CN106236638B - A kind of gel toothpaste with anti-inflammatory bactericidal and tooth-fixing effect and preparation method thereof - Google Patents

Abstract

The invention discloses a gel toothpaste with anti-inflammatory, bactericidal and tooth-fixing effects and a preparation method thereof. The toothpaste contains the following substances: sodium laureth sulfate SLES, PEG400, sodium carboxymethyl cellulose, calcium Bomer 941, Sodium Polyacrylate, Micropowder Silica Gel, Pearlescent Powder, Stevia Extract, Wild Chrysanthemum Extract, Peppermint Extract, Scutellariae Extract, Portulaca Extract, Stone Olive Extract, Eclipta Root Extract, Eucommia Leaf extract, methylparaben, propylene glycol, distilled water, essence. Compared with the prior art, the present invention adds a variety of natural plant extracts to the toothpaste, which can fully activate the regeneration function of the dental pulp, so that the teeth can receive sufficient nutrition to solve the stubborn diseases of loose teeth and fragile dentin; The invented toothpaste has the functions of solidifying teeth, antibacterial and anti-inflammatory, anti-aging of teeth, killing insects, curing ulcers, clearing fire and improving eyesight, and can also improve the immunity of teeth.

Description

A kind of gel toothpaste with anti-inflammatory bactericidal and tooth-fixing effect and preparation method thereof

technical field

The invention relates to a toothpaste, in particular to a gel toothpaste with anti-inflammatory, bactericidal and tooth-fixing effects and a preparation method thereof.

Background technique

With the development of science and technology and the progress of the times, people pay more and more attention to personal health and interpersonal communication. Loose teeth and various bacteria are located in the teeth and oral cavity, affecting people's mood and lifestyle, such as: low mood , difficulty in eating, embarrassed to open your mouth to communicate with others, etc. Of course, this is closely related to the toothpaste we use every day. As a daily necessities, toothpaste is a kind of oral cleaning and care products. Its basic function is to clean the teeth (oral cavity) and maintain the health of the oral cavity.

At present, the trend of "health, harmony, and return to nature" prevails in the global consumer market, and the inevitable side effects of chemical preparations have been plaguing the toothpaste industry. Taking fluoride toothpaste as an example, although fluoride toothpaste can inhibit the formation of dental plaque, if the concentration of fluoride is too high, it is easy to form dental fluorosis after use, resulting in hypoplasia of tooth surface enamel, partial tooth loss, and tooth not only Yellow and bumpy. At the same time, as long as the fluoride content in drinking water is 0.7 mg/L, there is no need to use sodium fluoride to prevent tooth decay. Excessive intake of fluoride can cause fluorosis, manifested as dental fluorosis, heart and kidney damage, degeneration of muscle fibers and liver cells, and skeletal fluorosis in which joint pain and bone deformity occur. In addition, in the ecological environment of different regions, the content of fluorine itself is high and low. Therefore, fluoride toothpaste is not suitable for everyone, especially in my country, except Shanghai, other provinces, municipalities and autonomous regions have high fluoride problems in some areas. The characteristics of Chinese herbal medicines are natural and environmentally friendly and have few side effects, which is in line with people's consumption concept of pursuing nature and health. The purchasing motives of Chinese consumers are the motives of seeking practicality first, followed by the motives of seeking honesty and the pursuit of famous brands and comparisons. Therefore, efficacy, price, and brand are the three main factors that affect consumers' purchasing behavior. In these three aspects, Chinese herbal toothpaste brands have incomparable advantages. First of all, Chinese herbal medicine, as the national medicine of the Chinese nation, has a high status in the minds of the Chinese people. People's trust in Chinese herbal medicine has psychologically generated confidence in the efficacy of Chinese herbal medicine toothpaste. At present, Chinese herbal toothpastes on the market are mainly anti-inflammatory and hemostatic toothpastes, which are also the types of toothpastes with the most medical effects. In terms of price, domestic Chinese herbal toothpaste is moderately priced, mainly concentrated in the low-end market, bringing consumers a sense of benefit. As far as brands are concerned, most of the domestic Chinese herbal toothpastes are traditional old brands with a certain popularity and reputation. Therefore, Chinese herbal toothpaste is a sharp sword for domestic toothpaste brands to break the market monopoly of foreign giants. It can be seen that with the increasing awareness of environmental protection, returning to nature and advocating green has become an inevitable trend, and it is also an inevitable choice for toothpaste development and production.

From the above analysis, it can be seen that in line with the concept of health, harmony and return to nature, and to invent a gel toothpaste with anti-inflammatory, bactericidal and tooth-fixing effects, the following methods are required:

(1) Adding a bacteriostatic agent to the toothpaste formula, on the one hand, makes the toothpaste have a rapid bacteriostatic function, because a large number of bacteria multiply at night, and there are many bacteria on the teeth in the morning, and brushing in the morning needs to be able to quickly remove the bacteria to achieve the purpose of cleaning the oral environment; On the other hand, toothpaste has long-lasting antibacterial and antibacterial effects. After using toothpaste at night, it can inhibit bacterial reproduction for a long time.

(2) Strengthen the cleaning effect of surfactants and enhance the decontamination ability of toothpaste, so as to efficiently remove the residual food in the oral cavity and the toxic substances produced by bacterial metabolism.

(3) Add high-quality essence with moderate cooling feeling to improve the freshness of toothpaste. Let the brusher experience a clean, cool, refreshing, refreshing and pleasant feeling.

Through the discussion of the above solutions, we started to study the raw materials and proportions of toothpaste abrasives, flavors, surfactants, additives, and functional components of traditional Chinese medicine.

SUMMARY OF THE INVENTION

The first object of the present invention is to provide a new gel toothpaste containing natural ingredient extracts with anti-inflammatory, bactericidal and tooth-fixing effects.

