CN107485584A - A kind of oral care composition - Google Patents
A kind of oral care composition Download PDFInfo
- Publication number
- CN107485584A CN107485584A CN201710635933.1A CN201710635933A CN107485584A CN 107485584 A CN107485584 A CN 107485584A CN 201710635933 A CN201710635933 A CN 201710635933A CN 107485584 A CN107485584 A CN 107485584A
- Authority
- CN
- China
- Prior art keywords
- cordyceps militaris
- oral care
- care composition
- elite
- alcohol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K33/00—Medicinal preparations containing inorganic active ingredients
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- A—HUMAN NECESSITIES
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- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
- A61K36/068—Cordyceps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention discloses a kind of oral care composition, includes Cordyceps militaris elite, the alcohol of O cymenes 5 and sylvite.Oral care composition each component compounding use of the present invention, there is high efficiency anti-inflammatory bacteriostasis.The invention also discloses a kind of application of oral care composition in oral care product is prepared；The oral care product is toothpaste, mouthwash or buccal cavity gel, routine use contains the oral care product of the oral cavity composition of the present invention, it can more effectively treat and prevent mouth disease, such as the bleeding of gum redness, gingivitis, hemodia oral problem.
Description
Technical field
The present invention relates to a kind of composition, and in particular to a kind of oral care composition.
Background technology
With the enhancing of consciousness and the raising of quality of the life of the people to health, have greatly to the attention degree of oral care
Enhancing.Most of diseases of people are all by caused by oral cavity, and it is prophylactic important step to keep oral hygiene, if
Tooth is unhygienic, and substantial amounts of microorganism breeds wherein, corrodes tooth, causes halitosis, gum swelling etc., more serious tooth disease
Disease can also result in other serious systemic diseases.
The inflammatory disorderses that gingivitis refers to that gum gum edge and gum nipple are congested, infiltrates, oozes out, are that department of stomatology Emergency call is common
The category such as disease, the toothache of the category traditional Chinese medical science, third molar abscess, bleeding from the gum, gingivitis is one of most common oral diseases of the mankind, all over the world
Each department, each ethnic, each age level, its illness rate are up to more than 90%, and gingivitis turns into prominent oral health problem.
Gingivitis is the inflammation of gingiva tissue, using bleeding gums as principal character, is typically easily gone out when brushing teeth, sucking and chew hard thing
Blood, gum are in scarlet or aubergine, and swelling or soft, surface is shinny, locally there is dental calculus, soft dirt, plaque build-up, advantage gum
Edge is rotten to the corn, and extruding gum edge has a small amount of fester to discharge, and may occur in which that gum papilledema and gingival sulcus are deepened, or even forms gum purulence
It is swollen.The pathogenic factor of most of gingivitis case is caused by local factor, mainly embedding by the bacterial plaque, calculus or food in neck portion
Plug, which stimulates, causes bleeding gums, and oedema produces gingivitis, periodontitis.Gingival sulcus endothelial tissue is congested, and inflammatory reaction makes granulation tissue shape
Into easily causing angiorrhoxis bleeding (such as visit examine method is improper, scaling bleeding) once being upset.The morbidity of some cases
Reason is caused by systemic factor, such as hypertension, coronary heart disease, diabetes, hepatic sclerosis, blood disease.
Clinical treatment gingivitis uses periodental non-surgical treatment more, while coordinates whole body or topical application antibiotic and chemistry
Synthetic drug.Although periodental non-surgical treatment is effective to removing bacterial plaque and controlling inflammation, bacterial plaque is controlled to exist for a long time
Desirable level is highly difficult.Whole body long-term use antibiotic is likely to result in flora imbalance, produces the adverse consequences such as drug resistance,
And medicine local concentration is relatively low.Although periodontal local application can avoid the adverse consequences that systemic administration is likely to occur,
There is in-convenience in use, cause a variety of side effects, produce drug resistance the shortcomings of.In addition, various periodontal local applications agent at present
Most of type predominantly restraining and sterilizing bacteria preparation, or some biological membrane preparations are only capable of playing a part of promoting gingiva tissue regeneration, because
This people expects that one kind both has antiinflammatory and bacteriostatic functions, the oral care substance having no side effect again.
The content of the invention
A kind of oral care composition is provided it is an object of the invention to overcome the shortcomings of the prior art part.
To achieve the above object, the technical scheme taken of the present invention is：A kind of oral care composition, include Cordyceps militaris essence
China, O- cymene -5- alcohol and sylvite；The Cordyceps militaris elite is the mixture of Cordyceps militaris extract and fruiting bodies of cordyceps militaris.
Cordyceps militaris, be the edible mushroom of food and medicament dual-purpose, Cordyceps militaris extract of the present invention, can by commercially available,
It can be the refined extract of fruiting bodies of cordyceps militaris gained after water extract-alcohol precipitation.Fruiting bodies of cordyceps militaris is to pass through Cordyceps militaris spawn
It is inoculated on solid medium, after the regular hour cultivates, the stroma of crocus is differentiated to form from hyphostoma development
(fructification), and this new fresh sporophore is gathered into laggard sector-style again and dry grinded obtained by the processing of powder；Fructification powder passes through water extracting alcohol
After refined processing after heavy, cordycepin, adenosine, cordycepic acid, polysaccharide, SOD enzymes and other functional ingredient are efficiently concentrated, especially
It is cordycepin functional component.
