CN106580770A - Protective toothpaste capable of beautifying teeth - Google Patents
Protective toothpaste capable of beautifying teeth Download PDFInfo
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- CN106580770A CN106580770A CN201611110770.7A CN201611110770A CN106580770A CN 106580770 A CN106580770 A CN 106580770A CN 201611110770 A CN201611110770 A CN 201611110770A CN 106580770 A CN106580770 A CN 106580770A
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- Prior art keywords
- tooth
- active component
- toothpaste
- shea
- solid
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- 229940034610 toothpaste Drugs 0.000 title claims abstract description 33
- 230000001681 protective effect Effects 0.000 title abstract 2
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- 238000002360 preparation method Methods 0.000 claims description 39
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- 238000000605 extraction Methods 0.000 claims description 25
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 24
- 239000007788 liquid Substances 0.000 claims description 23
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- 239000000463 material Substances 0.000 claims description 20
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- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 claims description 2
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- IBDVBNUJEGRVQN-RHNLGMIQSA-N persin Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(=O)C[C@@H](O)COC(C)=O IBDVBNUJEGRVQN-RHNLGMIQSA-N 0.000 description 1
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- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
The invention provides protective toothpaste capable of beautifying teeth. Natural active components serve as the main components of the toothpaste, the components are reasonably matched, a toothpaste formula re designed by selecting raw materials with low irritation and the toothpaste has little harm on mouth cavities of children. The toothpaste is rich in pure natural active components with natural germicidal and nutritional ingredients, can provide an effective protection for mouth cavities and teeth though synergetic effects of all components and effectively inhibit dental plaque, and keep the health of the teeth and the mouth cavities.
Description
Technical field
The invention belongs to daily-use chemical industry product technical field, and in particular to a kind of anti-tooth-protecting paste of U.S. tooth.
Background technology
Dental care product has had the applicating history of upper a century.Wherein most frequently be exactly toothpaste, toothpaste is usual
It is that a kind of gentle friction powder is dispersed in into gelinite or soft paste, and adds cleaning agent to help clean tooth, adds fluorine
Compound reduces teeth corrosion etc..In actual life, typically to chew, the mode swallowed is by intestinal for the supply of nutritional substance
Digest and assimilate.It is exactly in the form of compositions by contacting oral mucosa by some drugses however, also there is another kind of therapy
Directly absorbed.Based on some drugses material can by the principle of buccal absorption and evidence, some nutritional substances or
Some active ingredients are also proved to absorb by means of which.Additionally, the homeopathic therapeutic method in terms of medical science, follows at the very start certainly
This principle carries out the rehabilitation of patient.
Although the different degrees of benefit for emphasizing to clean tooth and give fluoride of dental care product in the market
Fill, or the strong tooth of Chinese herbal medicine.Medicated toothpaste generally adds Chinese herbal medicine in toothpaste, can treat oral disease.The Huang sold on market
Stilbene toothpaste, Herba Pileae Scriptae toothpaste, pseudo-ginseng toothpaste etc., to red swelling of gingiva, halitosis and dentin hypersensitiveness disease etc. have and slow down and therapeutical effect.To the greatest extent
Pipe is thus, in the market still without a product is using the raw material of edibility and is supplied to certain trophism thing of oral cavity
Matter or active ingredient suppress dental plaque tackling periodontal, keep the health in tooth and oral cavity etc..It will be acknowledged that certain
A little nutritional substances or active ingredient have substantial role to reducing main liability oral cavity chronic disease and dental care.
The content of the invention
In view of this, the present invention provides a kind of U.S. tooth anti-tooth-protecting paste, in particular for the U.S. tooth protection of children population exploitation
Toothpaste, the toothpaste of the present invention is little to oral cavity irritation on mucous membrane, safe and harmless after eating by mistake orally using natural plant composition, passes through
The specific composite formula of present invention design, the formula is not only rich in vitamin, also comprising natural plant active component, so as to
Keep tooth and oral health.
The technical scheme is that：A kind of anti-tooth-protecting paste of U.S. tooth, is made up of following parts by weight meter raw material：Pteria martensii shellfish
Shell powder 22-35, dicalcium phosphate dehydrate 8-14, sodium lauroamphopg-acetate phosphate 5-8, hydroxyethyl cellulose
3-9, xylitol 33-42 parts, xanthan gum 0.2-0.7, C14 alkyl polyglucoside 2-5, Sorbitol 5-9, Cananga odorata quintessence oil 0.9-
1.3rd, lycopene 1-2, active components A 11-17, active component B 2-6, active component C 17-21；The active component A
For Flos Hostae Plantagineae crude extract；Active component B is shea enzymatic hydrolysate；Active component C is Folium Eriobotryae Flos Camelliae Japonicae water extract.
