CN103157178B - Seal type tool capable of accurately controlling microneedle insertion length - Google Patents
Seal type tool capable of accurately controlling microneedle insertion length Download PDFInfo
- Publication number
- CN103157178B CN103157178B CN201310045474.3A CN201310045474A CN103157178B CN 103157178 B CN103157178 B CN 103157178B CN 201310045474 A CN201310045474 A CN 201310045474A CN 103157178 B CN103157178 B CN 103157178B
- Authority
- CN
- China
- Prior art keywords
- microneedle
- length
- baffle
- skin
- connecting piece
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000003780 insertion Methods 0.000 title claims abstract 6
- 230000037431 insertion Effects 0.000 title claims abstract 6
- 230000001681 protective effect Effects 0.000 claims abstract 9
- 239000000758 substrate Substances 0.000 claims description 14
- 239000000463 material Substances 0.000 claims description 3
- 238000005452 bending Methods 0.000 claims description 2
- 230000008859 change Effects 0.000 claims description 2
- 239000002184 metal Substances 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims description 2
- 230000035515 penetration Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 8
- 229940079593 drug Drugs 0.000 abstract description 3
- 238000013270 controlled release Methods 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 26
- 238000010586 diagram Methods 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 4
- 210000002615 epidermis Anatomy 0.000 description 4
- 210000004204 blood vessel Anatomy 0.000 description 3
- 210000005036 nerve Anatomy 0.000 description 3
- 206010020880 Hypertrophy Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 229920000832 Cutin Polymers 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000010612 desalination reaction Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000004531 microgranule Substances 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
精确控制微针插入长度的印章式工具，涉及药物控释与皮肤微创装置技术领域，包括针体，挡板，保护壳，和后部的针体长度调节机构几个部分。由于皮肤厚度不同或者某些治疗阶段需要不同长度的微针，本发明的微针插入长度调整工具，对不同部位的皮肤治疗有较强的适应性。整体设计采用印章的形式，微针的长度的调节可以通过扭动端盖，调节端盖与保护壳之间间隙的距离。以达到调节微针探出挡板的长度，定位销可以落在连接柱不同的槽内以达到对微针探出长度的精确控制。
A stamp tool for precisely controlling the insertion length of a microneedle relates to the technical field of drug controlled release and skin minimally invasive devices, including a needle body, a baffle, a protective shell, and a rear needle body length adjustment mechanism. Because the thickness of the skin is different or microneedles of different lengths are required in certain treatment stages, the tool for adjusting the insertion length of the microneedles of the present invention has strong adaptability to the skin treatment of different parts. The overall design is in the form of a seal, and the length of the microneedle can be adjusted by twisting the end cap to adjust the distance between the end cap and the protective case. In order to adjust the length of the microneedle protruding baffle, the positioning pin can fall into different grooves of the connecting column to achieve precise control of the protruding length of the microneedle.
Description
Technical field:
The present invention relates to medicine controlled releasing and skin Wicresoft device, particularly accurately control the seal style instrument of micropin intubating length.
Background technology:
Traditional percutaneous dosing is that medicine enters corium by epidermis passage Passive diffusion, then enters body circulation through blood capillary.Cuticular obstruction causes most drug molecule to pass through, and rate of release is difficult to the object reaching treatment too slowly, and people take various measure to destroy horny layer to strengthen the infiltration of skin to medicine for this reason.The microneedle array be made up of the micropin of 10-2000 μm is a kind of relatively new route of administration, it can not only pierce through upper strata epidermis and create and allow the medicine macromole even micron-sized channels that passes through of microgranule, and unlikely exciting nerve produces the damage that pain causes clinical meaning again.
Skin is divided into three layers from outside to inside: horny layer, epidermal area and skin corium.Cutin thickness is about 10-20 μm, is that one deck is extremely organized, does not have blood vessel and nerve, but the controlled release layer of percutaneous drug absorption; Epidermal area is positioned at outer subcutaneous about 50-100 μm of place, containing a small amount of living cells and nerve, not containing blood vessel; Containing a large amount of living cells, nerve and blood vessel in the corium of more depths.Micropin is the micron-sized pin of difformity, structure and the material be made up of Micrometer-Nanometer Processing Technology, and by producing the permeability that medicine is improved in small duct at keratodermatitis, this is a kind of administering mode between subcutaneous injection and transdermal patch.
Generally traditional method, active nutrient can only infiltrate through the barrier layer (i.e. horny layer) of epidermis, and effect is not significantly (only reaching the effect of 0. 3 about percent).The syringe needle chafe utilizing micropin small, makes active component effectively infiltrate skin, and micropin stimulates skin corium simultaneously, percutaneous self-healing ability, promote ossein hypertrophy, can make the thickness hypertrophy about 8 percent of skin epidermis, its effect can match in excellence or beauty the plastic operation of laser and filled type.And the side effect of micropin technology is extremely low, safe and reliable.