Fruiting bodies of cordyceps militaris in the present invention, it is made up of materials such as moisture, ash content, protein, fat, wherein containing more
Kind volatile compound, it is in the majority with aromatic aldehydes material, there is certain antibacterial and anti-inflammatory effect, but aromatic volatile composition is equal
More than one hour can not be retained under 50 DEG C of extraction temperature.Therefore, the active ingredient in fruiting bodies of cordyceps militaris definitely can not
Remained in above-mentioned refined heating purification process, therefore the present invention is by the addition of fruiting bodies of cordyceps militaris, can allow pupa worm
The grass seed entity volatile ingredient of itself completely enters toothpaste system.
Cordycepin, is first nucleosides separated from fungi antibiotics, molecular structure 3 ,-desoxyadenossine,
There is broad-spectrum antiseptic, research is found, it can suppress the growth of the pathogens such as streptococcus, staphylococcus, and cordycepin
Also there is stronger antiviral activity, therefore be applied to that in oral cavity composition natural antibacterial, anti-inflammatory, antiviral work(can be played
Effect.Because cordycepin is the main antipathogenic composition in Cordyceps militaris elite, and Cordyceps militaris elite addition directly affects cordycepin and existed
Content in oral cavity composition.
The present invention uses fruiting bodies of cordyceps militaris collocation Cordyceps militaris extract, can make in system containing cordycepin, cordyceps sinensis
Outside the multiple efficacies compositions such as acid, polysaccharide, SOD enzymes, the also volatile ingredient containing fruiting bodies of cordyceps militaris itself, so as to allow shield gum
The effect of protecting tooth is played to optimal.
O- cymene -5- alcohol, it is a kind of bactericide of wide spectrum, there is potent infiltration bactericidal action, to golden yellow grape
The oral cavity pathogens such as coccus, porphyromonas gingivalis all have good antibacterial effect, can penetrate into bacterial plaque inner sterilization,
Suitable for inflammatory patients such as gingivitis, periodontitis, optional commercially available prod, such as Nanjing Si Baike biochemistry Industrial Co., Ltd.
Isopropyl Methylphenol etc..
The release of potassium ion, the nerve endings of dentinal tubule can be prevented to be activated, under enough potassium concentrations,
It can avoid pressing Intradental nerve to be upset, the permeability of dentine be reduced, so as to slow down the situation of dentine hypersensitivity.Therefore work as
When in composition containing enough soluble potassium salt and applied in oral care product formulation, help to alleviate tooth to it is cold,
Heat, acid, sweet tea or sensitiveness pain caused by contact.
Cordyceps militaris elite, O- cymene -5- alcohol and sylvite are together applied in oral care composition of the present invention,
Energy compound synergic, while playing hemostasis, shield gum, Shu Min effects, it greatly strengthen the respective anti-inflammatory in oral care respectively
Fungistatic effect.
Preferably, the weight ratio of the Cordyceps militaris elite and the O- cymenes -5- alcohol is：0.5~50:0.1~1；
The ratio between the weight of the O- cymenes -5- alcohol and the amount of material of the Potassium In Potassium ion are：(0.1~1) g：(0.3~1)
mol。
The ratio between the weight of the O- cymenes -5- alcohol and the amount of material of the Potassium In Potassium ion are：(0.1~1) g：
(0.3~1) mol, can also be expressed as：The amount of the weight of the O- cymenes -5- alcohol and the material of the Potassium In Potassium ion
The ratio between be：0.1~1：0.3~1g/mol.
In view of the medicinal effects of composition, when Cordyceps militaris elite, O- cymene -5- alcohol and sylvite use said ratio
When, this effects of antiinflammation and bacteriostasis significantly increases, and can effectively mitigate gum redness bleeding problems.
It is highly preferred that the weight ratio of the Cordyceps militaris elite and the O- cymenes -5- alcohol is：1~30:0.5~
0.8；The ratio between the weight of the O- cymenes -5- alcohol and the amount of material of the Potassium In Potassium ion are：(0.5~0.8) g：
(0.3~0.53) mol.
The ratio between the weight of the O- cymenes -5- alcohol and the amount of material of the Potassium In Potassium ion are：(0.5~0.8)
g：(0.3~0.53) mol, can also be expressed as：The weight of the O- cymenes -5- alcohol and the material of the Potassium In Potassium ion
The ratio between amount be：0.5~0.8：0.3~0.53g/mol.
Cordyceps militaris elite, O- cymene -5- alcohol and sylvite cooperate under aforementioned proportion, anti-inflammatory fungistatic effect more preferably,
Bleeding gums, sensitivity of tooth problem can be efficiently solved.
Preferably, weight percentage of the fruiting bodies of cordyceps militaris in Cordyceps militaris elite is 0.01~20%.
