CN112263606A - Traditional Chinese medicine gargle and preparation method thereof - Google Patents
Traditional Chinese medicine gargle and preparation method thereof Download PDFInfo
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- CN112263606A CN112263606A CN202011157058.9A CN202011157058A CN112263606A CN 112263606 A CN112263606 A CN 112263606A CN 202011157058 A CN202011157058 A CN 202011157058A CN 112263606 A CN112263606 A CN 112263606A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Botany (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Birds (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to the technical field of traditional Chinese medicines and daily chemical products, in particular to a traditional Chinese medicine gargle with heat clearing and bacteriostasis functions and a preparation method thereof. The traditional Chinese medicine gargle is prepared from the following raw materials in parts by weight: 5 parts of honeysuckle, 10 parts of chrysanthemum, 15 parts of mint, 10 parts of eupatorium and 10 parts of liquorice. According to the traditional Chinese medicine gargle provided by the invention, 5 traditional Chinese medicinal materials of honeysuckle, chrysanthemum, mint, eupatorium and liquorice are combined to synergically have the health-care effects of clearing heat, removing toxicity, resisting bacteria and diminishing inflammation, so that the gargle can effectively inhibit bacterial breeding and eliminate peculiar smell, has natural fragrance to refresh breath, can prevent diseases, reduce dental plaque and has remarkable effects of preventing and treating oral inflammation. The traditional Chinese medicine gargle disclosed by the invention is simple in formula, easily available in raw materials and low in cost, the traditional Chinese medicine mixture is subjected to water boiling and alcohol precipitation to obtain a traditional Chinese medicine combined extract, the preparation method is simple, the process is stable, and large-scale production can be realized.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines and daily chemical products, in particular to a traditional Chinese medicine gargle with heat clearing and bacteriostasis functions and a preparation method thereof.
Background
The old bedridden patients have the digestive function and the swallowing function declined due to the old, weak and long-term bedridden patients and the degeneration of the functional activities of viscera. The lack of nutrition and the decline of the immunity of the organism are often caused by the reduction of food intake; or food intake choking or aspiration caused by swallowing dysfunction repeatedly causes lung infection, and the oral intake can not be performed. Therefore, nasal feeding was selected for all the final cases. The nasal feeding brings oral hygiene problems, on one hand, because of lack of chewing movement of food, the self-cleaning capability of oral machinery is reduced; on the other hand, when the food is not taken through the oral cavity, saliva secretion in the oral cavity cannot be stimulated, and the saliva secretion is reduced, so that the mucous membrane of the oral cavity is dried. The oral lip and oral secretion are firmly attached and remain in the oral cavity to become a good culture medium for bacteria, and the bacteria are decomposed and propagated in a large quantity to easily cause halitosis. And the bedridden nasal feeding patients are often in a mouth-opening breathing state, so that the pulmonary infection caused by xerostomia, ulceration, bad breath, tongue fur dirt, red and swollen gum, mucosal ulcer, mycotic infection and oral bacteria aspiration is aggravated.
At present, 0.9 percent of normal saline is generally used for oral care in clinic, and only the function of cleaning the oral cavity is achieved. But has no effect on removing bad breath, preventing infection, and clearing heat and removing toxicity in the oral cavity. At present, the common mouthwash in the market mainly focuses on cleaning, sterilization and the like, and has little attention on the efficacy of oral care, maintenance and the like.
However, the traditional Chinese medicine mouth wash has the problems of various raw materials, difficult raw material acquisition, high raw material cost, complex preparation process of the extract, unsatisfactory antibacterial effect and the like, and is not easy to apply to industrial production. Therefore, the problem to be solved at present is to develop a traditional Chinese medicine gargle with heat clearing and bacteriostasis functions.