Summary of the invention:
The object of this invention is to provide the seal style instrument accurately controlling micropin intubating length, because skin thickness is different, or some treatment stage needs the micropin of different length, so the length-adjustable seal style micropin of the present invention.
The seal style instrument of accurate control micropin intubating length, the side of substrate 5 is provided with microneedle array, the opposite side of substrate 5 is provided with the connector 4 of fixing base 5 cylindrical bump, connector 4 circumferentially on have some locating slots, connector 4 and end cap 3 are threaded connection, and end cap 3 is positioned at side connector 4 not being provided with microneedle array, end cap 3 is connected with positioning tube 1, spring and alignment pin 2 are installed in positioning tube 1, spring between positioning tube 1 and alignment pin 2, in the locating slot that alignment pin 2 is against on connector 4; Containment vessel 6 is opened the cylinder engagement with boss on reeded circular hole and connector 4, prevent from relatively rotating between connector 4 and containment vessel 6.The coupling part of substrate 5 and connector 4 is in containment vessel 6.Baffle plate 7 has the micropore corresponding with micropin, is located mutually by the small boss on baffle plate 7 and the groove fit on containment vessel 6, the micropin on substrate 5 leans out baffle plate 7 by micropore.When micropin uses, pressing end cap 3, end cap 3 can be conflicted containment vessel 6, and the distance of now the advancing micropin be on substrate 5 leans out the length of baffle plate 7.And due to the existence of micropore on baffle plate 7, can micropin be constrained in hole, improve the bending resistance of micropin.During rotary end cover 3, the distance that can change and regulate gap between end cap 3 and containment vessel 6 that is threaded of connector 4 and end cap 3, alignment pin 2 drops in the different groove of connector 4, to reach the length that fine adjustment micropin leans out baffle plate 7.Alignment pin in positioning tube 1 drops in the different groove of connector 4 to reach accurate control micropin being leant out to length.There are the scale demarcated and lean out pin length, the groove that end cap 3 has in the outside of containment vessel 6.When not having baffle plate 7, the baffle plate 7 in the outside of containment vessel 6 can make skin smooth, reduce cause due to the radian of skin when microneedle array penetrates skin thrust error, accurate micropin inserts the length of skin, and micropin leans out the length of baffle plate between 0.2mm ~ 2mm.
In described microneedle array, the material of pin is metal or polymer.
In described microneedle array, the shape of pin is conical, triangular pyramid or rectangular pyramid shape.
The syringe needle chafe utilizing micropin small, makes active component effectively infiltrate skin, and micropin stimulates skin corium simultaneously, and percutaneous self-healing ability, can be used for the desalination of small rut and skin scar.
The present invention is compared with background technology, and the useful effect had is:
Different local skin thickness differs, the length of the length adjustable system scalable micropin of micropin, to reach the object of reply different-thickness skin, baffle plate accurately can insert the length of skin, and the micropin of different length different Wicresofts is produced to skin, the growth of chafe.
Micropin baffle plate can stop most of dirt, is convenient to cleaning.And baffle plate contributes to skin-tightening, be beneficial to the treatment of micropin.
Accompanying drawing illustrates:
Fig. 1 is the structural representation of entirety of the present invention.
Fig. 2 is the schematic diagram of micropin substrate.
Fig. 3 is the schematic diagram of micropin baffle plate.
Fig. 4 is micropin containment vessel schematic diagram.
Fig. 5 is micropin connector schematic diagram.
Fig. 6 is micropin alignment pin schematic diagram.
Fig. 7 is micropin end cap schematic diagram.
In figure: 1, positioning tube, 2, alignment pin, 3, end cap, 4, connector, 5, substrate, 6, containment vessel, 7, baffle plate.
Detailed description of the invention:
Further illustrate below in conjunction with accompanying drawing, shown in Fig. 2, Fig. 3, Fig. 4, Fig. 5, due to micropin in not used time also probably because extraneous factor is damaged and pollute, the dust that prevents with the baffle plate 7 of contact skin of the present invention enters micropin gap on substrate 5, micropin is made to be convenient to cleaning, it is not only accurate, and micropin enters the length of skin, and micro-rigidity helping raising micropin.
Different local skin thickness differs, the length of the length adjustable system scalable micropin of micropin, to reach the object of reply different-thickness skin, baffle plate 7 accurately can insert the length of skin, and the micropin of different length different Wicresofts is produced to skin, at different treatment stages, different stimulations is produced to skin, be beneficial to the growth of skin.
The fit depressions of the outer ring of containment vessel 6 in projection in Fig. 3 on baffle plate 7 and Fig. 4; The fit depressions of containment vessel 6 inner ring in the projection of connector 4 and Fig. 4 in Fig. 5.
