CN102293725A - Manufacture process for gargle used for oral cavity cleanness - Google Patents

Abstract

The invention relates to a manufacture process for gargle used for oral cavity cleanness. The process comprises the following procedures: putting dried felon herb leaves with water content of 3 to 10% into a heating vessel; adding purified water; boiling the mixture; cooling the mixture to room temperature and carrying out filtration to obtain a filtrate; condensing the filtrate to prepare an extract of felon herb leaves; evenly mixing, on a mass percentage basis, 10 to 30% of an felon herb leaf extract, 1 to 5% of glycerin, 0.1 to 0.5% of peppermint, 0.1 to 0.3% of sodium saccharin, 0.1 to 0.4% of tween 80 and 4 to 24% of edible alcohol, and adding water so as to obtain 100% of a mixed solution; allowing the solution to stand, filtering the solution and carrying out packaging to obtain the product. The gargle for oral cavity cleanness provided in the invention has the characteristics of bacteriostasis, anti-inflammation, comfortable mouthfeel, no toxic and side effects and cheap raw materials. The manufacturing process for the gargle is simple and practicable.

Description

Oral cleaning and mouthwash preparation method

Field

The invention relates to the technical field of oral cleaning and dental hygiene products and its manufacturing process, in particular to a manufacturing method of oral cleaning and mouthwash.

Background technique

As everyone knows, my country is a populous country, and more than 80% of the population suffers from dental caries, periodontitis, gingivitis, halitosis and other oral diseases. Oral disease is one of the common human diseases, mainly caused by bacterial or viral infection. According to statistics from the World Health Organization and the United Nations Center for the Prevention and Development of Stomatological Diseases, there were 720 million oral disease patients worldwide in 1999, of which severe patients were 430 million, and 1.9 million deaths from malignant transformation; my country is a country with a high incidence of oral diseases. In 1999, there were 40 million patients with oral diseases in my country, and the rate of increase was 13.27%. According to the "Third National Oral Health Epidemiological Survey" in 2008, the prevalence of oral diseases in my country is as high as 90%. At present, there are mainly two methods for the prevention of oral diseases. One is to use antibiotics, such as the patented product of Abbort Pharmaceuticals in the United States-antibiotic CC10232, which has a strong inhibitory effect on Gram-positive bacteria such as Staphylococcus aureus and Streptococcus. , Gargling with 0.01% CC10232 has a good effect on controlling the growth of dental plaque, inhibiting the formation of tartar and eliminating gingivitis. However, long-term use of antibiotics will increase the drug resistance of bacteria or cause bacterial imbalance in the body or even cause allergic reactions. At the same time, some antibiotics will produce toxic and side effects in the body, endangering people's health. The second is to use natural active substances, mainly adding sugar-degrading enzymes such as dextranase and glucose oxidase to toothpaste to degrade the sticky polysaccharides formed by oral bacteria, eliminate the living conditions of bacteria, destroy the bacterial cell wall, and inhibit the growth of bacteria. However, the activity and function of biological enzymes are affected by various environmental conditions such as temperature and pH, and the control effect is unstable and individual differences are large. Simultaneously, the improper use of toothbrush often causes the mechanical damage of tooth, even causes other oral diseases.

In recent years, a class of bactericides represented by chlorhexidine, oral cleaning and mouthwash have been widely used for oral antibacterial, and foreign countries have recently developed quaternary ammonium compounds for oral antibacterial. Although the above active substances all have good antibacterial effects, the effect of removing bad breath is not obvious, and the taste is bitter, which has certain irritation and certain toxicity to mucous membranes.

The gargle is easy to use, can fully contact the oral cavity, and penetrate into the parts between the teeth that the toothbrush cannot reach. Practice has shown that the use of the gargle can obtain effective oral cleaning and health care effects. It has been widely used as an oral cleaning and health care product abroad. There are also a small amount of gargle products in China, but they are all limited to clinical treatment. There are very few gargle products that can be used as oral health care for most people. The reason is that most gargles contain antibacterial agents such as chlorhexidine. Element. There is almost no safe, non-toxic, non-irritating, high-efficiency gargle that can be used as oral cleaning and health care for most people. Therefore, new and efficient oral hygiene products need to be developed urgently.

Authorized notification number is that the patent of CN100420432C discloses a kind of mouthwash, contains green tea, honeysuckle, ageratum, peppermint, borneol, has effects such as sterilization, pain relief, deodorization. The patent application whose publication number is CN101721336A and whose publication date is 2010.6.09 discloses a mouthwash with reference safety, which contains tea polyphenols, magnolol, paeonol, sodium phytate, glycyrrhizic acid, ethanol, peppermint, Compositions such as propyl gallate, cyclamate, and surfactant, the raw material cost of this mouthwash is higher than the mouthwash cost of a single Chinese herbal medicine, and the preparation method is also more complicated. The patent application with the publication number CN102008399A and the publication date of 2011.04.13 discloses a preparation method of antibacterial mouthwash, including the preparation of raw materials, the preparation of stable chlorine dioxide, and finally the preparation of antibacterial mouthwash products. The preparation method more complicated.