Further, the grain diameter of the pteria martensii shell powder is 110-130 mesh.
Further, the preparation method of the active component A is：By Flos Hostae Plantagineae dry materials, crush, use plant pulverizer
Crush, with the screen filtration of 150 mesh, collect the ultra-micro powder after sieving, it is standby；By 60% (volume fraction) (volume of ethanol+10%
Fraction) ethyl acetate preparation aqueous two-phase extraction solvent, the preparation aqueous two-phase extraction solvent of solid-liquid ratio 1: 40g/mL, the leaching at 60 DEG C
30 min are steeped, 50min is then extracted under ultrasonic extraction instrument, condition are horn 6mm, ultrasonic power 800W, 50 DEG C of temperature,
Ultrasonic 6s, interval 5s, centrifuging and taking supernatant after extraction, Jing is filtered, and removes solid precipitation slag, filtrate is placed in into Multi-example parallel
Concentrating under reduced pressure in evaporimeter, obtains thick extracted extract, and 4 DEG C save backup.
Further, the preparation method of active component B is：Shea obtains shea Jing after remove impurity, stripping and slicing pretreatment
Sarcocarp, with solid-liquid ratio 2: 3（m/V）Add water, soaked overnight, by the way of trypsin and papain mixed enzymolysis, enzyme
Solution condition is：The enzyme concentration of 45 DEG C of temperature, pH 7.5, the .5h of hydrolysis time 1, trypsin and papain is respectively
800 U/g and 1100U/g；Enzymolysis terminates rear enzyme denaturing, and by enzymolysis solution, 4500r/min is centrifuged 10min at 4 DEG C, takes supernatant, then
Shea enzymatic hydrolysate is obtained through microfiltration.
Further, the preparation method of active component C is：Folium Eriobotryae Flos Camelliae Japonicae after drying is by solid-liquid ratio 2（g）:3
（mL）In adding distilled water, 15min is boiled, filtered, the soluble solid content being concentrated in water extract is 48-54%.
Further, the material composition of the toothpaste is food stage or pharmaceutical grade.
Folium Eriobotryae Eriobotrya japonica are Rosaceae Eriobotryas in the present invention, with higher medicinal valency
Value.Flos Eriobotryae is circular cone titbit, and surface covers brown fine hair, and fragrance is unique, the effects such as with stomach function regulating sending down the abnormal ascending QI, relieving cough and resolving phlegm.
It is to improve its fruit quality in Folium Eriobotryae cultivation management, often takes flower thinning measure in florescence, the flower of excision is mostly as useless
Gurry is wasted, and the main material of health tea and beverage is only used as on a small quantity.At present, for the research of Flos Eriobotryae has been concentrated mainly on
It is relatively fewer to its effect Journal of Sex Research in the extraction and identification of effect composition.Research shows that the Flos Eriobotryae water extract of high dose has
Preferable town expectorant, cough-relieving and antiinflammatory action, and the Flos Eriobotryae ethanol extract of high dose also has preferable eliminating the phlegm and antiphlogistic effects.Folium Eriobotryae
The colored extract inhibitory action certain for gram-negative bacteria has, for gram-positive bacteria, funguses inhibitory action then
It is relatively preferable.Zhou Chunhua has done anti-oxidation efficacy research to Flos Eriobotryae extract, it is found that Flos Eriobotryae shows stronger antioxidation
Ability.
Flos Hostae Plantagineae is the dry of Liliaceae hosta Flos Hostae Plantagineae (Hosta plantaginea (Lam.) Aschers)
Dry flower, also known as internal diabetes flower, white crane flower, beautiful flower bulb etc., the provinces and regions such as Sichuan, Hubei, Hunan, Jiangsu are distributed in, there is cultivation all parts of the country
Training.It is bitter in the mouth, sweet, it is cool in nature, it is slightly poisonous, it is China Mongolian medicine pharmacy tradition medicinal herbs most in use, its entitled " Haas-Kazakhstan of mongolian medicine transliteration Chinese
Ta Huer-its its lattice ", is included《Drug Standard of Ministry of Public Health of the Peoples Republic of China mongolian medicine fascicle》With《Inner Mongol medical material
Standard》In, with long Mongolian medicine's clinical application history and definite curative effect, for treating laryngopharynx swelling and pain, silent, lung-heat, poison
Heat etc..Modern study shows, containing steroid, flavonoid, fatty acid and ceramide type compound in Flos Hostae Plantagineae, with town
Bitterly, the effect of antitumor and antibacterial.
