug residues, and has a good development prospect. For example, Pulsatilla pulsatillae has been proven to have good effects of clearing heat and detoxifying, cooling blood and stopping dysentery, and drying dampness and stopping dysentery.

Pulsatilla Latin scientific name: Pulsatilla chinensis (Bunge) Regel), Ranunculaceae, Anemone is a perennial herb with rhizomes, ovate leaves, and blue-purple calyx. Aliases include Naihe grass, pink milk grass, bald head grass, old aunt grass and so on. Distributed in hills, barren slopes and fields in Jilin, Liaoning, Hebei, Shandong, Henan, Shanxi, Shaanxi, Heilongjiang and other provinces in China, it has high medicinal value. Pulsatilla has the effects of clearing away heat and detoxification, cooling blood and stopping dysentery, drying dampness and killing insects. Pulsatillae bitter in the mouth, cold in nature; returns stomach, large intestine meridian, cures mainly heat-toxic dysentery, epistaxis, blood hemorrhoid, leukorrhagia, pruritus vulvae, carbuncle sore, scrofula. The medicinal effects of Pulsatillae mainly include: anti-oxidation and anti-inflammatory effects. Yao D et al. found that Pulsatilla can prevent the release of peroxides in liver tissue, increase the activity of MnSOD, and prevent the infection of hepatitis B virus. Long Shengjing et al. used the luminol luminescent system to study and found that the water extract of Pulsatilla chinensis has a strong anti-active oxidation effect, can effectively remove hydrogen peroxide, and prevent cell or tissue damage caused by lipid peroxidation caused by it. Zhang Wenyuan et al found that Pulsatillae Alcohol Extract had a significant inhibitory effect on dextran sulfate-induced colitis in rats. Insecticidal and antibacterial effects. Lan Jiyu et al found that Pulsatilla decoction has a better effect on killing Entamoeba histolytica. Cao Jinghua et al. used the K-B disc diffusion method to measure that the water extract of Pulsatillae had obvious inhibitory effects on Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus anthracis, Bacillus typhi, Streptococcus A, and Streptococcus B. Enhance the immune function of the body. Dai Ling et al. added different concentrations of Pulsatilla glycoprotein to mouse peritoneal macrophages cultured in vitro, the phagocytosis of neutrophils by mouse peritoneal macrophages was significantly enhanced, and the macrophages could be induced to produce carbon monoxide, which had an effect on macrophages. Cell secretion of IL-1 also has a certain role in improving. Anti-oxidize effect. According to the latest research, changing the saponins of 5 glycosides of Pulsatillae Radix into low-sugar saponins is beneficial to human body absorption, and the enzymatic hydrolysis products of Pulsatillae Radix Saponins can significantly promote the synthesis of collagen in skin fibroblast cells, and prepare anti-aging cosmetics by mixing them. It can significantly increase the amount of collagen in the skin, effectively improve skin elasticity, anti-wrinkle, and anti-aging. Anti-inflammatory effect. Chronic colitis is one of the common intractable diseases in clinic. Pulsatilla has analgesic, sedative, antispasmodic and astringent hemostatic effects on intestinal mucosa. The treatment of chronic colitis with Pulsatilla can enhance the body's immunity and promote the repair of intestinal mucosa. Studies have found that the mechanism of Pulsatilla Decoction in treating ulcerative colitis lies in its ability to reduce excessive humoral immunity and reduce immune responses mediated by cytokines.

Codonopsis pilosula (scientific name; Codonopsis pilosula) is oval or sub-circular thick slice, the surface is yellow-brown or gray-yellow, the cut surface is yellow-white or yellow-brown, with cracks or chrysanthemum patterns, and a light yellow center in the center. Periphery pale yellowish white to yellowish brown, with longitudinal wrinkles. It has a special aroma and slightly sweet taste. It is grown in mountain forests and shrubs at an altitude of 1560-3100 meters in northern China. There are about 40 species of Codonopsis genus plants in the world, about 39 species in China, 21 species and 4 varieties for medicinal purposes. Codonopsis Codonopsis is a traditional tonic medicine commonly used in China. In ancient times, Codonopsis Codonopsis produced in Shangdang area of Shanxi was the top grade. It has the effects of nourishing the middle and Qi, strengthening the spleen and lungs. According to modern research, Codonopsis pilosula has the effects of enhancing immunity, dilating blood vessels, lowering blood pressure, improving microcirculation, and enhancing hematopoietic function. In addition, it can improve the leukopenia caused by chemotherapy and radiotherapy.