Mugwort, also known as Artemisia argyi, also known as Bingtai, Medical Herb, Moxibustion Herb, Fragrant Artemisia, etc., is a perennial wild herb of the genus Artemisia in the Asteraceae family. Artemisia mugwort is a traditional Chinese medicine in my country. The leaves are used as medicine. It has the effects of warming the meridian and stopping bleeding, dispelling cold and relieving pain. It can cure ringworm and itching. Since ancient times, Artemisia argyi has been widely used in traditional Chinese medicine. It has few side effects and good safety. It has been recorded in medical books of all ages. Although this medicinal plant has been used by folks for thousands of years, the scientific analysis and utilization of the medicinal components of Artemisia argyi began in modern times. The chemical constituents of mugwort mainly include volatile oil, flavonoids, eucalyptol, triterpenoids and trace chemical elements. Artemisia argyi in vitro on Bacillus anthracis, α-hemolytic streptococcus, B-hemolytic streptococcus, diphtheria bacillus, pseudodiphtheria bacillus, pneumococci, staphylococcus aureus, staphylococcus citrin, staphylococcus albus, Bacillus subtilis, etc. 10 All Gram-positive aerophilic bacteria are antibacterial. Another study showed that mugwort contains antibacterial substances. Recently, 39 compounds have been identified in Artemisia argyi by gas chromatography/mass spectrometry, including 1,8-cineole, camphor, borneol, α-pinene, isocyanobutane, 1,2-propylenediamine, caryophyllales ene etc. α-pinene has broad-spectrum antibacterial effect, 1,2-propanediamine has the activity of inhibiting and killing microorganisms, camphor has strong bactericidal ability, and borneol can significantly inhibit bacteria and yeast. Therefore, Artemisia argyi can inhibit and kill bacteria, viruses, and fungi.

Contents of the invention

The technical problem to be solved by the present invention is to provide a method for preparing oral cavity cleaning and mouthwash with antibacterial and anti-inflammatory properties, comfortable taste, no toxic and side effects, low raw material price, and simple and easy manufacturing process.

The technical scheme that the present invention adopts to solve the technical problem is: a kind of manufacture method of oral cavity cleaning mouthwash, produces through following process:

A, get fresh mugwort leaves to remove impurities, wash and sterilize;

B. Dry the mugwort leaves indoors for 3-4 days after being washed and sterilized, and the water content of the mugwort leaves is 3-10%;

C. Take a certain amount of dry mugwort leaves after drying in the shade and put them into a heating vessel, add 40-50 times pure water of the certain amount of dried mugwort leaves, boil for 20-30 minutes, cool to room temperature and filter to obtain the filtrate, and concentrate the filtrate The mugwort extract to 1/10-1/20 of the original volume is set aside;

D. The mass percentages are 1-5% glycerin, 0.1-0.5% peppermint essential oil, 0.1-0.3% sodium saccharin, 0.1-0.4% Tween, 4-24% edible alcohol, 10-30% mugwort extract, and Measure water, reserve;

E. Take 10-30% of the mugwort extract in the D process, add 1-5% glycerin, 0.1-0.5% peppermint essential oil, 0.1-0.3% sodium saccharin, 800.1-0.4% Tween, and edible alcohol 4-24%, mix evenly, then add the remaining water to 100%, mix evenly;

F. Stand still for 12-24 hours, and pack after membrane filtration to be the finished product.

An oral cavity cleaning and mouthwash produced by the above-mentioned manufacturing method comprises the following components in the following mass percentages: 10-30% of mugwort leaf extract, 1-5% of glycerin, 0.1-0.5% of peppermint essential oil, and 0.1-0.1% of sodium saccharin 0.3%, Tween 800.1-0.4%, edible alcohol 4-24%, and the balance is water, wherein the preparation method of the mugwort leaf extract is to put the dried mugwort leaves into a heating vessel, add pure water, and boil After being cooled to room temperature, it is filtered, and the filtrate is concentrated to get final product. This preparation method is a conventional method in the art, and the mugwort leaf extract obtained by this method can be used as the raw material of the present invention to achieve the purpose of the present invention. Among them, the dried Put 100 grams of mugwort leaves into a heating vessel, add 40-50 times of pure water, boil for 20-30 minutes, cool to room temperature and filter to obtain the filtrate, which is concentrated to 1/10-1/20 of the original volume.

