CN110692984A - Rose chewable tablet for removing oral odor and preparation method thereof - Google Patents

Abstract

The invention discloses a rose chewable tablet for removing oral peculiar smell and a preparation method thereof, belonging to the field of foods for removing oral peculiar smell. The chewable tablet comprises effective components and auxiliary materials/additives, wherein the effective components comprise 4.2-5.7 parts of rose aqueous extract, 2-2.6 parts of tuckahoe aqueous extract, 2-2.6 parts of honeysuckle aqueous extract, 0.3-0.5 part of white chrysanthemum aqueous extract, 1.2-1.5 parts of dandelion aqueous extract, 2.5-3.2 parts of hawthorn aqueous extract, 0.5-0.6 part of green tea aqueous extract, 0.5-1.2 parts of lentinan, 1.5-2 parts of liquorice aqueous extract and 3.3-4.1 parts of polished round-grained rice; the auxiliary material/auxiliary agent is one or more of soybean protein isolate powder, maltodextrin and deodorized goat milk. The chewable tablet has the advantages of quick response, light medicinal taste, good effect, safety, no side effect and no drug resistance.

Description

Rose chewable tablet for removing oral odor and preparation method thereof

Technical Field

The invention belongs to the field of daily functional food, particularly relates to the field of food for removing oral peculiar smell, and particularly relates to rose chewable tablets for removing oral peculiar smell and a preparation method thereof.

Background

Oral malodor is a common clinical symptom caused by various reasons, and the causes mainly include: 1) various oral diseases, such as dental caries, gingivitis, periodontitis, oral mucositis and the like cause the breeding of bacteria in the oral cavity, and particularly, sulfide, indole and ammonia are generated by anaerobic bacteria fermentation, so that oral peculiar smell is generated; 2) oral cavity adjacent tissue diseases such as suppurative tonsillitis, chronic maxillary sinusitis, atrophic rhinitis, etc. with purulent secretion to generate odor, and simultaneously, peptic ulcer, acute and chronic gastritis, functional dyspepsia, etc. can be accompanied with halitosis; 3) saliva secretion caused by various reasons is reduced, so that the scouring and buffering effects of saliva are reduced, a large amount of bacteria are bred and decomposed to organic components in saliva, gingival crevicular fluid and food residues, and a large amount of volatile sulfide, indole and other substances are generated to cause bad breath; 4) the food residues are largely decomposed by bacteria caused by eating pungent foods such as shallot, garlic and leek and smoking, drinking and the like, so that the oral cavity peculiar smell is caused; 5) the bad breath can be aggravated and the frequency can be increased due to the reasons of short life rhythm, high working strength, overwork and the like. The patients with bad breath are not dared to communicate with people in short distance, which affects normal interpersonal communication and is very annoying, thus seriously affecting people's life.

At present, no effective prevention and treatment means for the bad breath exists, and most people cover the bad breath by chewing gum or using mouthwash. However, most chewing gums contain plasticizers, which affect the health; the mouth wash contains alcohol, has great irritation to oral mucosa, and may change the oral micro-ecological environment after long-term use. In addition, western medicines are easy to generate drug resistance when used for treating the oral odor, frequently cause repeated outbreak of the oral odor and have high possibility of generating side effects, and traditional Chinese medicine considers that the reasons for causing the oral odor are complex, but mainly cause the oral odor to attack by wind fire or damp heat and cause the oral odor to attack by stomach yin deficiency, gastrointestinal dysfunction, dyspepsia and the like due to exuberant stomach fire. However, the existing traditional Chinese medicine for treating the peculiar smell of the oral cavity has heavy medicine taste and poor mouthfeel, and is very annoying to patients.

Disclosure of Invention

The invention aims to: provides the rose chewable tablet which has good effect of eliminating the peculiar smell in the oral cavity, light medicinal flavor, good taste and no toxic or side effect and the preparation method thereof.

In order to achieve the purpose, the invention adopts the following technical scheme:

the rose chewable tablet for removing the peculiar smell in the oral cavity comprises effective components and auxiliary materials/auxiliaries, wherein the effective components comprise 4.2-5.7 parts by weight of rose aqueous extract, 2-2.6 parts by weight of tuckahoe aqueous extract, 2-2.6 parts by weight of honeysuckle aqueous extract, 0.3-0.5 part by weight of white chrysanthemum aqueous extract, 1.2-1.5 parts by weight of dandelion aqueous extract, 2.5-3.2 parts by weight of hawthorn aqueous extract, 0.5-0.6 part by weight of green tea aqueous extract, 0.5-1.2 parts by weight of lentinan, 1.5-2 parts by weight of liquorice aqueous extract and 3.3-4.1 parts by weight of polished round-grained rice.