When Cordyceps militaris extract and fruiting bodies of cordyceps militaris use above-mentioned weight ratio, both can give full play to respective effect,
System is set to contain cordycepin, cordycepic acid, polysaccharide, SOD enzymes and a variety of volatile compounds, so as to reach the work(of shield gum shield tooth
Effect.
It is highly preferred that weight percentage of the fruiting bodies of cordyceps militaris in Cordyceps militaris elite is 8~15%.
When Cordyceps militaris extract and fruiting bodies of cordyceps militaris use above-mentioned weight ratio, what the oral care composition reached kills
Bacterium best results.
Preferably, the sylvite is at least one of potassium nitrate, potassium citrate, potassium chloride and potassium oxalate.
Present invention also offers a kind of application of above-mentioned oral care composition in oral care product is prepared；The mouth
Chamber care product is toothpaste, mouthwash or buccal cavity gel.
Preferably, the concentration for the potassium ion that the Potassium In Potassium ion provides in oral care product is 0.3~1mol/
kg。
, can be in oral care product preferably when addition of the potassium ion in oral care product is above-mentioned content
Effects of antiinflammation and bacteriostasis is played, the oral problems such as the bleeding of gum redness, gingivitis, hemodia can be improved.
The beneficial effects of the present invention are：The invention provides a kind of oral care composition, the oral care combination
Thing each component compounding use, there is stronger effects of antiinflammation and bacteriostasis, by oral care composition of the present invention be applied to toothpaste,
In the product of the oral cares such as mouthwash, buccal cavity gel, routine use contains the oral care production of the oral cavity composition of the present invention
Product, it can more effectively treat and prevent mouth disease, such as the bleeding of gum redness, gingivitis, hemodia oral problem.
Embodiment
To better illustrate the object, technical solutions and advantages of the present invention, below in conjunction with specific embodiment to the present invention
It is described further.
Embodiment 1
A kind of toothpaste for including oral care composition of the present invention, the preparation comprising following weight percentage are former
Material：Oral care composition 3.09%, NMF 50%, rubbing agent 22%, thickener 2%, foaming agent 2%, sweetener 1%,
The deionized water of pH adjusting agent 2%, spices 1% and surplus；
Wherein, in the oral care composition, the sylvite is potassium nitrate, the Cordyceps militaris elite, O- cymenes -5-
The weight ratio of alcohol and potassium nitrate is：Cordyceps militaris elite：O- cymene -5- alcohol：Potassium nitrate=0.05:0.01:3.03；The pupa
Lungfit is the mixture of Cordyceps militaris extract and fruiting bodies of cordyceps militaris, the Cordyceps militaris extract and fruiting bodies of cordyceps militaris
Weight ratio is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=99.9：0.01；The NMF is D-sorbite；The thickener
For sodium carboxymethylcellulose；The foaming agent is sodium lauroyl sarcosine and the mixture of lauryl sodium sulfate；The friction
The mixture of agent precipitated silica and superfine silicon dioxide, weight of the superfine silicon dioxide in the preparing raw material of the toothpaste
Percentage composition is 2%；The sweetener is saccharin sodium；The spices is menthol；The pH adjusting agent be alkaline phosphate and
Sodium dihydrogen phosphate.
Embodiment 2
A kind of toothpaste for including oral care composition of the present invention, the preparation comprising following weight percentage are former
Material：Oral care composition 15.3%, NMF 50%, rubbing agent 22%, thickener 2%, foaming agent 2%, sweetener 1%,
The deionized water of pH adjusting agent 2%, spices 1% and surplus；
Wherein, in the oral care composition, the sylvite is potassium citrate, the Cordyceps militaris elite, O- cymenes-
The weight ratio of 5- alcohol and potassium citrate is：Cordyceps militaris elite：O- cymene -5- alcohol：Potassium citrate=5:0.1:10.2；It is described
Cordyceps militaris elite is the mixture of Cordyceps militaris extract and fruiting bodies of cordyceps militaris, the Cordyceps militaris extract and fruiting bodies of cordyceps militaris
Weight ratio be：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=80：20；The NMF is D-sorbite；The thickener is
Sodium carboxymethylcellulose；The foaming agent is sodium lauroyl sarcosine and the mixture of lauryl sodium sulfate；The rubbing agent
The mixture of precipitated silica and superfine silicon dioxide, weight hundred of the superfine silicon dioxide in the preparing raw material of the toothpaste
It is 2% to divide content；The sweetener is saccharin sodium；The spices is menthol；The pH adjusting agent is alkaline phosphate and phosphorus
Acid dihydride sodium.
