CN102670442B - Panax notoginseng active ingredient-containing medicinal toothpaste and preparation method and application thereof - Google Patents
Panax notoginseng active ingredient-containing medicinal toothpaste and preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses panax notoginseng active ingredient-containing medicinal toothpaste and a preparation method and application thereof. The panax notoginseng active ingredient-containing medicinal toothpaste comprises 0.1 to 0.4 weight percent of total panax notoginseng saponins and 0.2 to 0.5 weight percent of panax notoginseng polysaccharide which are panax notoginseng active ingredients,abrasive, a wetting agent, surfactant, a foaming agent, adhesive, a stabilizing agent and deionized water. The preparation method for the toothpaste comprises the following steps of: preparing materials, mixing, grinding, and degassing to obtain a toothpaste body. According to the toothpaste, total panax notoginseng saponins and panax notoginseng polysaccharide are used as the core functional components of the toothpaste, so that the toothpaste has the function of cleaning teeth, and the obvious effects of promoting recovery of dental ulcer, gingivitis and periodontitis, inhibiting swelling and aching of gums, relieving bleeding of gums, and delaying gingival atrophy and aging. The total panax notoginseng saponins and the panax notoginseng polysaccharide which are used as the active ingredients are natural plant extract, so that damage to ecological environment of normal flora in an oral cavity can be avoided, and the panax notoginseng active ingredient-containing medicinal toothpasteis suitable to be used for a long tome and is good in effect.
Description
Technical field
The present invention relates to oral cleaning nursing article, be specifically related to a kind of medicated toothpaste that contains the pseudo-ginseng activity composition and its preparation method and application.
Background technology
Radix Notoginseng is dry root and the rhizome of panax araliaceae plant Panax Notoginseng (Burk.) F.H.Chen.What the famous physician's Li Shizhen (1518-1593 A.D.) of the Ming Dynasty was praised in Compendium of Material Medica is " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) ", claims " ginseng south, north seven ", is the most precious person of Chinese medicine.Compendium of Material Medica cloud: " Radix Notoginseng hemostasis, the blood that looses, analgesic therapy." modern scientific research shows that Radix Notoginseng total arasaponins (PNS) comprises 24 kinds of dammarane (Dammarane) type saponin, its total saponin content is about 12%, and Radix Notoginseng is described as " king of Radix Ginseng ".Radix Notoginseng total arasaponins comprises ginsenoside and arasaponin, is the main effectively active component of Radix Notoginseng, has cardiovascular protection effect, pre-preventing thrombosis and anti thrombotic action, analgesic activity, anti-inflammatory effect, radiation resistance and defying age, antioxidation.Radix Notoginseng polysaccharide has been confirmed sanchinan-A (sanchinan A) and stem and leaf of Radix Notoginseng polysaccharide etc. since the 1980's were found, animal experiment confirms that Radix Notoginseng polysaccharide has the effect of enhancing immunity.Ministry of Public Health " health food check and assessment technique standard " (version in 2003) record, Radix Notoginseng polysaccharide has the function of enhancing immunity.
Heat clearing away in the market, except implication, mothproof, antiallergic toothpaste is more, can solve problems such as gingival hemorrhage, antiinflammatory, inhibition gingival swelling and pain, reparation oral ulcer though also there is toothpaste to claim, but can only solve part the problems referred to above, DeGrain maybe can only play temporary transient effect, or is easy to generate Drug resistance and unsuitable life-time service.Radix Notoginseng is as oral cavity nursing agent, though the toothpaste of panax mixed extract is arranged at present, because effective ingredient is wayward, difference on effect is bigger; Part contains the toothpaste of Radix Notoginseng single component such as dencichine, arasaponin, owing to reasons such as preparation method or function singlenesses, its effect for mouth care comparatively limit to or effect unreliable.Therefore, take full advantage of ginsenoside in the Radix Notoginseng total arasaponins and the effect of arasaponin and Radix Notoginseng polysaccharide, the oral cavity nursing agent of the Radix Notoginseng class that the exploitation therapeutic efficiency is better is necessary.