The second object of the present invention is a method for producing the above-mentioned toothpaste.

In order to achieve the above purpose, the present invention provides a gel toothpaste with anti-inflammatory, bactericidal and tooth-fixing effects, comprising the following substances:

The fragrance is selected from one or more of lemon essence, sweet-scented osmanthus essence and pineapple essence.

A preparation method of a gel toothpaste with anti-inflammatory sterilization and tooth-fixing effect, comprising the following steps:

a) Weigh 0.5-1.5 g of sodium carboxymethyl cellulose, add it to a beaker containing 10-30 ml of distilled water, let it stand for 1-3 days at room temperature, and allow it to fully expand until it is used;

b) Weigh 0.1-0.2g of sodium polyacrylate, add it to a beaker with 0.1-0.15g of glycerin, add 5-10ml of distilled water to it after stirring and mix well, let it stand for 1-2 days, let it fully swell, wait for use;

c) Weigh Carbomer 9410.15-0.6g, add it to a beaker containing 2.5-10ml of distilled water, let it stand for 1-3 days at room temperature, and allow it to fully expand for later use;

d) Weighing 0.01-0.05g of methylparaben, adding it to a beaker containing 1-5ml propylene glycol, heating at 80°C until it is fully dissolved and then stopping, to obtain a preservative solution, which is ready for use;

e) Take centrifuged Eucommia ulmoides leaf extract 0.5-2g, stevia extract 0.5-2g, wild chrysanthemum extract 0.5-2g, mint extract 0.5-2g, skullcap extract 0.5-1.5g, purslane extract 0.5-2g of liquid, 0.5-2g of stone olive extract, 0.5-2g of Eclipta chinensis extract, mixed evenly to obtain an extract mixture, which is ready for use;

f) Mix all the swollen products obtained in steps a), b) and c), stir in the same direction for 5-10 minutes, until there are no small bubbles in the gel, then add the extract mixture and preservative solution, and stir for 10- 15 minutes, until the color is evenly distributed in the beaker;

g) Then add 0.5-1.5g essence, PEG4001-5g, 0.2-2g micropowder silica gel and 0.01-0.1g white pearl powder in sequence, stir with a mixer at 400rpm for 10-15 minutes, after complete mixing, place in a refrigerator at 4°C Let stand for 8-12 hours, take out, add 0.5-2 g of sodium laureth sulfate SLES, and stir for 5-10 minutes to obtain a gel toothpaste with anti-inflammatory, bactericidal and tooth-fixing effects.

Various components in the present invention are as follows:

Purslane is also known as longevity grass in my country. "Compendium of Materia Medica" records "dispelling blood and swelling, benefiting intestines and slipping tires, detoxifying and dredging stranguria, and treating postpartum sweating". Purslane is rich in a large number of flavonoids, adrenaline, polysaccharides and various vitamins, amino acids and other compounds. Its extract has a good scavenging effect on oxidative free radicals, and has pharmacological and nutritional health care effects. Because purslane has inhibitory effect on Shigella, Typhoid Bacillus, Escherichia coli and Staphylococcus aureus, etc., its extract is added to toothpaste to play anti-inflammatory and anti-inflammatory effects.

Stevia, also known as stevia and sugar grass, is one of the sugar plants known to have high sweetness. The stevia contained in the leaves has the characteristics of low calorie, high sweetness, good taste, high temperature resistance, good stability, etc. It is safe and non-toxic to the human body, and also has the functions of lowering blood pressure, promoting metabolism, and treating hyperacidity. It also has a certain auxiliary effect on patients with obesity, diabetes, cardiovascular disease, hypertension, arteriosclerosis, and dental caries. Because of its heat-resistant, stable, anti-corrosion properties, it is not easy to be denatured or deteriorated when added to food or toothpaste daily chemicals. Therefore, the use of stevia extract in toothpaste can not only solve the sweetness of the product, but also reduce the proliferation rate of bacteria in the oral cavity and reduce the occurrence of dental caries, which is in line with the spirit of the State Council's notice on reducing the use of saccharin.

Wild chrysanthemum is bitter in taste and slightly cold in nature. The medicinal part of wild chrysanthemum is mainly the flower head, and its main active components are volatile oil, flavonoids and lactones. Adding wild chrysanthemum extract as an additive to toothpaste not only has antipyretic and detoxifying effects, but also has obvious antibacterial and anti-inflammatory effects; in addition, it also has a certain effect on patients with periodontitis and gingivitis, and long-term use can improve Oral and dental health issues for the benefit of consumers.

Eclipta has the functions of hemostasis, invigorating the kidney, annealing, reducing swelling, cooling blood and stopping bleeding. Eclipta contains many chemical components such as coumarin, triterpenoid saponins and flavonoids. As an additive to toothpaste, it not only has the effect of preventing caries and fixing teeth, but also cooling blood to stop bleeding, anti-inflammatory, annealing and reducing swelling. effect.

Stone olive contains terpenes, phenols, polysaccharides and other natural active ingredients, which have the functions of nourishing yin and moistening the lung, clearing away heat and dampness, resolving phlegm and relieving cough, dispelling wind and relieving pain, purging fire and detoxifying, and clearing heat and cooling blood. Flavonoids are a class of polyphenols that exist in plants and have antibacterial, antioxidant, and antiviral properties. The use of stony olive extract in toothpaste can increase the anti-inflammatory and bactericidal effect of toothpaste, and long-term use can improve the environment of teeth and make people comfortable.