Embodiment 3
A kind of toothpaste for including oral care composition of the present invention, the preparation comprising following weight percentage are former
Material：Oral care composition 5.18%, NMF 50%, rubbing agent 22%, thickener 2%, foaming agent 2%, sweetener 1%,
The deionized water of pH adjusting agent 2%, spices 1% and surplus；
Wherein, in the oral care composition, the sylvite is potassium nitrate, the Cordyceps militaris elite, O- cymenes -5-
The weight ratio of alcohol and potassium nitrate is：Cordyceps militaris elite：O- cymene -5- alcohol：Potassium nitrate=0.1：0.08：5；The Cordyceps militaris
Elite is the mixture of Cordyceps militaris extract and fruiting bodies of cordyceps militaris, the weight of the Cordyceps militaris extract and fruiting bodies of cordyceps militaris
Than for：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=92：8；The NMF is D-sorbite；The thickener is carboxymethyl
Sodium cellulosate；The foaming agent is sodium lauroyl sarcosine and the mixture of lauryl sodium sulfate；The rubbing agent precipitation two
The mixture of silica and superfine silicon dioxide, weight percentage of the superfine silicon dioxide in the preparing raw material of the toothpaste
For 2%；The sweetener is saccharin sodium；The spices is menthol；The pH adjusting agent is alkaline phosphate and biphosphate
Sodium.
Embodiment 4
A kind of toothpaste for including oral care composition of the present invention, the preparation comprising following weight percentage are former
Material：Oral care composition 8.4%, NMF 50%, rubbing agent 22%, thickener 2%, foaming agent 2%, sweetener 1%, pH
The deionized water of conditioning agent 2%, spices 1% and surplus；
Wherein, in the oral care composition, the sylvite is potassium nitrate, the Cordyceps militaris elite, O- cymenes -5-
The weight ratio of alcohol and potassium nitrate is：Cordyceps militaris elite：O- cymene -5- alcohol：Potassium nitrate=3：0.05：5.35；The pupa worm
Careless elite is the mixture of Cordyceps militaris extract and fruiting bodies of cordyceps militaris, the weight of the Cordyceps militaris extract and fruiting bodies of cordyceps militaris
Measuring ratio is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=85：15；The NMF is D-sorbite；The thickener is carboxylic first
Base sodium cellulosate；The foaming agent is sodium lauroyl sarcosine and the mixture of lauryl sodium sulfate；The rubbing agent precipitation
The mixture of silica and superfine silicon dioxide, weight percent of the superfine silicon dioxide in the preparing raw material of the toothpaste contain
Measure as 2%；The sweetener is saccharin sodium；The spices is menthol；The pH adjusting agent is alkaline phosphate and di(2-ethylhexyl)phosphate
Hydrogen sodium.
Embodiment 5
A kind of toothpaste for including oral care composition of the present invention, the preparation comprising following weight percentage are former
Material：Oral care composition 4.84%, NMF 50%, rubbing agent 22%, thickener 2%, foaming agent 2%, sweetener 1%,
The deionized water of pH adjusting agent 2%, spices 1% and surplus；
Wherein, in the oral care composition, the sylvite is potassium oxalate, the Cordyceps militaris elite, O- cymenes -5-
The weight ratio of alcohol and potassium oxalate is：Cordyceps militaris elite：O- cymene -5- alcohol：Potassium oxalate=2：0.08：2.76；The pupa worm
Careless elite is the mixture of Cordyceps militaris extract and fruiting bodies of cordyceps militaris, the weight of the Cordyceps militaris extract and fruiting bodies of cordyceps militaris
Measuring ratio is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=90：10；The NMF is D-sorbite；The thickener is carboxylic first
Base sodium cellulosate；The foaming agent is sodium lauroyl sarcosine and the mixture of lauryl sodium sulfate；The rubbing agent precipitation
The mixture of silica and superfine silicon dioxide, weight percent of the superfine silicon dioxide in the preparing raw material of the toothpaste contain
Measure as 2%；The sweetener is saccharin sodium；The spices is menthol；The pH adjusting agent is alkaline phosphate and di(2-ethylhexyl)phosphate
Hydrogen sodium.
Embodiment 6
A kind of mouthwash for including oral care composition of the present invention, the preparation comprising following weight percentage are former
Material：Oral care composition 5.29%, NMF 16%, food-grade ethanol 4%, surfactant 1.5%, sweetener 0.2%,
Spices 0.5%, sodium fluoride 0.23%, the deionized water of surplus.
Wherein, in the oral care composition, the sylvite is potassium chloride, the Cordyceps militaris elite, O- cymenes -5-
The weight ratio of alcohol and potassium chloride is：Cordyceps militaris elite：O- cymene -5- alcohol：Potassium chloride=3：0.05：2.24；The pupa worm
Careless elite is the mixture of Cordyceps militaris extract and fruiting bodies of cordyceps militaris, the weight of the Cordyceps militaris extract and fruiting bodies of cordyceps militaris
Measuring ratio is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=92：8；The NMF is D-sorbite；The surfactant is
The mixture of lauryl sodium sulfate and PEG-60 rilanit specials；The flavouring agent is spearmint oil；The sweetener is sugar
Smart sodium.
Embodiment 7
A kind of mouthwash for including oral care composition of the present invention, the preparation comprising following weight percentage are former
Material：Oral care composition 8.05%, NMF 16%, food-grade ethanol 4%, surfactant 1.5%, sweetener 0.2%,
Spices 0.5%, sodium fluoride 0.23%, the deionized water of surplus.