Summary of the invention
First purpose of the present invention is, a kind of medicated toothpaste that contains the pseudo-ginseng activity composition is provided, and second purpose is to provide the preparation method of above-mentioned toothpaste, and the 3rd purpose is to provide the application of above-mentioned toothpaste.
First purpose of the present invention is achieved in that and comprises pseudo-ginseng activity composition and abrasivus, wetting agent, surfactant and foaming agent, binding agent, stabilizing agent, deionized water, described pseudo-ginseng activity composition be weight percentage 0.1～0.4% Radix Notoginseng total arasaponins and 0.2～0.5% Radix Notoginseng polysaccharide.
Second purpose of the present invention is achieved in that and may further comprise the steps:
A, get the raw materials ready by component ratio, get Radix Notoginseng total arasaponins, Radix Notoginseng polysaccharide, tetrasodium pyrophosphate, deionized water in getting the raw materials ready, drop in the water device, fully stand-by behind the mixed dissolution;
B, get abrasivus, surfactant and foaming agent, binding agent in getting the raw materials ready, wetting agent joins respectively in the obtained mixture of A step, is stirred to abundant mixing in the time of adding, grinds, the degassing makes mastic.
The 3rd purpose of the present invention is achieved in that the described pseudo-ginseng activity composition medicated toothpaste that contains is alleviating gingival hemorrhage, antiinflammatory, inhibition gingival swelling and pain, repairing the application in the oral ulcer.
Radix Notoginseng total arasaponins (PNS) and Radix Notoginseng polysaccharide are the active component that extracts from Radix Notoginseng.Modern scientific research shows that Radix Notoginseng total arasaponins raises to capillary permeability and has the obvious suppression effect, and cardiovascular system is had pharmacologically active widely, and dissipating blood stasis, detumescence, hemostasis are had positive effect; Panaxadiol saponin in the Radix Notoginseng total arasaponins has definite analgesia and antiinflammation; Panax ginsenoside Rb1 has tangible central inhibitory action, has calm function; Radix Notoginseng total arasaponins has the expansion external vessel, reduces the effect of Peripheral resistance, has the effect of improving blood supply; Radix Notoginseng total arasaponins also has defying age, antioxidative effect simultaneously, can obviously improve the gingiva blood supply, thereby delay gingival atrophy.Radix Notoginseng polysaccharide has the activate immunity receptor, strengthens immunologic function, promotes the effect of macrophage and antibody secreting cell activity, is conducive to suppress gingival swelling and pain and promotes the oral ulcer healing.With the nucleus of the two combination of Radix Notoginseng total arasaponins and Radix Notoginseng polysaccharide as toothpaste, to realize Radix Notoginseng in the rehabilitation that promotes oral ulcer, gingivitis, periodontitis, suppress gingival swelling and pain, alleviate gingival hemorrhage, delay the effect of gingival atrophy aging.Life-time service neither can destroy oral cavity normal flora balance, because the effect of the enhancing immunity that Radix Notoginseng polysaccharide and Radix Notoginseng total arasaponins have, more is conducive to the health in oral cavity.The preparation method of medicated toothpaste of the present invention can guarantee the activity of Radix Notoginseng total arasaponins and Radix Notoginseng polysaccharide, and each component of the medicated toothpaste of preparation is abundant more mix homogeneously also, to guarantee the result of use of toothpaste in the shelf-life.Medicated toothpaste of the present invention uses, behind the Radix Notoginseng total arasaponins and Radix Notoginseng polysaccharide of oral cavity in absorbing toothpaste, effective ingredient acts on oral environment, repairs and promote the rehabilitation of oral ulcer, gingivitis, periodontitis, suppresses gingival swelling and pain, alleviates gingival hemorrhage, delays the gingival atrophy aging.
The specific embodiment
Below the present invention is further illustrated, but never in any form the present invention is limited, any change or replacement according to training centre of the present invention is done all belong to protection scope of the present invention.
The pseudo-ginseng activity composition medicated toothpaste that contains of the present invention, comprise containing pseudo-ginseng activity composition and abrasivus, wetting agent, surfactant and foaming agent, binding agent, stabilizing agent, deionized water, it is characterized in that described pseudo-ginseng activity composition be weight percentage 0.1～0.4% Radix Notoginseng total arasaponins and 0.2～0.5% the Radix Notoginseng polysaccharide of containing.