Preferably, the effective component further comprises 0.3-1 part by weight of honey.

Preferably, the effective components comprise 5 parts of rose aqueous extract, 2.4 parts of tuckahoe aqueous extract, 2.4 parts of honeysuckle aqueous extract, 0.4 part of white chrysanthemum aqueous extract, 1.8 parts of dandelion aqueous extract, 3 parts of hawthorn aqueous extract, 0.6 part of green tea aqueous extract, 0.6 part of lentinan, 1.8 parts of liquorice aqueous extract, 0.5 part of honey and 3.5 parts of polished round-grained rice by weight.

Preferably, the auxiliary material/auxiliary agent is one or a mixture of more of soybean protein isolate powder, maltodextrin and deodorized goat milk.

Preferably, the rose chewable tablet for removing the oral odor is goat milk obtained by adding 3 wt% of almond into the goat milk and decocting for 20-30 minutes.

Compared with the prior art, the invention has the beneficial effects that:

in the rose chewable tablet for removing the peculiar smell in the oral cavity, the rose has the effects of refreshing breath, softening liver, refreshing stomach, relaxing qi and activating blood; poria has effects in invigorating spleen, regulating stomach function, promoting diuresis, purging pathogenic fire, resolving food stagnation, and resisting bacteria; the flos Chrysanthemi has effects of invigorating spleen, regulating stomach function, killing bacteria, and relieving inflammation; herba Taraxaci has effects in invigorating spleen, regulating stomach function, purging pathogenic fire, and killing bacteria; the fructus crataegi has effects of resolving food stagnation, promoting appetite, activating qi-flowing, removing blood stasis, and resisting bacteria; lentinan has effects of invigorating qi, invigorating spleen, tonifying deficiency and strengthening body resistance; the liquorice has the functions of clearing stomach fire, lung fire and promoting qi circulation; semen oryzae Sativae has effects of invigorating spleen and regulating stomach function, and can be used as carrier of effective component; the honey has the effects of sterilizing, disinfecting, lubricating intestines and stomach and aiding digestion, so that the components have the effects of helping digestion and regulating stomach, clearing stomach fire and aiding digestion by being matched together, and the problems of gastrointestinal dysfunction and dyspepsia caused by excessive stomach fire are solved; the honeysuckle has the functions of clearing away heat and toxic materials, cooling and dispelling wind heat and sterilizing; the green tea contains catechin, and has effects of promoting digestion, diminishing inflammation, killing bacteria, and eliminating halitosis; the two components have antibacterial and antibacterial effects when being matched with Poria, flos Chrysanthemi, herba Taraxaci, fructus crataegi and Mel, thereby solving the problem of oral bacteria breeding; meanwhile, the honeysuckle flower and the white chrysanthemum flower can clear heat and purge fire by matching. Therefore, the rose chewable tablet can effectively solve the problems of gastrointestinal dysfunction, dyspepsia and oral bacteria breeding caused by excessive stomach fire, and achieves the effect of removing oral peculiar smell. The chewable tablet is prepared from medicinal and edible materials, and particularly the faint scent of the rose can quickly cover up the peculiar smell of the oral cavity, so the chewable tablet has the advantages of quick response, light medicinal taste, good effect, safety, no side effect and no drug resistance.

Detailed Description

The technical solution and effects of the present invention will be further explained with reference to specific embodiments. It should be understood that the following examples are only for illustrating and explaining the present invention and are not intended to limit the scope of the present invention.

In the following examples, all the medicinal materials are those collected in the pharmacopoeia of 2015 edition, and all indexes are in accordance with the regulations after identification; the auxiliary materials/auxiliary agents are conventional products sold in the market.

Example 1

A chewable tablet of flos Rosae Rugosae for removing oral odor is prepared from 18-25% of effective components and 82-75% of adjuvants/adjuvants, and its components and dosage are shown in Table 1 below.

TABLE 1 Rose chewing tablet composition and dosage for eliminating oral malodor

The deodorized goat milk is obtained by adding 3% of almond by weight into goat milk and decocting for 20-30 minutes.

Preparing the materials according to the components and the dosage, and then preparing the material by adopting the following steps:

1) preparing the aqueous extract: weighing raw materials with the dosage 120 times of that of each component, respectively adding distilled water with the weight 10 times of that of the components, carrying out reflux decoction for 2 times (2 hours each time), filtering, and then combining the filtrates to obtain water extract of each component; uniformly mixing the water extracts of the components, and concentrating under reduced pressure until the relative density is 1.2 to obtain a concentrated solution; centrifuging the concentrated solution to obtain clear solution; concentrating the clear solution to relative density of 1.4 to obtain water extract;