Raw Dangshen Tablets benefit Qi and promote body fluid. It is often used for qi-jin injury or qi-blood deficiency. Codonopsis is sweet in taste and flat in nature. There are invigorating vital energy, quenching thirst, invigorating the spleen and lungs, nourishing blood and promoting body fluid. It is used for deficiency of spleen and lung qi, lack of food and fatigue, cough and shortness of breath, lack of qi and blood, sallow complexion, palpitation, shortness of breath, thirsty body fluid wound, internal heat and thirst, laziness and shortness of breath, weakness of limbs, poor appetite, deficiency of qi, and dual qi and body fluid. Deficiency, qi and blood deficiency, and blood deficiency and chlorosis embolism. However, it cannot be used if the evidence is not clear and the middle is full of evil. The effect of this product is similar to that of ginseng, but its medicinal power is weak. It can be used instead of ginseng to treat general deficiency syndromes; it is still advisable to use ginseng for severe collapse syndromes. Excavated in autumn, washed and dried in the sun.

Radix Paeoniae Rubra is the dried root of Paeonia lactifloraPal.l or P.veitchiiLynch. It is bitter in the mouth, slightly cold, and returns to the liver meridian, has the effects of clearing away heat and cooling blood, dispelling blood stasis and relieving pain. The main components include monoterpenes with a pinane structure and their glycosides, such compounds include paeoniflorin, hydroxypaeoniflorin, benzoylpaeoniflorin, benzoylhydroxypaeoniflorin, hydroxybenzoylpaeoniflorin, paeoniflorin, 8(Z)-(1S,5R)-B-pinene-10-hydroxy-B-nestrel glycoside, paeonifloride glycoside, etc.; monoterpene with lactone structure and its glycosides, such compounds include paeonifloride A, B, C; Lactinolide, 6-O-B-D-glucopyranosyl-lactinolide, etc. In addition, there are oxidized paeoniflorin, paeoniflorin, paeoniflorin, galloyl paeoniflorin and so on.

The pharmacological effects of Radix Paeoniae Rubra include effects on the blood system. Pharmacological studies have shown that Radix Paeoniae Rubra inhibits platelet aggregation, improves the permeability of red blood cells, increases the resistance of red blood cells to hypotonic tension, and has a certain effect on stabilizing the membrane structure of red blood cells. In addition, total glucosides of paeony can significantly prolong the coagulation time of rats and mice, and can prolong the time of electrical stimulation of rat common carotid artery thrombosis, suggesting that total glucosides of paeony exert anti-inflammatory effects through the influence of coagulation system and platelet function. Thrombosis. effect on cardiovascular. Radix Paeoniae Rubra is a traditional traditional Chinese medicine for promoting blood circulation and removing blood stasis. It has a strong anti-atherosclerosis effect. The drug can also expand coronary vessels, increase coronary blood flow and thereby increase myocardial nutritional blood flow; Myocardial tolerance to hypoxia; reduce pulmonary vascular resistance, reduce afterload. At the same time, Radix Paeoniae Rubra can reduce portal hypertension and also affect microcirculation. effect on tumors. Paeoniflorin can inhibit the activity of adenosine triphosphate (ATP) enzyme on the tumor cell membrane and increase the activity of adenylate cyclase. Zhu Jianhua et al. conducted mutagenic and anti-mutagenic experiments on the water-soluble extract of Radix Paeoniae Rubra, and the results showed that the water-soluble extract of Radix Paeoniae Rubra had obvious anti-mutagenic effects, and it was enhanced with the increase of concentration. effect on the liver. Radix Paeoniae Rubra and other blood-activating and stasis-removing drugs have the effects of reducing jaundice, inhibiting the production of thromboxane B2 in plasma, promoting liver hydrolysis, resisting liver fibrosis, and promoting liver cell regeneration. Radix Paeoniae Rubra also has anti-inflammation, anti-allergic effects, the effect of scavenging active oxygen free radicals, also has the effect of nourishing and strengthening, and also has a certain effect on the nervous system.

