CN103157178A - Seal type tool capable of accurately controlling microneedle insertion length - Google Patents
Seal type tool capable of accurately controlling microneedle insertion length Download PDFInfo
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- CN103157178A CN103157178A CN2013100454743A CN201310045474A CN103157178A CN 103157178 A CN103157178 A CN 103157178A CN 2013100454743 A CN2013100454743 A CN 2013100454743A CN 201310045474 A CN201310045474 A CN 201310045474A CN 103157178 A CN103157178 A CN 103157178A
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- micropin
- length
- connector
- baffle plate
- end cap
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
精确控制微针插入长度的印章式工具，涉及药物控释与皮肤微创装置技术领域，包括针体，挡板，保护壳，和后部的针体长度调节机构几个部分。由于皮肤厚度不同或者某些治疗阶段需要不同长度的微针，本发明的微针插入长度调整工具，对不同部位的皮肤治疗有较强的适应性。整体设计采用印章的形式，微针的长度的调节可以通过扭动端盖，调节端盖与保护壳之间间隙的距离。以达到调节微针探出挡板的长度，定位销可以落在连接柱不同的槽内以达到对微针探出长度的精确控制。
A stamp tool for precisely controlling the insertion length of a microneedle relates to the technical field of drug controlled release and skin minimally invasive devices, including a needle body, a baffle, a protective shell, and a rear needle body length adjustment mechanism. Because the thickness of the skin is different or microneedles of different lengths are required in certain treatment stages, the tool for adjusting the insertion length of the microneedles of the present invention has strong adaptability to the skin treatment of different parts. The overall design is in the form of a seal, and the length of the microneedle can be adjusted by twisting the end cap to adjust the distance between the end cap and the protective case. In order to adjust the length of the microneedle protruding baffle, the positioning pin can fall into different grooves of the connecting column to achieve precise control of the protruding length of the microneedle.
Description
Technical field:
The present invention relates to medicine controlled releasing and skin Wicresoft device, particularly the seal style instrument of accurate control micropin intubating length.
Background technology:
Traditional percutaneous dosing be medicine by the passive corium that diffuses into of epidermis passage, then enter body circulation through blood capillary.Cuticular obstruction causes the most drug molecule to pass through, and rate of release is difficult to reach the purpose for the treatment of too slowly, and people have taked various measures to destroy horny layer to strengthen skin to the infiltration of medicine for this reason.The microneedle array that is comprised of the micropin of 10-2000 μ m is a kind of relatively new route of administration, it not only can pierce through the upper strata epidermis and create and allow the even micron-scale passage that passes through of microgranule of medicine macromole, and unlikely exciting nerve produces the damage that pain causes clinical meaning again.
Skin is divided into three layers from outside to inside: horny layer, epidermal area and skin corium.The cutin bed thickness is 10-20 μ m approximately, is that one deck is extremely organized, and there is no blood vessel and nerve, but the controlled release layer of percutaneous drug absorption; Epidermal area is positioned at outer subcutaneous approximately 50-100 μ m place, contains a small amount of living cells and nerve, does not contain blood vessel; More contain a large amount of living cells, nerve and blood vessel in the corium of depths.Micropin is the micron-sized pin of difformity, structure and the material made by Micrometer-Nanometer Processing Technology, and by producing at keratodermatitis the permeability that medicine is improved in small duct, this is a kind of administering mode between subcutaneous injection and transdermal patch.
General traditional method, active nutrient can only infiltrate through the barrier layer (being horny layer) of epidermis, and effect is remarkable (only reaching approximately 0. 3 percent effect) not.Utilize the small syringe needle chafe of micropin, make active component effectively infiltrate skin, micropin stimulates skin corium simultaneously, percutaneous self-healing ability, promote the ossein hypertrophy, can the match in excellence or beauty plastic operation of laser and filled type of the thickness hypertrophy that can make skin epidermis approximately 8 percent, its effect.And the side effect of micropin technology is extremely low, and is safe and reliable.
Summary of the invention:
The seal style instrument that the purpose of this invention is to provide accurate control micropin intubating length, because skin thickness is different, perhaps some treatment stage needs the micropin of different length, so the length-adjustable seal style micropin of the present invention.