Scutellaria baicalensis is mainly used to treat febrile diseases, upper respiratory tract infection, cough due to lung heat, damp-heat jaundice, pneumonia, dysentery, etc. The infection of the oral cavity by bacteria and viruses is also a part of the factors leading to the above diseases, so it is more necessary to solve the problem of oral infection by bacteria and viruses. The extract of Scutellaria baicalensis has pharmacological effects such as antioxidant, free radical scavenging, anti-inflammatory, anti-viral, anti-allergic, etc., and has protective effects on immune, cardiovascular, cerebrovascular, digestive, nervous and other systems. Its main active ingredient is baicalin, which has an inhibitory effect on Gram-positive and negative bacteria. Adding its extract to toothpaste makes the toothpaste have anti-inflammatory and hemostatic effects, and has a certain auxiliary effect on relieving gingival inflammation. Inflammation and viral infection of oral teeth.

Eucommia ulmoides leaf decoction has antibacterial and anti-inflammatory effects, especially for Mycobacterium tuberculosis, Shigella flexneri, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Pneumococcus, Bacillus anthracis, etc. Eucommia ulmoides leaves can significantly improve the immunity of the human immune system, defend against diseases, inhibit the invasion of pathogens, and also have anti-immune deficiency and anti-virus effects. In addition, Eucommia ulmoides leaves also have the effect of preventing loose teeth and preventing periodontal disease.

Peppermint has the functions of adding fragrance, returning to the lung and liver meridians, dissipating wind-heat, clearing the throat, dispelling rash and detoxifying, soothing the liver, relieving depression and relieving itching, so it is used in toothpaste, food, refreshing drinks, cosmetics, and soaps. fragrant. Adding the essence of mint extract to toothpaste can effectively remove bacteria and tartar that cause tooth decay, relieve toothache and nourish gums; it can whiten teeth, maintain the firmness of teeth, and remove tooth dirt from the inside out , It has a strong cleaning effect on the oral cavity, especially it can solve the problem of dead corners in the oral cavity, and it will not stimulate the oral cavity after long-term use.

Micro-powder silica gel particles are smooth and uniform, with moderate hardness, which can increase the friction between toothpaste and teeth in toothpaste daily necessities. Toothpaste using micro-powder silica gel friction agent will not damage the tooth surface and periodontal tissue, thereby cleaning teeth.

Sodium laureth sulfate SLES is used as a foaming agent in toothpaste. It has rich and stable foam, strong decontamination ability, low alkalinity, and little irritation to oral mucosa. The toothpaste made with it has good temperature stability. . The surfactant can reduce the surface tension, make the toothpaste spread rapidly in the mouth, penetrate and loosen the dirt and food residues on the tooth surface, so that it is emulsified and suspended by the rich foam, and washed away when gargling, so as to achieve cleaning The purpose of the teeth and mouth is a common foaming agent in toothpaste daily necessities.

The beneficial effects of the present invention are: a large amount of natural plant extracts are added to the toothpaste prescription, on the one hand, the growth of bacteria and fungi is reduced by cleaning and fixing teeth; on the other hand, the growth of bacteria and fungi is inhibited by anti-inflammatory sterilization. Purpose. At the same time, it can fully activate the reconstruction function of the dental pulp, so that the teeth can get sufficient nutrition to solve the stubborn diseases of loose teeth and fragile dentin; in addition, the toothpaste of the present invention can solidify teeth, antibacterial and anti-inflammatory, anti-aging of teeth, kill insects, and cure ulcers. , clearing fire and improving eyesight, etc., can improve the immunity of teeth.

Detailed ways

Specific embodiments of the present invention will be described in detail below. It should be understood that the specific embodiments described herein are only used to illustrate and explain the present invention, but not to limit the present invention. In the embodiment, methyl paraben, SLES, PEG400, sodium polyacrylate, micropowder silica gel, carbomer, sodium carboxymethyl cellulose, propylene glycol and pearl powder are all commercially available products of Beijing Xinnuo Jiuheng Technology and Trade Co., Ltd. .

Example 1

A gel toothpaste with anti-inflammatory, bactericidal and tooth-fixing effects, comprising the following substances: sodium laureth sulfate SLES 1.0g, polyethylene glycol 400PEG400 1.5g, sodium carboxymethyl cellulose 1.3g, carbomer 941 0.15g, Sodium Polyacrylate 0.2g, Micropowder Silica Gel 1.5g, Pearlescent Powder 0.06g, Stevia Extract 1.0g, Wild Chrysanthemum Extract 1.0g, Peppermint Extract 1.0g, Scutellariae Extract 0.5g, Purslane Extract 1.0g of liquid, 1.0g of stone olive extract, 1.3g of eucalyptus extract, 1.2g of Eucommia ulmoides leaf extract, 0.01g of methylparaben, 0.15g of glycerin, 1ml of propylene glycol, 32.5ml of distilled water, and 0.9g of lemon essence.

1.1 Preparation of Eucommia ulmoides leaf extract:

Weigh 20 g of Eucommia ulmoides leaves, put it into a round-bottomed flask, add 30 times the amount of water, soak it for 0.5 hours, then place it in an electric heating mantle, extract it with a continuous reflux extractor for 1.5 hours, and add 20 times the amount of water for the second time. , extract for 1.0h, add 15 times the amount of water for the third time, extract for 0.5h, filter each time, combine the filtrate, and finally concentrate the volume of the filtrate to 4 times the weight of Eucommia ulmoides leaves, centrifuge at 2500r/min for 15 minutes, take the supernatant and set aside.

1.2 Preparation of stone olive extract:

Weigh 25g of stone olives, soak for 0.5h, heat and decoct for 3 times, add 30 times the amount of water for the first time, extract for 2 hours, add 20 times the amount of water for the second time, extract 1.0 hours, and add 12 times the amount of water for the third time. , extract for 0.5h, filter each time, combine the filtrates, and finally concentrate the volume of the filtrate to 3 times the weight of the stone olive, centrifuge at 2500r/min for 15 minutes, take the supernatant and set it aside.

