CN103007112A - Traditional medicinal composition for preventing and treating infantile eczema and preparation method thereof - Google Patents
Traditional medicinal composition for preventing and treating infantile eczema and preparation method thereof Download PDFInfo
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- CN103007112A CN103007112A CN2012105835107A CN201210583510A CN103007112A CN 103007112 A CN103007112 A CN 103007112A CN 2012105835107 A CN2012105835107 A CN 2012105835107A CN 201210583510 A CN201210583510 A CN 201210583510A CN 103007112 A CN103007112 A CN 103007112A
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- 239000000203 mixture Substances 0.000 title claims abstract description 41
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 206010014198 Eczema infantile Diseases 0.000 title abstract 3
- 201000008937 atopic dermatitis Diseases 0.000 title abstract 3
- 239000003814 drug Substances 0.000 claims abstract description 55
- 239000000843 powder Substances 0.000 claims abstract description 24
- 239000002994 raw material Substances 0.000 claims abstract description 19
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 32
- 201000004624 Dermatitis Diseases 0.000 claims description 18
- QQILFGKZUJYXGS-UHFFFAOYSA-N Indigo dye Chemical compound C1=CC=C2C(=O)C(C3=C(C4=CC=CC=C4N3)O)=NC2=C1 QQILFGKZUJYXGS-UHFFFAOYSA-N 0.000 claims description 18
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Abstract
本发明涉及一种预防和治疗婴幼儿湿疹的中药组合物及其制备方法，属于中药领域。它的原料以重量份计包含：马齿苋5～8份、败酱草3～7份、地肤子1～5份、黄柏1～5份、土茯苓1～5份、蛇床子1～5份、苍术1～5份、玄明粉0.2～1.8份、青黛0.2～1.8份。本发明的有益效果是：能很好地预防和治疗婴幼儿湿疹，安全可靠。The invention relates to a traditional Chinese medicine composition for preventing and treating infantile eczema and a preparation method thereof, belonging to the field of traditional Chinese medicines. Its raw materials include in parts by weight: 5-8 parts of purslane, 3-7 parts of Patrinia, 1-5 parts of Kochia scoparia, 1-5 parts of Cortex Phellodendri, 1-5 parts of Smilax cocos, 1-5 parts of Cnidium 5 parts, 1-5 parts of Cangzhu, 0.2-1.8 parts of Xuanming powder, 0.2-1.8 parts of Qingdai. The beneficial effect of the invention is that it can well prevent and treat infantile eczema, and is safe and reliable.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to Chinese medicine composition of a kind of prevention and treatment infant eczema and preparation method thereof.
Background technology
Infant eczema is one of common dermatosis in infant period, usually betides Head And Face.Disease is main mainly with very itching, so infant repeatedly scratches under uncontrollable situation and rub when antipruritic, can make tender and lovely skin diabrosis, forms the erosion of large stretch of flushing, thereby has had a strong impact on the healthy of infant.
At present, doctor trained in Western medicine there is no specific short to eczema, adopts symptomatic treatment more.Take antihistamine drug (17-hydroxy-11-dehydrocorticosterone) treatment for oral administration as many, external-use drug form is decided according to clinical skin lesion performance, mostly is ointment.And long-time or the heavy dose of external hormone preparation of short-term, also can addiction cause the series of side effects such as steroid-dependent dermatitis, such as thinning of skin, fragility, atrophy, telangiectasis, purpura, fungal infection, acne sample dermatitis, hirsutism, hyperhidrosis, subcutaneous hemorrhage and wound healing difficulty etc.And Chinese medicine and preparation thereof can reduce or stop side effect when treatment eczema, can be used for for a long time prevention and the obstinate eczema for the treatment of, greatly demonstrate its superiority.Its usage mostly is for oral administration and external.But for the infant patient, decoction difficulty for oral administration, in addition relatively more dangerous, external drug application meeting brings inconvenience to life, adopt in addition the method that Chinese medicine is decocted, its process is very loaded down with trivial details, thereby and can't grasp best decocting time and affect therapeutic effect.
Summary of the invention
Main purpose of the present invention provides the Chinese medicine composition of a kind of safe and effective prevention and treatment infant eczema.
Another object of the present invention provides the preparation method of this prevention and treatment infant eczema Chinese medicine composition.