The oral cavity cleansing liquid that aforesaid method obtains is wherein preferably produced through the following procedures:

A. Take fresh mugwort leaves, wash them and dry them indoors for 3-4 days. The water content of mugwort leaves is 8%. Take a certain amount of dry mugwort leaves and put them into a heating vessel. 50 times the pure water of mugwort leaves, boiled for 25 minutes, cooled to room temperature and filtered to obtain the filtrate, the filtrate was concentrated to 1/20 of the original volume of the mugwort extract for later use;

B. Weigh 30 grams of glycerin, 3 grams of peppermint essential oil, 2 grams of sodium saccharin, 2.5 grams of Tween 80, 140 grams of 95% (v/v) edible alcohol, mix well, add 200 grams of mugwort concentrate, and the remaining water To 1000 grams, after mixing, let it stand for 12-24 hours, and pack it after membrane filtration to be the finished product.

Wherein the membrane filtration method is a conventional filtration and sterilization technology in the field, which is widely used in the field of food and medicine.

Oral cleaning mouthwash of the present invention and manufacturing method thereof, the extract of natural plant mugwort is used as the main component to prepare mouthwash, without adding any other chemical antibacterial agents, the mouthwash of the present invention not only has better antibacterial activity, Moreover, compared with other similar products, its toxicity is greatly reduced, its safety is improved, it is non-irritating to the oral mucosa, and it has a significant effect on eliminating bad breath. By using mouthwash to rinse the mouth, it can achieve the effect of anti-inflammatory and analgesic, which is effective for periodontitis, gingivitis and other diseases It can play the role of prevention and treatment, and the oral cavity cleaning and mouthwash of the present invention also has the characteristics of comfortable taste, convenient use and low raw material price. The manufacturing process of the mouthwash of the invention is simple and easy, and is beneficial to industrialized production.

Detailed ways

The above and other technical features and advantages of the present invention will be described in more detail below in conjunction with examples and test data.

Example 1:

a. Take fresh mugwort leaves, wash them and dry them in the shade indoors for 3-4 days. The water content of mugwort leaves is 8%. Weigh 100 grams of dried mugwort leaves and put them in a heating vessel, add 50 times of pure water 5000ml , boiled for 25 minutes, cooled to room temperature and filtered to obtain the filtrate. The mugwort extract that filtrate is concentrated to 1/20 of the original volume is standby;

b. Weigh 30 grams of glycerin, 3 grams of peppermint essential oil, 2 grams of sodium saccharin, 2.5 grams of Tween 80, 140 grams of 95% (v/v) edible alcohol, mix well, add 200 grams of mugwort concentrate, and add the remainder Water to 1000g, mix and let stand for 12 hours, membrane filter and pack to be the finished product.

Example 2:

a. Take fresh mugwort leaves, wash them and dry them in the shade indoors for 3-4 days. When the mugwort leaves are crushed by hand, the water content of the mugwort leaves is 5%. Weigh 100 grams of dried mugwort leaves and put them in a heating vessel In, add 5000 ml of pure water, boil for 20 minutes, cool to room temperature and filter to obtain the filtrate. Concentrate the filtrate to 1/10 and put it in a beaker for later use;

b. Weigh 10 grams of glycerin, 1 gram of peppermint essential oil, 1 gram of sodium saccharin, 1 gram of Tween 80, 40 grams of 95% (v/v) edible alcohol, mix well, add 100 grams of mugwort concentrate, and add the remainder Water to 1000g, mix and let stand for 20 hours, membrane filter and pack to be the finished product.

Example 3:

a. Take fresh mugwort leaves, wash them and dry them in the shade indoors for 3-4 days. When the mugwort leaves are crushed by hand, the water content of the mugwort leaves is 10%. Weigh 100 grams of dried mugwort leaves and put them into a beaker , add 5000 ml of purified water, boil for 30 minutes, cool to room temperature and filter to obtain the filtrate. Concentrate the filtrate to 1/20 and put it in a beaker for later use;

b. Weigh 50 grams of glycerin, 5 grams of peppermint essential oil, 3 grams of sodium saccharin, 4 grams of Tween 80, 240 grams of 95% (v/v) edible alcohol, mix well, add 300 grams of mugwort concentrate, add the remainder Water to 1000 grams, mixed and left to stand for 24 hours, membrane filtered and packaged to be the finished product.

Test example:

In the clinical experiment of the present invention, the subjects are between 18 and 60 years old, in good general health condition, with no less than 20 teeth in the whole mouth, and the modified plaque index ≥ 1.5 and the gingivitis index ≥ 1.0. Firstly, the baseline values of the plaque index and gingivitis index of the subjects were recorded, and then a thorough scaling and tooth surface polishing was performed. The experimental group used mugwort gargle of the present invention, and the control group gargled with physiological saline, twice a day, 20 mL each time, for 30 seconds. Brush your teeth with a uniform standard toothpaste and toothbrush, 2 times a day, 3 minutes each time. Check back in a month.

