CN107213351B - Dendrobium nobile buccal tablet and preparation method thereof - Google Patents

Abstract

The invention belongs to the technical field of medicine processing, and particularly relates to a dendrobium nobile buccal tablet and a preparation method thereof. The dendrobe buccal tablet is prepared from the following raw materials in parts by weight: 180-235 parts of dendrobium, 12-26 parts of menthol, 18-28 parts of rhizoma polygonati, 17-22 parts of honeysuckle, 5-7 parts of sorbitol, 12-15 parts of chitosan, 2-6 parts of glycerol, 8-12 parts of maltodextrin and 23-40 parts of magnesium stearate. The dendrobium nobile buccal tablet provided by the invention keeps proper sweet taste, color and smell of the medicine through reasonable compatibility, has the effects of clearing away heat and toxic materials, resisting bacteria and diminishing inflammation, promoting the production of body fluid and moistening the throat and the like, and has obvious effects on treating sphagitis, oral ulcer and the like; the preparation method of the dendrobium nobile buccal tablet can preserve the effective ingredients in the raw materials, has reasonable production process and is suitable for industrial production.

Description

A kind of dendrobium buccal tablet and preparation method thereof

technical field

The invention relates to the technical field of pharmaceutical processing, in particular to a dendrobium buccal tablet and a preparation method thereof.

Background technique

Buccal tablets refer to compressed tablets that dissolve slowly in the oral cavity, which can produce lasting medicinal effects on the oral cavity and pharynx. They are used for local anti-inflammatory, disinfection, swelling, and mucosal secretion stimulation. drug. Buccal tablets are welcomed by the majority of patients because of their excellent taste and convenient taking method. However, there are also the following problems in traditional Chinese medicine buccal tablets: 1. The compatibility of traditional Chinese medicine is unreasonable and the efficacy is not good; 2. There are many excipients such as sugars, flavors and pigments, which cause patients, especially children, to mistake the lozenges as "sugar". Edible, overdose will cause adverse reactions; 3. The preparation method is not refined enough to fully exert the medicinal effect.

SUMMARY OF THE INVENTION

Aiming at the deficiencies of the above prior art, the present invention provides a dendrobium lozenge and a preparation method thereof, through reasonable compatibility, maintaining the appropriate sweetness, color and smell of the medicine, and having the functions of clearing away heat and detoxifying, antibacterial and anti-inflammatory, promoting body fluid and moistening the throat, etc. It has a significant effect in the treatment of pharyngitis and oral ulcers. The preparation method of the dendrobium buccal tablet of the invention can preserve the effective components in the raw materials, has a reasonable production process, and is suitable for industrial production. In order to solve the above technical problems, the technical scheme adopted by the present invention is as follows:

A dendrobium lozenge, which is composed of the following components (in parts by weight): 180-235 parts of dendrobium, 12-26 parts of menthol, 18-28 parts of Polygonatum chinensis, 17-22 parts of honeysuckle, 5-7 parts of sorbitol, chitosan 12-15 parts of sugar, 2-6 parts of glycerin, 8-12 parts of maltodextrin, 23-40 parts of magnesium stearate.

Preferably, a dendrobium lozenge according to the present invention is composed of the following components (in parts by weight): 200 parts of dendrobium, 26 parts of menthol, 20 parts of Polygonatum chinensis, 22 parts of honeysuckle, 5 parts of sorbitol, 15 parts of chitosan parts, 6 parts of glycerin, 8 parts of maltodextrin, 30 parts of magnesium stearate.

