CN108014070A - Visualization propolis acidity mouthwash of hemostasis and anti-inflammation and preparation method thereof - Google Patents
Visualization propolis acidity mouthwash of hemostasis and anti-inflammation and preparation method thereof Download PDFInfo
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- CN108014070A CN108014070A CN201810137169.XA CN201810137169A CN108014070A CN 108014070 A CN108014070 A CN 108014070A CN 201810137169 A CN201810137169 A CN 201810137169A CN 108014070 A CN108014070 A CN 108014070A
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- Prior art keywords
- mouthwash
- propolis
- hemostasis
- agent
- acidity
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- 239000002324 mouth wash Substances 0.000 title claims abstract description 68
- 229940051866 mouthwash Drugs 0.000 title claims abstract description 56
- 241000241413 Propolis Species 0.000 title claims abstract description 41
- 229940069949 propolis Drugs 0.000 title claims abstract description 41
- 206010061218 Inflammation Diseases 0.000 title claims abstract description 37
- 230000023597 hemostasis Effects 0.000 title claims abstract description 37
- 238000012800 visualization Methods 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 52
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 27
- 239000002253 acid Substances 0.000 claims abstract description 26
- 239000000243 solution Substances 0.000 claims abstract description 26
- 239000002904 solvent Substances 0.000 claims abstract description 25
- 239000000022 bacteriostatic agent Substances 0.000 claims abstract description 24
- 235000003599 food sweetener Nutrition 0.000 claims abstract description 24
- 239000003765 sweetening agent Substances 0.000 claims abstract description 24
- 239000004909 Moisturizer Substances 0.000 claims abstract description 23
- 230000003213 activating effect Effects 0.000 claims abstract description 23
- 230000001333 moisturizer Effects 0.000 claims abstract description 23
- 239000003755 preservative agent Substances 0.000 claims abstract description 21
- 230000002335 preservative effect Effects 0.000 claims abstract description 21
- 238000003756 stirring Methods 0.000 claims abstract description 21
- 239000007864 aqueous solution Substances 0.000 claims abstract description 12
- 238000000034 method Methods 0.000 claims abstract description 12
- 239000008367 deionised water Substances 0.000 claims abstract description 8
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 8
- 238000002242 deionisation method Methods 0.000 claims abstract description 6
- 238000001914 filtration Methods 0.000 claims abstract description 6
- 230000008569 process Effects 0.000 claims abstract description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 24
- 239000002826 coolant Substances 0.000 claims description 22
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 16
- 244000269722 Thea sinensis Species 0.000 claims description 16
- 235000013616 tea Nutrition 0.000 claims description 12
- 244000131316 Panax pseudoginseng Species 0.000 claims description 10
- 235000003181 Panax pseudoginseng Nutrition 0.000 claims description 10
- 150000008442 polyphenolic compounds Chemical class 0.000 claims description 10
- 235000013824 polyphenols Nutrition 0.000 claims description 10
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical group CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 9
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 9
- 229940041616 menthol Drugs 0.000 claims description 9
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 8
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical group [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 8
- 239000003205 fragrance Substances 0.000 claims description 8
- 235000011187 glycerol Nutrition 0.000 claims description 8
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 8
- 239000004302 potassium sorbate Substances 0.000 claims description 8
- 235000010241 potassium sorbate Nutrition 0.000 claims description 8
- 229940069338 potassium sorbate Drugs 0.000 claims description 8
- 229940085605 saccharin sodium Drugs 0.000 claims description 8
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 7
- 239000004376 Sucralose Substances 0.000 claims description 7
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 claims description 7
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 7
- 235000019408 sucralose Nutrition 0.000 claims description 7
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims description 7