Atractylodes macrocephala is one of the commonly used traditional Chinese medicines in my country. It is the dry rhizome of Atractylodes macrocephala Koidz. of Compositae. It is warm in nature, sweet in taste and bitter in taste. Weakness of breath, diarrhea, sweating, restless fetal movement, etc. It is mainly produced in Zhejiang and Anhui, with the largest output in Yinxian and Xinchang, Zhejiang. The quality of Yuqian is the best. It is specially called "Yushu". The chemical composition of Atractylodes macrocephala is relatively complex, and it is known that it mainly contains volatile oil, lactones, and polysaccharides. The volatile oil in the rhizome of Atractylodes Rhizome contains about 1.4%, and its main components are atratylon, atractylodes alcohol, etc. Atractylodes atractylodes is extracted by percolation with ethanol, separated by silica gel chromatography, and then eluted with petroleum ether-ether gradient to obtain Atractylodes lactone Ⅰ (atractylenolide Ⅰ), atractylenolide Ⅱ (atractylenolide Ⅱ), atractyl-enolide Ⅲ (atractyl-enolide Ⅲ), 8B-ethoxy atractylenolide Ⅲ (8B-ethoxyatractylenolide Ⅲ). Atractylodes macrocephala contains Atractylodes polysaccharide PM, mannan Am-3 and so on. Two heteropolysaccharides, PSAM-1 and PSAM-2, were obtained by separating the extract and sediment of Atractylodes Rhizoma Atractylodes Rhizome through 732 strong-acid cation exchange resin and boric acid-type DEAE-cellulose column. In addition, Atractylodes macrocephala also contains 12A-methylbutyryl-14-acetyl-8-cis-atractyltriol, 12A-methylbutyryl-14-acetyl-8-trans-atractyltriol, 14A-methylbutyryl -8-cis-atractyltriol, 14A-methylbutyryl-8-trans-atractyltriol[5], atratylenolactam, taraxerylacetate, junipercomphor, palm Acid, B-myringin acetate, C-sitosterol, B-sitosterol, C-spinasterol. Atractylodes macrocephala also contains 14 kinds of amino acids such as glutamic acid, resin, vitamin A and other substances.

Atractylodes macrocephala is the most commonly used medicine for invigorating qi. It has the effects of invigorating the spleen and replenishing qi, drying dampness and diuresis, strengthening the surface and antiperspirant. Modern pharmacological studies have shown that Atractylodes macrocephala has immune regulation, diuretic, anti-tumor, antibacterial and anti-inflammatory, hypoglycemic, anti-aging, etc. It also has a certain effect on the nervous system, digestive tract, and uterine smooth muscle, and can also regulate immune function.

Phellodendron phellodendron, also known as Phellodendron chinense Schneid. or Phello-dendron amurense Rupr, is the dry bark of Phellodendron chinense Schneid. or Phello-dendron amurense Rupr. Yellow bark is mainly produced in Sichuan, Guizhou and other provinces of my country. Phellodendron amurense is mainly produced in Jilin, Liaoning, Heilongjiang and other provinces. Traditional Chinese medicine believes that Cortex Phellodendri is cold in nature and bitter in taste, governs the kidney and bladder meridians, has the effects of clearing away heat and dampness, purging fire and detoxification, and clearing away asthenic heat. It is mainly used to treat gastrointestinal diseases. Studies have shown that Phellodendron Phellodendri has anti-pathogenic microorganisms: according to [PhytotherRes] records, the alcohol extracts of Phellodendron Phellodendri and Coptis Rhizoma have obvious inhibitory effect on mouse auricle inflammation induced by xylene (P<0.05); Inject 200mg (kg), produce the same antibacterial effect as intravenous dexamethasone 100mlPmg. Phellodendron Phellodendri has inhibitory effect on gastric ulcer: Experiments have proved that the water-soluble components of Phellodendron Phellodendron without alkaloids can inhibit the reduction of SOD activity in water immersion restraint stress mice, can significantly increase the amount of PFE2 before water immersion, and inhibit the water immersion after water immersion. The trend of reducing the amount of PGE2. It shows that it has inhibitory effect on gastric ulcer.