Disclosure of Invention
Aiming at the problems, the invention aims to provide a traditional Chinese medicine gargle with heat clearing and bacteriostasis functions and a preparation method thereof. The traditional Chinese medicine gargle provided by the invention is used for oral care, and has the function of strengthening oral care to a certain extent for nasal feeding patients lying in bed for the elderly. The traditional Chinese medicine has the effects of clearing away heat and toxic materials, promoting the production of body fluid and moistening dryness, so that the risk of side effects of nasal feeding is reduced to the maximum extent. The traditional Chinese medicine gargle has good heat-clearing and bacteriostatic effects, low production cost, safety and no side effects, and the preparation method is suitable for industrial production and is convenient for development and application.
In order to achieve the above object, the present invention adopts the following technical solutions.
A traditional Chinese medicine gargle with heat clearing and bacteriostasis functions is composed of the following raw materials in parts by weight: 5 parts of honeysuckle, 10 parts of chrysanthemum, 15 parts of mint, 10 parts of eupatorium and 10 parts of liquorice.
The preparation method of the traditional Chinese medicine gargle with heat-clearing and bacteriostatic effects specifically comprises the following steps: weighing honeysuckle, chrysanthemum, mint, eupatorium and liquorice according to the proportion of the formula, uniformly mixing, adding water which is 7 times of the mass of the raw materials, decocting for one time for 20 minutes, filtering, concentrating, subpackaging, capping, and sterilizing at 115 ℃ for 30 minutes. Sealing and packaging, and storing in refrigerator at 4 deg.C for 7 days.
The pharmacological action and the efficacy of each component of the traditional Chinese medicine gargle with the functions of clearing heat and inhibiting bacteria are as follows.
Honeysuckle flower: in Shen nong Ben Cao Jing, it is recorded that: honeysuckle flower, flos Lonicerae, with cold nature and sweet taste, has the effects of clearing away heat and toxic material, cooling blood and removing blood stasis. It is mainly used for treating wind-heat common cold, early pestilence, red swelling and pain of pyocutaneous disease and furunculosis, etc. And honeysuckle enters lung, heart and stomach meridians. Can eliminate heat accumulation in lung, heart and stomach channels, and has heat clearing, detoxicating, antiinflammatory and antibacterial effects. Modern pharmacological research that honeysuckle is a broad-spectrum antibacterial drug contains chlorogenic acid which is one of effective components for resisting bacteria and viruses. Therefore, the honeysuckle has stronger bacteriostatic action on staphylococcus aureus, escherichia coli and herpes virus. Plays an important role in the Chinese medicinal gargle for clearing flowers.
Chrysanthemum: cold in nature, bitter and pungent in flavor. It enters lung and liver meridians. Has the effects of clearing away heat and toxic materials, dispelling pathogenic wind, suppressing hyperactive liver, and improving eyesight. It is often used for wind-heat type common cold, liver yang hyperactivity, conjunctival congestion, swelling and pain, sore, carbuncle, pyogenic infections, and tracheitis. The chrysanthemum is often used as an additive of food and a tea substitute for drinking, has the effects of clearing heat and removing toxicity, is a traditional Chinese medicine for clearing heat and removing toxicity, has fresh and proper mouthfeel, and is not a mor as gargle chrysanthemum. Is easy to be accepted by patients. Modern pharmacological research shows that chrysanthemum has the effects of resisting bacteria, resisting inflammation and the like. The volatile oil in the chrysanthemum has certain inhibition effect on staphylococcus aureus, staphylococcus albus, pseudomonas aeruginosa, various fungi and the like, and the inhibition effect on staphylococcus aureus is particularly obvious.
Mint: cool in nature and pungent in flavor, entering lung and liver meridians. Has effects of dispelling pathogenic wind and heat, refreshing mind, relieving sore throat, and promoting eruption. It is often used for treating wind-heat common cold, sore throat, aphtha, toothache, etc. It is often combined with jin Yin Hua to treat exogenous febrile disease. Has the effects of clearing away heat and toxic materials. The gargle is used for traditional Chinese medicine gargle, has the property of fragrance and acrid powder, has the feeling of instant cooling and dispersion, and has the effect of clearing dead corners of oral cavity. Modern pharmacological studies show that the mint decoction has the effects of resisting viruses and pathogens, can inhibit herpes simplex virus infection, and has stronger antibacterial effects on staphylococcus aureus, pseudomonas aeruginosa and the like. There are data research reports: the mint is used as the main ingredient of the toothpaste, has the antibacterial effect, and has the effects of relieving toothache, nourishing gum and removing tartar.