As preferred implementation:
Described containing in the pseudo-ginseng activity composition medicated toothpaste: abrasivus is in 25 ~ 60% dicalcium phosphate dihydrate, hydration Silicon stone, calcium carbonate, the aluminium hydroxide one or more for accounting for the toothpaste percentage by weight; Wetting agent is in 10 ~ 55% glycerol, propylene glycol, the sorbitol one or more for accounting for the toothpaste percentage by weight; Surfactant and foaming agent be 1.5 ~ 2.5% sodium lauryl sulfate for accounting for the toothpaste percentage by weight, in the sodium N-lauroyl sarcosinate one or more; Binding agent is in 0.3 ~ 1.5% sodium carboxymethyl cellulose, carboxyethyl cellulose, xanthan gum, melon Lovell glue, the carrageenan one or more for accounting for the toothpaste percentage by weight; Stabilizing agent is 1.5 ~ 3.0% tetrasodium pyrophosphate for accounting for the toothpaste percentage by weight; Surplus is deionized water.
Described containing in the pseudo-ginseng activity composition medicated toothpaste: abrasivus is to account for the calcium hydrogen phosphate two water things of toothpaste percentage by weight 40%～45% and/or 20%～35% hydration Silicon stone; Wetting agent is to account for the sorbitol of toothpaste percentage by weight 15～20% and/or 10～15% glycerol; Surfactant and foaming agent are for accounting for the sodium lauryl sulfate of toothpaste percentage by weight 2.0 ~ 2.3%; Binding agent is to account for the sodium carboxymethyl cellulose of toothpaste percentage by weight 0.5～0.7% and/or 0.3～0.4% xanthan gum; Stabilizing agent is for accounting for the tetrasodium pyrophosphate of toothpaste percentage by weight 1.5 ~ 3.0%; Surplus is deionized water.
Above-mentioned abrasivus, wetting agent, surfactant and foaming agent, binding agent, stabilizing agent can also be used in the toothpaste preparation field raw material commonly used and substitute:
Describedly contain that to contain percentage by weight in the pseudo-ginseng activity composition medicine toothpaste component be 2.5～3.5% saccharin sodium, 1～1.2% essence and 0.01 ~ 0.02% CI42090.Saccharin sodium also can be selected sweeting agents such as xylitol, acesulfame potassium as sweeting agent; Described blue pigment CI42090, the also color pigments that can select other medical preparations to use.
Describedly contain that to contain percentage by weight in the pseudo-ginseng activity composition medicine toothpaste component be 0.1～0.2% sodium benzoate.
The preparation method that contains pseudo-ginseng activity composition medicated toothpaste of the present invention may further comprise the steps:
A, get the raw materials ready by component ratio, get Radix Notoginseng total arasaponins, Radix Notoginseng polysaccharide, tetrasodium pyrophosphate, deionized water in getting the raw materials ready, drop in the water device, fully stand-by behind the mixed dissolution;
B, get abrasivus, surfactant and foaming agent, binding agent, wetting agent in getting the raw materials ready, join respectively in the obtained mixture of A step, be stirred to abundant mixing in the time of adding, grind, the degassing makes mastic.
As preferred implementation:
In the described component of A step, add saccharin sodium, CI42090, sodium benzoate, stir into colloidal in the lump; When entering the B step, in the mixture that the B step obtains, add essence, be stirred well to abundant mixing in the lump, make mastic.
Homogenizer is adopted in the described stirring of B step, and speed of agitator is 1000r/min, continues to stir 25 ~ 40min.
The described pseudo-ginseng activity composition medicated toothpaste that contains is alleviating gingival hemorrhage, antiinflammatory, inhibition gingival swelling and pain, is repairing the application in the oral ulcer.