The compatibility of the traditional Chinese medicine composition needs to treat the disease according to the theory of traditional Chinese veterinary medicine based on syndrome differentiation, screening of prescriptions, and reasonable compatibility, so as to achieve a significant effect on the prevention and treatment of the disease. Therefore, the pharmacological effects of drugs with different compatibility are also different. The above-mentioned pulsatilla, codonopsis, red peony, Atractylodes macrocephala, dried ginger, tangerine peel, Phellodendron cortex, licorice and other medicines are combined together, and the whole prescription has the effects of clearing away heat and detoxification, strengthening the spleen and nourishing the stomach, strengthening the body and eliminating pathogens, drying dampness and stopping dysentery.

The beneficial effect of the present invention compared with the prior art: the present invention is based on the principles of antibacterial and anti-inflammation, stopping dysentery and hemostasis, improving body immunity, and repairing intestinal function. The composition is reasonable, the preparation process is simple, and the application range is wide. The invention is made of pure Chinese herbal medicinal materials, has wide sources, low cost, high cure rate, no drug residue, no toxic and side effects, especially the same decoction and extraction, which maintains the traditional Chinese medicine technology and is easier to absorb. It has obvious functions of clearing away heat and detoxifying, drying dampness and stopping dysentery, warming and tonifying the stomach and intestines, and regulating body functions. It can effectively treat various types of diarrhea and shorten the recovery period. Easy to use. Clinical trials have proved that the cure rate is over 85%, and it has a unique curative effect.

Detailed ways

Below in conjunction with preferred embodiment, the specific implementation mode provided according to the present invention is described in detail as follows:

Example 1

According to the weight ratio of 8000g: 1000g: 1000g: 1000g: 1000g: 1000g: 1000g: 1000g, weigh Pulsatilla, Codonopsis Radix, Radix Paeoniae Rubra, Atractylodes Rhizoma Atractylodes Rhizome, Dried Ginger, Tangerine Peel, Phellodendron Phellodendri, and Licorice, and decoct the above eight Chinese herbal medicines with water twice, Combine the decoctions for 0.5 hours each time, filter, concentrate the filtrate to obtain extracts, dry and pulverize the extracted medicinal residues, and pass through an 8-mesh sieve to obtain medicinal residues powder. According to extract: sucrose powder (weight ratio) 1:1 ratio, add sucrose powder into the extract, stir evenly, add appropriate amount of dregs powder, stir evenly until hand-kneaded into pieces, and then dry to prepare granules, pass through a 10-mesh sieve, and dry Subpackaged afterwards; when used to prevent and treat various types of piglet diarrhea, add 10g per kilogram of feed to the feed, mix feed, and use continuously for 3 days.

Example 2

According to the weight ratio of 9000g: 1500g: 1500g: 1000g: 1000g: 1000g: 1000g: 1000g, weigh Pulsatilla, Codonopsis, Radix Paeoniae Rubra, Atractylodes Rhizoma Atractylodes Rhizome, Dried Ginger, Tangerine Peel, Phellodendron Phellodendri, and Licorice, and decoct the above eight Chinese herbal medicines with water twice, Combine the decoctions for 0.5 hours each time, filter, concentrate the filtrate to obtain extracts, dry and pulverize the extracted medicinal residues, and pass through a 10-mesh sieve to obtain medicinal residues powder. According to the extract: sucrose powder (weight ratio) 1:1 ratio, add sucrose powder to the extract, stir evenly, add appropriate amount of dregs powder, stir evenly until hand-kneaded into pieces, and then dry to prepare granules, pass through a 15-mesh sieve, and dry Subpackage later. When used to prevent and treat various types of piglet diarrhea, add 20g per kilogram of feed to the feed, and mix it for 4 consecutive days.

