CN105168793A - Externally-applied medicine for treating chilblain and preparing method and application thereof - Google Patents
Externally-applied medicine for treating chilblain and preparing method and application thereof Download PDFInfo
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- CN105168793A CN105168793A CN201510712214.6A CN201510712214A CN105168793A CN 105168793 A CN105168793 A CN 105168793A CN 201510712214 A CN201510712214 A CN 201510712214A CN 105168793 A CN105168793 A CN 105168793A
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- chilblain
- treatment
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- used medicine
- medicine
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- 208000010445 Chilblains Diseases 0.000 title claims abstract description 32
- 239000003814 drug Substances 0.000 title claims abstract description 32
- 238000000034 method Methods 0.000 title abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000002994 raw material Substances 0.000 claims abstract description 15
- 239000011812 mixed powder Substances 0.000 claims abstract description 12
- 238000005325 percolation Methods 0.000 claims abstract description 7
- 238000003756 stirring Methods 0.000 claims abstract description 4
- 238000002360 preparation method Methods 0.000 claims description 9
- 230000001476 alcoholic effect Effects 0.000 claims description 6
- 239000002245 particle Substances 0.000 claims description 6
- 230000000694 effects Effects 0.000 abstract description 3
- 231100000957 no side effect Toxicity 0.000 abstract description 3
- 208000003251 Pruritus Diseases 0.000 abstract description 2
- 235000019441 ethanol Nutrition 0.000 abstract 6
- 240000000233 Melia azedarach Species 0.000 abstract 2
- 241000245136 Scilla scilloides Species 0.000 abstract 2
- 235000013399 edible fruits Nutrition 0.000 abstract 2
- 208000001034 Frostbite Diseases 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 230000002500 effect on skin Effects 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 206010015150 Erythema Diseases 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 210000001367 artery Anatomy 0.000 description 2
- 210000000481 breast Anatomy 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
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- 208000014674 injury Diseases 0.000 description 2
- 230000003908 liver function Effects 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 206010003011 Appendicitis Diseases 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- 241000723346 Cinnamomum camphora Species 0.000 description 1
- 208000009084 Cold Injury Diseases 0.000 description 1
- 206010049077 Hernia pain Diseases 0.000 description 1
- 206010020565 Hyperaemia Diseases 0.000 description 1
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- 208000008930 Low Back Pain Diseases 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 240000000249 Morus alba Species 0.000 description 1
- 235000008708 Morus alba Nutrition 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 206010039710 Scleroderma Diseases 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 210000000467 autonomic pathway Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 229960000846 camphor Drugs 0.000 description 1
- 229930008380 camphor Natural products 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 230000002595 cold damage Effects 0.000 description 1
- 238000011443 conventional therapy Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
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- 230000006870 function Effects 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 208000006750 hematuria Diseases 0.000 description 1
- 230000036543 hypotension Effects 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 230000001861 immunosuppressant effect Effects 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000008338 local blood flow Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 206010025135 lupus erythematosus Diseases 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 235000008935 nutritious Nutrition 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 206010040882 skin lesion Diseases 0.000 description 1
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- 230000008736 traumatic injury Effects 0.000 description 1
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- 229940046009 vitamin E Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses externally-applied medicine for treating chilblain and the preparing method and application thereof. The externally-applied medicine is prepared from, by weight, 10-20 parts of scilla scilloides and 5-12 parts of szechwan Chinaberry fruits. Scilla scilloides and szechwan Chinaberry fruits are weighed, mixed and placed in an ultrafine grinder to be ground into mixed powder with grain diameter smaller than 0.1 micron, ethyl alcohol is added to the mixed powder to generate an ethanol solution through stirring and dissolution, the ethanol solution stands for 20 h at the temperature of 15 DEG C, percolation is conducted slowly at the speed of 3 ml/min, and then percolate is collected, concentrated, dried and placed in the ultrafine grinder to be ground for 30 min to generate the externally-applied medicine for treating chilblain, wherein the grain diameter of the medicine is smaller than 0.1 micron, the mass of the ethyl alcohol is eight times that of the mixed powder, and the ethanol concentration of the ethyl alcohol is 75%. The sources of raw materials are wide, raw materials are convenient to get, skin-irritating ingredients are not added, the effect on skin itch and fester after chilblain or frostbite appears is fast, treatment effect is remarkable, no side effect is caused, and recurrence rate is low.