1.3 Preparation of purslane extract:

Weigh 20g of purslane, soak for 0.5h, heat and decoct for 3 times, add 20 times the amount of water for the first time, extract for 1.5h, add 15 times the amount of water for the second time, extract 1.0h, add 10 times the amount of water for the third time The volume of the filtrate was concentrated to 4 times the weight of purslane, centrifuged at 2500 r/min for 15 minutes, and the supernatant was taken for use.

1.4 Preparation of peppermint extract:

Weigh 50g of mint, put it into a round-bottomed flask, add 20 times the amount of water, soak it for 0.5h, then place it in an electric heating mantle, extract it with a continuous reflux extractor for 2.5h, add 15 times the amount of water for the second time, Extract for 1.5h, add 10 times the amount of water for the third time, extract for 1h, filter each time, combine the filtrate, and finally concentrate the volume of the filtrate to 3 times the weight of the mint, centrifuge at 2500r/min for 15 minutes, take Supernatant, ready to use.

1.5 Preparation of Eclipta chinensis extract:

Weigh 40g of Eclipta, soak for 0.5h, heat and decoct for 3 times, add 20 times the amount of water for the first time, extract for 1.5h, add 15 times the amount of water for the second time, extract 1.0h, add 10 times the amount of water for the third time amount of water, extract for 0.5h, filter each time, combine the filtrates, and finally concentrate the volume of the filtrate to 3 times the weight of Eclipta, centrifuge at 2500r/min for 15 minutes, take the supernatant and set it aside.

1.6 Preparation of Stevia Extract:

Weigh 30g of stevia, soak for 0.5h, heat and decoct for 3 times, add 20 times the amount of water for the first time, extract for 1.5h, add 13 times the amount of water for the second time, extract 1.0h, add 9 times the amount for the third time Water, extracted for 0.5h, filtered each time, combined the filtrate, and finally concentrated the volume of the filtrate to 3 times the weight of Stevia, centrifuged at 2500r/min for 15 minutes, and took the supernatant for later use.

1.7 Preparation of wild chrysanthemum extract:

Weigh 20 g of wild chrysanthemum, put it into a round-bottomed flask, add 17 times the amount of 70% ethanol solution, soak it for 0.5 h, then place it in an electric heating mantle, extract it with a continuous reflux extractor for 1.5 h, and add 13 times the second time. Amount of 70% ethanol solution, extract for 1.0h, add 8 times the amount of 70% ethanol solution for the third time, extract for 0.5h, filter each time, combine the filtrates, and finally concentrate the volume of the filtrate to 3 times the weight of wild chrysanthemum flowers, at 2500r /min centrifuge for 15 minutes, take the supernatant, set aside.

1.8 Preparation of Scutellaria baicalensis extract:

Weigh 30g of Scutellaria baicalensis coarse powder, soak for 0.5h, heat and decoct for 3 times, add 20 times the amount of water for the first time, extract for 1.5h, add 15 times the amount of water for the second time, extract 1.0h, add 10 times the amount of water for the third time The volume of the filtrate was concentrated to 4 times the weight of Scutellaria baicalensis, centrifuged at 2500 r/min for 15 minutes, and the supernatant was taken for later use.

1.9 The preparation method of the above-mentioned gel toothpaste with anti-inflammatory bactericidal tooth-fixing effect, comprises the following steps:

a) Weigh 1.3 g of sodium carboxymethyl cellulose, add it to a beaker containing 20 ml of distilled water, let it stand for 2 days at room temperature, and allow it to fully expand until it is used;

b) Weigh 0.2 g of sodium polyacrylate, add it to a beaker containing 0.15 g of glycerin, add 10 ml of distilled water to it after stirring and mix well, and let it stand for 1 day to fully swell until it is used;

c) Weigh 0.15g of Carbomer 941, add it to a beaker containing 2.5ml of distilled water, let stand for 2 days at room temperature, allow it to fully expand, and stand by;

d) Weighing 0.01 g of methylparaben, adding it to a beaker containing 1 ml of propylene glycol, heating at 80°C until it is fully dissolved and then stopping, to obtain a preservative solution, which is ready for use;

e) Take centrifuged Eucommia ulmoides leaf extract 1.2g, Stevia rebaudiana extract 1.0g, Wild chrysanthemum extract 1.0g, Peppermint extract 1.0g, Scutellaria baicalensis extract 0.5g, Portulaca oleracea extract 1.0g, Caraway 1.0 g of the extract and 1.3 g of the Eclipta extract are mixed evenly to obtain an extract mixture, which is ready for use;

f) Mix all the swollen products obtained in steps a), b) and c), stir in the same direction for 10 minutes, until there are no small bubbles in the gel, then add the extract mixture and preservative solution, and stir for 15 minutes until The color distribution in the beaker is uniform;

g) Add 0.9g lemon essence, 1.5g PEG400, 1.5g micropowder silica gel and 0.06g white pearl powder in sequence, stir with a mixer at 400 rpm for 15 minutes, after complete mixing, place it in a 4°C refrigerator for 10 hours, take out Then, 1.0 g of sodium laureth sulfate SLES was added, and after stirring for 10 minutes, a gel toothpaste with anti-inflammatory, bactericidal and tooth-fixing effects was obtained.

Example 2

A gel toothpaste with anti-inflammatory, bactericidal and tooth-fixing effects, comprising the following substances: sodium laureth sulfate SLES 1.2g, polyethylene glycol 400PEG400 2g, sodium carboxymethyl cellulose 1.4g, carbomer 941 0.15g, sodium polyacrylate 0.2g, micropowder silica gel 1.5g, pearl powder 0.04g, stevia extract 0.8g, wild chrysanthemum extract 0.8g, mint extract 1.2g, skullcap extract 0.6g, purslane extract 0.9g, stone olive extract 1.0g, eucalyptus extract 1.0g, Eucommia ulmoides leaf extract 1.0g, methylparaben 0.01g, glycerin 0.1g, propylene glycol 1ml, distilled water 32.5ml, osmanthus essence 1.1g.