2) preparing auxiliary materials/auxiliary agents: weighing soybean protein isolate powder, maltodextrin and deodorized goat milk, mixing, adding appropriate amount of water, stirring at 60 deg.C to make the soybean protein isolate powder and maltodextrin uniformly dispersed in deodorized goat milk, and concentrating to relative density of 1.0 to obtain adjuvant/auxiliary agent;

3) grinding the polished round-grained rice: weighing japonica rice, steaming, drying, pulverizing, and sieving with 30 mesh sieve to obtain japonica rice powder;

4) blending: adding the japonica rice powder, the water extract and the lentinan into the auxiliary materials/aids, and uniformly mixing at a constant temperature of 60 ℃ to obtain an extract;

4) forming and packaging: and (3) feeding the extract into a tablet press to be pressed and dried into 0.5 g/tablet, and packaging after the inspection is qualified.

Example 2

Is prepared from 18-25% of active ingredients and 82-75% of auxiliary materials/auxiliary agents, and the components and the dosage are shown in the following table 1.

TABLE 2 Rose chewing tablet composition and dosage for eliminating oral malodor

The deodorized goat milk is obtained by adding 3% of almond by weight into goat milk and decocting for 20-30 minutes.

Preparing the materials according to the components and the dosage, and then preparing the material by adopting the following steps:

1) preparing the aqueous extract: weighing raw materials with the dosage 120 times of that of each component, respectively adding distilled water with the weight 10 times of that of the components, carrying out reflux decoction for 2 times (2 hours each time), filtering, and then combining the filtrates to obtain water extract of each component; uniformly mixing the water extracts of the components, and concentrating under reduced pressure until the relative density is 1.2 to obtain a concentrated solution; centrifuging the concentrated solution to obtain clear solution; concentrating the clear solution to relative density of 1.4 to obtain water extract;

2) preparing auxiliary materials/auxiliary agents: weighing soybean protein isolate powder, maltodextrin and deodorized goat milk, mixing, adding appropriate amount of water, stirring at 60 deg.C to make the soybean protein isolate powder and maltodextrin uniformly dispersed in deodorized goat milk, and concentrating to relative density of 1.0 to obtain adjuvant/auxiliary agent;

3) grinding the polished round-grained rice: weighing japonica rice, steaming, drying, pulverizing, and sieving with 30 mesh sieve to obtain japonica rice powder;

4) blending: adding the japonica rice powder, the water extract, lentinan and honey into the auxiliary materials/aids, and uniformly mixing at a constant temperature of 60 ℃ to obtain an extract;

4) forming and packaging: and (3) feeding the extract into a tablet press to be pressed and dried into 0.5 g/tablet, and packaging after the inspection is qualified.

1. Toxicity test

1.1 acute toxicity test

The astragalus particles are fed to 10 healthy female mice according to the dose of 3mg/kg female mice per day, and under the normal feeding condition, the female mice are continuously fed for 7 days, so that no acute toxicity phenomenon is found in the female mice, and no other adverse conditions are found, which indicates that the astragalus particles have no acute toxicity;

1.2 Long term toxicity test

The astragalus particles are fed to 10 healthy female mice according to the dose of 1 mg/female mouse per day, and are continuously fed for 30 days under the normal feeding condition, so that the toxicity phenomenon of the female mice is not found, and other adverse conditions are not found, which indicates that the astragalus particles have no long-term toxicity.

After the toxicity test determines that the rose chewable tablet is safe and reliable, clinical tests are carried out:

2.1 general data

Patients with halitosis have 18 cases, wherein 10 cases are male and 8 cases are female; the age is 15-56 years, with an average of 32 years. All patients have no oral diseases, and the oral hygiene habit is good, and the clinical manifestations are halitosis, accompanied by symptoms such as eructation, constipation, dyspepsia, etc.

2.2 methods of treatment

All patients take the rose chewable tablets 3 times a day, 1.5g each time, 1 time respectively in the morning, the noon and the evening, 1 treatment course for 7 days, and 2 treatment courses for continuous taking.

2.3 method for determining oral malodor

A medical plastic tube with the diameter of 1cm and the length of 10cm is used, one end of the medical plastic tube is placed at the mouth of a testee, and the other end of the medical plastic tube is placed at the nose of the testee, so that the testee can exhale.

2.4 symptom score evaluation criteria:

the total integral is 70% + times the secondary symptom integral 30%.

① the main symptom score, namely halitosis score, adopts the nose diagnosis method proposed by eight-fold constant health, and the subjective score of halitosis symptoms is (0-10), wherein 0 score is that no odor is detected, 2 score is that odor can be detected or not, 4 score is that odor is slight but can be clearly detected, 6 score is that middle odor is used for very clear halitosis, 8 score is that strong odor is allowed but can be tolerated, and 10 score is that extremely strong intolerable malodor is used.