Correspondingly, the present invention also provides a preparation method of dendrobium lozenges, the preparation method comprising the following steps:

(1) a, take by weighing the dendrobium, Polygonatum chinensis and honeysuckle of the recipe quantity, pulverize, cross 400-500 mesh sieves, obtain ultrafine powder, adopt 40%-45% ethanol aqueous solution extraction, the extracting liquid is evaporated under reduced pressure to remove ethanol, obtain extraction liquid and the extracted medicinal residues; b. the extract of step a is placed on a macroporous resin column, and eluted with distilled water and alkali solution successively; wherein, the distilled water eluent is effluent A; the alkali solution is eluted to obtain effluent B The effluent B is neutralized to neutrality with acid, leached with 40%-50% ethanol aqueous solution for 1.5-3h, and evaporated to dryness under reduced pressure to obtain powder ①; c, by mass ratio 1:5, the medicinal residues described in step a are Mix it with water, keep it in a water bath at 40°C-60°C for 4-6 hours, combine it with the effluent A described in step b after cooling, concentrate, add anhydrous ethanol to produce precipitation, filter and dry to obtain powder ②; combine powder ① with powder ②Mix evenly to get the traditional Chinese medicine mixture for use;

(2) the traditional Chinese medicine mixture of step (1) and the menthol, sorbitol, chitosan, glycerol of recipe quantity are mixed, for subsequent use;

(3) adding the magnesium stearate and maltodextrin of the recipe quantity to the mixture in step (2), mixing uniformly, drying, and sieving to obtain the composition, and tableting to obtain dendrobium buccal tablets.

Preferably, the dendrobium in the dendrobium buccal tablet of the present invention includes one or more of the group consisting of Dendrobium goldenchai, Dendrobium candidum, Dendrobium Huoshan, and Dendrobium dendrobium.

The proportioning mechanism of each component of a dendrobium buccal tablet of the present invention is as follows:

Dendrobium (scientific name: Dendrobium nobile Lindl), also known as Wanzhangxu, Chlorophytum, Linlan, forbidden life, golden hairpin flowers, etc. The main active ingredients of Dendrobium are: Dendrobine, Dendrobium polysaccharide, Dendrobium amine, Dendrobium hydrino. Studies have shown that Dendrobium has antibacterial, antioxidant, antitumor, immune-enhancing and neuroprotective effects.

Honeysuckle: Contains chlorogenic acid, luteolin glycosides and other pharmacologically active ingredients, has strong inhibitory effect on various pathogenic bacteria such as hemolytic streptococcus, Staphylococcus aureus, and upper respiratory tract infection pathogenic viruses, and can also enhance Immunity, anti-early pregnancy, liver protection, anti-tumor, anti-inflammatory, antipyretic, hemostasis (coagulation), inhibition of intestinal absorption of cholesterol, etc.

Polygonatum chinensis: It has the functions of lowering blood pressure, blood sugar, blood lipid, preventing atherosclerosis, delaying aging and antibacterial, etc. Polysaccharide polysaccharide has immune activation effect.

Menthol: Menthol is extracted from the leaves and stems of peppermint and is the main component of peppermint and peppermint essential oils. Menthol can selectively stimulate the cold receptors of human skin or mucous membranes, producing cold reflexes and cold sensations, causing vasoconstriction of skin and mucous membranes (in fact, the skin remains normal); in addition, it can also cause contraction of blood vessels in deep tissues, resulting in Therapeutic effect. Oral administration can relieve local inflammation (pharyngitis) and treat colds, and has the effect of strengthening the stomach and carminative wind.

Sorbitol: used as a moisturizing agent, flavor-preserving agent, and antioxidant for food or medicine.

Chitosan: Chitosan has good antibacterial activity and can inhibit the growth and reproduction of fungi, bacteria and viruses. At the same time, chitosan is used as a thickener and coating agent in the food field.

Glycerin: used as a humectant, lubricant for food or medicine.

Maltodextrin: It is used to increase the viscosity, enhance the dispersibility and solubility of the product. Maltodextrin has a good emulsification and thickening effect.

Magnesium stearate: mainly used as a lubricant, so that the prepared powder has good fluidity and compressibility.

Compared with the prior art, the beneficial effects of the present invention are: the product of the present invention maintains the appropriate sweetness, color and odor of the medicine through reasonable compatibility, and has the functions of clearing away heat and detoxifying, antibacterial and anti-inflammatory, promoting body fluid and moistening the throat, etc. It has remarkable effects on the treatment of oral ulcers and the like; the preparation method of the dendrobium buccal tablet of the present invention can preserve the effective components in the raw materials, and the production process is reasonable and suitable for industrial production.