The technical solution used in the present invention is the Chinese medicine composition of a kind of prevention and treatment infant eczema, and its raw material comprises in weight portion: 5～8 parts of Herba Portulacaes, 3～7 parts of Herba Patriniae, 1～5 part of the Fructus Kochiae, 1～5 part of Cortex Phellodendri, 1～5 part of Rhizoma Smilacis Glabrae, 1～5 part of Fructus Cnidii, 1～5 part of Rhizoma Atractylodis, 0.2～1.8 part of Matrii Sulfas Exsiccatus, 0.2～1.8 part of Indigo Naturalis.
As preferably, its raw material comprises in weight portion: 6～7 parts of Herba Portulacaes, 4～6 parts of Herba Patriniae, 2～4 parts of the Fructus Kochiae, 2～4 parts of Cortex Phellodendris, 2～4 parts of Rhizoma Smilacis Glabraes, 2～4 parts of Fructus Cnidiis, 2～4 parts of Rhizoma Atractylodis, 0.5～1.5 part of Matrii Sulfas Exsiccatus, 0.5～1.5 part of Indigo Naturalis.
As preferably, its raw material comprises in weight portion: 6 parts of Herba Portulacaes, 5 parts of Herba Patriniae, 3 parts of the Fructus Kochiae, 3 parts of Cortex Phellodendris, 3 parts of Rhizoma Smilacis Glabraes, 3 parts of Fructus Cnidiis, 3 parts of Rhizoma Atractylodis, 1 part of Matrii Sulfas Exsiccatus, 1 part of Indigo Naturalis.
As preferably, the dosage form that Chinese medicine composition of the present invention and pharmaceutically acceptable excipient can be made comprises lotion, unguentum, liniment or liniment.
As preferably, Chinese medicine composition of the present invention can be made the external-use lotion of medicine bag.
Chinese medicine composition of the present invention can adopt the conventional preparation method of Chinese medicine to prepare.And above-mentioned each raw material of Chinese medicine is made the preferred preparation method of Chinese medicine composition of the present invention, may further comprise the steps:
A, get Rhizoma Atractylodis and pulverize, get the Rhizoma Atractylodis powder for subsequent use;
B, with Herba Portulacae, Herba Patriniae, the Fructus Kochiae, Cortex Phellodendri, Rhizoma Smilacis Glabrae and Fructus Cnidii extracting in water, extracting solution filters, and gets filtrate simmer down to extractum;
C, with described extractum in stirring the lower ethanol that adds, leave standstill, get the supernatant Recycled ethanol, be evaporated to thick paste;
D, will described Matrii Sulfas Exsiccatus, Indigo Naturalis and Rhizoma Atractylodis powder add mix homogeneously in the described thick paste after mixing, drying, for subsequent use after pulverizing.
As preferably, the granularity of the Rhizoma Atractylodis powder among the described step a is 10～40 orders.
As preferably, described step b is specially and gets the water extraction 3 times that Herba Portulacae, Herba Patriniae, the Fructus Kochiae, Cortex Phellodendri, Rhizoma Smilacis Glabrae and Fructus Cnidii add 10～12 times of amounts, each 1 hour, extracting solution merged filtration, and being evaporated to the raw material weight that extracts under 50～60 ℃ condition is the extractum of 1 times of amount.
As preferably, described step c is specially and adds 1 times of 95% ethanol that amount is heavy in described extractum under stirring, and standing over night is got the supernatant Recycled ethanol, is evaporated to proportion and is 1.20～1.30 thick paste under 50～60 ℃ condition.
As preferably, described thick paste is that to measure proportion under 50～60 ℃ of conditions be 1.25 thick paste.
As preferably, described steps d is specially described Matrii Sulfas Exsiccatus, Indigo Naturalis and the mixing of Rhizoma Atractylodis powder after 10 minutes, join again and mixed in the described thick paste 10～20 minutes, make its mix homogeneously, under 50～60 ℃ condition, be dried to moisture≤10%, after pulverizing was 10～40 purpose powder, sealing is preserved, and was for subsequent use.
Chinese medicine composition of the present invention is take Herba Portulacae as monarch drug, and Herba Patriniae is ministerial drug, and the Fructus Kochiae, Cortex Phellodendri, Rhizoma Smilacis Glabrae, Fructus Cnidii and Rhizoma Atractylodis are adjuvant drug, and Matrii Sulfas Exsiccatus and Indigo Naturalis are for making medicine.The collaborative compatibility in full side gathers heat clearing and damp drying, eliminating carbuncle eliminating stagnation, antipruritic effect altogether, is used for prevention and treats various eczema, particularly infant eczema.