Embodiment 1
Get the raw materials ready in following ratio (percentage by weight): 0.4% Radix Notoginseng total arasaponins, 0.5% Radix Notoginseng polysaccharide, abrasivus are that 25% hydration Silicon stone, wetting agent are that sorbitol, surfactant and the foaming agent of 15% glycerol and 35% is that 2.5% sodium lauryl sulfate, binding agent are that xanthan gum, the stabilizing agent of 1% sodium carboxymethyl cellulose and 0.4% is 3.0% tetrasodium pyrophosphate, and all the other are 17.2% deionized water.Get Radix Notoginseng total arasaponins, Radix Notoginseng polysaccharide, tetrasodium pyrophosphate, deionized water in getting the raw materials ready, drop in the water device, fully mixed dissolution is stand-by; With abrasivus, wetting agent, surfactant and foaming agent, binding agent, join respectively in the mixture, use blender to continue to stir 40min with the 1000r/min rotating speed in the time of adding, to abundant mixing, mastic is made in grinding, the degassing, packing.
Embodiment 2
Get the raw materials ready in following ratio (percentage by weight): 0.1% Radix Notoginseng total arasaponins, 0.2% Radix Notoginseng polysaccharide, abrasivus are that hydration Silicon stone, the wetting agent of 40% calcium hydrogen phosphate two water things and 20% is that sorbitol, surfactant and the foaming agent of 10% glycerol and 15% is that 1.5% sodium lauryl sulfate, binding agent are that xanthan gum, the stabilizing agent of 0.5% sodium carboxymethyl cellulose and 0.3% is 1.5% tetrasodium pyrophosphate, and all the other are 10.9% deionized water.Get Radix Notoginseng total arasaponins, Radix Notoginseng polysaccharide, tetrasodium pyrophosphate, deionized water in getting the raw materials ready, drop in the pre-mixing apparatus, fully mixed dissolution is stand-by; With abrasivus, wetting agent, surfactant and foaming agent, binding agent, join respectively in the mixture, use blender to continue to stir 25min with the 1000r/min rotating speed in the time of adding, to abundant mixing, mastic is made in grinding, the degassing, packing.
Embodiment 3
Get the raw materials ready in following ratio (percentage by weight): 0.25% Radix Notoginseng total arasaponins, 0.35% Radix Notoginseng polysaccharide, abrasivus are that 45% calcium hydrogen phosphate two water things, wetting agent are that sorbitol, surfactant and the foaming agent of 14% glycerol and 20% is that 2.0% sodium lauryl sulfate, binding agent are that 0.6% sodium carboxymethyl cellulose, stabilizing agent are 2.5% tetrasodium pyrophosphate, all the other are 15.3% deionized water.Get Radix Notoginseng total arasaponins, Radix Notoginseng polysaccharide, tetrasodium pyrophosphate, deionized water in getting the raw materials ready, drop in the water device, fully mixed dissolution is stand-by; With abrasivus, wetting agent, surfactant and foaming agent, binding agent, join respectively in the colloidal mixture, use blender to continue to stir 32min with the 1000r/min rotating speed in the time of adding, to abundant mixing, mastic is made in grinding, the degassing, packing.
Embodiment 4
Get the raw materials ready in following ratio (percentage by weight): 0.2% Radix Notoginseng total arasaponins, 0.3% Radix Notoginseng polysaccharide, abrasivus are that aluminium hydroxide, the wetting agent of 20% calcium carbonate and 20% is that propylene glycol, surfactant and the foaming agent of 15% glycerol and 25% is that 2.0% sodium N-lauroyl sarcosinate, binding agent are that 1.0% carboxyethyl cellulose, stabilizing agent are 2.0% tetrasodium pyrophosphate, all the other are 14.5% deionized water.Get Radix Notoginseng total arasaponins, Radix Notoginseng polysaccharide, tetrasodium pyrophosphate, deionized water in getting the raw materials ready, drop in the water device, fully mixed dissolution is stand-by; With abrasivus, wetting agent, surfactant and foaming agent, binding agent, join respectively in the colloidal mixture, use blender to continue to stir 29min with the 1000r/min rotating speed in the time of adding, to abundant mixing, mastic is made in grinding, the degassing, packing.