Herba Eupatorii: is a traditional Chinese medicine of Compositae, has mild nature and pungent taste, and enters stomach, spleen and lung meridians. Has the effects of clearing away summer-heat, eliminating dampness and regulating the middle warmer. The eupatorium has fragrant smell, and can obviously improve symptoms of dry mouth and halitosis caused by damp-heat in spleen channels by matching with liquorice. The herba Eupatorii decoction can inhibit various bacteria and viruses, and the volatile oil of herba Eupatorii has expectorant effect.
Licorice root: in Chinese herbs, they have many actions. It is neutral in nature and sweet in taste. It enters spleen, stomach and lung meridians. The Chinese medicinal composition has the main effects of tonifying qi, benefiting spleen, clearing away heat and toxic materials, treating stranguria, promoting urination and harmonizing the medicaments. The licorice root has the inhibiting effect on staphylococcus aureus, hemolytic streptococcus, escherichia coli and the like. The traditional Chinese medicine gargle adopts liquorice, one of the liquorice is mainly taken to contain glycyrrhizin, the light and sweet taste covers the bitter taste of other medicines in oral care, the mouth feel is good, and the fragrant and sweet aftertaste is remained; and the second one, it has the functions of clearing away heat and toxic material, resisting infection and resisting ulcer.
Although the traditional Chinese medicine has no name of oral fungal infection, the understanding of fungal infection is already known. For example, oral candida infection and fungal enteritis in western medicine are respectively called as 'thrush' and 'diarrhea' in traditional Chinese medicine, and the oral cavity is the orifice of clearing yang and is fond of clearing, and the oral cavity can be kept clean only if the qi activity is protected to rise and fall, and the clear yang rises and the turbid yin falls. Dampness is a yin pathogen and has the function of stopping the ascending and descending of qi, while the spleen governs transportation and transformation, distributes essence and micro, the stomach governs reception and rotten food, and dampness blocks middle energizer to cause the disorder of ascending and descending of qi; the fire is added to the oral cavity to serve as yang pathogen, which causes inflammation, easily damages the orifices on the surface of the human body, and the oral cavity is located above, so that the inflammatory fire can gather in the oral cavity to form the disease. However, the disease is mostly characterized by deficiency of vital qi, which is mainly manifested by deficiency of both qi and yin. First, from the meridian point of view, the oral cavity belongs to the spleen meridian of foot taiyin, enters the abdomen and belongs to the spleen, collaterals and stomach, and is finally connected with the tongue root and scattered under the tongue. If spleen qi is deficient and placed in water and the distribution is not uniform, obstruction of middle energizer will cause water-dampness to accumulate in the mouth. The lung governs qi and governs respiration, mainly dispersing, purifying and descending, which is the upper source of water, and lung yin deficiency can cause the dispersing, purifying and descending functions of the lung to be declined, and water metabolism to be obstructed. Therefore, the pathogenesis of oral fungal infection is deficiency of vital qi and excess of pathogenic factors, and the syndrome type is deficiency of qi and yin and retention of damp-heat. The medicine has the functions of invigorating vital energy, nourishing yin, clearing away heat and wetness, killing bacteria and detoxicating.
Compared with the prior art, the invention has the following beneficial effects.
At present, the common mouthwash in the market mainly focuses on cleaning, sterilization and the like, and has little attention on the efficacy of oral care, maintenance and the like. According to the traditional Chinese medicine gargle provided by the invention, 5 traditional Chinese medicinal materials of honeysuckle, chrysanthemum, mint, eupatorium and liquorice are combined to realize synergistic interaction, so that the gargle has the health-care effects of clearing heat and toxic materials, resisting bacteria and diminishing inflammation, can effectively inhibit bacterial breeding and eliminate peculiar smell, has natural fragrance to refresh breath, can prevent diseases, reduce dental plaque and has remarkable effects of preventing and treating oral inflammation.