Description
Technical field
The present invention relates to field of medicaments, specifically a kind of external used medicine for the treatment of chilblain and its production and use.
Background technology
Chilblain is common in winter, and due to local skin erythema, the tumidus infringement repeatedly that very cold causes, vesicle, ulcer can appear in severe patient, and the course of disease is slow, and weather turns warm rear spontaneous recovery, easily recurs.Cold is the main cause of chilblain morbidity.Its pathogenic factor be the skin of chilblain patient when running into cold (0 ~ 10 DEG C), the moist or changes in temperature sudden turn of events, local small artery shrinks, arteries paralysis of a specified duration and expanding, venous congestion, and local blood circulation is bad and fall ill.In addition, the factor such as humidity of skin, tip blood capillary deformity, autonomic nerve dysfunction, malnutrition, dyshormonia of patient self also may participate in morbidity.Lack the generation that the factors such as motion, acrohyperhidrosis humidity, footgear tension and long-term outdoor low operating temperatures all can cause chilblain.
Summary of the invention
The object of the present invention is to provide a kind of evident in efficacy, have no side effect, the external used medicine for the treatment of chilblain that relapse rate is low and its production and use, to solve the problem proposed in above-mentioned background technology.
For achieving the above object, the invention provides following technical scheme:
Treat an external used medicine for chilblain, be made up of the following raw material according to weight portion: Bulbus scillae scilloidis 10-20 part, Fructus Toosendan 5-12 part.
As the further scheme of the present invention: the external used medicine of described treatment chilblain, be made up of the following raw material according to weight portion: Bulbus scillae scilloidis 12-15 part, Fructus Toosendan 6-8 part.
As the further scheme of the present invention: the external used medicine of described treatment chilblain, be made up of the following raw material according to weight portion: Bulbus scillae scilloidis 13 parts, Fructus Toosendan 7 parts.
The preparation method of the external used medicine of described treatment chilblain, takes Bulbus scillae scilloidis, Fructus Toosendan by weight, mixes, and puts into super micron mill and is ground into the mixed powder that particle diameter is less than 0.1 μm; Adding relative to the determining alcohol of the quality 8 times of mixed powder in mixed powder is the ethanol of 75%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 20 hours under the condition of 15 DEG C, adopt percolation with the speed of 3ml per minute slowly percolation, collect percolate, concentrated and dry, and again put into super micron mill and pulverize 30 minutes, acquisition particle diameter is less than the external used medicine of the treatment chilblain of 0.1 μm.
Described external used medicine is for the preparation of the purposes in the medicine for the treatment of chilblain.
Bulbus scillae scilloidis promoting blood circulation and detoxication in the present invention, reducing swelling and alleviating pain.Control breast to gather around, acute appendicitis, traumatic injury, lumbago and skelalgia.
Fructus Toosendan is soothing the liver to expel the heat-evil, promoting the circulation of QI to relieve pain, parasite killing.For pathogenic fire derived from stagnation of liver-QI, the breast side of body, abdominal distention, hernia pain, abdominal pain due to worm stagnation.