It has been investigated that, in shea enzymatic hydrolysate be rich in persin compositions, this composition be it is a kind of can sterilize it is poisonous
Material, it is harmless to humans, if but domestic animal is in a large number edible can cause danger, and it is the good natural antimicrobial substances of a class.
The beneficial effects of the present invention is：In the anti-tooth-protecting paste of U.S. tooth of the present invention, using active skull cap components toothpaste is used as
Main component, by the reasonably combined of component, selects the raw material design formulation of tooth-paste that zest is low, the injury pole to Pediatric Oral Emergency
It is little；Rich in the pure natural active component with natural disinfection and nutritional labeling in the present invention, by the collaboration of each component of the present invention
Potentiation, can provide for oral cavity and tooth and be effectively protected, and can effectively suppress the strong of dental plaque, holding tooth and oral cavity
Health.
Specific embodiment
Technical scheme is clearly and completely described below in conjunction with the embodiment of the present invention, it is clear that retouched
The embodiment stated is only a part of embodiment of the invention, rather than the embodiment of whole.Based on the embodiment in the present invention, this
The every other embodiment that field those of ordinary skill is obtained under the premise of creative work is not made, belongs to the present invention
The scope of protection.
Embodiment 1
A kind of anti-tooth-protecting paste of U.S. tooth, is made up of following parts by weight meter raw material：Pteria martensii shell powder 22, phosphate dihydrate
Hydrogen calcium 8, sodium lauroamphopg-acetate phosphate 5, hydroxyethyl cellulose 3,33 parts of xylitol, xanthan gum 0.2,
C14 alkyl polyglucoside 2, Sorbitol 5, Cananga odorata quintessence oil 0.9, lycopene 1, active components A 11, active component B 2, activity
Component C 17；The active component A is Flos Hostae Plantagineae crude extract；Active component B is shea enzymatic hydrolysate；Active component C
For Folium Eriobotryae Flos Camelliae Japonicae water extract.
Further, the grain diameter of the pteria martensii shell powder is 120 mesh.
Further, the preparation method of the active component A is：By Flos Hostae Plantagineae dry materials, crush, use plant pulverizer
Crush, with the screen filtration of 150 mesh, collect the ultra-micro powder after sieving, it is standby；By 60% (volume fraction) (volume of ethanol+10%
Fraction) ethyl acetate preparation aqueous two-phase extraction solvent, the preparation aqueous two-phase extraction solvent of solid-liquid ratio 1: 40g/mL, the leaching at 60 DEG C
30 min are steeped, 50min is then extracted under ultrasonic extraction instrument, condition are horn 6mm, ultrasonic power 800W, 50 DEG C of temperature,
Ultrasonic 6s, interval 5s, centrifuging and taking supernatant after extraction, Jing is filtered, and removes solid precipitation slag, filtrate is placed in into Multi-example parallel
Concentrating under reduced pressure in evaporimeter, obtains thick extracted extract, and 4 DEG C save backup.
Further, the preparation method of active component B is：Shea obtains shea Jing after remove impurity, stripping and slicing pretreatment
Sarcocarp, with solid-liquid ratio 2: 3（m/V）Add water, soaked overnight, by the way of trypsin and papain mixed enzymolysis, enzyme
Solution condition is：The enzyme concentration of 45 DEG C of temperature, pH 7.5, the .5h of hydrolysis time 1, trypsin and papain is respectively
800 U/g and 1100U/g；Enzymolysis terminates rear enzyme denaturing, and by enzymolysis solution, 4500r/min is centrifuged 10min at 4 DEG C, takes supernatant, then
Shea enzymatic hydrolysate is obtained through microfiltration.
Further, the preparation method of active component C is：Folium Eriobotryae Flos Camelliae Japonicae after drying is by solid-liquid ratio 2（g）:3
（mL）In adding distilled water, 15min is boiled, filtered, the soluble solid content being concentrated in water extract is 48-54%.