Accurately control the seal style instrument of micropin intubating length, be provided with microneedle array on a side of substrate 5, the opposite side of substrate 5 is provided with the connector 4 of fixing base 5 cylindrical bumps, connector 4 is along week upwards having some locating slots, connector 4 and end cap 3 are threaded connection, and end cap 3 is positioned at a side that is not provided with microneedle array on connector 4, end cap 3 is connected with positioning tube 1, spring and alignment pin 2 are installed in positioning tube 1, spring is against in locating slot on connector 4 alignment pin 2 between positioning tube 1 and alignment pin 2; Open on containment vessel 6 that on reeded circular hole and connector 4, the cylinder with boss coordinates, prevent from relatively rotating between connector 4 and containment vessel 6.The coupling part of substrate 5 and connector 4 is in containment vessel 6.Have the micropore corresponding with micropin on baffle plate 7, located mutually by the small boss on baffle plate 7 and the groove fit on containment vessel 6, the micropin on substrate 5 can lean out baffle plate 7 by micropore.When micropin uses, press end cap 3, end cap 3 containment vessel 6 of can conflicting, the distance of advancing this moment is the length that micropin on substrate 5 leans out baffle plate 7.And due to the existence of micropore on baffle plate 7, micropin can be constrained in the hole, improve the counter-bending ability of micropin.During rotary end cover 3, being threaded of connector 4 and end cap 3 can change the distance of regulating end cap 3 and containment vessel 6 gaps, and alignment pin 2 drops in the different groove of connector 4, leans out the length of baffle plate 7 to reach the fine adjustment micropin.Alignment pin in positioning tube 1 drops in the different groove of connector 4 to reach the accurate control that micropin is leant out length.The outside of containment vessel 6 has demarcates the scale that leans out pin length, the groove that end cap 3 has.When there is no baffle plate 7, the baffle plate 7 in the outside of containment vessel 6 can make skin smooth, thrusts error due to what the radian of skin caused when reducing microneedle array and penetrating skin, and accurately micropin inserts the length of skin, and micropin leans out the length of baffle plate between 0.2mm～2mm.
In described microneedle array, the material of pin is metal or polymer.
In described microneedle array, pin is shaped as taper shape, rhizoma sparganic taper or rectangular pyramid shape.
Utilize the small syringe needle chafe of micropin, make active component effectively infiltrate skin, micropin stimulates skin corium simultaneously, and percutaneous self-healing ability can be used for the desalination of small rut and skin scar.
The present invention compares with background technology, and the useful effect that has is:
Different local skin thickness differ, the length of the length adjustable system scalable micropin of micropin, to reach the purpose of reply different-thickness skin, baffle plate can accurately insert the length of skin, and the micropin of different length skin is produced different Wicresofts, the growth of chafe.
The micropin baffle plate can stop most of dirt, is convenient to cleaning.And baffle plate helps skin-tightening, is beneficial to the treatment of micropin.
Description of drawings:
Fig. 1 is the structural representation of integral body of the present invention.
Fig. 2 is the schematic diagram of micropin substrate.
Fig. 3 is the schematic diagram of micropin baffle plate.
Fig. 4 is micropin containment vessel schematic diagram.
Fig. 5 is micropin connector schematic diagram.
Fig. 6 is micropin alignment pin schematic diagram.
Fig. 7 is micropin end cap schematic diagram.
In figure: 1, positioning tube, 2, alignment pin, 3, end cap, 4, connector, 5, substrate, 6, containment vessel, 7, baffle plate.
The specific embodiment:
Further illustrate below in conjunction with accompanying drawing, referring to Fig. 2, Fig. 3, Fig. 4, shown in Figure 5, because micropin is also probably damaged due to extraneous factor and pollute in used time not, of the present invention and baffle plate 7 contact skin prevents that dust from entering the micropin gap on substrate 5, make micropin be convenient to cleaning, length that micropin enters skin that it is not only accurate, and little rigidity that helps to improve micropin.
Different local skin thickness differ, the length of the length adjustable system scalable micropin of micropin, to reach the purpose of reply different-thickness skin, baffle plate 7 can accurately insert the length of skin, and the micropin of different length skin is produced different Wicresofts, at different treatment stages, skin is produced different stimulations, be beneficial to the growth of skin.
In projection in Fig. 3 on baffle plate 7 and Fig. 4, the groove of the outer ring of containment vessel 6 matches; In Fig. 5 in the projection of connector 4 and Fig. 4 the groove of containment vessel 6 inner rings match.