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 6
- 244000144730 Amygdalus persica Species 0.000 claims description 6
- OJIYIVCMRYCWSE-UHFFFAOYSA-M Domiphen bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CCOC1=CC=CC=C1 OJIYIVCMRYCWSE-UHFFFAOYSA-M 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 244000024873 Mentha crispa Species 0.000 claims description 6
- 235000014749 Mentha crispa Nutrition 0.000 claims description 6
- QZTLGJIUZACNEG-UHFFFAOYSA-N NCl.N1C=CC=C1 Chemical class NCl.N1C=CC=C1 QZTLGJIUZACNEG-UHFFFAOYSA-N 0.000 claims description 6
- 235000006040 Prunus persica var persica Nutrition 0.000 claims description 6
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 6
- 229960001859 domiphen bromide Drugs 0.000 claims description 6
- 235000013399 edible fruits Nutrition 0.000 claims description 6
- 235000009569 green tea Nutrition 0.000 claims description 6
- 235000012907 honey Nutrition 0.000 claims description 6
- 239000001630 malic acid Substances 0.000 claims description 6
- 235000011090 malic acid Nutrition 0.000 claims description 6
- 239000004299 sodium benzoate Substances 0.000 claims description 6
- 235000010234 sodium benzoate Nutrition 0.000 claims description 6
- 229920002690 Polyoxyl 40 HydrogenatedCastorOil Polymers 0.000 claims description 4
- 238000007792 addition Methods 0.000 claims description 4
- 239000002304 perfume Substances 0.000 claims description 3
- 241000220324 Pyrus Species 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 235000021017 pears Nutrition 0.000 claims description 2
- 238000005260 corrosion Methods 0.000 claims 1
- 230000003020 moisturizing effect Effects 0.000 claims 1
- 229920000136 polysorbate Polymers 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 abstract description 20
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 8
- 238000004140 cleaning Methods 0.000 abstract description 7
- 230000008439 repair process Effects 0.000 abstract description 4
- 230000002439 hemostatic effect Effects 0.000 abstract description 3
- 230000000694 effects Effects 0.000 description 13
- 239000003814 drug Substances 0.000 description 10
- 241000894006 Bacteria Species 0.000 description 7
- 230000003110 anti-inflammatory effect Effects 0.000 description 5
- 239000002994 raw material Substances 0.000 description 5
- 241000205585 Aquilegia canadensis Species 0.000 description 4
- 208000032843 Hemorrhage Diseases 0.000 description 4
- 230000000740 bleeding effect Effects 0.000 description 4
- 239000000284 extract Substances 0.000 description 4
- 244000247747 Coptis groenlandica Species 0.000 description 3
- 235000002991 Coptis groenlandica Nutrition 0.000 description 3
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 3
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 3
- 239000000811 xylitol Substances 0.000 description 3
- 235000010447 xylitol Nutrition 0.000 description 3
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 3
- 229960002675 xylitol Drugs 0.000 description 3
- 244000118350 Andrographis paniculata Species 0.000 description 2
- 208000006558 Dental Calculus Diseases 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 2
- 244000246386 Mentha pulegium Species 0.000 description 2
- 235000016257 Mentha pulegium Nutrition 0.000 description 2
- 235000004357 Mentha x piperita Nutrition 0.000 description 2
- UILPJVPSNHJFIK-UHFFFAOYSA-N Paeonol Chemical compound COC1=CC=C(C(C)=O)C(O)=C1 UILPJVPSNHJFIK-UHFFFAOYSA-N 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- 230000003385 bacteriostatic effect Effects 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 208000034158 bleeding Diseases 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 235000001050 hortel pimenta Nutrition 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 208000003265 stomatitis Diseases 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 229940034610 toothpaste Drugs 0.000 description 2
- 239000000606 toothpaste Substances 0.000 description 2
- 239000005711 Benzoic acid Substances 0.000 description 1
- 206010006326 Breath odour Diseases 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 244000004281 Eucalyptus maculata Species 0.000 description 1
- 208000032139 Halitosis Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 240000008821 Menyanthes trifoliata Species 0.000 description 1
- 241000972672 Phellodendron Species 0.000 description 1
- 235000004443 Ricinus communis Nutrition 0.000 description 1
- 240000006079 Schisandra chinensis Species 0.000 description 1
- 235000008422 Schisandra chinensis Nutrition 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 240000001519 Verbena officinalis Species 0.000 description 1