The traditional Chinese medicine gargle provided by the invention can effectively kill candida albicans and is beneficial to restoring balance of other flora in the oral cavity, in addition, the toxicity and drug resistance of antifungal drugs are high, and the traditional Chinese medicine gargle is used according to the physique of a patient, so that the traditional Chinese medicine gargle can help healthy qi, resist pathogen going out and quickly treat oral fungal infection.
The traditional Chinese medicine gargle provided by the invention adopts a gargle dosage form, can be used locally, takes effect quickly, avoids other infections caused by fungi entering the body from the digestive tract after oral administration, and has a very good application prospect. The traditional Chinese medicine gargle disclosed by the invention is good in antibacterial effect, no preservative is added during preparation, and the product is more green and safe. The traditional Chinese medicine gargle disclosed by the invention is simple in formula, easily available in raw materials and low in cost, the traditional Chinese medicine mixture is subjected to twice water boiling and once alcohol precipitation to obtain a traditional Chinese medicine combined extract, the preparation method is simple, the process is stable, and the large-scale production can be realized.
Detailed Description
The present invention will be described in detail with reference to specific examples. The foregoing shows and describes the general principles and broad features of the present invention and advantages thereof. It will be understood by those skilled in the art that the following examples and descriptions are only illustrative of the principles of the invention and that various changes and modifications may be made without departing from the spirit and scope of the invention as defined by the appended claims. The scope of the invention is defined by the appended claims and equivalents thereof.
Example 1 screening experiment of the amount of raw materials of a Chinese medicinal gargle formula.
The formula of the traditional Chinese medicine gargle comprises the following raw materials according to the dosage scheme.
The formula comprises the following raw materials in a dosage scheme: 5g of honeysuckle, 10g of chrysanthemum, 10g of mint, 10g of eupatorium and 10g of liquorice.
The formula comprises the following raw materials in a dosage scheme II: 5g of honeysuckle, 10g of chrysanthemum, 10g of mint, 10g of eupatorium and 20g of liquorice.
The formula comprises the following raw materials in a dosage scheme III: 5g of honeysuckle, 10g of chrysanthemum, 15g of mint, 10g of eupatorium and 10g of liquorice.
Weighing the honeysuckle, the chrysanthemum, the mint, the eupatorium and the liquorice according to the proportion of the formula respectively, mixing uniformly, adding water which is 7 times of the weight of the raw materials, decocting for one time for 20 minutes, filtering, concentrating, subpackaging, capping, and sterilizing at 115 ℃ for 30 minutes to prepare the traditional Chinese medicine gargle. And randomly selecting 30 clinicians, nurses and patients, and evaluating the color, smell, taste and mouthfeel of the traditional Chinese medicine gargle, wherein the test evaluation results are shown in table 1. The evaluation result of the formula composition raw material dosage scheme III is best, and the prepared traditional Chinese medicine gargle is fresh and non-irritating.
Table 1. evaluation results of color, smell, taste and mouthfeel of the traditional Chinese medicine gargle.
| Color | Smell(s) | Taste of the product | Taste of the product | |
| Scheme one | Light yellow | Fragrance | Slightly bitter | Slight astringent and no irritation |
| Scheme two | Light yellow | Fragrance | Sweet taste | Sweet and greasy without irritation |
| Scheme three | Light yellow | Fragrance | Slightly sweet | Refreshing without irritation |
Example 2 preparation method of Chinese medicinal gargle with heat clearing and antibacterial effects.
A traditional Chinese medicine gargle with heat clearing and bacteriostasis functions is composed of the following raw materials by weight: 5g of honeysuckle, 10g of chrysanthemum, 15g of mint, 10g of eupatorium and 10g of liquorice.