Wherein, in the oral care composition, the sylvite is potassium chloride, the Cordyceps militaris elite, O- cymenes -5-
The weight ratio of alcohol and potassium chloride is：Cordyceps militaris elite：O- cymene -5- alcohol：Potassium chloride=1：0.05：7；The Cordyceps militaris essence
The mixture of Huawei's Cordyceps militaris extract and fruiting bodies of cordyceps militaris, the weight ratio of the Cordyceps militaris extract and fruiting bodies of cordyceps militaris
For：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=92：8；The NMF is D-sorbite；The surfactant is 12
The mixture of sodium alkyl sulfate and PEG-60 rilanit specials；The flavouring agent is spearmint oil；The sweetener is saccharin sodium.
Embodiment 8
A kind of mouthwash for including oral care composition of the present invention, the preparation comprising following weight percentage are former
Material：Oral care composition 7%, NMF 16%, food-grade ethanol 4%, surfactant 1.5%, sweetener 0.2%, perfume
Material 0.5%, sodium fluoride 0.23%, the deionized water of surplus.
Wherein, in the oral care composition, the sylvite is potassium chloride, the Cordyceps militaris elite, O- cymenes -5-
The weight ratio of alcohol and potassium chloride is：Cordyceps militaris elite：O- cymene -5- alcohol：Potassium chloride=3：0.05：3.95；The pupa worm
Careless elite is the mixture of Cordyceps militaris extract and fruiting bodies of cordyceps militaris, the weight of the Cordyceps militaris extract and fruiting bodies of cordyceps militaris
Measuring ratio is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=92：8；The NMF is D-sorbite；The surfactant is
The mixture of lauryl sodium sulfate and PEG-60 rilanit specials；The flavouring agent is spearmint oil；The sweetener is sugar
Smart sodium.
Embodiment 9
A kind of buccal cavity gel for including oral care composition of the present invention, includes the preparation of following weight percentage
Raw material：Oral care composition 11.05%, thickener 2%, NMF 10%, surfactant 1%, sweetener 0.1%, perfume
Material 0.5%, sodium fluoride 0.23%, the deionized water of surplus.
Wherein, in the oral care composition, the sylvite is potassium nitrate, the Cordyceps militaris elite, O- cymenes -5-
The weight ratio of alcohol and potassium nitrate is：Cordyceps militaris elite：O- cymene -5- alcohol：Potassium nitrate=4：0.05：7；The Cordyceps militaris essence
The mixture of Huawei's Cordyceps militaris extract and fruiting bodies of cordyceps militaris, the weight ratio of the Cordyceps militaris extract and fruiting bodies of cordyceps militaris
For：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=80：20；The thickener is the mixing of sodium carboxymethylcellulose and carbomer
Thing, the mixture that the surfactant is poloxamer and PEG-60 rilanit specials；The spices is menthol；The sweet tea
Taste agent is Sucralose.
Embodiment 10
A kind of buccal cavity gel for including oral care composition of the present invention, includes the preparation of following weight percentage
Raw material：Oral care composition 9.63%, thickener 2%, NMF 10%, surfactant 1%, sweetener 0.1%, spices
0.5%th, sodium fluoride 0.23%, the deionized water of surplus.
Wherein, in the oral care composition, the sylvite is potassium nitrate, the Cordyceps militaris elite, O- cymenes -5-
The weight ratio of alcohol and potassium nitrate is：Cordyceps militaris elite：O- cymene -5- alcohol：Potassium nitrate=3：0.08：6.55；The pupa worm
Careless elite is the mixture of Cordyceps militaris extract and fruiting bodies of cordyceps militaris, the weight of the Cordyceps militaris extract and fruiting bodies of cordyceps militaris
Measuring ratio is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=80：20；The thickener is sodium carboxymethylcellulose and carbomer
Mixture, the mixture that the surfactant is poloxamer and PEG-60 rilanit specials；The spices is menthol；Institute
It is Sucralose to state sweetener.
Embodiment 11
A kind of buccal cavity gel for including oral care composition of the present invention, includes the preparation of following weight percentage
Raw material：Oral care composition 7.4%, thickener 2%, NMF 10%, surfactant 1%, sweetener 0.1%, spices
0.5%th, sodium fluoride 0.23%, the deionized water of surplus.
Wherein, in the oral care composition, the sylvite is potassium nitrate, the Cordyceps militaris elite, O- cymenes -5-
The weight ratio of alcohol and potassium nitrate is：Cordyceps militaris elite：O- cymene -5- alcohol：Potassium nitrate=2：0.05：5.35；The pupa worm
Careless elite is the mixture of Cordyceps militaris extract and fruiting bodies of cordyceps militaris, the weight of the Cordyceps militaris extract and fruiting bodies of cordyceps militaris
Measuring ratio is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=80：20；The thickener is sodium carboxymethylcellulose and carbomer
Mixture, the mixture that the surfactant is poloxamer and PEG-60 rilanit specials；The spices is menthol；Institute
It is Sucralose to state sweetener.