Further, the material composition of the toothpaste is food stage or pharmaceutical grade.
The anti-tooth-protecting paste of present invention U.S. tooth can adopt completely the conventional method of this area to prepare, such as《Detergent compositions technique
Handbook》(Xu Baocai etc. writes, Chemical Industry Press, chemistry and applied chemistry publishing centre, January the 1st edition in 2006
) toothpaste making process disclosed in the 594-597 page is prepared.Specifically, the preparation of the anti-tooth-protecting paste of the present embodiment U.S. tooth
Method is：After above-mentioned raw materials component is weighed, dispersion, mixing in pre-dispersed kettle are opened cream kettle vacuum pump processed and suck above-mentioned liquid
Material, then drives scraper, agitator and colloid mill, closes colloid mill, agitator and scraper after 50 minutes successively, and vacuum breaker is obtained
The anti-tooth-protecting paste of U.S. tooth.
Obviously, in the present invention the preparation method of toothpaste is prior art, not special character, and the present invention's mainly changes
Enter to be that the difference of formula.
Embodiment 2
A kind of anti-tooth-protecting paste of U.S. tooth, is made up of following parts by weight meter raw material：Pteria martensii shell powder 28, phosphate dihydrate
Hydrogen calcium 11, sodium lauroamphopg-acetate phosphate 7, hydroxyethyl cellulose 7,38 parts of xylitol, xanthan gum
0.4th, C14 alkyl polyglucoside 3, Sorbitol 7, Cananga odorata quintessence oil 1.1, lycopene 1.7, active components A 14, active component B
5th, active component C 18；The active component A is Flos Hostae Plantagineae crude extract；Active component B is shea enzymatic hydrolysate；The activity
Component C is Folium Eriobotryae Flos Camelliae Japonicae water extract.
Further, the grain diameter of the pteria martensii shell powder is 110 mesh.
Further, the preparation method of the active component A is：By Flos Hostae Plantagineae dry materials, crush, use plant pulverizer
Crush, with the screen filtration of 150 mesh, collect the ultra-micro powder after sieving, it is standby；By 60% (volume fraction) (volume of ethanol+10%
Fraction) ethyl acetate preparation aqueous two-phase extraction solvent, the preparation aqueous two-phase extraction solvent of solid-liquid ratio 1: 40g/mL, the leaching at 60 DEG C
30 min are steeped, 50min is then extracted under ultrasonic extraction instrument, condition are horn 6mm, ultrasonic power 800W, 50 DEG C of temperature,
Ultrasonic 6s, interval 5s, centrifuging and taking supernatant after extraction, Jing is filtered, and removes solid precipitation slag, filtrate is placed in into Multi-example parallel
Concentrating under reduced pressure in evaporimeter, obtains thick extracted extract, and 4 DEG C save backup.
Further, the preparation method of active component B is：Shea obtains shea Jing after remove impurity, stripping and slicing pretreatment
Sarcocarp, with solid-liquid ratio 2: 3（m/V）Add water, soaked overnight, by the way of trypsin and papain mixed enzymolysis, enzyme
Solution condition is：The enzyme concentration of 45 DEG C of temperature, pH 7.5, the .5h of hydrolysis time 1, trypsin and papain is respectively
800 U/g and 1100U/g；Enzymolysis terminates rear enzyme denaturing, and by enzymolysis solution, 4500r/min is centrifuged 10min at 4 DEG C, takes supernatant, then
Shea enzymatic hydrolysate is obtained through microfiltration.
Further, the preparation method of active component C is：Folium Eriobotryae Flos Camelliae Japonicae after drying is by solid-liquid ratio 2（g）:3
（mL）In adding distilled water, 15min is boiled, filtered, the soluble solid content being concentrated in water extract is 48-54%.
Further, the material composition of the toothpaste is food stage or pharmaceutical grade.
Embodiment 3
A kind of anti-tooth-protecting paste of U.S. tooth, is made up of following parts by weight meter raw material：Pteria martensii shell powder 35, hydrogen phosphate dihydrate
Calcium 14, sodium lauroamphopg-acetate phosphate 8, hydroxyethyl cellulose 9,42 parts of xylitol, xanthan gum 0.7, C14
Alkyl polyglucoside 5, Sorbitol 9, Cananga odorata quintessence oil 1.3, lycopene 2, active components A 17, active component B 6, active component C
21；The active component A is Flos Hostae Plantagineae crude extract；Active component B is shea enzymatic hydrolysate；Active component C is Folium Eriobotryae
Flos Camelliae Japonicae water extract.