- 235000018718 Verbena officinalis Nutrition 0.000 description 1
- 230000000675 anti-caries Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 239000010231 banlangen Substances 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000002308 calcification Effects 0.000 description 1
- 150000001669 calcium Chemical class 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 208000020670 canker sore Diseases 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- YLTGFGDODHXMFB-UHFFFAOYSA-N isoacetovanillon Natural products COC1=CC=C(C(C)=O)C=C1O YLTGFGDODHXMFB-UHFFFAOYSA-N 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229940105902 mint extract Drugs 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000037257 muscle growth Effects 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- MLIBGOFSXXWRIY-UHFFFAOYSA-N paeonol Natural products COC1=CC=C(O)C(C(C)=O)=C1 MLIBGOFSXXWRIY-UHFFFAOYSA-N 0.000 description 1
- 206010034754 petechiae Diseases 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 229940013618 stevioside Drugs 0.000 description 1
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 1
- 235000019202 steviosides Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 235000012976 tarts Nutrition 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4993—Derivatives containing from 2 to 10 oxyalkylene groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/49—Solubiliser, Solubilising system
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Zoology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of visualization propolis acidity mouthwash of hemostasis and anti-inflammation, component：Sweetener 0.003% ~ 0.1%；Acid 0.01%~0.3%；Moisturizer 2%~15%；Essence 0.05%~0.5%；Activating agent 0.1%~2%；Solubilizer 0.5%~2.5%；Bacteriostatic agent 0.02%~0.05%；Preservative 0.1%~0.4%；Deionized water surplus；The PH of mouthrinse product is 3~5.6th, preparation method includes：Sweetener and acid are added into stirring and dissolving in water deionization, then moisturizer is added in aqueous solution, is stirred evenly；Solubilizer, essence are stirred to form uniform oily solution；Oily solution is added in water miscible clarified solution, is uniformly mixed；Activating agent, bacteriostatic agent, preservative are added in aqueous solution, are mixed evenly；Stand 24 it is small when, filtering, after aseptic process PH be 3~5 mouthwash finished product.To oral cleaning, dispel implication and antibacterial hemostatic function while, repair oral cavity, dispel oral cavity and hemostasis and anti-inflammation one-time-reach-place.
Description
Technical field
A kind of visualization propolis acidity the present invention relates to oral care product technical field, more particularly to hemostasis and anti-inflammation is gargled
Saliva and preparation method thereof.
Background technology
With the improvement of living standards, people increasingly improve the attention rate of oral health, common oral care is also no longer
It is confined to brush teeth twice sooner or later, the species and form demand to oral care product tend to diversification and fashion-orientation.Mouthwash is
Through into the necessity in for people's lives, it is easy to use, and effect can be equal to toothpaste, and use is more convenient than toothpaste, but mesh
The mouthwash of preceding market often act on it is single, and for a long time use protective effect is not had to tooth.It is also, existing at present
The acid-base value of mouthwash be generally neutrality, main function include antibacterial bacteriostatic, improve oral peculiar smell, anti-inflammatory, cleaning oral cavity it is thin
Bacterium and tartar etc., species include Chinese medicine draft class, natural plant extracts class and drug ingedient composite class.
105687083 A of CN disclose a kind of antibacterial hemostasis mouthwash and preparation method thereof, and the mouthwash is by following weight
Raw material be made：0.5~1 part of activated calcium powder, 0.1~2 part of Honegsukle flower P.E, 0.1~1.5 part of propolis, Paeonol 0.2
~0.5 part, 0.1~2 part of deep sea salt, 0.1~0.5 part of mint extract, 0.5~3 part of stevioside, 0.5~1 part of loguat leaf, eucalyptus
0.1~0.3 part of tree oil, 2~3 parts of old tea liquid, 90~95 parts of pure water.Old tea is added in mouthwash of the present invention, it contains abundant
Acid element, capillary hemorrhage can be prevented.There is obvious therapeutic effect to suffering from stomatitis, glossanthrax, eczema, bleeding gums etc..
