CN103111019B - Straight inserting type self-pressing medication injecting hollow microneedle device - Google Patents

Abstract

The invention provides a hollow microneedle device for in-line self-compressing drug injection, which includes a hollow needle body and a substrate cavity, an end cover, a handle, an elastic air storage membrane, a check valve, a vent hole, an infusion hole and the like. The hollow needle body is on the structure of the substrate cavity, the end cap is on the handle, the end cap is connected with the substrate cavity, an elastic air storage film is formed between the end cap and the substrate cavity, and the end cap is equipped with an air check valve and air Vent. The present invention utilizes the force exerted on the handle to the end cap when applying medicine, so that the deformable end cap and the air check valve realize the increase of the air pressure in the space formed between the elastic air storage film and the end cap, and when the deformation of the end cap recovers Through the action of the air check valve, the air in this space is increased, the air pressure is restored, and the elastic air storage membrane is used to separate the medicine from the air, avoiding the pollution of the air to the medicine. And the air check valve restores the air pressure in the space formed between the elastic air storage film and the end cap in time, avoiding the backflow of the medicine.

Description

In-line self-compression hollow microneedle device for drug injection

technical field

The invention relates to a drug controlled release and skin minimally invasive device, in particular to an in-line self-pressing drug injection hollow microneedle device.

Background technique

Traditional transdermal drug delivery involves passive diffusion of drugs into the dermis through epidermal channels, and then enters the systemic circulation through capillaries. The hindrance of the stratum corneum leads to the inability of most drug molecules to pass through and the least amount of drug administration, and the slow release rate is difficult to achieve the purpose of treatment. Therefore, various measures have been taken to destroy the stratum corneum to enhance skin penetration of drugs . The microneedle array composed of 10-2000μm microneedles is a relatively new drug delivery route, which can not only pierce the upper epidermis to create micron-sized channels that allow drug macromolecules and even particles to pass through, but will not stimulate nerves to cause pain cause clinically significant damage.

The skin is divided into three layers from outside to inside: stratum corneum, epidermis and dermis. The stratum corneum is about 10-20 μm thick, which is a layer of dead tissue without blood vessels and nerves, but it is a controlled release layer for drug percutaneous absorption; Contains blood vessels; the deeper dermis contains a large number of living cells, nerves and blood vessels. Microneedles are micron-sized needles of different shapes, structures and materials made by microfabrication technology, which can improve the permeability of drugs by creating tiny pores in the stratum corneum of the skin, which is between subcutaneous injection and transdermal patch. a method of administration.

In general traditional methods, active nutrients can only penetrate into the barrier layer of the epidermis (ie, the stratum corneum), and the effect is not significant (only about 0.3% of the effect is achieved). Stimulate the skin with the tiny needles of microneedles, so that the active ingredients can effectively penetrate into the skin. At the same time, the microneedles stimulate the dermis, promote the proliferation of collagen through the self-healing ability of the skin, and increase the thickness of the epidermis by about 8%. The effect is comparable to laser and filling plastic surgery. The microneedle technology has extremely low side effects and is safe and reliable.

Contents of the invention

The object of the present invention is to provide a hollow microneedle device for in-line self-pressing drug injection, because the traditional injection method will cause pain and is not suitable for local drug administration to the human body. The invention provides a painless hollow microneedle drug delivery method, which is convenient for precise drug delivery to patients.

Hollow needle body and base plate cavity, end cap, handle, elastic air storage membrane, air check valve, vent hole, infusion hole, etc.

The hollow needle body is on the base plate cavity, the end cover is connected to the handle, the end cover is connected with the base plate cavity, an elastic air storage film is formed between the end cover and the base plate cavity, and an air check valve and an air release hole are provided on the end cover.

The force exerted by the handle on the end cap during drug application enables the deformable end cap and air check valve to increase the air pressure in the space formed between the elastic air storage film and the end cap, thereby pushing the drug in the substrate cavity. Injection, when the deformation of the end cap recovers, the air in this space is increased through the action of the air check valve, and the air pressure is restored, and due to the action of the air check valve 3, the above process can be repeated.

The elastic air storage membrane separates the air from the medicine, avoiding the pollution of the medicine by the air.

The existence of the air check valve restores the air pressure in the space formed between the elastic air storage membrane and the end cap in time, avoiding the backflow of the drug.

The substrate cavity and the end cover are provided with grooves to prevent the elastic air storage film from sliding and leaking, and the elastic air storage film has protrusions on the edge, which cooperate with the grooves on the substrate cavity and the end cover.

The air check valve is in the form of a patch, which exists inside the end cap, or is another form of check valve.

The end caps are elastic material.

The height of the hollow microneedle is 0.2mm-3mm, the outer diameter of the needle is 0.05mm-1mm, and the inner diameter is 0.02mm-0.8mm.