Example 3

According to the weight ratio of 10000g: 2000g: 1000g: 1500g: 1500g: 1500g: 1500g: 1500g, weigh Pulsatilla, Codonopsis, Radix Paeoniae Rubra, Atractylodes Rhizoma Atractylodes Rhizome, Dried Ginger, Tangerine Peel, Phellodendron Phellodendri, and Licorice, and decoct the above eight Chinese herbal medicines with water twice, Combine the decoctions for 0.5 hours each time, filter, concentrate the filtrate to obtain extracts, dry and pulverize the extracted medicinal residues, and pass through a 15-mesh sieve to obtain medicinal residues powder. According to extract: sucrose powder (weight ratio) 1:1 ratio, add sucrose powder into the extract, stir evenly, add appropriate amount of dregs powder, stir evenly until hand-kneaded into pieces, and then dry to prepare granules, pass through a 20-mesh sieve, and dry Subpackage later. When used to prevent and treat various types of piglet diarrhea, add 30g per kilogram of feed to the feed, and mix it for 5 consecutive days.

Example 4

According to the weight ratio of 10000g: 2000g: 1000g: 1500g: 1500g: 1500g: 1500g: 1500g, weigh Pulsatilla, Codonopsis, Radix Paeoniae Rubra, Atractylodes Rhizoma Atractylodes Rhizome, Dried Ginger, Tangerine Peel, Phellodendron Phellodendri, and Licorice, and decoct the above eight Chinese herbal medicines with water twice, Each time for 0.5 hours, the decoctions were combined, filtered, and the filtrate was concentrated to obtain an extract, and the extracted dregs were dried and pulverized, and passed through a 20-mesh sieve to obtain a dregs powder. According to extract: sucrose powder (weight ratio) 1:1 ratio, add sucrose powder into the extract, stir evenly, add appropriate amount of dregs powder, stir evenly until hand-kneaded into pieces, and then dry to prepare granules, pass through a 20-mesh sieve, and dry Subpackage later. When used to prevent and treat various types of piglet diarrhea, add 30g per kilogram of feed to the feed, and mix it for 5 consecutive days.

Clinical Trials:

Example 1:

Some kind of pig farm in Fushan, Landrace pigs

The farm raised 1,000 Landrace piglets, about 150 of which died 3 days after weaning (15% mortality rate), and another 200 or so had diarrhea, watery feces, and loss of appetite. The clinical and laboratory diagnosis was bacterial piglet diarrhea caused by Escherichia coli. 100 affected piglets were given oral antibiotics such as enrofloxacin, 30 recovered, 15 died, and 55 remained ill. Due to the inability to be completely cured, the last part of the piglets was eliminated. The remaining 100 sick piglets were given the pharmaceutical composition of Example 1 orally. After 4 days, the number of sick piglets dropped to 15, and 5 died. The remaining 80 piglets recovered and were reared for 150 days before being slaughtered.

The pharmaceutical composition of Example 1 was given orally to all piglets without disease, and no symptoms of diarrhea occurred in the piglets, and they were fed to 150 days, and all piglets were slaughtered.

Example 2:

Some kind of pig farm in Laiyang, Yantai, Duroc pigs

The farm raised 1,500 piglets, 500 of which had diarrhea, watery feces, and loss of appetite 2 days after weaning, and 210 of them died. The clinical and laboratory diagnosis was piglet diarrhea caused by rotavirus infection. 250 affected piglets were given antibiotics such as enrofloxacin. 45 piglets recovered, 75 piglets died, and 130 piglets remained ill. Another 250 diseased piglets took the pharmaceutical composition of Example 2 orally. After 3 days, the diseased piglets were reduced to 10, 3 died, and the remaining 237 recovered. They were fed to 150 days and finally all healthy for slaughter. After raising another batch until 3 days after weaning, the same clinical symptoms appeared. After judging as rotavirus infection, the whole group took the pharmaceutical composition of the invention embodiment 2 and the method of use orally, and the diarrhea condition was controlled after 3 days, and only 5 piglets died. Head, the effect is obvious.