Embodiment 5
Get the raw materials ready in following ratio (percentage by weight): 0.4% Radix Notoginseng total arasaponins, 0.5% Radix Notoginseng polysaccharide, abrasivus are that aluminium hydroxide, the wetting agent of 25% hydration Silicon stone and 20% is that propylene glycol, surfactant and the foaming agent of 15% sorbitol and 15% is that 2.0% sodium N-lauroyl sarcosinate and sodium N-lauroyl sarcosinate, binding agent are that 1.0% xanthan gum, 0.8% melon Lovell glue, 1.2 carrageenans, stabilizing agent are 2.0% tetrasodium pyrophosphate, all the other are 17.1% deionized water.Operating procedure is with embodiment 1.
Embodiment 6
Get the raw materials ready in following ratio (percentage by weight): 0.2% Radix Notoginseng total arasaponins, 0.2% Radix Notoginseng polysaccharide, abrasivus are that aluminium hydroxide, the wetting agent of 40% calcium hydrogen phosphate two water things, 20% hydration Silicon stone and 20% is that 10% sorbitol, surfactant and foaming agent are that 1.5% sodium lauryl sulfate, binding agent are that 0.3% carboxyethyl cellulose, 0.5% xanthan gum, stabilizing agent are 1.5% tetrasodium pyrophosphate, and all the other are 5.8% deionized water.Operating procedure is with embodiment 2.
Embodiment 7
Get the raw materials ready in following ratio (percentage by weight): 0.25% Radix Notoginseng total arasaponins, 0.3% Radix Notoginseng polysaccharide, abrasivus are that aluminium hydroxide, the wetting agent of 25% calcium carbonate and 20% is that propylene glycol, surfactant and the foaming agent of 18% glycerol and 20% is that 2.0% sodium N-lauroyl sarcosinate, stabilizing agent are that 0.6% sodium carboxymethyl cellulose, emulsifying agent are 2.5% tetrasodium pyrophosphate, all the other are 11.35% deionized water.Operating procedure is with embodiment 3.
Embodiment 8
Get the raw materials ready in following ratio (percentage by weight): 0.2% Radix Notoginseng total arasaponins, 0.35% Radix Notoginseng polysaccharide, abrasivus are that 48% calcium carbonate, wetting agent are that 30% propylene glycol, surfactant and foaming agent are that 2.0% sodium N-lauroyl sarcosinate, binding agent are that 1.2% sodium carboxymethyl cellulose, stabilizing agent are 3% tetrasodium pyrophosphate, all the other are 15.25% deionized water.Operating procedure is with embodiment 4.
Embodiment 9
Get the raw materials ready in following ratio (percentage by weight): 0.25% Radix Notoginseng total arasaponins, 0.35% Radix Notoginseng polysaccharide, abrasivus are that 43% calcium hydrogen phosphate two water things, wetting agent are that sorbitol, surfactant and the foaming agent of 14% glycerol and 18% is that 2.0% sodium lauryl sulfate, binding agent are that 0.6% sodium carboxymethyl cellulose, stabilizing agent are 2.5% tetrasodium pyrophosphate, 2.5% saccharin sodium, 0.1% sodium benzoate, 1% essence, 0.01% CI42090, and all the other are the deionized water of 15.69 %.Get Radix Notoginseng total arasaponins, Radix Notoginseng polysaccharide, tetrasodium pyrophosphate, saccharin sodium, sodium benzoate, CI42090, deionized water in getting the raw materials ready, drop in the water device, fully mixed dissolution is stand-by; With abrasivus, wetting agent, surfactant and foaming agent, binding agent, essence, join respectively in the mixture, use blender to continue to stir 32min with the 1000r/min rotating speed in the time of adding, to abundant mixing, mastic is made in grinding, the degassing, packing.