Comparative example 1
A kind of comparative example of toothpaste of the present invention, this comparative example the difference is that only with toothpaste described in embodiment 4
The composition of the oral care composition is different, and oral care composition described in this comparative example is O- cymene -5- alcohol and nitric acid
The mixture of potassium, the mass ratio of the O- cymenes -5- alcohol and potassium nitrate are：O- cymene -5- alcohol：Potassium nitrate=0.05:
5.35。
Comparative example 2
A kind of comparative example of toothpaste of the present invention, this comparative example the difference is that only with toothpaste described in embodiment 4
The composition of the oral care composition is different, and oral care composition described in this comparative example is Cordyceps militaris elite and potassium nitrate
The mass ratio of mixture, the Cordyceps militaris elite and potassium nitrate is：Cordyceps militaris elite：Potassium nitrate=3:5.35；The Cordyceps militaris
Elite is the mixture of Cordyceps militaris extract and fruiting bodies of cordyceps militaris, the weight of the Cordyceps militaris extract and fruiting bodies of cordyceps militaris
Than for：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=85：15.
Comparative example 3
A kind of comparative example of toothpaste of the present invention, this comparative example the difference is that only with toothpaste described in embodiment 4
The composition of oral care composition is different, and oral care composition described in this comparative example is O- cymene -5- alcohol and Cordyceps militaris essence
The mixture of China, the O- cymenes -5- alcohol and the mass ratio of Cordyceps militaris elite are：O- cymene -5- alcohol：Cordyceps militaris elite=
0.05:5.35；The Cordyceps militaris elite is the mixture of Cordyceps militaris extract and fruiting bodies of cordyceps militaris, the Cordyceps militaris extract
Weight ratio with fruiting bodies of cordyceps militaris is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=85：15.
Comparative example 4
A kind of comparative example of toothpaste of the present invention, this comparative example the difference is that only with toothpaste described in embodiment 4
This comparative example is free of oral care composition, and other preparing raw materials are same as Example 4.
Comparative example 5
The difference of mouthwash described in a kind of comparative example of mouthwash of the present invention, this comparative example and embodiment 7 is only
It is that this comparative example is free of oral care composition, other preparing raw materials are same as Example 7.
Comparative example 6
A kind of comparative example of buccal cavity gel of the present invention, this comparative example it is different from buccal cavity gel described in embodiment 10 it
Place is only that this comparative example is free of oral care composition, and other preparing raw materials are same as in Example 10.
Embodiment 12
By 1~5 toothpaste of embodiment, 6~8 mouthwash of embodiment, 9~11 buccal cavity gel of embodiment and right
1~3 toothpaste of ratio carries out antibacterial test for common several bacteriums in oral cavity.
Antibacterial method of testing：According to《Disinfection technology standard》2.1.8. anti-(suppression) equal test method, passes through third party's machine
Structure is tested.
The preparation of bacteria inhibition tablet：In the sterilized petri dishes of cleaning, a diameter of 5mm is made, thickness is no more than the suppression of 4mm disks (block)
Microbial inoculum original cream piece, one group of every 4 (blocks).
The preparation of negative control piece：Take sterile dry filter paper piece, every be added dropwise it is standby after sterile distilled water.
The inoculation of test organisms：Concentration is dipped as 5 × 10 with sterile cotton swab5Cfu/ml~5 × 106Cfu/ml test organisms hangs
Liquid, nutrient agar planar surface uniformly smear 3 times, often smear 1 time, flat board should rotate 60 °, finally by cotton swab around
Plate edge is smeared one week, is covered plate, is put drying at room temperature 5min.
Bacteriostatic agent print is placed with：Experiment is placed with 1 microbiological contamination flat board every time, and each flat board is placed with the examination of 4 same test groups
Test print, 1 negative control piece, totally 5.It is placed with aseptic nipper coupongs in planar surface.Between each print center apart
More than 25mm, the periphery with flat board is at a distance of more than 15mm.After being placed with, with the light pressure-like piece of aseptic nipper, it is set to be close to flat board
Surface.Plate is covered, puts 37 DEG C of incubators, culture 16h~18h observation results.With the direct of vernier caliper measurement antibacterial ring size and remember
Record, experiment are repeated 3 times.
The bacterial strain of this test has selected common oral cavity pathogen：Staphylococcus aureus, streptococcus mutans and gum
Porphyrin monococcus.
Antibacterial test evaluation standard：Inhibition zone diameter is more than 7mm person, has been judged to bacteriostasis；Inhibition zone diameter be less than or
Equal to 7mm person, no bacteriostasis is judged to.Test result is shown in Table 1.
1 antibacterial test result of table
As it can be seen from table 1 described in 1~5 toothpaste of embodiment, 6~8 mouthwash of embodiment, embodiment 9~11
The fungistatic effect of staphylococcus aureus, streptococcus mutans and porphyromonas monococcus is superior to buccal cavity gel and comparative example 1
The fungistatic effect of mouthwash described in~4 toothpaste, comparative example 5, buccal cavity gel described in comparative example 6, tooth especially described in comparative example 4
Mouthwash described in cream, comparative example 5, buccal cavity gel described in comparative example 6 can be considered no bacteriostasis, from embodiment 4 and comparative example 1~
The fungistatic effect contrast of 4 toothpaste can show that the fungistatic effect of toothpaste described in embodiment 4 does not add more than comparative example 1~4
Add or only with the addition of Cordyceps militaris elite, the fungistatic effect of the toothpaste of potassium nitrate and O- cymene -5- alcohol two of which, illustrate pupa
Lungfit, potassium nitrate and O- cymene -5- alcohol compound in certain proportion can play a part of Synergistic.