Detailed ways

The present invention will be further described below with reference to specific embodiments, and the advantages and characteristics of the present invention will become clearer with the description, but the protection scope of the present invention is not limited to the following embodiments.

Example 1:

A dendrobium buccal tablet, comprising the following components (in parts by weight): 200 parts of Dendrobium officinale, 26 parts of menthol, 20 parts of Polygonatum chinensis, 22 parts of honeysuckle, 5 parts of sorbitol, 15 parts of chitosan, 6 parts of glycerin, and malt 8 parts of dextrin, 30 parts of magnesium stearate.

The preparation method is as follows:

(1) a, take by weighing the dendrobium, Rhizoma Polygonatidis and honeysuckle of recipe quantity, pulverize, cross 400 mesh sieves, obtain ultrafine powder, adopt 40% ethanol aqueous solution extraction, extracting solution is decompressed and evaporate ethanol, obtain extracting solution and after extraction dregs; b. the extract of step a is placed on a macroporous resin column, and eluted with distilled water and alkali solution successively; wherein, the distilled water eluent is effluent A; the alkali solution is eluted to obtain effluent B; The acid was neutralized to neutral, leached with 40% ethanol aqueous solution for 3 hours, and evaporated to dryness under reduced pressure to obtain powder ①; the medicinal residues described in step a were mixed with water at a mass ratio of 1:5, kept in a 60°C water bath for 6 hours, and after cooling Combine with the effluent A described in step b, concentrate, add absolute ethanol to produce precipitation, filter, and dry to obtain powder 2; Mix powder 1 and powder 2 to obtain a Chinese medicine mixture, for subsequent use;

(2) the traditional Chinese medicine mixture of step (1) and the menthol, sorbitol, chitosan, glycerol of recipe quantity are mixed, for subsequent use;

(3) adding the magnesium stearate and maltodextrin of the recipe quantity to the mixture in step (2), mixing uniformly, drying, and sieving to obtain the composition, and tableting to obtain dendrobium buccal tablets.

Example 2:

A dendrobium buccal tablet is composed of the following components (in parts by weight): 180 parts of Dendrobium officinale, 12 parts of menthol, 18 parts of Polygonatum chinensis, 17 parts of honeysuckle, 5 parts of sorbitol, 12 parts of chitosan, 2 parts of glycerin, 8 parts of maltodextrin, 23 parts of magnesium stearate.

The preparation method is as follows:

(1) a, take by weighing the dendrobium, Rhizoma Polygonatidis and honeysuckle of recipe quantity, pulverize, cross 500 mesh sieves, obtain ultrafine powder, adopt 45% ethanol aqueous solution extraction, extracting solution decompression steams ethanol, obtains extracting solution and after extraction dregs; b. the extract of step a is placed on a macroporous resin column, and eluted with distilled water and alkali solution successively; wherein, the distilled water eluent is effluent A; the alkali solution is eluted to obtain effluent B; The acid was neutralized to neutrality, extracted with 50% ethanol aqueous solution for 1.5 hours, and evaporated to dryness under reduced pressure to obtain powder ①; the medicinal residues described in step a were mixed with water at a mass ratio of 1:5, kept in a 50°C water bath for 4 hours, and cooled. Then combine with the effluent A described in step b, concentrate, add absolute ethanol to produce precipitation, filter, and dry to obtain powder ②; Mix powder ① and powder ② uniformly to obtain a traditional Chinese medicine mixture for subsequent use;

(2) the traditional Chinese medicine mixture of step (1) and the menthol, sorbitol, chitosan, glycerol of recipe quantity are mixed, for subsequent use;

(3) adding the magnesium stearate and maltodextrin of the recipe quantity to the mixture in step (2), mixing uniformly, drying, and sieving to obtain the composition, and tableting to obtain dendrobium buccal tablets.