Embodiment 10
Get the raw materials ready in following ratio (percentage by weight): 0.1% Radix Notoginseng total arasaponins, 0.2% Radix Notoginseng polysaccharide, abrasivus are that hydration Silicon stone, the wetting agent of 38% calcium hydrogen phosphate two water things and 18% is that sorbitol, surfactant and the foaming agent of 10% glycerol and 15% is that 1.5% sodium lauryl sulfate, binding agent are that xanthan gum, the stabilizing agent of 0.5% sodium carboxymethyl cellulose and 0.3% is 1.5% tetrasodium pyrophosphate, 3.5% saccharin sodium, 0.2% sodium benzoate, 1.2% essence and 0.02% CI42090, and all the other are 9.98% deionized water.Get Radix Notoginseng total arasaponins, Radix Notoginseng polysaccharide, tetrasodium pyrophosphate, saccharin sodium, sodium benzoate, CI42090, deionized water in getting the raw materials ready, drop in the water device, fully mixed dissolution is stand-by; With abrasivus, wetting agent, surfactant and foaming agent, binding agent, essence, join respectively in the mixture, use blender to continue to stir 25min with the 1000r/min rotating speed in the time of adding, to abundant mixing, mastic is made in grinding, the degassing, packing.
Embodiment 11
Get the raw materials ready in following ratio (percentage by weight): 0.2% Radix Notoginseng total arasaponins; 0.3% Radix Notoginseng polysaccharide; abrasivus is 25% calcium carbonate and 25% aluminium hydroxide; wetting agent is 25% glycerol; surfactant and foaming agent are 2.0% sodium N-lauroyl sarcosinate; binding agent is 1.0% carboxyethyl cellulose; stabilizing agent is 2.0% tetrasodium pyrophosphate; 3% saccharin sodium; 0.15% sodium benzoate; 1.1% essence; 0.015% CI42090; all the other are 15.235% deionized water.Get Radix Notoginseng total arasaponins, Radix Notoginseng polysaccharide, tetrasodium pyrophosphate, saccharin sodium, sodium benzoate, CI42090, deionized water in getting the raw materials ready, drop in the water device, fully mixed dissolution is stand-by; With abrasivus, wetting agent, surfactant and foaming agent, binding agent, essence, join respectively in the mixture, use blender to continue to stir 29min with the 1000r/min rotating speed in the time of adding, to abundant mixing, mastic is made in grinding, the degassing, packing.
Embodiment 12:
Medicated toothpaste with above-described embodiment preparation carries out the antiinflammatory test with the blank toothpaste that does not add Radix Notoginseng total arasaponins and Radix Notoginseng polysaccharide.
Be regardless of male and female and get 40 of healthy guinea pigs, body weight 240 ~ 260g is divided into 4 groups at random, 10 every group.With 3 positions of pricking wound Cavia porcellus gums, artificial induction's gingivitis.The swelling and aching of gum degree is divided into 5 grades and score: pneumonedema 0 minute; Slight swollen 1 minute; Obviously swollen 2 minutes; Quite swollen 3 minutes; Very swollen 4 minutes.After the acupuncture 24 hours, observe to scribble embodiment 1 to 3 and blank toothpaste to the influence of 3 position swelling of 4 groups of Cavia porcellus gingivas degree, calculate the 2nd to the recovery rate of Cavia porcellus swelling and aching of gum on the 10th.The recovery rate computing formula is as follows:
Recovery rate=(1-observed the same day score value total/acupuncture 24 backs observe score values add up to) * 100%
Table 1: the test Cavia porcellus is respectively organized gingiva recovery rate (%)
| Group | 2 days | 3 days | 4 days | 5 days | 6 days | 7 days | 8 days | 9 days | 10 days |
| Blank toothpaste group | 3.3 | 12.5 | 24.2 | 44.2 | 66.7 | 80.8 | 85.0 | 87.5 | 89.2 |
| 1 group of embodiment | 17.6 | 32.8 | 47.9 | 62.2 | 77.3 | 93.3 | 95.0 | 96.6 | 98.3 |
| 2 groups of embodiment | 14.2 | 27.5 | 44.2 | 57.5 | 73.3 | 91.7 | 93.3 | 95.0 | 95.8 |
| 3 groups of embodiment | 16.7 | 30.0 | 46.7 | 60.8 | 75.0 | 92.5 | 93.3 | 95.8 | 96.7 |