Preparation method of the present invention, technical maturity is reasonable, has fully taken into account the abundant extraction of various ingredients in the compositions, can make crude drug give full play to the effect of prevention and treatment disease.Wherein, adopt concentrating under reduced pressure under 50～60 ℃ condition, be in order to guarantee better in the Chinese medicine that effective ingredient can be because of long-time concentrated decomposition under hot conditions, thereby improve the therapeutic effect of medicine.
Chinese medicine composition result in clinical application of the present invention shows that following advantage is arranged:
(1) to select Chinese medicine be raw material in the present invention, is natural drug, do not contain hormone, and safety non-toxic does not produce dependency.
(2) Chinese medicine composition of the present invention is made the external-use lotion of medicine bag, can avoid Chinese medicine extract and Chinese medicine powder to float on the water surface, and more Effective Component of Chinese Medicine is dissolved in the water, and therapeutic effect is good, also makes things convenient for the infant bathing.
(3) Chinese medicine composition of the present invention is made the external-use lotion of medicine bag, is easy to industrialization, and is easy to use, and can adjust consumption according to symptom.
(4) for proving that the present composition has the effect of good prevention and treatment infant eczema, the present invention is through the clinical observation of 100 routine systems, and to select medical history, the state of an illness, age, sex and the suitable infant eczema patient of former Therapeutic Method be the object of observation, male 42 examples wherein, women 58 examples.Observing time: 7 days.Using method and consumption: get the medicine bag of embodiment one, clean once a day the affected part, each 2 bags.The specification of this medicine bag is: 20 g/bags.
Efficacy determination: cure: skin lesion all disappears, and no conscious sympton occurs without new skin lesion; Produce effects: skin lesion disappears more than 70%, the dry incrustation of part, idol feel skin pruritus; Effectively: skin lesion disappears more than 50%, often feels skin pruritus; Invalid: the skin lesion less than 50% that disappears, skin pruritus still has the vesicle sepage without obvious improvement, even worsens.
Observed result: cure 40 examples, cure rate is 40%.Produce effects 32 examples, obvious effective rate are 32%.Effective 18 examples, effective percentage are 18%.Invalid 10 examples, inefficiency are 10%.
Chinese medicine composition of the present invention is got the medicine bag of embodiment one when the prevention infant eczema, clean once a day the affected part, each 1 bag.The specification of this medicine bag is: 20 g/bags.Using after 3 days continuously namely has preferably preventive effect, and the phenomenon of eczema can not occur substantially.
The specific embodiment
For making those skilled in the art understand in detail production technology of the present invention and technique effect, the below further introduces application of the present invention and technique effect with concrete production instance.
Embodiment one: prepare Chinese medicine composition of the present invention
Raw material is counted with weight portion:
6 parts of Herba Portulacaes, 5 parts of Herba Patriniae, 3 parts of the Fructus Kochiae, 3 parts of Cortex Phellodendris, 3 parts of Rhizoma Smilacis Glabraes, 3 parts of Fructus Cnidiis, 3 parts of Rhizoma Atractylodis, 1 part of Matrii Sulfas Exsiccatus, 1 part of Indigo Naturalis.
Get Rhizoma Atractylodis and pulverize, get granularity and be 10 purpose Rhizoma Atractylodis powder, for subsequent use; Get the water extraction 3 times that Herba Portulacae, Herba Patriniae, the Fructus Kochiae, Cortex Phellodendri, Rhizoma Smilacis Glabrae and Fructus Cnidii add 11 times of amounts, each 1 hour, extracting solution merged and filters, and being evaporated to the raw material weight that extracts under 50 ℃ condition is the extractum of 1 times of amount; Add 1 times of 95% ethanol that amount is heavy in extractum under stirring, standing over night is got the supernatant Recycled ethanol, to be evaporated to proportion under 50 ℃ the condition be to measure under the 1.25(60 ℃ of condition) thick paste; Get Matrii Sulfas Exsiccatus, Indigo Naturalis and Rhizoma Atractylodis powder and mix after 10 minutes, join in the thick paste again and mixed 15 minutes, make its mix homogeneously, being dried to moisture under 50 ℃ condition is 8%, and after pulverizing was 10 purpose powder, sealing is preserved, and was for subsequent use; Then pack with heat-sealing type tea filter paper, and get final product.