The preparation method of the traditional Chinese medicine gargle with heat clearing and bacteriostasis effects specifically comprises the following steps: weighing 5g of honeysuckle, 10g of chrysanthemum, 15g of mint, 10g of eupatorium and 15g of liquorice, adding 3000ml of water, decocting for one time for 20 minutes, filtering, concentrating to 2000ml, subpackaging with 4 bottles, capping, and sterilizing at 115 ℃ for 30 minutes.
Example 3 evaluation of the effectiveness of the mouthrinse provided in example 2.
1. And (4) an evaluation method.
And carrying out comprehensive evaluation on the observation items of the control group and the observation group before oral care, and after the experiment is finished, carrying out grading comparison according to evaluation scores to observe the clinical effect of the traditional Chinese medicine gargle.
2. And evaluating the content.
Oral mucosa ulcer, gingival atrophy and bleeding, halitosis, tongue, mucosa, dental/denture plaque, lip, and palate are seven items.
Scores of 3, 2 and 1 were calculated for the severe positive characteristics, the mild positive characteristics and the no positive characteristics, respectively.
3. And (4) carrying out comprehensive evaluation after the research is finished, and observing the effectiveness of the traditional Chinese medicine gargle.
Grading standard: 1 is superior, 3 is inferior, all items need to be scored, the score is 8 to 24, the higher the score, the worse the oral cleanliness, the more intensive the oral care is needed. Wherein 8 minutes of oral cavity conditions are normal, 9-16 oral cavity conditions are mild defects, and 17-24 oral cavity conditions are severe defects. The oral cavity cleaning cleanliness questionnaire is shown in table 2.
TABLE 2 oral cleaning cleanliness questionnaire.
4. And (5) carrying out statistical analysis.
All data involved in this study were statistically analyzed using a sps 20.0. Calculating data rate representation using x2Checking; the data are calculated by mean value + -standard deviation, the data comparison before and after treatment adopts paired t test, and the data comparison between two groups adopts grouped t test. With p<0.05 indicates that the difference is statistically significant.
5. The results are shown in Table 3.
Table 3 comparison of the respective index conditions of the two groups of oral care before and after the experiment.
Note: p < 0.05, P < 0.01, compared to pre-treatment; compared with the control group, # P < 0.05, # P < 0.01.
The study showed that the comparison of the evaluation scores before and after treatment for the two groups of oral care results were as follows: the traditional Chinese medicine gargle has different inhibiting effects on dental plaque, periodontal redness and swelling, gingival bleeding, oral mucosa ulcer, oral peculiar smell and generation and aggravation of halitosis, wherein the inhibiting effect of the traditional Chinese medicine gargle on dental plaque, gingival bleeding, oral mucosa ulcer, oral peculiar smell and generation and aggravation of halitosis is better than that of normal saline oral care, and the inhibiting effect is shown in table 3.
Table 3 comparison of the respective index conditions of the two groups of oral care before and after the experiment.
Example 4 bacteriostatic effect experiment.
1. And detecting the item.
Escherichia coli, staphylococcus aureus and candida albicans.
2. And (6) detection basis.
Bacteria and fungus bacteriostasis test: GB15979-2002 hygienic Standard for Disposable sanitary articles appendix C.
3. And detecting a conclusion.
1) Coli inhibition experiments (suspension method).
The test is repeated for three times, the test temperature is 20 +/-1 ℃, the traditional Chinese medicine gargle stock solution with the functions of clearing heat and inhibiting bacteria in the example 2 has the action time of 2 minutes, the inhibition rate to escherichia coli is 98.84 percent, the requirement of GB15979-2002 appendix C of sanitary standards for disposable sanitary articles is met, and the traditional Chinese medicine gargle has strong inhibition function.
2) Staphylococcus aureus bacteriostasis assay (suspension method).
The test is repeated for three times, the test temperature is 20 +/-1 ℃, the traditional Chinese medicine gargle stock solution with the functions of clearing heat and inhibiting bacteria in the example 2 has the action time of 2 minutes, the bacteria inhibition rate on staphylococcus aureus is 98.72 percent, the requirement of GB15979-2002 appendix C of sanitary standards for disposable sanitary articles is met, and the traditional Chinese medicine gargle has strong bacteria inhibition function.