| 4 groups of embodiment | 16.9 | 31.8 | 48.9 | 61.2 | 74.9 | 91.3 | 94.9 | 95.6 | 97.3 |
| 5 groups of embodiment | 15.2 | 26.5 | 45.2 | 56.5 | 72.3 | 90.7 | 94.3 | 94.0 | 95.7 |
| 6 groups of embodiment | 17.7 | 29.4 | 44.7 | 59.4 | 74.0 | 92.2 | 92.3 | 92.8 | 94.7 |
| 7 groups of embodiment | 15.5 | 31.0 | 46.9 | 60.1 | 75.0 | 93.8 | 94.5 | 96.1 | 96.3 |
| 8 groups of embodiment | 17.2 | 24.5 | 40.2 | 56.5 | 71.3 | 89.7 | 92.3 | 94.8 | 96.2 |
| 9 groups of embodiment | 16.5 | 28.8 | 45.7 | 59.4 | 74.6 | 91.5 | 94.3 | 96.8 | 95.7 |
| 10 groups of embodiment | 15.6 | 30.8 | 45.9 | 61.2 | 76.3 | 92.3 | 94.5 | 95.2 | 97.3 |
| 11 groups of embodiment | 16.2 | 29.5 | 45.2 | 58.5 | 77.1 | 92.7 | 91.3 | 94.0 | 97.8 |
Can find out from table 1, the Cavia porcellus gingivitis that uses three groups of medicated toothpaste being added with Radix Notoginseng total arasaponins and Radix Notoginseng polysaccharide obviously than blank toothpaste group recover fast, recovery effects is obvious.
Embodiment 13:
Carry out thrombotest with Radix Notoginseng total arasaponins and Radix Notoginseng polysaccharide 1:1 mixture, YUNNAN BAIYAO (Yunnan Paiyao Group Corp., Ltd, lot number 20081120).
Get totally 36 of Kunming mouse 18 ~ 22g, male and female half and half are divided into 3 groups at random, and 12 every group, each group is used normal saline, Radix Notoginseng total arasaponins and Radix Notoginseng polysaccharide 8g/kg, YUNNAN BAIYAO 10g/kg, continuous irrigation stomach 5d, 1 time/d respectively.Get blood with capillary tube in mice left eye endosphere rear vein beard behind last administration 1 h, drip two and drop on the slide and timing simultaneously, chose the blood streak once with the cleaning syringe needle at slide in per 30 seconds, timing finishes when the blood streak occurs, and namely gets clotting time.Other gets mice and is divided into 3 groups at random, once irritates stomach respectively and gives normal saline, Radix Notoginseng total arasaponins and Radix Notoginseng polysaccharide 8g/kg, YUNNAN BAIYAO 10g/kg, measures clotting time according to above method behind 1 h.
Table 2: the disposable administration of mice to clotting time influence (
± s)
Compare YUNNAN BAIYAO group, Radix Notoginseng total arasaponins and Radix Notoginseng polysaccharide group P＜0.05 with the normal saline group.
As can be seen from Table 2, be administered once and give mice continuous gastric infusion 5d to mouse stomach, all observe Radix Notoginseng total arasaponins and Radix Notoginseng polysaccharide group and normal saline group comparison P＜0.05 with carrying a glass method, clotting time obviously shortens.
Embodiment 14:
Carry out bleeding time influence test with Radix Notoginseng total arasaponins and Radix Notoginseng polysaccharide 1:1 mixture, YUNNAN BAIYAO (Yunnan Paiyao Group Corp., Ltd, lot number 20081120).
Get totally 30 of Kunming mouse 18 ~ 22g, male and female half and half are divided into 3 groups at random, 10 every group.Disposable filling stomach gives Radix Notoginseng total arasaponins and Radix Notoginseng polysaccharide 1:1 mixture (8g/kg), YUNNAN BAIYAO (10 g/kg) and normal saline respectively, press 0.1 ml/10 g lumbar injection, 0.7 % penthiobarbital behind 1 h, after treating that mice enters narcotism fully, the mm place is horizontal cuts off apart from mouse tail point 3 with dissecting scissors, treat that blood overflows timing voluntarily, sucked blood 1 time with filter paper in per 30 seconds, and stopped the bleeding time that the required time is this Mus naturally until blood.Other gets mice and is divided into 3 groups at random, irritate stomach respectively and give Radix Notoginseng total arasaponins and Radix Notoginseng polysaccharide 1:1 mixture (8g/kg), YUNNAN BAIYAO (10 gkg-1) and normal saline, continuous irrigation stomach 5 d, 1 time/d, behind last administration 1 h, measure the bleeding time of mice as stated above.