Claims (3)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310045474.3A CN103157178B (en) | 2013-02-05 | 2013-02-05 | Seal type tool capable of accurately controlling microneedle insertion length |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310045474.3A CN103157178B (en) | 2013-02-05 | 2013-02-05 | Seal type tool capable of accurately controlling microneedle insertion length |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103157178A CN103157178A (en) | 2013-06-19 |
| CN103157178B true CN103157178B (en) | 2014-12-31 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310045474.3A Expired - Fee Related CN103157178B (en) | 2013-02-05 | 2013-02-05 | Seal type tool capable of accurately controlling microneedle insertion length |
Country Status (1)
| Country | Link |
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| CN (1) | CN103157178B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3925599A1 (en) * | 2015-07-24 | 2021-12-22 | Sorrento Therapeutics, Inc. | Methods for better delivery of active agents to tumors |
| CN105126243B (en) * | 2015-09-06 | 2018-08-07 | 台州薇凯生物科技有限公司 | Microneedle injection bullet and preparation method thereof and microneedle injection equipment |
| WO2018099437A1 (en) * | 2016-12-01 | 2018-06-07 | Huang Sin Ger | Microneedle array chip |
| CN106693159B (en) * | 2017-01-24 | 2023-12-22 | 北京欧扬医疗美容门诊部有限公司 | Injection type beauty instrument |
| CN107487091B (en) * | 2017-05-09 | 2023-09-19 | 盛利涛 | Intelligent seal with printing plate protection function |
| CN108245775A (en) * | 2017-12-25 | 2018-07-06 | 中山大学 | The portable microneedle transdermal delivery auxiliary device of controllable dynamics and depth |
| CN108310616A (en) * | 2018-01-24 | 2018-07-24 | 苑凯华 | A kind of micro- needle roller device of adjustable skin with synchronous injection administration functions |
| CN113975619B (en) * | 2021-11-11 | 2023-02-10 | 浙江大学 | Device and method for controlling microneedle penetration based on light |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4109655A (en) * | 1975-10-16 | 1978-08-29 | Manufacture Francaise d'Armes et Cycles de Saint-Etienne Manufrance | Multi-penetration vaccination apparatus |
| CN1190904A (en) * | 1995-07-14 | 1998-08-19 | 贝林格尔·英格海姆公司 | Drug delivery system for corneal cortex |
| US6558361B1 (en) * | 2000-03-09 | 2003-05-06 | Nanopass Ltd. | Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems |
| CN101208129A (en) * | 2005-06-27 | 2008-06-25 | 3M创新有限公司 | Microneedle cartridge assembly and method of applying |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6908453B2 (en) * | 2002-01-15 | 2005-06-21 | 3M Innovative Properties Company | Microneedle devices and methods of manufacture |
-
2013
- 2013-02-05 CN CN201310045474.3A patent/CN103157178B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4109655A (en) * | 1975-10-16 | 1978-08-29 | Manufacture Francaise d'Armes et Cycles de Saint-Etienne Manufrance | Multi-penetration vaccination apparatus |
| CN1190904A (en) * | 1995-07-14 | 1998-08-19 | 贝林格尔·英格海姆公司 | Drug delivery system for corneal cortex |
| US6558361B1 (en) * | 2000-03-09 | 2003-05-06 | Nanopass Ltd. | Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems |
| CN101208129A (en) * | 2005-06-27 | 2008-06-25 | 3M创新有限公司 | Microneedle cartridge assembly and method of applying |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103157178A (en) | 2013-06-19 |
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| C53 | Correction of patent for invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Zhang Yajun Inventor after: Zhuang Jian Inventor after: Xue Ling Inventor after: Hao Junjiao Inventor after: Zhou Gang Inventor after: Wang Shengdan Inventor before: Zhang Yajun Inventor before: Zhuang Jian Inventor before: Xue Ling Inventor before: Zhang Shaojing Inventor before: Hao Junjiao Inventor before: Zhou Gang |
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Free format text: CORRECT: INVENTOR; FROM: ZHANG YAJUN ZHUANG JIAN XUE LING ZHANG SHAOJING HAO JUNJIAO ZHOU GANG TO: ZHANG YAJUN ZHUANG JIAN XUE LING HAO JUNJIAO ZHOU GANG WANG SHENGDAN |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C53 | Correction of patent for invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Zhang Yajun Inventor after: Zhuang Jian Inventor after: Xue Ling Inventor after: Hao Junjiao Inventor after: Zhou Gang Inventor after: Wang Shengdan Inventor after: Li Meijiao Inventor before: Zhang Yajun Inventor before: Zhuang Jian Inventor before: Xue Ling Inventor before: Hao Junjiao Inventor before: Zhou Gang Inventor before: Wang Shengdan |
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| COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: ZHANG YAJUN ZHUANG JIAN XUE LING HAO JUNJIAO ZHOU GANG WANG SHENGDAN TO: ZHANG YAJUN ZHUANG JIAN XUE LING HAO JUNJIAO ZHOU GANG WANG SHENGDAN LI MEIJIAO |
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| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20141231 Termination date: 20160205 |
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| CF01 | Termination of patent right due to non-payment of annual fee |