The hollow microneedles are made of medical stainless steel, biocompatible materials, degradable materials or polymers such as PMMA.

Compared with the background technology, the present invention has the beneficial effects that:

The invention utilizes the force exerted on the handle during drug application, so that the deformable end cap and the air check valve realize the increase of air in the elastic air storage film, thereby promoting the injection of the drug in the cavity of the substrate. The invention separates the medicine from the air, avoiding the pollution of the medicine by the air. And due to the existence of the air check valve, the backflow of the medicine is avoided.

Description of drawings

Fig. 1 is a schematic diagram of the overall structure of the present invention.

Fig. 2 is a schematic diagram of the back side of the substrate chamber.

Fig. 3 is a schematic front view of the substrate cavity.

Figure 4 is a schematic diagram of an elastic air storage membrane.

Figure 5 is a schematic diagram of the connection of the end cap.

Figure 6 is a schematic diagram of the handle.

Detailed ways

The following will be further described in conjunction with the accompanying drawings, as shown in Figure 2, Figure 3, Figure 4, Figure 5, and Figure 6. The hollow needle body is on the substrate cavity, the end cover is connected to the handle, the end cover is connected to the substrate cavity, and the end cover is connected to the substrate cavity. There is an elastic air storage film between the substrate cavities, and an air check valve and an air release hole are provided on the end cover.

The force exerted by the handle on the end cap enables the deformable end cap and the air check valve to increase the air pressure in the space formed between the elastic air storage membrane and the end cap, thereby pushing the injection of the drug in the substrate cavity, and the end cap When the deformation recovers, the air in this space is increased by the action of the air check valve, and the air pressure is restored. When the drug is administered, the air vent hole is closed, and when the microneedle is filled with medicine, the air vent hole is opened.

The substrate cavity and the end cover are provided with grooves to prevent the elastic air storage film from sliding and leaking, and the elastic air storage film has protrusions on the edge, which cooperate with the grooves on the substrate cavity and the end cover.

Claims (8)

1. In-line self-compressing hollow microneedle device for drug injection, characterized in that it includes: a hollow needle body (1) and a substrate cavity (2), a deformable end cap (5), a handle (6), and an elastic air storage membrane (8), air check valve (3), vent hole (7), infusion hole (4); the connection relationship is: the hollow needle body (1) is on the substrate cavity (2), and the deformable end cap (5) Connected to the handle (6), the deformable end cap (5) is connected to the substrate cavity (2), and the elastic air storage film (8) is between the deformable end cap (5) and the substrate cavity (2), and is deformable There is an air check valve (3) and an air vent hole (7) on the end cover; the force exerted on the deformable end cover (5) by the handle (6) makes the deformable end cover (5) and the The air check valve (3) increases the air pressure in the space formed between the elastic air storage membrane (8) and the deformable end cap (5), thereby promoting the injection of the drug in the substrate cavity (2), and the deformable end cap When the deformation of the cover (5) recovers, the air in this space is increased by the action of the air check valve (3), and the air pressure is restored, and due to the action of the air check valve (3), the above process can be repeated. 2. The in-line self-pressing hollow microneedle device for drug injection according to claim 1, characterized in that: the elastic air storage membrane (8) separates the air from the drug, avoiding air pollution to the drug. 3. The in-line self-compression hollow microneedle device for drug injection according to claim 1, characterized in that: the presence of the air check valve (3) restores the elastic air storage membrane (8) and the deformable end cap in time (5) The air pressure that forms the space between has avoided the reflux of medicine. 4. The in-line self-compressing hollow microneedle device for drug injection according to claim 1, characterized in that: the substrate cavity (2) and the deformable end cap (5) are provided with anti-elastic air storage membranes to prevent sliding and air leakage There are grooves on the edge of the elastic air storage film (8), and the projections cooperate with the grooves on the substrate cavity (2) and the deformable end cover (5). 5. The in-line self-compression hollow microneedle device for drug injection according to claim 1, characterized in that the air check valve (3) is in the form of a patch and exists inside the deformable end cap (5). 6. The in-line self-pressing hollow microneedle device for drug injection according to claim 1, characterized in that the deformable end cap (5) is made of elastic material. 7. The in-line self-compression hollow microneedle device for drug injection according to claim 1, characterized in that: the height of the hollow microneedle is 0.2 mm to 3 mm, the outer diameter of the needle is 0.05 mm to 1 mm, and the inner diameter is 0.02 mm. mm ~ 0.8mm. 8. The in-line self-compressing hollow microneedle device for drug injection according to claim 1, characterized in that: the material of the hollow microneedle is medical stainless steel, biocompatible material or degradable material, PMMA polymethyl methacrylate .