Compared with prior art, the invention has the beneficial effects as follows:
Raw material of the present invention is wide, and draw materials conveniently, do not add the irritant composition of skin, fester rapid-action for skin pruritus after chilblain, cold injury, evident in efficacy, have no side effect, relapse rate is low.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment 1
In the embodiment of the present invention, a kind of external used medicine for the treatment of chilblain, is made up of the following raw material according to weight portion: Bulbus scillae scilloidis 10 parts, Fructus Toosendan 5 parts.Bulbus scillae scilloidis, Fructus Toosendan are taken by weight, mix, puts into super micron mill and be ground into the mixed powder that particle diameter is less than 0.1 μm; Adding relative to the determining alcohol of the quality 8 times of mixed powder in mixed powder is the ethanol of 75%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 20 hours under the condition of 15 DEG C, adopt percolation with the speed of 3ml per minute slowly percolation, collect percolate, concentrated and dry, and again put into super micron mill and pulverize 30 minutes, acquisition particle diameter is less than the external used medicine of the treatment chilblain of 0.1 μm.
Embodiment 2
In the embodiment of the present invention, a kind of external used medicine for the treatment of chilblain, is made up of the following raw material according to weight portion: Bulbus scillae scilloidis 20 parts, Fructus Toosendan 12 parts.Preparation method is identical with embodiment 1.
Embodiment 3
In the embodiment of the present invention, a kind of external used medicine for the treatment of chilblain, is made up of the following raw material according to weight portion: Bulbus scillae scilloidis 12 parts, Fructus Toosendan 6 parts.Preparation method is identical with embodiment 1.
Embodiment 4
In the embodiment of the present invention, a kind of external used medicine for the treatment of chilblain, is made up of the following raw material according to weight portion: Bulbus scillae scilloidis 15 parts, Fructus Toosendan 8 parts.Preparation method is identical with embodiment 1.
Embodiment 5
In the embodiment of the present invention, a kind of external used medicine for the treatment of chilblain, is made up of the following raw material according to weight portion: Bulbus scillae scilloidis 13 parts, Fructus Toosendan 7 parts.Preparation method is identical with embodiment 1.
In order to show the clinical therapeutic efficacy of Chinese medicine composition of the present invention to chilblain, the present invention designs following research approach and carries out efficacy experiment.
1, case inclusion criteria:
It is buccal, auricle, ear-lobe, nose, finger, instep, heel that chilblain damages typical predilection site.Skin lesion feature: the edematous erythema of the congestive mulberry of limitation or red protuberance, forms rotten to the corn or ulcer after serious generation vesicle is broken.Fall ill when at the beginning of annual winter autumn Mo, spring, temperature is low.Eliminating cardiorenal function is complete, liver function injury is heavier, lupus erythematosus, scleroderma etc., severe hypotension, anemia of pregnant woman, life-time service immunosuppressant and corticosteroid patient.
2, case is selected in
According to above case inclusion criteria, select the routine random packet treatment of case 400.Totally 8 groups, often organize 50 examples, treatment group has 5 groups; Age in 13-70 year, average 35 years old.Matched group totally 3 groups, the age in 14-75 year, average 36 years old.Each group difference, without significance (p>0.05), has comparability.
3, Therapeutic Method
Treatment group has 5 groups, adopts the medicine of embodiment 1-5 respectively, smears affected part.
Contrast 1 group of external application 10% camphor ointment, contrast 2 groups only containing Bulbus scillae scilloidis, contrast 3 groups only containing Fructus Toosendan, all the other preparation processes are consistent with embodiment 5.
Each group of equal every day twice, whole body is cold-proof, warming, balanced nutritious simultaneously for each group, simultaneously the conventional therapy such as oral nicotinic acid tablet, vitamin E ball.
4, observational technique
Observe the curative effect after two weeks, redness is eliminated as curing completely; Red and swollen scope is reduced to effectively.With the case of curing for radix, Second Year adds up relapse rate winter.
5, therapeutic effect is as shown in table 1.
Table 1
Comparitive study: the present invention is better than matched group, has significant difference (p<0.05).And the present invention concurs under the mutual compatibility effect of each raw material.