Embodiment 13
Clinical test is carried out to toothpaste of the present invention and 1~4 toothpaste of comparative example, specific testing program is as follows：
First, testing program
Double-blind randomized clinical trial designs, aspirations of the collection 127 with different degrees of gum redness bleeding problems by
Examination person, trial volunteer's age distribution are randomly divided into test group and control group I, II, III, IV at 15~59 years old, by subject, its
The middle people of test group 27, the people of control group I 26, the people of control group II 27, the people of control group III 23, the people of control group IV 24, test group and control
Group I, II, III, IV using 1~4 toothpaste of toothpaste of the present invention and comparative example is used, is adjusted using oral epidemiology respectively
The index of correlation of tooth and gum of the method inspection trial volunteer looked into when using toothpaste 4 weeks and 8 weeks.
2nd, application method
Toothbrush：Soft wire type toothbrush；
Dosage：Test group, the subject of control group I~IV are brushed teeth 2 times sooner or later daily, use 2 grams of toothpaste every time.
3rd, observation item and index
1st, gingival index (GI)
Check gingival margin near, it is remote in, cheek side, the situation in 4 regions of tongue side, be divided into 0~3 grade of standard, 0 point of (gum
Normally)；1 point (not bleeding is examined in gum mild inflammation, color mild change, Mild edema, spy)；2 points of (gum moderate inflammation, colors
Bleeding is examined in red, oedema, light, spy)；3 points (gingivitis is obvious, red and swollen, there is ulcer, automatic hemorrhagic tendency).
2nd, gingival sulcus bleeding index (SBI)
Check gingival margin near, it is remote in, cheek side, the situation in 4 regions of tongue side, be divided into 4 grades, 1 point (not bleeding)；2 points
(bleeding during light spy gingival sulcus, gum outward appearance are normal)；3 points (bleeding when visiting gingival sulcus, gum redden, no swelling)；4 points (gum has ulcer
Or other symptoms).
3rd, plaque index (PLI)
It is divided into 4 grades according to bacterial plaque amount, 0 point (Yin Yuan areas are without bacterial plaque)；1 point (visual examination without bacterial plaque, but can be in free gum with probe
And proximity scrapes thin layer bacterial plaque)；2 points (in gingival pocket, dissociate gum area or the soft deposit adjacent to the visible moderate bulk amount of facing
Thing)；3 points (in gingival pocket or free gum area and neighbouring facing have a large amount of soft deposit things).
4th, test result
GI, SBI, PLI value take the average value of trial volunteer's situation in every group, and result of the test is shown in Table 2~4.
The test group of table 2 and the GI values of control group compare
| Test group | Before experiment | After 4 weeks | After 8 weeks |
| Test group | 1.71±0.45 | 1.24±0.45 | 0.55±0.50 |
| Control group I | 1.63±0.36 | 1.50±0.55 | 1.42±0.36 |
| Control group II | 1.69±0.49 | 1.50±0.46 | 1.40±0.59 |
| Control group III | 1.70±0.47 | 1.59±0.48 | 1.45±0.48 |
| Control group IV | 1.69±0.68 | 1.62±0.59 | 1.60±0.63 |
The test group of table 3 and the SBI values of control group compare
| Test group | Before experiment | After 4 weeks | After 8 weeks |
| Test group | 3.27±0.43 | 2.03±0.53 | 1.44±0.59 |
| Control group I | 3.45±0.63 | 3.03±0.50 | 2.85±0.45 |
| Control group II | 3.52±0.45 | 3.02±0.44 | 2.81±0.20 |
| Control group III | 3.42±0.54 | 2.75±0.58 | 2.56±0.60 |
| Control group IV | 3.39±0.58 | 3.26±0.45 | 2.96±0.61 |
The test group of table 4 and the PLI values of control group compare
| Test group | Before experiment | After 4 weeks | After 8 weeks |
| Test group | 2.37±0.55 | 1.64±0.45 | 1.02±0.60 |
| Control group I | 2.41±0.63 | 2.23±0.40 | 2.02±0.52 |
| Control group II | 2.46±0.50 | 2.06±0.55 | 1.60±0.55 |
| Control group III | 2.36±0.49 | 1.92±0.57 | 1.49±0.44 |
| Control group IV | 2.36±0.56 | 2.30±0.57 | 2.20±0.45 |
From table 2~4 as can be seen that compared with comparative example 1~4, the toothpaste containing oral care composition of the present invention
Effectively treatment gingivitis, more effectively treats bleeding gums, swelling and pain relieving, and test group is compared with control group, has conspicuousness
Difference (P ＜ 0.05).
Embodiment 14
Bacteriostatic test is carried out to mouthwash described in embodiment 6~8, comparative example 5, specific test method is as follows：
First, test strain：Staphylococcus aureus (ATCC 6538).