3) Candida albicans bacteriostasis test (suspension method).
The test is repeated for three times, the test temperature is 20 +/-1 ℃, the traditional Chinese medicine gargle stock solution with the functions of clearing heat and inhibiting bacteria in the example 2 has the action time of 2 minutes, the bacteria inhibition rate on candida albicans is 98.33 percent, the requirement of GB15979-2002 appendix C of sanitary standards for disposable sanitary articles is met, and the traditional Chinese medicine gargle has strong bacteria inhibition function.
Example 4 clinical data.
The clinical application shows that the traditional Chinese medicine gargle with the functions of clearing heat and inhibiting bacteria, which is prepared in the embodiment 2 of the invention, has a remarkable curative effect on oral diseases such as common toothache, oral ulcer and the like, and the following examples show that the gargle has the effects of clearing heat and inhibiting bacteria.
Case 1.
The patients: zhang some; sex: a woman; age: age 87.
Description of the disorders: initial lesion: severe dental plaque, mild bad breath, mild red and swollen periodontal pockets, red tongue with thin and white coating, and smooth and rapid pulse. The ulcer surfaces of 2 points are on the tip of the tongue, the left side of the tongue and the lower lip, the small is as big as mung bean, the big is as big as soybean, the color is red, a white false membrane is on the large, and the acute burning pain is caused after the ulcer is formed, especially the obvious position of the tip of the tongue. Even more so when exposed to harsh foods.
The treatment method comprises the following steps: cleaning the oral cavity by gargling with clear water, diluting the finished oral bacteriostatic solution prepared by the method in the first embodiment by 3-5 times, keeping gargling for 2-5 minutes, spitting out, keeping for one quarter, gargling with clear water for 3 times a day, and forming a treatment course for three days.
The treatment effect is as follows: the pain is relieved after one day of use, the ulcer surface is reduced after one treatment course, dental plaque disappears, the oral cavity has no peculiar smell, and the oral cavity is completely cured after two treatment courses.
Case 2.
The patients: korean certain; sex: male; age: and age 85.
Description of the disorders: patients with nasal feeding lying in bed are often in mouth-opening breathing state, severe oral odor, dry mouth, bitter taste, moderate dental plaque, red tongue and yellow and thick tongue coating.
The treatment method comprises the following steps: cleaning the oral cavity by gargling with clear water, and then taking the finished gargle with the functions of clearing heat and inhibiting bacteria prepared by the method in the embodiment I to perform oral care 2 times a day, cleaning the oral cavity, wherein seven days are a treatment course.
The treatment effect is as follows: after two courses, all symptoms disappeared.
In conclusion, through clinical observation of the traditional Chinese medicine gargle provided by the invention, the gargle has the advantages that the oral fungal infection condition is well inhibited, and the oral mucosa is promoted to heal; the comparison study with the reference medicament physiological saline shows that the traditional Chinese medicine gargle provided by the invention has better curative effect than the reference medicament, has simple and convenient use method, low production cost and low price, does not influence the balance of other floras, has good curative effect on the traditional Chinese medicine compound extract in the traditional Chinese medicine gargle, and is suitable for clinical popularization.
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| CN113350239A (en) * | 2021-06-25 | 2021-09-07 | 山西工商学院 | Multifunctional mouthwash containing mature vinegar and preparation method of multifunctional mouthwash |
| CN113413343A (en) * | 2021-06-28 | 2021-09-21 | 乐草元生物医药研究院(广州)有限公司 | Chinese herbal medicine mouthwash formula for stomatitis and preparation method thereof |
| CN115887582A (en) * | 2023-01-05 | 2023-04-04 | 文德志 | Aromatic turbid-removing traditional Chinese medicine mouthwash |
| CN116687998A (en) * | 2023-07-17 | 2023-09-05 | 阿勒泰地区中医医院(阿勒泰地区哈萨克医医院) | A kind of oral care liquid and preparation method thereof |
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