A kind of Chinese medicine mouth washs of 104688850 A of CN, raw material of the present invention consist predominantly of radix scutellariae, honeysuckle,
The coptis, Fructus Forsythiae, xylitol, 95% ethanol, the ratio of selected raw material use radix scutellariae：Honeysuckle：The coptis：Fructus Forsythiae：Xylitol is 1：
1：0.8：0.8 ：1, extract four kinds of selected Chinese medicines, obtain the extracting solution of radix scutellariae, honeysuckle, the coptis, Fructus Forsythiae, to extracting solution into
Row sterilization treatment, adds xylitol according to ratio and is allocated, be finally made mouthwash.The present invention chooses Chinese herbal medicine and makees
For the raw material of mouthwash, the tradition that mouthwash is prepared using irritation chemicals is breached, quintessence of Chinese culture Chinese medicine has been played and has existed
Unique effects in terms of antibacterial, clearing heat and removing internal heat, and its safety, it is gentle the advantages of.
A kind of long-acting bacteriostatic type mouthwashes of 106038389 A of CN, it at least adds using deionized water as main component
Added with the combination of phellodendron extract, capillary extract, Andrographis Paniculata and Herba Verbenae.This case is extracted using Cortex Phellodendri
The mode that thing, capillary extract, Andrographis Paniculata and Herba Verbenae are used in combination, can play quickly prevents gum from going out
The effect of blood, long-acting suppression oral bacteria, achieve the purpose that to treat both principal and secondary aspect of disease.
105769718 A of CN are a kind of to be used to clean the Chinese medicine mouth wash in oral cavity, is by following weight in the Chinese medicine mouth wash
The Chinese medicine material composition of part proportioning：40~60 parts of kuh-seng, 80~110 parts of Radix Isatidis, 20~40 parts of honeysuckle, rhizoma atractylodis 30~50
Part, 30~40 parts of Verbena officinalis, 30~40 parts of Schisandra chinensis, 15~25 parts of peppermint.This Chinese medicine mouth wash has clearing away heat,cooling blood and removing toxin, resists
The effect of bacterium anti-inflammatory analgesic, is cleaned suitable for mouth cavity daily, while suitable for that can lack of proper care because of bacterium, the position such as oral cavity, throat, tonsillotome
By bacterium, virogenetic infection, and swelling and aching of gum, canker sore, halitosis etc., can make oral cavity thoroughly it is fragrant, clean it is refreshing, comfortable, naturally,
Can long-time service.
Various mouthwashes described in above-mentioned patent, although play the antibacterial anti-inflammatory to tooth and oral cavity, cleaning oral cavity and
Tooth and the effect for being effectively improved oral peculiar smell, but it is substantially neutrality, cleans the effect of tartar and oral foreign body
And unobvious, and oral cavity cannot be repaired, dispel oral cavity and hemostasis and anti-inflammation one-time-reach-place, how effectively, quickly, thoroughly realize
The removing of the adhesion and staining of tooth, while repair oral cavity, dispel oral cavity and hemostasis and anti-inflammation one-time-reach-place, it is to restrict
One problem of the industry of mouth cavity daily nursing at present, and the mouthwash of pure Chinese medicine component primarily serves the effect of reparation, anti-inflammatory,
And the Chinese medicine effect for acting on outside is often slow, for the effect and unobvious of bacteriostasis antibiosis and hemostasis.
The content of the invention
In view of the deficienciess of the prior art, the technical problem to be solved by the invention is to provide it is a kind of to oral cleaning,
While dispelling implication and antibacterial hemostatic function, repair oral cavity, dispel the hemostasis and anti-inflammation of oral cavity and hemostasis and anti-inflammation one-time-reach-place
Visualize propolis acidity mouthwash and preparation method thereof.
In order to solve the above technical problems, the technical solution used in the present invention is：A kind of visualization propolis of hemostasis and anti-inflammation
Acid mouthwash, is made of the component of following percentage by weight：
Sweetener 0.003% ~ 0.1%；
Acid 0.01%~0.3%；
Moisturizer 2%~15%；
Essence 0.05%~0.5%；
Activating agent 0.1%~2%；
Solubilizer 0.5%~2.5%；
Bacteriostatic agent 0.02%~0.05%；
Preservative 0.1%~0.4%；
Deionized water surplus；
The PH of the mouthrinse product is 3~5.