Claims (3)
1. accurately control the seal style instrument of micropin intubating length, it is characterized in that: be provided with microneedle array on a side of substrate (5), the opposite side of substrate (5) is provided with the connector (4) of fixing base (5) cylindrical bump, connector (4) is along week upwards having some locating slots, connector (4) and end cap (3) are threaded connection, and end cap (3) is positioned at a side that is not provided with microneedle array on connector (4), end cap (3) is connected with positioning tube (1), spring and alignment pin (2) are installed in positioning tube (1), spring is between positioning tube (1) and alignment pin (2), alignment pin (2) is against in locating slot on connector (4), open reeded circular hole on containment vessel (6) and coordinate with the upper cylinder with boss of connector (4), prevent from relatively rotating between connector (4) and containment vessel (6), the coupling part of substrate (5) and connector (4) is in containment vessel (6), baffle plate has the micropore corresponding with micropin on (7), is located mutually by the small boss on baffle plate (7) and the groove fit on containment vessel (6), and the micropin on substrate (5) can lean out baffle plate (7) by micropore, when micropin uses, press end cap (3), end cap (3) containment vessel (6) of can conflicting, the distance of advancing this moment is the length that micropin on substrate (5) leans out baffle plate (7), and the existence due to the upper micropore of baffle plate (7) can constrain in micropin in the hole, improves the counter-bending ability of micropin, during rotary end cover (3), being threaded of connector (4) and end cap (3) can change the distance of regulating end cap (3) and containment vessel (6) gap, alignment pin (2) drops in the different groove of connector (4), leans out the length of baffle plate (7) to reach the fine adjustment micropin, alignment pin in positioning tube (1) drops in the different groove of connector (4) to reach the accurate control that micropin is leant out length, the outside of containment vessel (6) has demarcates the scale that leans out pin length, the groove that end cap (3) has, when there is no baffle plate (7), the baffle plate (7) in the outside of containment vessel (6) can make skin smooth, thrust error due to what the radian of skin caused when reducing microneedle array and penetrating skin, accurately micropin inserts the length of skin, and micropin leans out the length of baffle plate between 0.2mm～2mm.
2. the seal style instrument of accurate control micropin intubating length according to claim 1, it is characterized in that: in described microneedle array, the material of pin is metal or polymer.
3. the seal style instrument of accurate control micropin intubating length according to claim 1 is characterized in that: in described microneedle array, pin is shaped as taper shape, rhizoma sparganic taper or rectangular pyramid shape.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310045474.3A CN103157178B (en) | 2013-02-05 | 2013-02-05 | Seal type tool capable of accurately controlling microneedle insertion length |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310045474.3A CN103157178B (en) | 2013-02-05 | 2013-02-05 | Seal type tool capable of accurately controlling microneedle insertion length |
Publications (2)
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| CN103157178A true CN103157178A (en) | 2013-06-19 |
| CN103157178B CN103157178B (en) | 2014-12-31 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201310045474.3A Expired - Fee Related CN103157178B (en) | 2013-02-05 | 2013-02-05 | Seal type tool capable of accurately controlling microneedle insertion length |
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| CN (1) | CN103157178B (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105126243A (en) * | 2015-09-06 | 2015-12-09 | 游学秋 | Microneedle injection bullet, manufacturing method thereof and mirconeedle injection device |
| CN106693159A (en) * | 2017-01-24 | 2017-05-24 | 北京欧扬医疗美容门诊部有限公司 | Injecting type cosmetic instrument |
| CN107487091A (en) * | 2017-05-09 | 2017-12-19 | 盛利涛 | It is a kind of can authorizing band printing forme protection intelligent seal |
| CN107921248A (en) * | 2015-07-24 | 2018-04-17 | 金伯利-克拉克环球有限公司 | Method for more preferably delivering from activating agent to tumour |
| WO2018099437A1 (en) * | 2016-12-01 | 2018-06-07 | Huang Sin Ger | Microneedle array chip |