2.1 Preparation of Eucommia ulmoides leaf extract:

Weigh 40 g of Eucommia ulmoides leaves, put it into a round-bottomed flask, add 30 times the amount of water, soak it for 0.5 hours, then place it in an electric heating mantle, extract it with a continuous reflux extractor for 2 hours, add 20 times the amount of water for the second time, Extract for 1.0h, add 15 times the amount of water for the third time, extract for 0.5h, filter each time, combine the filtrate, and finally concentrate the volume of the filtrate to 3 times the weight of Eucommia ulmoides leaves, centrifuge at 2500r/min for 15 minutes , take the supernatant, set aside.

2.2 Preparation of stone olive extract:

Weigh 30 g of stone olives, soak for 0.5 hours, heat and decoct for 3 times, add 20 times the amount of water for the first time, extract for 2 hours, add 15 times the amount of water for the second time, extract 1.0 hours, and add 10 times the amount of water for the third time. , extract for 0.5h, filter each time, combine the filtrates, and finally concentrate the volume of the filtrate to 3 times the weight of the stone olive, centrifuge at 2500r/min for 15 minutes, take the supernatant and set it aside.

2.3 Preparation of purslane extract:

Weigh 25g of purslane, soak for 0.5h, heat and decoct for 3 times, add 25 times the amount of water for the first time, extract for 1.5h, add 15 times the amount of water for the second time, extract 1.0h, add 10 times the amount of water for the third time The volume of the filtrate was concentrated to 4 times the weight of purslane, centrifuged at 2500 r/min for 15 minutes, and the supernatant was taken for use.

2.4 Preparation of peppermint extract:

Weigh 50g of mint, put it into a round-bottomed flask, add 20 times the amount of water, soak for 0.5h, then place it in an electric heating mantle, extract it with a continuous reflux extractor for 2.5h, add 13 times the amount of water for the second time, Extract for 1.5h, add 10 times the amount of water for the third time, extract for 1h, filter each time, combine the filtrate, and finally concentrate the volume of the filtrate to 2 times the weight of the mint, centrifuge at 2500r/min for 15 minutes, take Supernatant, ready to use.

2.5 Preparation of Eclipta chinensis extract:

Weigh 20g of Eclipta, soak for 0.5h, heat and decoct for 3 times, add 20 times the amount of water for the first time, extract 1.5h, add 15 times the amount of water for the second time, extract 1.0h, add 10 times the amount of water for the third time amount of water, extract for 0.5h, filter each time, combine the filtrates, and finally concentrate the volume of the filtrate to 4 times the weight of Eclipta, centrifuge at 2500r/min for 15 minutes, take the supernatant and set it aside.

2.6 Preparation of Stevia Extract:

Weigh 30g of stevia, soak for 0.5h, heat and decoct for 3 times, add 25 times the amount of water for the first time, extract for 1.5h, add 15 times the amount of water for the second time, extract 1.0h, add 10 times the amount for the third time Water, extracted for 0.5h, filtered each time, combined the filtrate, and finally concentrated the volume of the filtrate to 3 times the weight of Stevia, centrifuged at 2500r/min for 15 minutes, and took the supernatant for later use.

2.7 Preparation of wild chrysanthemum extract:

Weigh 20 g of wild chrysanthemum, put it into a round-bottomed flask, add 17 times the amount of 70% ethanol solution, soak it for 0.5 h, then place it in an electric heating mantle, extract it with a continuous reflux extractor for 1.5 h, and add 13 times the second time. Amount of 70% ethanol solution, extract for 1.0h, add 8 times the amount of 70% ethanol solution for the third time, extract for 0.5h, filter each time, combine the filtrates, and finally concentrate the volume of the filtrate to 3 times the weight of wild chrysanthemum flowers, at 2500r /min centrifuge for 15 minutes, take the supernatant, set aside.

2.8 Preparation of Scutellaria baicalensis extract:

Weigh 40g of Scutellaria baicalensis coarse powder, soak for 0.5h, heat and decoct for 3 times, add 25 times the amount of water for the first time, extract for 1.5h, add 15 times the amount of water for the second time, extract 1.0h, add 10 times the amount of water for the third time The volume of the filtrate was concentrated to 3 times the weight of Scutellaria baicalensis, centrifuged at 2500 r/min for 15 minutes, and the supernatant was taken for later use.

2.9 The preparation method of the above-mentioned gel toothpaste with anti-inflammatory bactericidal and tooth-fixing effect, comprises the following steps:

a) Weigh 1.4 g of sodium carboxymethyl cellulose, add it to a beaker containing 20 ml of distilled water, let it stand for 1 day at room temperature, and allow it to fully expand until it is used;

b) Weigh 0.2 g of sodium polyacrylate, add it to a beaker containing 0.1 g of glycerin, add 10 ml of distilled water to it after stirring and mix well, and let it stand for 1 day to fully swell until it is used;

c) Weigh 0.15g of carbomer, add it to a beaker containing 2.5ml of distilled water, let it stand for 2 days at room temperature, and allow it to fully expand for use;

d) Weighing 0.01 g of methylparaben, adding it to a beaker containing 1 ml of propylene glycol, heating at 80°C until it is fully dissolved and then stopping, to obtain a preservative solution, which is ready for use;