Table 3: the mice administration to bleeding time influence (
± s)
As can be seen from Table 3, give mouse stomach 1 time, YUNNAN BAIYAO group, Radix Notoginseng total arasaponins and Radix Notoginseng polysaccharide group and normal saline group be P＜0.05 relatively, and the bleeding time obviously shortens.Give the continuous gastric infusion 5d of mice, relatively do not have significant difference with carrying glass method observation Radix Notoginseng total arasaponins and Radix Notoginseng polysaccharide group and normal saline group, but there is the trend of obvious shortening in the bleeding time.
Claims (5)
1. medicated toothpaste that contains the pseudo-ginseng activity composition, comprise pseudo-ginseng activity composition and abrasivus, wetting agent, surfactant and foaming agent, binding agent, stabilizing agent, deionized water, it is characterized in that described pseudo-ginseng activity composition be weight percentage 0.2% Radix Notoginseng total arasaponins and 0.2% Radix Notoginseng polysaccharide, described abrasivus is in 25 ~ 60% dicalcium phosphate dihydrate, hydration Silicon stone, calcium carbonate, the aluminium hydroxide one or more for accounting for the toothpaste percentage by weight; Wetting agent is in 10 ~ 55% glycerol, propylene glycol, the sorbitol one or more for accounting for the toothpaste percentage by weight; Surfactant and foaming agent be 1.5 ~ 2.5% sodium lauryl sulfate for accounting for the toothpaste percentage by weight, in the sodium N-lauroyl sarcosinate one or more; Binding agent is in 0.3 ~ 1.5% sodium carboxymethyl cellulose, carboxyethyl cellulose, xanthan gum, melon Lovell glue, the carrageenan one or more for accounting for the toothpaste percentage by weight; Stabilizing agent is 1.5 ~ 3.0% tetrasodium pyrophosphate for accounting for the toothpaste percentage by weight; Supply surplus with deionized water; This medicated toothpaste preparation method may further comprise the steps:
A, get the raw materials ready by component ratio, get Radix Notoginseng total arasaponins, Radix Notoginseng polysaccharide, tetrasodium pyrophosphate, deionized water in getting the raw materials ready, drop in the water device, fully stand-by behind the mixed dissolution;
B, get abrasivus, surfactant and foaming agent, binding agent, wetting agent in getting the raw materials ready, join respectively in the obtained mixture of A step, be stirred to abundant mixing in the time of adding, grind, the degassing makes mastic.
2. the medicated toothpaste that contains the pseudo-ginseng activity composition according to claim 1 is characterized in that abrasivus is to account for the dicalcium phosphate dihydrate of toothpaste percentage by weight 40%～45% or 25%～35% hydration Silicon stone; Wetting agent is to account for the sorbitol of toothpaste percentage by weight 15～20% and/or 10～15% glycerol; Surfactant and foaming agent are for accounting for the sodium lauryl sulfate of toothpaste percentage by weight 2.0 ~ 2.3%; Binding agent is to account for the sodium carboxymethyl cellulose of toothpaste percentage by weight 0.5～0.7% and/or 0.3～0.4% xanthan gum; Stabilizing agent is for accounting for the tetrasodium pyrophosphate of toothpaste percentage by weight 1.5 ~ 3.0%; Supply surplus with deionized water.
3. the medicated toothpaste that contains the pseudo-ginseng activity composition according to claim 1 is characterized in that also containing in the described toothpaste component percentage by weight and is 2.5～3.5% saccharin sodium, 0.01 ~ 0.02% CI42090 and 1～1.2% essence.
4. the medicated toothpaste that contains the pseudo-ginseng activity composition according to claim 1 is characterized in that also containing in the described toothpaste component percentage by weight and is 0.1～0.2% sodium benzoate.
5. the medicated toothpaste that contains the pseudo-ginseng activity composition according to claim 1 is characterized in that the described stirring employing of B step homogenizer, and speed of agitator is 1000r/min, continues to stir 25 ~ 40min.
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