Plaque index: 0-no plaque; 1-there are scattered plaques on the edge of the tooth neck; 2-a continuous thin plaque band can be seen on the edge of the tooth neck (1 mm) wide; 3-the plaque band on the tooth neck is larger than 1 mm but less than 1/3 of the tooth surface; 4-plaque covering 1/3-2/3 of the tooth surface; 5-plaque covering more than 2/3 of the tooth surface. The mean value of the plaque index for each subject was calculated.

Gingivitis index: 0-no gingivitis; 1-mild gingivitis, slight change in color and texture of the gums, but no bleeding on probing; 2-moderate inflammation, bright redness, hyperplasia, and bleeding on probing; 3-severe Inflammation, gingival swelling, hyperplasia, and spontaneous bleeding. The mean value of the gingivitis index was calculated for each subject. The specific experimental results are shown in Table 1:

Table 1 clinical curative effect of mugwort gargle of the present invention

Compared with the control group, P<0.05, the plaque index and gingivitis index of the subjects who used the mouthwash both decreased, and the gingival inflammation was effectively controlled.

In the present invention, the natural plant extract is adopted as the main component, and no other chemical antibacterial agents are added, so that oral hygiene products such as mouthwash not only have good antibacterial activity, but also have less toxicity than other similar products. It is greatly reduced, the safety is improved, it is not irritating to the oral mucosa, and the effect of eliminating bad breath is remarkable. The gargle of the invention also has the characteristics of convenient use, comfortable taste, good tooth protection and good mouth cleaning effect; the mugwort of the invention has wide sources of raw materials, low price, simple and easy manufacturing process, and is suitable for industrial production.

The above-mentioned embodiments are only descriptions of preferred implementations of the present invention, and are not intended to limit the scope of the present invention. Variations and improvements should fall within the scope of protection defined by the claims of the present invention.

Claims (3)

1. the manufacture method of an oral cavity cleaning collutory is characterized in that, the following operation production of process:

A, get fresh Folium Artemisiae Argyi decontamination and clean sterilization;

B, will clean sterilization back Folium Artemisiae Argyi at the indoor 3-4 of drying in the shade days, the Folium Artemisiae Argyi water content is 3～10%;

C, the dried Folium Artemisiae Argyi of getting after a certain amount of the drying in the shade are put into heating vessel, the 40-50 times of pure water that adds this a certain amount of dried Folium Artemisiae Argyi, boiled 20-30 minute, and be cooled to room temperature and filter to get filtrate, it is standby that filtrate is concentrated into 1/10～1/20 felon herb raffinate of original volume;

D, to get mass percent be glycerol 1～5%, Herba Menthae quintessence oil 0.1～0.5%, saccharin sodium 0.1～0.3%, Tween 80 0.1～0.4%, edible ethanol 4～24%, felon herb raffinate 10～30%, and surplus is water to 100%, and is standby;

E, get the felon herb raffinate 10～30% in the D operation, the batching glycerol 1～5%, Herba Menthae quintessence oil 0.1～0.5%, saccharin sodium 0.1～0.3%, Tween 80 0.1～0.4%, the edible ethanol 4～24% that add the D operation, mix homogeneously adds excess water to 100%, mix homogeneously again;

F, left standstill 12-24 hour, packing is finished product behind the membrane filtration.

2. oral cavity cleaning Su mouth liquid that the described manufacture method of claim 1 obtains.

3. according to the described oral cavity cleaning collutory of claim 2, it is characterized in that the following operation production of process:

A, get fresh Folium Artemisiae Argyi, cleaning the back dried in the shade 3-4 days indoor, the Folium Artemisiae Argyi water content is 8%, the dried Folium Artemisiae Argyi of getting after 100 grams dry in the shade is put into heating vessel, 50 times of pure water that add this a certain amount of dried Folium Artemisiae Argyi, boiled 25 minutes, and be cooled to room temperature and filter to get filtrate, it is standby that filtrate is concentrated into 1/20 felon herb raffinate of original volume;

B, take by weighing glycerol 30 gram, Herba Menthae quintessence oil 3 grams, saccharin sodium 2 grams, Tween 80 2.5 grams, 95% (v/v) edible ethanol, 140 grams, mix homogeneously adds Radix Artemisia ordosicae concentrated solution 200 grams, excess water to 1000 gram, left standstill after the mixing 12-24 hour, packing is finished product behind the membrane filtration.