e) Take 1.0 g of Eucommia ulmoides leaf extract, 0.8 g of stevia extract, 0.8 g of wild chrysanthemum extract, 1.2 g of peppermint extract, 0.6 g of scutellariae extract, 0.9 g of purslane extract, 0.9 g of cassava 1.0 g of the extract, 1.0 g of the Eclipta extract, mixed evenly to obtain an extract mixture, which is ready for use;

f) Mix all the swollen materials obtained in steps a), b) and c), stir in the same direction for 10 minutes, until there are no small bubbles in the gel, then add the extract mixture and preservative solution, and stir for 13 minutes until The color distribution in the beaker is uniform;

g) Add 1.1g sweet-scented osmanthus essence, 2g PEG400, 1.5g micropowder silica gel and 0.04g white pearl powder in sequence, stir with a mixer at 400 rpm for 12 minutes, and after complete mixing, place it in a 4°C refrigerator for 12 hours, and take it out. 1.2 g of sodium laureth sulfate SLES was added and stirred for 10 minutes to obtain a gel toothpaste with anti-inflammatory, bactericidal and tooth-fixing effects.

Example 3

A gel toothpaste with anti-inflammatory, bactericidal and tooth-fixing effects, comprising the following substances: sodium laureth sulfate SLES 1.5g, polyethylene glycol 400PEG400 1.3g, sodium carboxymethyl cellulose 1.2g, carbomer 941 0.15g, Sodium Polyacrylate 0.1g, Micropowder Silica Gel 0.8g, Pearlescent Powder 0.03g, Stevia Extract 0.7g, Wild Chrysanthemum Extract 1.2g, Peppermint Extract 0.7g, Scutellariae Extract 0.6g, Purslane Extract 0.7g of liquid, 0.7g of stone olive extract, 1.0g of eucalyptus extract, 0.5g of Eucommia ulmoides leaf extract, 0.01g of methylparaben, 0.1g of glycerin, 1ml of propylene glycol, 27.5ml of distilled water, and 1.4g of pineapple essence.

3.1 Preparation of Eucommia ulmoides leaf extract:

Weigh 30g of Eucommia ulmoides leaves, put it into a round-bottomed flask, add 28 times the amount of water, soak it for 0.5h, then place it in an electric heating mantle, extract it with a continuous reflux extractor for 1.5h, and add 20 times the amount of water for the second time , extract for 1.0h, add 15 times the amount of water for the third time, extract for 0.5h, filter each time, combine the filtrate, and finally concentrate the volume of the filtrate to 3 times the weight of Eucommia ulmoides leaves, centrifuge at 2500r/min for 15 minutes, take the supernatant and set aside.

3.2 Preparation of stone olive extract:

Weigh 30g of stone olives, soak for 0.5h, heat and decoct for 3 times, add 25 times the amount of water for the first time, extract for 2 hours, add 18 times the amount of water for the second time, extract 1.0 hours, and add 10 times the amount of water for the third time. , extract for 0.5h, filter each time, combine the filtrates, and finally concentrate the volume of the filtrate to 3 times the weight of the stone olive, centrifuge at 2500r/min for 15 minutes, take the supernatant and set it aside.

3.3 Preparation of purslane extract:

Weigh 30g of purslane, soak for 0.5h, heat and decoct for 3 times, add 25 times the amount of water for the first time, extract for 1.5h, add 15 times the amount of water for the second time, extract 1.0h, add 10 times the amount of water for the third time The volume of the filtrate was concentrated to 4 times the weight of purslane, centrifuged at 2500 r/min for 15 minutes, and the supernatant was taken for use.

3.4 Preparation of peppermint extract:

Weigh 30g of mint, put it into a round-bottomed flask, add 25 times the amount of water, soak it for 0.5h, then place it in an electric heating mantle, use a continuous reflux extractor for reflux extraction 3 times, the first extraction is 2.5h, and the first extraction is 2.5h. Add 18 times the amount of water twice, extract for 1.5h, add 12 times the amount of water for 1 hour, filter each time, combine the filtrates, and finally concentrate the volume of the filtrate to 3 times the weight of the mint, at 2500r/min. Centrifuge under the centrifuge for 15 minutes, take the supernatant and set aside.

3.5 Preparation of Eclipta extract:

Weigh 30g of Eclipta, soak for 0.5h, heat and decoct for 3 times, add 25 times the amount of water for the first time, extract 1.5h, add 18 times the amount of water for the second time, extract 1.0h, add 12 times the amount of water for the third time amount of water, extract for 0.5h, filter each time, combine the filtrates, and finally concentrate the volume of the filtrate to 3 times the weight of Eclipta, centrifuge at 2500r/min for 15 minutes, take the supernatant and set it aside.

3.6 Preparation of Stevia Extract:

Weigh 30g of stevia, soak for 0.5h, heat and decoct for 3 times, add 25 times the amount of water for the first time, extract for 1.5h, add 15 times the amount of water for the second time, extract 1.0h, add 10 times the amount for the third time Water, extract for 0.5h, filter each time, combine the filtrates, and finally concentrate the volume of the filtrate to 4 times the weight of Stevia, centrifuge at 2500 r/min for 15 minutes, and take the supernatant for later use.

3.7 Preparation of wild chrysanthemum extract:

Weigh 20g of wild chrysanthemum, put it into a round-bottomed flask, add 16 times the amount of 70% ethanol solution, soak it for 0.5h, then place it in an electric heating mantle, extract it with a continuous reflux extractor for 1.5h, add 12 times the second time amount of 70% ethanol solution, extract for 1.0h, add 9 times the amount of 70% ethanol solution for the third time, extract for 0.5h, filter each time, combine the filtrates, and finally concentrate the volume of the filtrate to 3 times the weight of wild chrysanthemum flowers, at 2500r /min centrifuge for 15 minutes, take the supernatant, set aside.