The visualization propolis acidity mouthwash of above-mentioned hemostasis and anti-inflammation, is made of the component of following percentage by weight：
Sweetener 0.05%；；
Acid 0.1%；
Moisturizer 8%；
Essence 0.3%；
Activating agent 1%；
Solubilizer 1.5%；
Bacteriostatic agent 0.03%；
Preservative 0.2%；
Deionized water surplus；
The PH of the mouthrinse product is 4.
The visualization propolis acidity mouthwash of above-mentioned hemostasis and anti-inflammation, the sweetener is saccharin sodium, D-sorbite, trichlorine
One or more in sucrose, acid are citric acid or malic acid, and moisturizer is glycerine, one kind in sorbierite, propane diols
Or it is several, essence is polysorbas20 or PEG-40 hydrogenated castors for the fruit such as green tea, spearmint, honey peach perfume or the fragrance of a flower, solubilizer
Oil, activating agent are the one or more in tea polyphenols, propolis, pseudo-ginseng, and preservative is potassium sorbate, sodium benzoate, methyl hydroxybenzoate
In one or more, bacteriostatic agent uses Domiphen bromide, western pyrrole chloramines or chlorohexidene.
The visualization propolis acidity mouthwash of above-mentioned hemostasis and anti-inflammation, the mouthwash are also added with percentage by weight
0.5% coolant agent.
The visualization propolis acidity mouthwash of above-mentioned hemostasis and anti-inflammation, the coolant agent are menthol.
A kind of method for the visualization propolis acidity mouthwash for preparing hemostasis and anti-inflammation, includes the following steps：
（1）, sweetener and acid are added to stirring and dissolving in water deionization, then moisturizer is added in aqueous solution, stirring is equal
It is even and form finely dispersed water miscible clarified solution；
（2）, solubilizer, essence stirred to form uniform oily solution；
（3）, in the state of stirring, oily solution is slowly added into water miscible clarified solution, be uniformly mixed；
（4）, by activating agent, bacteriostatic agent, preservative add step（3）In the aqueous solution of acquisition, it is mixed evenly；
（5）, stop stirring, stand 24 it is small when, filtering, after aseptic process PH be 3~5 mouthwash finished product.
The preparation method of the visualization propolis acidity mouthwash of above-mentioned hemostasis and anti-inflammation, the step（2）Middle addition weight
Percentage is 0.5% coolant agent.
The preparation method of the visualization propolis acidity mouthwash of above-mentioned hemostasis and anti-inflammation, the sweetener is saccharin sodium, mountain
One or more in pears sugar alcohol, Sucralose, acid are citric acid or malic acid, moisturizer is glycerine, sorbierite, the third two
One or more in alcohol, essence are polysorbas20 or PEG- for the fruit such as green tea, spearmint, honey peach perfume or the fragrance of a flower, solubilizer
40 rilanit specials, activating agent are the one or more in tea polyphenols, propolis, pseudo-ginseng, and preservative is potassium sorbate, benzoic acid
One or more in sodium, methyl hydroxybenzoate, bacteriostatic agent use Domiphen bromide, western pyrrole chloramines or chlorohexidene.
The preparation method of the visualization propolis acidity mouthwash of above-mentioned hemostasis and anti-inflammation, the coolant agent is menthol.
The advantages of visualization propolis acidity mouthwash of hemostasis and anti-inflammation of the present invention and preparation method thereof is：Addition it is acid into
Point, to oral cleaning, dispel implication and antibacterial hemostatic function while, repair oral cavity, dispel oral cavity and hemostasis and anti-inflammation once arrives
Position.Mouthwash of the present invention is applied widely, easy to use, has the function that cleaning, antibacterial, anti-caries and fresh breath, and nothing is appointed
What toxic side effect；Meanwhile, it is capable to promote the calcification of tooth, bleeding gums are prevented.Tea polyphenols, propolis, pseudo-ginseng are added, hair can be prevented
Thin angiorrbagia.There is obvious therapeutic effect to suffering from stomatitis, glossanthrax, eczema, bleeding gums etc..Tea polyphenols, propolis, pseudo-ginseng,
The effect of mode that solubilizer is used in combination, can play quickly prevents bleeding gums, long-acting suppression oral bacteria, reaches sample
The simultaneous purpose controlled.The component of this mouthwash is green and healthy raw material, and formula is unique, fastidious, manufacture method is simple, through excessive
Secondary clinical research, there is uniqueness to resist the oral inflammation caused by the pathogenic bacteria such as Candida albicans, staphylococcus aureus
Bacterium anti-inflammatory, analgesic promoting muscle growth functions, can effectively suppress the formation of oral inflammation, maintain Oral Bacteria state balance, moment cleaning oral cavity, prevents
It is good to control effect.