In above-mentioned clinical experiment, inspection is done and record to hematuria routine, hepatic and renal function, electrocardiogram etc. before and after patient medication, has contrasted no abnormal.
To those skilled in the art, obviously the invention is not restricted to the details of above-mentioned one exemplary embodiment, and when not deviating from spirit of the present invention or basic feature, the present invention can be realized in other specific forms.Therefore, no matter from which point, all should embodiment be regarded as exemplary, and be nonrestrictive, scope of the present invention is limited by claims instead of above-mentioned explanation, and all changes be therefore intended in the implication of the equivalency by dropping on claim and scope are included in the present invention.
In addition, be to be understood that, although this description is described according to embodiment, but not each embodiment only comprises an independently technical scheme, this narrating mode of description is only for clarity sake, those skilled in the art should by description integrally, and the technical scheme in each embodiment also through appropriately combined, can form other embodiments that it will be appreciated by those skilled in the art that.
Claims (5)
1. treat an external used medicine for chilblain, it is characterized in that, be made up of the following raw material according to weight portion: Bulbus scillae scilloidis 10-20 part, Fructus Toosendan 5-12 part.
2. the external used medicine for the treatment of chilblain according to claim 1, is characterized in that, is made up of the following raw material according to weight portion: Bulbus scillae scilloidis 12-15 part, Fructus Toosendan 6-8 part.
3. the external used medicine for the treatment of chilblain according to claim 2, is characterized in that, is made up of the following raw material according to weight portion: Bulbus scillae scilloidis 13 parts, Fructus Toosendan 7 parts.
4. the preparation method of the external used medicine of the treatment chilblain as described in as arbitrary in claim 1-3, is characterized in that, Bulbus scillae scilloidis, Fructus Toosendan are taken by weight, mixed, and puts into super micron mill and is ground into the mixed powder that particle diameter is less than 0.1 μm; Adding relative to the determining alcohol of the quality 8 times of mixed powder in mixed powder is the ethanol of 75%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 20 hours under the condition of 15 DEG C, adopt percolation with the speed of 3ml per minute slowly percolation, collect percolate, concentrated and dry, and again put into super micron mill and pulverize 30 minutes, acquisition particle diameter is less than the external used medicine of the treatment chilblain of 0.1 μm.
5. the external used medicine as described in as arbitrary in claim 1-3 is for the preparation of the purposes in the medicine for the treatment of chilblain.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510712214.6A CN105168793A (en) | 2015-10-28 | 2015-10-28 | Externally-applied medicine for treating chilblain and preparing method and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510712214.6A CN105168793A (en) | 2015-10-28 | 2015-10-28 | Externally-applied medicine for treating chilblain and preparing method and application thereof |
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| Publication Number | Publication Date |
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| CN105168793A true CN105168793A (en) | 2015-12-23 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201510712214.6A Pending CN105168793A (en) | 2015-10-28 | 2015-10-28 | Externally-applied medicine for treating chilblain and preparing method and application thereof |
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| Country | Link |
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| CN (1) | CN105168793A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105560797A (en) * | 2016-02-25 | 2016-05-11 | 王景明 | External-application medicine composition for treating chilblain |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1857517A (en) * | 2006-03-18 | 2006-11-08 | 叶志军 | Frostbite treating soak and its preparing method |
-
2015
- 2015-10-28 CN CN201510712214.6A patent/CN105168793A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1857517A (en) * | 2006-03-18 | 2006-11-08 | 叶志军 | Frostbite treating soak and its preparing method |
Non-Patent Citations (2)
| Title |
|---|
| 敏涛等: "《精选妙用中草药治疗常见皮肤科疾病》", 30 June 2006 * |
| 祁公任等: "《现代实用临床中药学》", 31 May 2010 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105560797A (en) * | 2016-02-25 | 2016-05-11 | 王景明 | External-application medicine composition for treating chilblain |
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Application publication date: 20151223 |