3.8 Preparation of Scutellaria baicalensis extract:

Weigh 40g of Scutellaria baicalensis coarse powder, soak for 0.5h, heat and decoct for 3 times, add 30 times the amount of water for the first time, extract for 1.5h, add 20 times the amount of water for the second time, extract 1.0h, add 10 times the amount of water for the third time The volume of the filtrate was concentrated to 4 times the weight of Scutellaria baicalensis, centrifuged at 2500 r/min for 15 minutes, and the supernatant was taken for later use.

3.9 The preparation method of the above-mentioned gel toothpaste with anti-inflammatory bactericidal tooth-fixing effect, comprising the following steps:

a) Weigh 1.2 g of sodium carboxymethyl cellulose, add it to a beaker containing 20 ml of distilled water, let it stand for 1 day at room temperature, and allow it to fully expand until it is used;

b) Weigh 0.1 g of sodium polyacrylate, add it to a beaker containing 0.1 g of glycerol, add 5 ml of distilled water to it after stirring and mix well, and let it stand for 1 day to fully swell until it is used;

c) Weigh 0.15g of Carbomer 941, add it to a beaker containing 2.5ml of distilled water, let stand for 2 days at room temperature, allow it to fully expand, and stand by;

d) Weighing 0.01 g of methylparaben, adding it to a beaker containing 1 ml of propylene glycol, heating at 80°C until it is fully dissolved and then stopping, to obtain a preservative solution, which is ready for use;

e) Take centrifuged Eucommia ulmoides leaf extract 0.5g, Stevia rebaudiana extract 0.7g, wild chrysanthemum extract 1.2g, mint extract 0.7g, skullcap extract 0.6g, purslane extract 0.7g, stone olive 0.7 g of the extract, 1.0 g of the Eclipta extract, mixed evenly to obtain an extract mixture, which is ready for use;

f) Mix all the swollen products obtained in steps a), b) and c), stir in the same direction for 10 minutes, until there are no small bubbles in the gel, then add the extract mixture and preservative solution, and stir for 15 minutes until The color distribution in the beaker is uniform;

g) Add 1.4g of pineapple essence, 1.3g of PEG400, 0.8g of micropowder silica gel and 0.03g of white pearl powder in sequence, stir with a mixer at 400rpm for 12 minutes, after complete mixing, place it in a 4°C refrigerator for 12h, take out Then, 1.5 g of sodium laureth sulfate SLES was added, and after stirring for 10 minutes, a gel toothpaste with anti-inflammatory, bactericidal and tooth-fixing effects was obtained.

Test example

The physical and chemical indexes of embodiment 1,2,3 are as follows:

1. Character

The toothpaste prepared by the invention is pale yellow, with suitable viscosity, smooth and rich foam, fine and uniform, cool and comfortable taste, good stability and pleasant aroma.

2. pH value check

Dip a small amount of toothpaste with moistened pH paper, pH 5.5-7.3

3. Room temperature test

The toothpaste was encapsulated in a transparent toothpaste tube, and left to stand at room temperature for 6 months. The color, odor, wire drawing, viscosity, etc. did not change, and there was no delamination phenomenon.

4. Inspection of foaming phenomenon

Put a small amount of finished toothpaste on your hand, and rub it in your hands, and observe that the amount of lather is moderate.

5. Check for hard particles

Apply a little toothpaste to the glass and press it evenly with your fingers, and find that there are no hard particles.

6. Check for water seepage

Squeeze the formed toothpaste on the raw edge paper and spread it out evenly with your fingers. It can be seen that the toothpaste has less water seepage and better quality.

7. Irritant test, allergy test

The backs of mice were cut off, and the toothpastes prepared according to Examples 1, 2, and 3 were applied to the cut-off parts respectively, and compared with the uncoated parts, the results showed that there was no irritation or allergic reaction.

Take 1 gram of toothpaste prepared in Examples 1, 2 and 3 and apply it to the hands of volunteers (15-65 years old, 100 persons).

8. Washing effect

Volunteers (15-65 years old, 100 people) were selected, and the prepared toothpaste was rinsed by the volunteers. It was found that the foam was rich. The volunteers generally reported that the taste was good, the mouth was comfortable, and there was no thirst. After a period of continuous use, the teeth are white and firm, and there is no bleeding gums.

Claims (1)

1. a gel toothpaste with anti-inflammatory bactericidal tooth-fixing effect, is characterized in that, comprises the following substances:

Wherein, described Eucommia ulmoides leaf extract is prepared by the following method: Weigh an appropriate amount of Eucommia ulmoides leaves, put it into a round-bottomed flask, add 20-30 times the amount of water, soak it for 0.2-0.5h, then place it in an electric heating mantle, extract it with a continuous reflux extractor for 1.5-2.5h, the second Add 10-20 times the amount of water each time, extract for 1.0-1.5h, add 8-15 times the amount of water for the third time, extract 0.5-1h, filter each time, combine the filtrates, and finally concentrate the volume of the filtrate to 10% of the weight of Eucommia ulmoides leaves. 3-6 times, centrifuge at 2500r/min for 15 minutes, take the supernatant, set aside; Described stone olive extract is prepared by the following method: Weigh an appropriate amount of stone olives, soak in water for 0.2-0.5h, heat and decoct for 3 times, add 20-30 times the amount of water for the first time, extract for 1.5-2.5h, add 10-20 times the amount of water for the second time, extract 1.0 -1.5h, add 10-15 times the amount of water for the third time, extract for 0.5-1h, filter each time, combine the filtrate, and finally concentrate the volume of the filtrate to 3-7 times the weight of the stone olive, centrifuge at 2500r/min Centrifuge under the machine for 15 minutes, take the supernatant, set aside; Described purslane extract is prepared by the following method: Weigh an appropriate amount of purslane, soak it in water for 0.2-0.5h, heat and decoct for 3 times, add 18-25 times the amount of water for the first time, extract for 1.5-2.5h, add 10-18 times the amount of water for the second time, extract 1.0-1.5h, add 8-15 times the amount of water for the third time, extract 0.5-1h, filter each time, combine the filtrate, and finally concentrate the volume of the filtrate to 3-7 times the weight of purslane, at 2500r/min Centrifuge for 15 minutes, take the supernatant, set aside; Described peppermint extract is prepared by the following method: Weigh an appropriate amount of mint, put it into a round-bottomed flask, add 20-30 times the amount of water, soak it for 0.2-0.5h, then place it in an electric heating mantle, extract it with a continuous reflux extractor for 1.5-2.5h, the second time Add 10-20 times the amount of water, extract for 1.0-1.5h, add 10-15 times the amount of water for the third time, extract 0.5-1h, filter each time, combine the filtrates, and finally concentrate the volume of the filtrate to 3- 7 times, centrifuge at 2500r/min for 15 minutes, take the supernatant, set aside; Described eucalyptus extract is prepared by the following method: Weigh an appropriate amount of Eclipta, soak in water for 0.2-0.5h, heat and decoct for 3 times, add 20-30 times the amount of water for the first time, extract for 1.5-2.5h, add 10-18 times the amount of water for the second time, extract 1.0-1.5h, add 8-16 times the amount of water for the third time, extract 0.5-1h, filter each time, combine the filtrate, and finally concentrate the volume of the filtrate to 3-6 times the weight of Eclipta chinensis, at 2500r/min Centrifuge for 15 minutes, take the supernatant, set aside; Described stevia extract is prepared by the following method: Weigh an appropriate amount of stevia, soak in water for 0.2-0.5h, heat and decoct for 3 times, add 20-30 times the amount of water for the first time, extract for 1.5-2.5h, add 10-20 times the amount of water for the second time, extract 1.0 -1.5h, add 5-15 times the amount of water for the third time, extract for 0.5-1h, filter each time, combine the filtrates, and finally concentrate the volume of the filtrate to 3-6 times the weight of Stevia, centrifuge at 2500r/min Centrifuge under the machine for 15 minutes, take the supernatant, set aside; Described wild chrysanthemum extract is prepared by the following method: Weigh an appropriate amount of wild chrysanthemum, put it into a round-bottomed flask, add 15-25 times the amount of 70% ethanol solution, soak it for 0.2-0.5h, then place it in an electric heating mantle, extract it with a continuous reflux extractor for 1.5-2.5h, Add 10-18 times the amount of 70% ethanol solution for the second time, extract for 1.0-1.5 hours, add 8-12 times the amount of 70% ethanol solution for the third time, extract for 0.5-1 h, filter each time, combine the filtrates, and finally put the filtrate Concentrated to 3-6 times the weight of wild chrysanthemum, centrifuge at 2500r/min for 15 minutes, take the supernatant, set aside; The Scutellaria baicalensis extract is prepared by the following method: Weigh an appropriate amount of Scutellaria baicalensis coarse powder, soak it in water for 0.2-0.5h, heat and decoct for 3 times, add 15-25 times the amount of water for the first time, extract for 1.0-2.0h, add 10-15 times the amount of water for the second time, extract 1.0-1.5h, add 8-15 times the amount of water for the third time, extract 0.5-1h, filter each time, combine the filtrates, and finally concentrate the volume of the filtrate to 2-5 times the weight of Scutellaria baicalensis, centrifuge at 2500r/min Centrifuge under the machine for 15 minutes, take the supernatant, set aside; The above-mentioned preparation method of the gel toothpaste with anti-inflammatory bactericidal and tooth-fixing effect comprises the following steps: a) Weigh 0.5-1.5 g of sodium carboxymethyl cellulose, add it to a beaker containing 10-30 ml of distilled water, let it stand for 1-3 days at room temperature, and allow it to fully expand until it is used; b) Weigh 0.1-0.2g of sodium polyacrylate, add it to a beaker with 0.1-0.15g of glycerin, add 5-10ml of distilled water to it after stirring and mix well, let it stand for 1-2 days, let it fully swell, wait for use; c) Weigh Carbomer 9410.15-0.6g, add it to a beaker containing 2.5-10ml of distilled water, let it stand for 1-3 days at room temperature, and allow it to fully expand for later use; d) Weighing 0.01-0.05g of methylparaben, adding it to a beaker containing 1-5ml propylene glycol, heating at 80°C until it is fully dissolved and then stopping, to obtain a preservative solution, which is ready for use; e) Take centrifuged Eucommia ulmoides leaf extract 0.5-2g, stevia extract 0.5-2g, wild chrysanthemum extract 0.5-2g, mint extract 0.5-2g, skullcap extract 0.5-1.5g, purslane extract 0.5-2g of liquid, 0.5-2g of stone olive extract, 0.5-2g of Eclipta chinensis extract, mixed evenly to obtain an extract mixture, which is ready for use; f) Mix all the swollen products obtained in steps a), b) and c), stir in the same direction for 5-10 minutes, until there are no small bubbles in the gel, then add the extract mixture and preservative solution, and stir for 10- 15 minutes, until the color is evenly distributed in the beaker; g) Then add 0.5-1.5g essence, PEG4001-5g, 0.2-2g micropowder silica gel and 0.01-0.1g white pearl powder in sequence, stir with a mixer at 400rpm for 10-15 minutes, after complete mixing, place in a refrigerator at 4°C Let stand for 8-12 hours, take out, add 0.5-2 g of sodium laureth sulfate SLES, and stir for 5-10 minutes to obtain a gel toothpaste with anti-inflammatory, bactericidal and tooth-fixing effects.