Further, the grain diameter of the pteria martensii shell powder is 130 mesh.
Further, the preparation method of the active component A is：By Flos Hostae Plantagineae dry materials, crush, use plant pulverizer
Crush, with the screen filtration of 150 mesh, collect the ultra-micro powder after sieving, it is standby；By 60% (volume fraction) (volume of ethanol+10%
Fraction) ethyl acetate preparation aqueous two-phase extraction solvent, the preparation aqueous two-phase extraction solvent of solid-liquid ratio 1: 40g/mL, the leaching at 60 DEG C
30 min are steeped, 50min is then extracted under ultrasonic extraction instrument, condition are horn 6mm, ultrasonic power 800W, 50 DEG C of temperature,
Ultrasonic 6s, interval 5s, centrifuging and taking supernatant after extraction, Jing is filtered, and removes solid precipitation slag, filtrate is placed in into Multi-example parallel
Concentrating under reduced pressure in evaporimeter, obtains thick extracted extract, and 4 DEG C save backup.
Further, the preparation method of active component B is：Shea obtains shea Jing after remove impurity, stripping and slicing pretreatment
Sarcocarp, with solid-liquid ratio 2: 3（m/V）Add water, soaked overnight, by the way of trypsin and papain mixed enzymolysis, enzyme
Solution condition is：The enzyme concentration of 45 DEG C of temperature, pH 7.5, the .5h of hydrolysis time 1, trypsin and papain is respectively
800 U/g and 1100U/g；Enzymolysis terminates rear enzyme denaturing, and by enzymolysis solution, 4500r/min is centrifuged 10min at 4 DEG C, takes supernatant, then
Shea enzymatic hydrolysate is obtained through microfiltration.
Further, the preparation method of active component C is：Folium Eriobotryae Flos Camelliae Japonicae after drying is by solid-liquid ratio 2（g）:3
（mL）In adding distilled water, 15min is boiled, filtered, the soluble solid content being concentrated in water extract is 48-54%.
Further, the material composition of the toothpaste is food stage or pharmaceutical grade.
Embodiment 4
A kind of anti-tooth-protecting paste of U.S. tooth, is made up of following parts by weight meter raw material：Pteria martensii shell powder 28, phosphate dihydrate
Hydrogen calcium 11, sodium lauroamphopg-acetate phosphate 7, hydroxyethyl cellulose 7,38 parts of xylitol, xanthan gum
0.4th, C14 alkyl polyglucoside 3, Sorbitol 7, Cananga odorata quintessence oil 1.1, lycopene 1.7, active components A 13, active component B
4th, active component C 18；The active component A is Flos Hostae Plantagineae crude extract；Active component B is shea enzymatic hydrolysate；The activity
Component C is Folium Eriobotryae Flos Camelliae Japonicae water extract.
Further, the grain diameter of the pteria martensii shell powder is 120 mesh.
Further, the preparation method of the active component A is：By Flos Hostae Plantagineae dry materials, crush, use plant pulverizer
Crush, with the screen filtration of 150 mesh, collect the ultra-micro powder after sieving, it is standby；By 60% (volume fraction) (volume of ethanol+10%
Fraction) ethyl acetate preparation aqueous two-phase extraction solvent, the preparation aqueous two-phase extraction solvent of solid-liquid ratio 1: 40g/mL, the leaching at 60 DEG C
30 min are steeped, 50min is then extracted under ultrasonic extraction instrument, condition are horn 6mm, ultrasonic power 800W, 50 DEG C of temperature,
Ultrasonic 6s, interval 5s, centrifuging and taking supernatant after extraction, Jing is filtered, and removes solid precipitation slag, filtrate is placed in into Multi-example parallel
Concentrating under reduced pressure in evaporimeter, obtains thick extracted extract, and 4 DEG C save backup.