2nd, strain inoculum density is：With the good strain of normal saline dilution culture, 50cfu/g~200cfu/g bacterium solutions are made.
3rd, result count and evaluation
Result count：Result count is counted by bacterium colony technical method in GB/T 7918.2.
Evaluation method：The percentage declined using clump count is used as evaluation index.The calculation of the index is as follows：
In formula：A0The content of microorganisms of mouthwash during to be initially added microorganism；AnCounted for the detection time of different interval
Content of microorganisms.
4th, the standard of validity：
Microbiological indicator should be in attenuation state with time graph, and bacterium declines in strain sum in 30 minutes
99.9%, if can keep total number of bacteria in 12 hours, the fungistatic effect of judgement sample is good.Embodiment 6~8 and comparative example
The test result of 5 mouthwashes is shown in Table 5.
The test result of mouthwash described in the embodiment 6~8 of table 5 and comparative example 5
| Percentage (%) | Initially | 5 minutes | 30 minutes | 1 hour | 12 hours |
| Embodiment 6 | 100 | 100 | 99.9 | 99.9 | 99.6 |
| Embodiment 7 | 100 | 100 | 100 | 100 | 99.9 |
| Embodiment 8 | 100 | 100 | 100 | 100 | 100 |
| Comparative example 5 | 100 | 96.3 | 94.2 | 90.5 | 86.4 |
As can be seen from Table 5, embodiment 6~8 can keep the sum change of bacterium smaller within 12 hours, illustrate this hair
The fungistatic effect of the bright mouthwash is good.
Embodiment 15
Buccal cavity gel described in embodiment 9~11 and comparative example 6 is subjected to clinical test, specific method is as follows：
First, patient is grouped：100 patients of inclusive criteria will be met, random point 4 groups, every group 25, four groups of ages, property
Not, the course of disease and cardinal symptom are statistically analyzed, no significant difference (P>0.05), there is comparativity.
2nd, inclusive criteria：Clinical diagnosis is the patient of slight canker sore.
3rd, treatment method
Treatment group：2~3g of buccal cavity gel described in Example 9~11, after gargling, gel is applied to skin surface, often
Its medicine-feeding is twice.
Control group：Take 2~3g of buccal cavity gel described in comparative example 6, after gargling, gel is applied into skin surface, daily medicine-feeding
Twice.
4th, curative effect index
Criterion is used as with the minification for oozing out congested area of ulcer.Minification is considered as recovery from illness for 100%, reduces
Rate is that 80% to be considered as effect notable, and minification is 60% to be considered as effectively, and minification is 40% to be considered as that curative effect is weaker, and minification is less than
Or be considered as equal to 20% it is invalid.
5th, treatment results are shown in Table 6.
The treatment results of buccal cavity gel described in the embodiment 9~11 of table 6 and comparative example 6
As can be seen from Table 6, the therapeutic effect of 9~11 buccal cavity gel of embodiment is substantially better than mouth described in comparative example 6
Chamber gel, illustrate the problem of buccal cavity gel of the present invention can help to improve canker sore and promote repairing for canker sore
It is multiple.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than the present invention is protected
The limitation of scope is protected, although being explained in detail with reference to preferred embodiment to the present invention, one of ordinary skill in the art should
Understand, technical scheme can be modified or equivalent substitution, without departing from the essence of technical solution of the present invention
And scope.
Claims (7)
1. a kind of oral care composition, it is characterised in that include Cordyceps militaris elite, O- cymene -5- alcohol and sylvite；The pupa
Lungfit is the mixture of Cordyceps militaris extract and fruiting bodies of cordyceps militaris.
2. oral care composition as claimed in claim 1, it is characterised in that the Cordyceps militaris elite and the O- cymenes-
The weight ratio of 5- alcohol is：0.5~50:0.1~1；The weight of the O- cymenes -5- alcohol and the thing of the Potassium In Potassium ion
The ratio between amount of matter is：(0.1~1) g：(0.3~1) mol.
3. oral care composition as claimed in claim 1, it is characterised in that the Cordyceps militaris elite and the O- cymenes-
The weight ratio of 5- alcohol is：1~30:0.5~0.8；The weight of the O- cymenes -5- alcohol and the thing of the Potassium In Potassium ion
The ratio between amount of matter is：(0.5~0.8) g：(0.3~0.53) mol.
4. oral care composition as claimed in claim 1, it is characterised in that the fruiting bodies of cordyceps militaris is in Cordyceps militaris elite
Weight percentage be 0.01~20%.
5. oral care composition as claimed in claim 1, it is characterised in that the fruiting bodies of cordyceps militaris is in Cordyceps militaris elite
Weight percentage be 8~15%.
6. oral care composition as claimed in claim 1, it is characterised in that the sylvite is potassium nitrate, potassium citrate, chlorination
At least one of potassium and potassium oxalate.
A kind of 7. application of oral care composition as any one of claim 1~6 in oral care product is prepared；
The oral care product is toothpaste, mouthwash or buccal cavity gel.
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