Embodiment
The present invention is described in further details with reference to specific embodiment；
Embodiment 1：
A kind of visualization propolis acidity mouthwash of hemostasis and anti-inflammation, is made of the component of following percentage by weight：Sweetener
0.003%；Acid 0.01%；Moisturizer 2%；Essence 0.05%；Activating agent 0.1%；Solubilizer 0.5%；Bacteriostatic agent 0.02%；It is anti-
Rotten agent 0.1%；Deionized water surplus；The PH of the mouthrinse product is 5.Wherein, sweetener for saccharin sodium, D-sorbite, tart flavour
Agent is citric acid, and moisturizer is glycerine, sorbierite, and essence is green tea, the fragrance of a flower, and solubilizer is polysorbas20, activating agent is tea polyphenols,
Propolis, preservative is potassium sorbate, sodium benzoate, and bacteriostatic agent uses Domiphen bromide.The mouthwash is also added with percentage by weight
For 0.5% coolant agent.In the present embodiment, coolant agent is menthol.
The method that the present invention prepares the visualization propolis acidity mouthwash of hemostasis and anti-inflammation, includes the following steps：
（1）, sweetener and acid are added to stirring and dissolving in water deionization, then moisturizer is added in aqueous solution, stirring is equal
It is even and form finely dispersed water miscible clarified solution；
（2）, solubilizer, essence, 0.5% coolant agent stirred to form uniform oily solution；
（3）, in the state of stirring, oily solution is slowly added into water miscible clarified solution, be uniformly mixed；
（4）, by activating agent, bacteriostatic agent, preservative add step（3）In the aqueous solution of acquisition, it is mixed evenly；
（5）, stop stirring, stand 24 it is small when, filtering, after aseptic process PH be 5 mouthwash finished product.
The sweetener is saccharin sodium, D-sorbite, and acid is citric acid, and moisturizer is glycerine, sorbierite, and essence is
Green tea, the fragrance of a flower, solubilizer are polysorbas20, and activating agent is tea polyphenols, propolis, and preservative is potassium sorbate, sodium benzoate, bacteriostatic agent
Using Domiphen bromide.The mouthwash is also added with the coolant agent that percentage by weight is 0.5%.In the present embodiment, coolant agent is peppermint
Alcohol.
Embodiment 2：
A kind of visualization propolis acidity mouthwash of hemostasis and anti-inflammation, is made of the component of following percentage by weight：Sweetener
0.05%；Acid 0.1%；Moisturizer 8%；Essence 0.3%；Activating agent 1%；Solubilizer 1.5%；Bacteriostatic agent 0.03%；Preservative
0.2%；Deionized water surplus；The PH of the mouthrinse product is 4.Wherein, sweetener for D-sorbite, Sucralose, acid
For malic acid, moisturizer is sorbierite, propane diols, and essence is the spearmint fragrance of a flower, and solubilizer is Cremophor RH40, activity
Agent is propolis, in pseudo-ginseng, and preservative is sodium benzoate, methyl hydroxybenzoate, and bacteriostatic agent uses western pyrrole chloramines.Mouthwash is also added with weight
Percentage is measured as 0.5% coolant agent, in the present embodiment, coolant agent is menthol.