Further, the preparation method of active component B is：Shea obtains shea Jing after remove impurity, stripping and slicing pretreatment
Sarcocarp, with solid-liquid ratio 2: 3（m/V）Add water, soaked overnight, by the way of trypsin and papain mixed enzymolysis, enzyme
Solution condition is：The enzyme concentration of 45 DEG C of temperature, pH 7.5, the .5h of hydrolysis time 1, trypsin and papain is respectively
800 U/g and 1100U/g；Enzymolysis terminates rear enzyme denaturing, and by enzymolysis solution, 4500r/min is centrifuged 10min at 4 DEG C, takes supernatant, then
Shea enzymatic hydrolysate is obtained through microfiltration.
Further, the preparation method of active component C is：Folium Eriobotryae Flos Camelliae Japonicae after drying is by solid-liquid ratio 2（g）:3
（mL）In adding distilled water, 15min is boiled, filtered, the soluble solid content being concentrated in water extract is 48-54%.
Further, the material composition of the toothpaste is food stage or pharmaceutical grade.
Embodiment 5
A kind of anti-tooth-protecting paste of U.S. tooth, is made up of following parts by weight meter raw material：Pteria martensii shell powder 28, phosphate dihydrate
Hydrogen calcium 11, sodium lauroamphopg-acetate phosphate 7, hydroxyethyl cellulose 7,38 parts of xylitol, xanthan gum
0.4th, C14 alkyl polyglucoside 3, Sorbitol 7, Cananga odorata quintessence oil 1.1, lycopene 1.7, active components A 16, active component B
3rd, active component C 20；The active component A is Flos Hostae Plantagineae crude extract；Active component B is shea enzymatic hydrolysate；The activity
Component C is Folium Eriobotryae Flos Camelliae Japonicae water extract.
Further, the grain diameter of the pteria martensii shell powder is 110 mesh.
Further, the preparation method of the active component A is：By Flos Hostae Plantagineae dry materials, crush, use plant pulverizer
Crush, with the screen filtration of 150 mesh, collect the ultra-micro powder after sieving, it is standby；By 60% (volume fraction) (volume of ethanol+10%
Fraction) ethyl acetate preparation aqueous two-phase extraction solvent, the preparation aqueous two-phase extraction solvent of solid-liquid ratio 1: 40g/mL, the leaching at 60 DEG C
30 min are steeped, 50min is then extracted under ultrasonic extraction instrument, condition are horn 6mm, ultrasonic power 800W, 50 DEG C of temperature,
Ultrasonic 6s, interval 5s, centrifuging and taking supernatant after extraction, Jing is filtered, and removes solid precipitation slag, filtrate is placed in into Multi-example parallel
Concentrating under reduced pressure in evaporimeter, obtains thick extracted extract, and 4 DEG C save backup.
Further, the preparation method of active component B is：Shea obtains shea Jing after remove impurity, stripping and slicing pretreatment
Sarcocarp, with solid-liquid ratio 2: 3（m/V）Add water, soaked overnight, by the way of trypsin and papain mixed enzymolysis, enzyme
Solution condition is：The enzyme concentration of 45 DEG C of temperature, pH 7.5, the .5h of hydrolysis time 1, trypsin and papain is respectively
800 U/g and 1100U/g；Enzymolysis terminates rear enzyme denaturing, and by enzymolysis solution, 4500r/min is centrifuged 10min at 4 DEG C, takes supernatant, then
Shea enzymatic hydrolysate is obtained through microfiltration.
Further, the preparation method of active component C is：Folium Eriobotryae Flos Camelliae Japonicae after drying is by solid-liquid ratio 2（g）:3
（mL）In adding distilled water, 15min is boiled, filtered, the soluble solid content being concentrated in water extract is 48-54%.
Further, the material composition of the toothpaste is food stage or pharmaceutical grade.
Comparative example 1
A kind of anti-tooth-protecting paste of U.S. tooth, is made up of following parts by weight meter raw material：Pteria martensii shell powder 28, phosphate dihydrate
Hydrogen calcium 11, sodium lauroamphopg-acetate phosphate 7, hydroxyethyl cellulose 7,38 parts of xylitol, xanthan gum
0.4th, C14 alkyl polyglucoside 3, Sorbitol 7, Cananga odorata quintessence oil 1.1, lycopene 1.7, active components A 14, active component B
5；The active component A is Flos Hostae Plantagineae crude extract；Active component B is shea enzymatic hydrolysate.
Further, the grain diameter of the pteria martensii shell powder is 110 mesh.