Example 3:

A dendrobium buccal tablet, comprising the following components (parts by weight): 235 parts of Dendrobium Huoshan, 26 parts of menthol, 28 parts of Polygonatum chinensis, 22 parts of honeysuckle, 7 parts of sorbitol, 15 parts of chitosan, 6 parts of glycerin, and malt 12 parts of dextrin, 40 parts of magnesium stearate.

The preparation method is as follows:

(1) a, take by weighing the dendrobium, Rhizoma Polygonatidis and honeysuckle of the recipe quantity, pulverize, cross 450 mesh sieves, obtain ultrafine powder, adopt 45% ethanol aqueous solution extraction, the extracting solution is decompressed and evaporated ethanol, obtains extracting solution and after the extraction dregs; b. the extract of step a is placed on a macroporous resin column, and eluted with distilled water and alkali solution successively; wherein, the distilled water eluent is effluent A; the alkali solution is eluted to obtain effluent B; The acid was neutralized to neutral, leached with 45% ethanol aqueous solution for 2 hours, and evaporated to dryness under reduced pressure to obtain powder①; c. Mix the medicinal residues described in step a with water in a mass ratio of 1:5, and keep in a water bath at 40°C for 5 hours , after cooling, merge with the effluent A described in step b, concentrate, add absolute ethanol to produce precipitation, filter, and dry to obtain powder 2; Mix powder 1 and powder 2 homogeneously to obtain a traditional Chinese medicine mixture, for subsequent use;

(2) the traditional Chinese medicine mixture of step (1) and the menthol, sorbitol, chitosan, glycerol of recipe quantity are mixed, for subsequent use;

(3) adding the magnesium stearate and maltodextrin of the recipe quantity to the mixture in step (2), mixing uniformly, drying, and sieving to obtain the composition, and tableting to obtain dendrobium buccal tablets.

Example 4:

A dendrobium lozenge, comprising the following components (in parts by weight): 200 parts of Dendrobium Huoshan, 20 parts of menthol, 20 parts of Polygonatum chinensis, 20 parts of honeysuckle, 5 parts of sorbitol, 12 parts of chitosan, 6 parts of glycerin, and malt 10 parts of dextrin and 30 parts of magnesium stearate.

Preparation:

(1) a, take by weighing the dendrobium, Rhizoma Polygonatidis and honeysuckle flower of recipe quantity, pulverize, cross 500 mesh sieves, obtain ultrafine powder, adopt 40% ethanol aqueous solution extraction, extracting solution is decompressed and evaporate ethanol, obtain extracting solution and after extraction dregs; b. the extract of step a is placed on a macroporous resin column, and eluted with distilled water and alkali solution successively; wherein, the distilled water eluent is effluent A; the alkali solution is eluted to obtain effluent B; The acid is neutralized to neutrality, extracted with 45% ethanol aqueous solution for 2 hours, and evaporated to dryness under reduced pressure to obtain powder ①; c. Mix the medicinal residues described in step a with water at a mass ratio of 1:5, and keep in a 40°C water bath for 6 hours, After cooling, it is combined with the effluent A described in step b, concentrated, added with absolute ethanol to produce precipitation, filtered, and dried to obtain powder ②; powder ① and powder ② are mixed uniformly to obtain a traditional Chinese medicine mixture, which is for subsequent use;

(2) the traditional Chinese medicine mixture of step (1) and the menthol, sorbitol, chitosan, glycerol of recipe quantity are mixed, for subsequent use;

(3) adding the magnesium stearate and maltodextrin of the recipe quantity to the mixture in step (2), mixing uniformly, drying, and sieving to obtain the composition, and tableting to obtain dendrobium buccal tablets.

Comparative Example 1:

A dendrobium buccal tablet, comprising the following components (parts by weight): 100 parts of Dendrobium officinale, 5 parts of menthol, 7 parts of Polygoni Radix, 10 parts of honeysuckle, 1 part of sorbitol, 4 parts of chitosan, 1 part of glycerin, and malt 3 parts of dextrin, 10 parts of magnesium stearate.