Example 3:

A certain pig farm in Yantai, the local breed of black mountain pig

The farm raised 2,000 piglets, 900 piglets had diarrhea, watery feces, and loss of appetite 2 days after weaning, and 310 piglets died. Clinical and laboratory diagnosis of piglet diarrhea virus-infected piglets, 300 diseased piglets oral antibiotics such as enrofloxacin, 60 recovered, 90 died, and 150 still sick. Another 300 diseased piglets took the pharmaceutical composition of Example 3 orally. After 3 days, the diseased piglets were reduced to 12, 5 died, and the remaining 283 recovered. They were fed to 150 days and finally all healthy for slaughter. Remaining 300 orally took the medicine of embodiment 4, and 3 days later, the diseased piglets were reduced to 8, and 3 died, and the remaining 289 recovered, fed to 150 days, and finally all healthy piglets were slaughtered. After raising another batch until 2 days after weaning, the same clinical symptoms appeared. After judging that they were infected with rotavirus, half of them took the pharmaceutical composition and the method of use of the invention embodiment 3 orally, and the other half used the pharmaceutical composition of the invention embodiment 3 And the method of use, the diarrhea condition was controlled after 3 days, and only 5 piglets died, and the effect was obvious.

The medicine of the invention has no toxic and side effects and is convenient to use.

The above-mentioned detailed description of the Chinese medicine composition for preventing and treating piglet diarrhea with reference to the examples is illustrative rather than limiting, and several examples can be listed according to the limited scope, so without departing from the general concept of the present invention Changes and modifications should fall within the protection scope of the present invention.

Claims (3)

1. a Chinese medicine composition for prevention and therapy piglet diarrhea, is characterized in that it comprises following Chinese medicinal ingredients and weight portion: the Radix Pulsatillae 8 ~ 12 parts, Radix Codonopsis 1 ~ 3 part, Radix Paeoniae Rubra 1 ~ 3 part, the Rhizoma Atractylodis Macrocephalae 1 ~ 3 part, Rhizoma Zingiberis 1 ~ 3 part, Pericarpium Citri Reticulatae 1 ~ 3 part, Cortex Phellodendri 1 ~ 3 part, 1 ~ 3 part, Radix Glycyrrhizae composition.

2. the preparation method of Chinese medicine composition according to claim 1, it is characterized in that its step: by described 8 ~ 12 portions of Radix Pulsatillaes, 1 ~ 3 part of Radix Codonopsis, 1 ~ 3 part of Radix Paeoniae Rubra, 1 ~ 3 part of Rhizoma Atractylodis Macrocephalae, 1 ~ 3 portion of Rhizoma Zingiberis, 1 ~ 3 part of Pericarpium Citri Reticulatae, 1 ~ 3 portion of Cortex Phellodendri, 1 ~ 3 part of Radix Glycyrrhizae water drug-decocting concentrating liquid prepares extractum, medicinal residues crushed after being dried after extraction, cross 8 ~ 20 mesh sieves, obtain medicinal residues powder, in extractum: cane sugar powder (weight ratio) 1:1 ratio adds cane sugar powder in extractum, stir, add medicinal residues powder, stir, rear drying is prepared into granule and crosses 8 ~ 20 mesh sieves, subpackage and get final product.

3. the application process of Chinese medicine composition described in claim 1 or 2, add 20 ~ 60 grams of described Chinese medicine compositions according to per kilogram feedstuff when it is characterized in that described composition of medicine uses, mixed feeding 3 ~ 5 days is a course for the treatment of.