Embodiment two: prepare Chinese medicine composition of the present invention
Raw material is counted with weight portion:
5 parts of Herba Portulacaes, 4 parts of Herba Patriniae, 2 parts of the Fructus Kochiae, 2 parts of Cortex Phellodendris, 2 parts of Rhizoma Smilacis Glabraes, 2 parts of Fructus Cnidiis, 2 parts of Rhizoma Atractylodis, 0.5 part of Matrii Sulfas Exsiccatus, 0.5 part of Indigo Naturalis.
Get Rhizoma Atractylodis and pulverize, get granularity and be 40 purpose Rhizoma Atractylodis powder, for subsequent use; Get the water extraction 3 times that Herba Portulacae, Herba Patriniae, the Fructus Kochiae, Cortex Phellodendri, Rhizoma Smilacis Glabrae and Fructus Cnidii add 10 times of amounts, each 1 hour, extracting solution merged and filters, and being evaporated to the raw material weight that extracts under 60 ℃ condition is the extractum of 1 times of amount; Add 1 times of 95% ethanol that amount is heavy in extractum under stirring, standing over night is got the supernatant Recycled ethanol, to be evaporated to proportion under 50 ℃ the condition be to measure under the 1.30(50 ℃ of condition) thick paste; Matrii Sulfas Exsiccatus, Indigo Naturalis and the mixing of Rhizoma Atractylodis powder after 10 minutes, are joined in the thick paste again and mixed 10 minutes, make its mix homogeneously, being dried to moisture under 50 ℃ condition is 7%, and after pulverizing was 20 purpose powder, sealing is preserved, and was for subsequent use; Then pack with heat-sealing type tea filter paper, and get final product.
Embodiment three: prepare Chinese medicine composition of the present invention
Raw material is counted with weight portion:
7 parts of Herba Portulacaes, 6 parts of Herba Patriniae, 4 parts of the Fructus Kochiae, 4 parts of Cortex Phellodendris, 4 parts of Rhizoma Smilacis Glabraes, 4 parts of Fructus Cnidiis, 4 parts of Rhizoma Atractylodis, 1.5 parts of Matrii Sulfas Exsiccatus, 1.5 parts of Indigo Naturaliss.
Get Rhizoma Atractylodis and pulverize, get granularity and be 20 purpose Rhizoma Atractylodis powder, for subsequent use; Get the water extraction 3 times that Herba Portulacae, Herba Patriniae, the Fructus Kochiae, Cortex Phellodendri, Rhizoma Smilacis Glabrae and Fructus Cnidii add 12 times of amounts, each 1 hour, extracting solution merged and filters, and being evaporated to the raw material weight that extracts under 60 ℃ condition is the extractum of 1 times of amount; Add 1 times of 95% ethanol that amount is heavy in extractum under stirring, standing over night is got the supernatant Recycled ethanol, to be evaporated to proportion under 50 ℃ the condition be to measure under the 1.30(50 ℃ of condition) thick paste; Matrii Sulfas Exsiccatus, Indigo Naturalis and the mixing of Rhizoma Atractylodis powder after 10 minutes, are joined in the thick paste again and mixed 20 minutes, make its mix homogeneously, being dried to moisture under 50 ℃ condition is 10%, and after pulverizing was 40 purpose powder, sealing is preserved, and was for subsequent use; Then pack with heat-sealing type tea filter paper, and get final product.
Embodiment four: prepare Chinese medicine composition of the present invention
Raw material is counted with weight portion:
8 parts of Herba Portulacaes, 3 parts of Herba Patriniae, 1 part of the Fructus Kochiae, 1 part of Cortex Phellodendri, 1 part of Rhizoma Smilacis Glabrae, 1 part of Fructus Cnidii, 2 parts of Rhizoma Atractylodis, 0.2 part of Matrii Sulfas Exsiccatus, 0.2 part of Indigo Naturalis.