② symptoms are scored as 0-3 points for constipation, belching, and abdominal pain, 0 point for no symptom, 1 point for mild symptom without obvious symptom, 2 points for moderate symptom with obvious symptom, and 3 points for severe symptom without obvious symptom.

2.5 evaluation of therapeutic effects: the prescription is made according to the 'standard of curative effect for diagnosing the traditional Chinese medical symptoms'.

And (3) healing: the total score after treatment is reduced by more than or equal to 90 percent compared with that before treatment;

the effect is shown: the total score after treatment is reduced by more than or equal to 60-89% compared with that before treatment;

the method has the following advantages: the total score after treatment is reduced by more than or equal to 30-59 percent compared with that before treatment;

and (4) invalidation: the total score after treatment decreased by < 30% compared to before treatment.

2.6 results of the treatment, see Table 3 below

TABLE 3 oral malodour treatment efficacy

Cases of disease	Recovery method	Show effect	Is effective	Invalidation	Total effective rate (%)
						18	5	8	4	1	94.4

As can be seen from Table 3, the rose chewable tablet has an obvious effect of treating the oral odor, the total effective rate is as high as 94.4%, and no clinical adverse reaction occurs. In addition, the rose is reused in the chewable tablet, and the smell of the used medicine is light, so that a subject likes chewing and eating, and the chewable tablet has a good covering effect on pungent smells such as smoke smell, garlic, green Chinese onion and the like after eating.

Claims (6)

1. A rose chewable tablet for removing oral odor comprises effective components and auxiliary materials/auxiliary agents, and is characterized in that: the effective components comprise 4.2-5.7 parts of rose aqueous extract, 2-2.6 parts of tuckahoe aqueous extract, 2-2.6 parts of honeysuckle aqueous extract, 0.3-0.5 part of white chrysanthemum aqueous extract, 1.2-1.5 parts of dandelion aqueous extract, 2.5-3.2 parts of hawthorn aqueous extract, 0.5-0.6 part of green tea aqueous extract, 0.5-1.2 parts of lentinan, 1.5-2 parts of liquorice aqueous extract and 3.3-4.1 parts of polished round-grained rice by weight.

2. The chewable rose tablet for removing oral malodor according to claim 1, wherein: the effective components also comprise 0.3-1 part by weight of honey.

3. The chewable rose tablet for removing oral malodor according to claim 2, wherein: the effective components comprise 5 parts of rose aqueous extract, 2.4 parts of tuckahoe aqueous extract, 2.4 parts of honeysuckle aqueous extract, 0.4 part of white chrysanthemum aqueous extract, 1.8 parts of dandelion aqueous extract, 3 parts of hawthorn aqueous extract, 0.6 part of green tea aqueous extract, 0.6 part of lentinan, 1.8 parts of liquorice aqueous extract, 0.5 part of honey and 3.5 parts of polished round-grained rice by weight.

4. The chewable rose tablet for removing oral malodor according to any of claims 1 to 3, wherein: the auxiliary material/auxiliary agent is one or a mixture of more of soybean protein isolate powder, maltodextrin and deodorized goat milk.

5. The chewable rose tablet for removing oral malodor according to claim 4, wherein: the deodorized goat milk is obtained by adding 3% of almond into goat milk and decocting for 20-30 minutes.

6. A method for preparing the chewable rose tablet for removing halitosis according to claim 2, which comprises the following steps:

1) preparing the aqueous extract: weighing raw materials with the dosage 120 times of that of each component, respectively adding distilled water with the weight 10 times of that of the components, carrying out reflux decoction for 2 times (2 hours each time), filtering, and then combining the filtrates to obtain water extract of each component; uniformly mixing the water extracts of the components, and concentrating under reduced pressure until the relative density is 1.2 to obtain a concentrated solution; centrifuging the concentrated solution to obtain clear solution; concentrating the clear solution to relative density of 1.4 to obtain water extract;

2) preparing auxiliary materials/auxiliary agents: weighing soybean protein isolate powder, maltodextrin and deodorized goat milk, mixing, adding appropriate amount of water, stirring at 60 deg.C to make the soybean protein isolate powder and maltodextrin uniformly dispersed in deodorized goat milk, and concentrating to relative density of 1.0 to obtain adjuvant/auxiliary agent;

3) grinding the polished round-grained rice: weighing japonica rice, steaming, drying, pulverizing, and sieving with 30 mesh sieve to obtain japonica rice powder;

4) blending: adding the japonica rice powder, the water extract, lentinan and honey into the auxiliary materials/aids, and uniformly mixing at a constant temperature of 60 ℃ to obtain an extract;

4) forming and packaging: and (3) feeding the extract into a tablet press to be pressed and dried into 0.5 g/tablet, and packaging after the inspection is qualified.