The method that the present invention prepares the visualization propolis acidity mouthwash of hemostasis and anti-inflammation, includes the following steps：
（1）, sweetener and acid are added to stirring and dissolving in water deionization, then moisturizer is added in aqueous solution, stirring is equal
It is even and form finely dispersed water miscible clarified solution；
（2）, solubilizer, essence, 0.5% coolant agent stirred to form uniform oily solution；
（3）, in the state of stirring, oily solution is slowly added into water miscible clarified solution, be uniformly mixed；
（4）, by activating agent, bacteriostatic agent, preservative add step（3）In the aqueous solution of acquisition, it is mixed evenly；
（5）, stop stirring, stand 24 it is small when, filtering, after aseptic process PH be 4 mouthwash finished product.
Wherein, sweetener is D-sorbite, Sucralose, and acid is malic acid, and moisturizer is sorbierite, propane diols,
Essence is the spearmint fragrance of a flower, and solubilizer is Cremophor RH40, and activating agent is propolis, in pseudo-ginseng, and preservative is benzoic acid
Sodium, methyl hydroxybenzoate, bacteriostatic agent use western pyrrole chloramines.Mouthwash is also added with the coolant agent that percentage by weight is 0.5%, this implementation
In example, coolant agent is menthol.
Embodiment 3：
A kind of visualization propolis acidity mouthwash of hemostasis and anti-inflammation, is made of the component of following percentage by weight：Sweetener 0.1%；
Acid 0.3%；Moisturizer 15%；Essence 0.5%；Activating agent 2%；Solubilizer 2.5%；Bacteriostatic agent 0.05%；Preservative 0.4%；Go
Ion water surplus；The PH of the mouthrinse product is 3.Wherein, sweetener is saccharin sodium, Sucralose, and acid is citric acid,
Moisturizer is glycerine, propane diols, and essence is fragrant for honey peach fruit, and solubilizer is polysorbas20, and activating agent is tea polyphenols, pseudo-ginseng, is prevented
Rotten agent is potassium sorbate, methyl hydroxybenzoate, and bacteriostatic agent uses chlorohexidene.Mouthrinse components are also added with weight percent in the present embodiment
Than the coolant agent for 0.5%, the coolant agent is menthol.
The method that the present invention prepares the visualization propolis acidity mouthwash of hemostasis and anti-inflammation, includes the following steps：
（1）, sweetener and acid are added to stirring and dissolving in water deionization, then moisturizer is added in aqueous solution, stirring is equal
It is even and form finely dispersed water miscible clarified solution；
（2）, solubilizer, essence, 0.5% coolant agent stirred to form uniform oily solution；
（3）, in the state of stirring, oily solution is slowly added into water miscible clarified solution, be uniformly mixed；
（4）, by activating agent, bacteriostatic agent, preservative add step（3）In the aqueous solution of acquisition, it is mixed evenly；
（5）, stop stirring, stand 24 it is small when, filtering, after aseptic process PH be 3 mouthwash finished product.
Wherein, sweetener is saccharin sodium, Sucralose, and acid is citric acid, and moisturizer is glycerine, propane diols, essence
Fragrant for honey peach fruit, solubilizer is polysorbas20, and activating agent is tea polyphenols, pseudo-ginseng, and preservative is potassium sorbate, methyl hydroxybenzoate,
Bacteriostatic agent uses chlorohexidene.Mouthrinse components are described cool also added with the coolant agent that percentage by weight is 0.5% in the present embodiment
Taste agent is menthol.
Certainly, it is limitation of the present invention that described above, which is not, and the present invention is also not limited to the example above, the art
Those of ordinary skill, in the essential scope of the present invention, the variations, modifications, additions or substitutions made, should all belong to the present invention
Protection domain.
Claims (9)
1. the visualization propolis acidity mouthwash of a kind of hemostasis and anti-inflammation, it is characterised in that by the component group of following percentage by weight
Into：
Sweetener 0.003% ~ 0.1%；
Acid 0.01%~0.3%；
Moisturizer 2%~15%；
Essence 0.05%~0.5%；
Activating agent 0.1%~2%；
Solubilizer 0.5%~2.5%；
Bacteriostatic agent 0.02%~0.05%；
Preservative 0.1%~0.4%；
Deionized water surplus；
The PH of the mouthrinse product is 3~5.