Further, the preparation method of the active component A is：By Flos Hostae Plantagineae dry materials, crush, use plant pulverizer
Crush, with the screen filtration of 150 mesh, collect the ultra-micro powder after sieving, it is standby；By 60% (volume fraction) (volume of ethanol+10%
Fraction) ethyl acetate preparation aqueous two-phase extraction solvent, the preparation aqueous two-phase extraction solvent of solid-liquid ratio 1: 40g/mL, the leaching at 60 DEG C
30 min are steeped, 50min is then extracted under ultrasonic extraction instrument, condition are horn 6mm, ultrasonic power 800W, 50 DEG C of temperature,
Ultrasonic 6s, interval 5s, centrifuging and taking supernatant after extraction, Jing is filtered, and removes solid precipitation slag, filtrate is placed in into Multi-example parallel
Concentrating under reduced pressure in evaporimeter, obtains thick extracted extract, and 4 DEG C save backup.
Further, the material composition of the toothpaste is food stage or pharmaceutical grade.
Comparative example 2
A kind of anti-tooth-protecting paste of U.S. tooth, is made up of following parts by weight meter raw material：Pteria martensii shell powder 28, phosphate dihydrate
Hydrogen calcium 11, sodium lauroamphopg-acetate phosphate 7, hydroxyethyl cellulose 7,38 parts of xylitol, xanthan gum
0.4th, C14 alkyl polyglucoside 3, Sorbitol 7, Cananga odorata quintessence oil 1.1, lycopene 1.7, active components A 14, active component B
5th, active component C 18；Active component B is shea enzymatic hydrolysate；Active component C is Folium Eriobotryae Flos Camelliae Japonicae water extract.
Further, the grain diameter of the pteria martensii shell powder is 110 mesh.
Further, the preparation method of active component C is：Folium Eriobotryae Flos Camelliae Japonicae after drying is by solid-liquid ratio 2（g）:3
（mL）In adding distilled water, 15min is boiled, filtered, the soluble solid content being concentrated in water extract is 48-54%.
Further, the material composition of the toothpaste is food stage or pharmaceutical grade.
Experimental example
Experimental technique：Each tooth is divided into into four faces：A labial surfaces, b lingual surfaces, the nearly heart faces of c, d telecentricities face.
1. dental plaque indicator (being dental plaque indicator from 2% basic fuchsin) about three drops are stained with Cotton swab
On tooth of the uniform application after brushing teeth, gargled with water again after 30 seconds, the coloring speckle that afterwards observation is stayed on facing is
Bacterial plaque；
2. the change situation of color of teeth is observed；
3. every tooth is divided into into nearly heart face, telecentricity face, four faces such as labial surface and lingual surface；
4. the face that calculating has dental plaque accounts for the percentage ratio all exempted from by inspection, as dental plaque index；
5. dental plaque index (based on distribution face)=(having the face number of dental plaque) ÷ (by inspection the number of teeth × 4 face)
× 100%
6. for example：Chen people is 25 by inspection tooth number, and Jing tests the face Shuo Shi16 faces of dental plaque, then the tooth of Zhang people
Plaque index=16 ÷ (25 × 4) × 100%=16%
7. dental plaque index is range of normal value in 20%.
Experimental procedure：
1. toothpaste of the present invention and commercial toothpastes are to suppressing dental plaque effect to compare：Take embodiment of the present invention 1-3 formula toothpaste (
Respectively with A, B, C sign) and general commercial toothpastes (respectively with D, E, F, indicate), user after meal (about 20
Minute) brush teeth, G is toothpaste base of the present invention.(not containing any active component))
2. the dental plaque index after measuring every kind of toothpaste after brushing with developer, and recorded.
3. every kind of toothpaste is measured four times, and calculates meansigma methodss.As a result it is as shown in the table：
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, and do not carrying on the back
In the case of the spirit or essential attributes of the present invention, the present invention can be in other specific forms realized.Therefore, no matter from which
From the point of view of a bit, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention will by appended right
Ask rather than described above is limited, it is intended that all changes that will fall in the implication and scope of the equivalency of claim
Include in the present invention.
Moreover, it will be appreciated that although this specification is been described by according to embodiment, not each embodiment is only wrapped
Containing an independent technical scheme, this narrating mode of description is only that for clarity those skilled in the art should
Using description as an entirety, the technical scheme in each embodiment can also Jing it is appropriately combined, form those skilled in the art
Understandable other embodiment.The ins and outs not described in detail in the present invention, can pass through arbitrary in this area
Prior art is realized.Particularly, all technical characterstics not described in detail can be realized by any prior art in the present invention.