| CN108245775A (en) * | 2017-12-25 | 2018-07-06 | 中山大学 | The portable microneedle transdermal delivery auxiliary device of controllable dynamics and depth |
| CN108310616A (en) * | 2018-01-24 | 2018-07-24 | 苑凯华 | A kind of micro- needle roller device of adjustable skin with synchronous injection administration functions |
| CN113975619A (en) * | 2021-11-11 | 2022-01-28 | 浙江大学 | Device and method for controlling microneedle penetration based on light |
Citations (5)
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| US4109655A (en) * | 1975-10-16 | 1978-08-29 | Manufacture Francaise d'Armes et Cycles de Saint-Etienne Manufrance | Multi-penetration vaccination apparatus |
| CN1190904A (en) * | 1995-07-14 | 1998-08-19 | 贝林格尔·英格海姆公司 | Drug delivery system for corneal cortex |
| US6558361B1 (en) * | 2000-03-09 | 2003-05-06 | Nanopass Ltd. | Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems |
| US20030135161A1 (en) * | 2002-01-15 | 2003-07-17 | Fleming Patrick R. | Microneedle devices and methods of manufacture |
| CN101208129A (en) * | 2005-06-27 | 2008-06-25 | 3M创新有限公司 | Microneedle cartridge assembly and method of applying |
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2013
- 2013-02-05 CN CN201310045474.3A patent/CN103157178B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4109655A (en) * | 1975-10-16 | 1978-08-29 | Manufacture Francaise d'Armes et Cycles de Saint-Etienne Manufrance | Multi-penetration vaccination apparatus |
| CN1190904A (en) * | 1995-07-14 | 1998-08-19 | 贝林格尔·英格海姆公司 | Drug delivery system for corneal cortex |
| US6558361B1 (en) * | 2000-03-09 | 2003-05-06 | Nanopass Ltd. | Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems |
| US20030135161A1 (en) * | 2002-01-15 | 2003-07-17 | Fleming Patrick R. | Microneedle devices and methods of manufacture |
| CN101208129A (en) * | 2005-06-27 | 2008-06-25 | 3M创新有限公司 | Microneedle cartridge assembly and method of applying |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107921248A (en) * | 2015-07-24 | 2018-04-17 | 金伯利-克拉克环球有限公司 | Method for more preferably delivering from activating agent to tumour |
| CN105126243A (en) * | 2015-09-06 | 2015-12-09 | 游学秋 | Microneedle injection bullet, manufacturing method thereof and mirconeedle injection device |
| CN105126243B (en) * | 2015-09-06 | 2018-08-07 | 台州薇凯生物科技有限公司 | Microneedle injection bullet and preparation method thereof and microneedle injection equipment |
| WO2018099437A1 (en) * | 2016-12-01 | 2018-06-07 | Huang Sin Ger | Microneedle array chip |
| CN106693159A (en) * | 2017-01-24 | 2017-05-24 | 北京欧扬医疗美容门诊部有限公司 | Injecting type cosmetic instrument |
| CN106693159B (en) * | 2017-01-24 | 2023-12-22 | 北京欧扬医疗美容门诊部有限公司 | Injection type beauty instrument |
| CN107487091A (en) * | 2017-05-09 | 2017-12-19 | 盛利涛 | It is a kind of can authorizing band printing forme protection intelligent seal |
| CN107487091B (en) * | 2017-05-09 | 2023-09-19 | 盛利涛 | Intelligent seal with printing plate protection function |
| CN108245775A (en) * | 2017-12-25 | 2018-07-06 | 中山大学 | The portable microneedle transdermal delivery auxiliary device of controllable dynamics and depth |
| CN108310616A (en) * | 2018-01-24 | 2018-07-24 | 苑凯华 | A kind of micro- needle roller device of adjustable skin with synchronous injection administration functions |
| CN113975619A (en) * | 2021-11-11 | 2022-01-28 | 浙江大学 | Device and method for controlling microneedle penetration based on light |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103157178B (en) | 2014-12-31 |
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Inventor after: Zhang Yajun Inventor after: Zhuang Jian Inventor after: Xue Ling Inventor after: Hao Junjiao Inventor after: Zhou Gang Inventor after: Wang Shengdan Inventor before: Zhang Yajun Inventor before: Zhuang Jian Inventor before: Xue Ling Inventor before: Zhang Shaojing Inventor before: Hao Junjiao Inventor before: Zhou Gang |
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Inventor after: Zhang Yajun Inventor after: Zhuang Jian Inventor after: Xue Ling Inventor after: Hao Junjiao Inventor after: Zhou Gang Inventor after: Wang Shengdan Inventor after: Li Meijiao Inventor before: Zhang Yajun Inventor before: Zhuang Jian Inventor before: Xue Ling Inventor before: Hao Junjiao Inventor before: Zhou Gang Inventor before: Wang Shengdan |
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Free format text: CORRECT: INVENTOR; FROM: ZHANG YAJUN ZHUANG JIAN XUE LING HAO JUNJIAO ZHOU GANG WANG SHENGDAN TO: ZHANG YAJUN ZHUANG JIAN XUE LING HAO JUNJIAO ZHOU GANG WANG SHENGDAN LI MEIJIAO |
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