2. the visualization propolis acidity mouthwash of hemostasis and anti-inflammation according to claim 1, it is characterized in that, by following weight hundred
Divide the component composition of ratio：
Sweetener 0.05%；
Acid 0.1%；
Moisturizer 8%；
Essence 0.3%；
Activating agent 1%；
Solubilizer 1.5%；
Bacteriostatic agent 0.03%；
Preservative 0.2%；
Deionized water surplus；
The PH of the mouthrinse product is 4.
3. the visualization propolis acidity mouthwash of hemostasis and anti-inflammation according to claim 1, it is characterized in that：The sweetener is
One or more in saccharin sodium, D-sorbite, Sucralose, acid are citric acid or malic acid, and moisturizer is glycerine, mountain
One or more in pears alcohol, propane diols, essence are tween for the fruit such as green tea, spearmint, honey peach perfume or the fragrance of a flower, solubilizer
20 or Cremophor RH40, activating agent is tea polyphenols, propolis, the one or more in pseudo-ginseng, preservative is potassium sorbate,
One or more in sodium benzoate, methyl hydroxybenzoate, bacteriostatic agent use Domiphen bromide, western pyrrole chloramines or chlorohexidene.
4. the visualization propolis acidity mouthwash of hemostasis and anti-inflammation according to claim 1, it is characterized in that：The mouthwash is also
Added with the coolant agent that percentage by weight is 0.5%.
5. the visualization propolis acidity mouthwash of hemostasis and anti-inflammation according to claim 4, it is characterized in that：The coolant agent is
Menthol.
A kind of 6. method for the visualization propolis acidity mouthwash for preparing hemostasis and anti-inflammation, it is characterised in that include the following steps：
（1）, sweetener and acid are added to stirring and dissolving in water deionization, then moisturizer is added in aqueous solution, stirring is equal
It is even and form finely dispersed water miscible clarified solution；
（2）, solubilizer, essence stirred to form uniform oily solution；
（3）, in the state of stirring, oily solution is slowly added into water miscible clarified solution, be uniformly mixed；
（4）, by activating agent, bacteriostatic agent, preservative add step（3）In the aqueous solution of acquisition, it is mixed evenly；
（5）, stop stirring, stand 24 it is small when, filtering, after aseptic process PH be 3~5 mouthwash finished product.
7. the preparation method of the visualization propolis acidity mouthwash of hemostasis and anti-inflammation according to claim 6, it is characterized in that：Institute
State step（2）The coolant agent that middle addition percentage by weight is 0.5%.
8. the preparation method of the visualization propolis acidity mouthwash of hemostasis and anti-inflammation according to claim 6, it is characterized in that：Institute
Sweetener is stated as saccharin sodium, D-sorbite, the one or more in Sucralose, acid is citric acid or malic acid, moisturizing
Agent is glycerine, sorbierite, the one or more in propane diols, essence for the fruit such as green tea, spearmint, honey peach are fragrant or the fragrance of a flower,
Solubilizer is polysorbas20 or Cremophor RH40, and activating agent is tea polyphenols, propolis, the one or more in pseudo-ginseng, anti-corrosion
Agent is potassium sorbate, sodium benzoate, the one or more in methyl hydroxybenzoate, and bacteriostatic agent is using Domiphen bromide, western pyrrole chloramines or wash must
It is safe.
9. the preparation method of the visualization propolis acidity mouthwash of hemostasis and anti-inflammation according to claim 7, it is characterized in that：Institute
It is menthol to state coolant agent.
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| CN108464965A (en) * | 2018-06-15 | 2018-08-31 | 沈阳药科大学 | A kind of propolis mouthwash containing natural active ingredients and preparation method thereof |
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| WO2022088724A1 (en) * | 2020-10-28 | 2022-05-05 | 南京中科游子生物技术研究院有限公司 | Green tea active substance mouthwash composition and preparation method therefor |
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| WO2024016109A1 (en) * | 2022-07-18 | 2024-01-25 | 南京中科游子生物技术研究院有限公司 | Oral care composition of tea active substance and method for preparing same |
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| CN114917320A (en) * | 2022-04-18 | 2022-08-19 | 重庆功存科技有限公司 | Oral bacteriostatic spray synthesized by panax notoginseng saponins and tea polyphenol |
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Application publication date: 20180511 |