Claims (6)
1. the anti-tooth-protecting paste of a kind of U.S. tooth, it is characterised in that be made up of following parts by weight meter raw material：Pteria martensii shell powder
22-35, dicalcium phosphate dehydrate 8-14, sodium lauroamphopg-acetate phosphate 5-8, hydroxyethyl cellulose 3-9, wood
Sugar alcohol 33-42 parts, xanthan gum 0.2-0.7, C14 alkyl polyglucoside 2-5, Sorbitol 5-9, Cananga odorata quintessence oil 0.9-1.3, Fructus Lycopersici esculenti
Red pigment 1-2, active components A 11-17, active component B 2-6, active component C 17-21；The active component A is Flos Hostae Plantagineae
Crude extract；Active component B is shea enzymatic hydrolysate；Active component C is Folium Eriobotryae Flos Camelliae Japonicae water extract.
2. the anti-tooth-protecting paste of U.S. tooth according to claim 1, it is characterised in that the granule of the pteria martensii shell powder
Particle diameter is 110-130 mesh.
3. the anti-tooth-protecting paste of U.S. tooth according to claim 1, it is characterised in that the preparation method of the active component A is：Will
Flos Hostae Plantagineae dry materials, crush, and are crushed with plant pulverizer, with the screen filtration of 150 mesh, collect the ultra-micro powder after sieving,
It is standby；Aqueous two-phase extraction solvent is prepared by 60% (volume fraction) ethanol+10% (volume fraction) ethyl acetate, solid-liquid ratio 1:
40g/mL prepares aqueous two-phase extraction solvent, and 30 min are soaked at 60 DEG C, and 50min, condition are then extracted under ultrasonic extraction instrument
For horn 6mm, ultrasonic power 800W, 50 DEG C of temperature, ultrasonic 6s, interval 5s, centrifuging and taking supernatant after extraction, Jing filtrations, go
Except solid precipitation slag, filtrate is placed in into concentrating under reduced pressure in Multi-example Parallel evaporator, obtains thick extracted extract, 4 DEG C of preservations are standby
With.
4. the anti-tooth-protecting paste of U.S. tooth according to claim 1, it is characterised in that the preparation method of active component B is：Cattle
Oily fruit obtains shea sarcocarp Jing after remove impurity, stripping and slicing pretreatment, with solid-liquid ratio 2: 3（m/V）Add water, soaked overnight, using Trypsin
The mode of enzyme and papain mixed enzymolysis, enzymatic hydrolysis condition is：45 DEG C of temperature, pH 7.5, the .5h of hydrolysis time 1, pancreas egg
The enzyme concentration of white enzyme and papain is respectively 800 U/g and 1100U/g；Enzymolysis terminates rear enzyme denaturing, by enzymolysis solution at 4 DEG C
4500r/min is centrifuged 10min, takes supernatant, then obtains shea enzymatic hydrolysate through microfiltration.
5. the anti-tooth-protecting paste of U.S. tooth according to claim 1, it is characterised in that the preparation method of active component C is：Will
Folium Eriobotryae Flos Camelliae Japonicae after drying is by solid-liquid ratio 2（g）:3（mL）In adding distilled water, 15min is boiled, filtered, in being concentrated into water extract
Soluble solid content be 48-54%.
6. the anti-tooth-protecting paste of U.S. tooth according to claim 1, it is characterised in that the material composition of the toothpaste is food stage
Or pharmaceutical grade.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611110770.7A CN106580770A (en) | 2016-12-06 | 2016-12-06 | Protective toothpaste capable of beautifying teeth |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611110770.7A CN106580770A (en) | 2016-12-06 | 2016-12-06 | Protective toothpaste capable of beautifying teeth |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106580770A true CN106580770A (en) | 2017-04-26 |
Family
ID=58595975
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| Country | Link |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113398059A (en) * | 2021-07-13 | 2021-09-17 | 镇江市天益生物科技有限公司 | Toothpaste containing oral probiotics and preparation method thereof |
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2016
- 2016-12-06 CN CN201611110770.7A patent/CN106580770A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113398059A (en) * | 2021-07-13 | 2021-09-17 | 镇江市天益生物科技有限公司 | Toothpaste containing oral probiotics and preparation method thereof |
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