Preparation method: same as Example 1.

Comparative Example 2:

A dendrobium buccal tablet, comprising the following components (in parts by weight): 400 parts of Dendrobium officinale, 30 parts of menthol, 35 parts of Polygonatum chinensis, 40 parts of honeysuckle, 20 parts of sorbitol, 20 parts of chitosan, 15 parts of glycerin, and malt 40 parts of dextrin, 70 parts of magnesium stearate.

Preparation method: same as Example 1.

Comparative Example 3:

A dendrobium buccal tablet is composed of the following components (parts by weight): the same as in Example 1.

Preparation:

(1) get the Dendrobium officinale, Polygonatum chinensis, Honeysuckle flower of the recipe quantity after fully drying and pulverize, cross 75 mesh sieves for subsequent use;

(2) the powder of step (1) gained pulverization is fully stirred and mixed to obtain mixture for subsequent use;

(3) add the menthol, sorbitol, chitosan, glycerol, maltodextrin, magnesium stearate of recipe quantity in the compound obtained in step (2), mix, sieve to obtain the composition, and process on the tablet machine Into dendrobium lozenges.

Comparative Example 4:

A dendrobium lozenge, consisting of the following components (parts by weight):

(Houttuynia cordata replaces Polygonatum, sucrose replaces chitosan and sorbitol,) 200 parts of Dendrobium officinale, 26 parts of menthol, 20 parts of Houttuynia cordata, 22 parts of honeysuckle, 15 parts of sucrose, 6 parts of glycerin, 8 parts of maltodextrin 30 parts magnesium stearate

Preparation method: same as Example 1.

Experimental Example 1: Measurement of Sensory Indexes

Experimental method: Take the samples from the above-mentioned Examples 1 to 4 and Comparative Examples 1 to 4, and investigate their appearance, taste and disintegration degree respectively. The experimental results are shown in Table 1:

Table 1: Measurement results of sensory indicators

The experimental results show that: the samples from Example 1 to Example 4 all show excellent sensory indicators; the sample of Comparative Example 1 is not refreshing and slightly bitter in taste, and the sample of Comparative Example 2 is slightly refreshing and slightly sweet in taste, which may be It is due to the unreasonable ratio of the prescription and dosage of the two; the surface of the sample of Comparative Example 3 is slightly rough, because its processing technology is relatively simple, and the component processing process is not refined enough; the sample of Comparative Example 4 is added with a large amount of sweetener. Flavoring agent, resulting in heavy sweetness.

Experimental example 2: In vitro antibacterial experiment

MIC determination: respectively take the samples from Example 1 to Example 4 and Comparative Example 1 to Comparative Example 4 and dilute them with nutrient broth (double dilution method) to configure the experimental solution of each concentration, and place them in test tubes (1.0ml/ tube), add 1.0ml of bacterial solution (1.5×10 ⁶ CFU/ml) to each tube, mix well, and design blank control (only broth), positive control (without adding experimental solution), negative control (without adding bacteria) solution), placed in a biochemical incubator at 35 ± 1 °C for 24 h, and observed the growth of bacteria with the naked eye. The clear upper liquid is aseptic growth, the turbid upper liquid is bacterial growth, and the minimum drug concentration without bacterial growth in the test tube is the MIC. The experimental results are shown in Table 2.

MBC determination: On the basis of the measured MIC, inoculate the contents of each tube into a petri dish with a 0.01ml inoculation loop, and place it in a biochemical incubator at 35±1°C for 24h to observe the growth of bacteria. % The lowest drug concentration at which the original bacteria were added was MBC. The experimental results are shown in Table 3.

Table 2: In vitro bacteriostatic test results (MIC) unit mg/ml

Table 2: In vitro bacteriostatic test results (MBC) unit mg/ml

The experimental results show that the experimental results of Comparative Examples 1 to 4 are inferior to those of Examples 1 to 4. The samples from Example 1 to Example 4 have good bacteriostatic and bactericidal effects on Staphylococcus aureus, Streptococcus pneumoniae, Pseudomonas aeruginosa and Escherichia coli, and the minimum inhibitory concentration (MIC) is between 0.0625-0.125mg/ml The minimum bactericidal concentration (MBC) is between 0.125-0.25 mg/ml, indicating that the product of the present invention has a good bacteriostatic effect.

A kind of dendrobium buccal tablet is obtained through the prescription compatibility and preparation process of the present invention. The buccal tablet is in the shape of a round sheet, has a smooth and firm surface, has a refreshing taste and is not sweet and greasy, maintains the appropriate sweetness, color and smell of the medicine, and has the properties of clearing heat. It has the functions of detoxification, antibacterial and anti-inflammatory, invigorating body fluid and moisturizing throat. It has a significant effect in the treatment of pharyngitis and oral ulcers. The dendrobium buccal tablet of the invention adopts a refined preparation process, can fully extract the effective components of the traditional Chinese medicine components, the effective components of each component form a synergistic effect, exert the maximum therapeutic effect of the drug, and the production process is reasonable and suitable for industrial production.

The above descriptions are only preferred embodiments of the present invention, and are not intended to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention shall be included in the present invention. within the scope of protection.

Claims (3)

1. The dendrobe buccal tablet is characterized by being prepared from the following components in parts by weight: 180-235 parts of dendrobium, 12-26 parts of menthol, 18-28 parts of rhizoma polygonati, 17-22 parts of honeysuckle, 5-7 parts of sorbitol, 12-15 parts of chitosan, 2-6 parts of glycerol, 8-12 parts of maltodextrin and 23-40 parts of magnesium stearate;

the preparation method of the dendrobium nobile buccal tablet comprises the following steps:

(1) weighing dendrobium, polygonatum and honeysuckle according to the prescription amount, crushing, sieving with a 400-mesh sieve and a 500-mesh sieve to obtain superfine powder, extracting by adopting 40-45% ethanol water solution, and distilling the extracting solution under reduced pressure to remove ethanol to obtain extracting solution and extracted dregs; b. b, putting the extracting solution obtained in the step a on a macroporous resin column, and sequentially eluting with distilled water and alkali liquor; wherein the distilled water eluent is an effluent A; eluting with alkali solution to obtain effluent B; neutralizing the effluent B with acid to neutrality, leaching with 40-50% ethanol water solution for 1.5-3 hr, and vacuum evaporating to obtain powder I; c. mixing the medicine residues obtained in the step a with water according to the mass ratio of 1:5, keeping the mixture in a water bath at the temperature of 40-60 ℃ for 4-6h, cooling the mixture, combining the cooled mixture with the effluent liquid A obtained in the step b, concentrating the mixture, adding absolute ethyl alcohol to generate a precipitate, filtering the precipitate, and drying the precipitate to obtain powder II; uniformly mixing the powder I and the powder II to obtain a traditional Chinese medicine mixture for later use;

(2) uniformly mixing the traditional Chinese medicine mixture obtained in the step (1) with the menthol, sorbitol, chitosan and glycerol according to the prescription amount for later use;

(3) adding magnesium stearate and maltodextrin in the formula amount into the mixture obtained in the step (2), uniformly mixing, drying, sieving to obtain a composition, and tabletting to obtain the dendrobium buccal tablet.

2. The dendrobe buccal tablet according to claim 1, which is prepared from the following components in parts by weight: 200 parts of dendrobium, 26 parts of menthol, 20 parts of rhizoma polygonati, 22 parts of honeysuckle, 5 parts of sorbitol, 15 parts of chitosan, 6 parts of glycerol, 8 parts of maltodextrin and 30 parts of magnesium stearate.

3. The dendrobium nobile buccal tablet according to any one of claims 1 to 2, wherein the dendrobium nobile is one or more of dendrobium nobile, dendrobium officinale, dendrobium huoshanense and dendrobium verbena.