Get Rhizoma Atractylodis and pulverize, get granularity and be 10 purpose Rhizoma Atractylodis powder, for subsequent use; Get the water extraction 3 times that Herba Portulacae, Herba Patriniae, the Fructus Kochiae, Cortex Phellodendri, Rhizoma Smilacis Glabrae and Fructus Cnidii add 10 times of amounts, each 1 hour, extracting solution merged and filters, and being evaporated to the raw material weight that extracts under 55 ℃ condition is the extractum of 1 times of amount; Add 1 times of 95% ethanol that amount is heavy in extractum under stirring, standing over night is got the supernatant Recycled ethanol, to be evaporated to proportion under 55 ℃ the condition be to measure under the 1.25(60 ℃ of condition) thick paste; Matrii Sulfas Exsiccatus, Indigo Naturalis and the mixing of Rhizoma Atractylodis powder after 10 minutes, are joined in the thick paste again and mixed 15 minutes, make its mix homogeneously, being dried to moisture under 55 ℃ condition is 6%, and after pulverizing was 20 purpose powder, sealing is preserved, and was for subsequent use; Then pack with heat-sealing type tea filter paper, and get final product.
Claims (10)
- One kind the prevention and the treatment infant eczema Chinese medicine composition, its raw material comprises in weight portion: 5～8 parts of Herba Portulacaes, 3～7 parts of Herba Patriniae, 1～5 part of the Fructus Kochiae, 1～5 part of Cortex Phellodendri, 1～5 part of Rhizoma Smilacis Glabrae, 1～5 part of Fructus Cnidii, 1～5 part of Rhizoma Atractylodis, 0.2～1.8 part of Matrii Sulfas Exsiccatus, 0.2～1.8 part of Indigo Naturalis.
- 2. Chinese medicine composition according to claim 1, it is characterized in that: its raw material comprises in weight portion: 6～7 parts of Herba Portulacaes, 4～6 parts of Herba Patriniae, 2～4 parts of the Fructus Kochiae, 2～4 parts of Cortex Phellodendris, 2～4 parts of Rhizoma Smilacis Glabraes, 2～4 parts of Fructus Cnidiis, 2～4 parts of Rhizoma Atractylodis, 0.5～1.5 part of Matrii Sulfas Exsiccatus, 0.5～1.5 part of Indigo Naturalis.
- 3. Chinese medicine composition according to claim 1, it is characterized in that: its raw material comprises in weight portion: 6 parts of Herba Portulacaes, 5 parts of Herba Patriniae, 3 parts of the Fructus Kochiae, 3 parts of Cortex Phellodendris, 3 parts of Rhizoma Smilacis Glabraes, 3 parts of Fructus Cnidiis, 3 parts of Rhizoma Atractylodis, 1 part of Matrii Sulfas Exsiccatus, 1 part of Indigo Naturalis.
- 4. comprise the dosage form that the described Chinese medicine composition of claim 1 and pharmaceutically acceptable excipient are made.
- 5. the preparation method of described Chinese medicine composition according to claim 1 comprises following steps:A, get Rhizoma Atractylodis and pulverize, get the Rhizoma Atractylodis powder for subsequent use;B, with Herba Portulacae, Herba Patriniae, the Fructus Kochiae, Cortex Phellodendri, Rhizoma Smilacis Glabrae and Fructus Cnidii extracting in water, extracting solution filters, and gets filtrate simmer down to extractum;C, with described extractum in stirring the lower ethanol that adds, leave standstill, get the supernatant Recycled ethanol, be evaporated to thick paste;D, will described Matrii Sulfas Exsiccatus, Indigo Naturalis and Rhizoma Atractylodis powder add mix homogeneously in the described thick paste after mixing, drying, for subsequent use after pulverizing.
- 6. the preparation method of described Chinese medicine composition according to claim 5, it is characterized in that: the granularity of Rhizoma Atractylodis powder is 10～40 orders among the described step a.
- 7. the preparation method of described Chinese medicine composition according to claim 5, it is characterized in that: described step b is specially and gets the water extraction 3 times that Herba Portulacae, Herba Patriniae, the Fructus Kochiae, Cortex Phellodendri, Rhizoma Smilacis Glabrae and Fructus Cnidii add 10～12 times of amounts, each 1 hour, extracting solution merges filtration, and being evaporated to the raw material weight that extracts under 50～60 ℃ condition is the extractum of 1 times of amount.
- 8. the preparation method of described Chinese medicine composition according to claim 5, it is characterized in that: described step c is specially and adds 1 times of 95% ethanol that amount is heavy in described extractum under stirring, standing over night, get the supernatant Recycled ethanol, under 50～60 ℃ condition, be evaporated to proportion and be 1.20～1.30 thick paste.
- 9. the preparation method of described Chinese medicine composition according to claim 8 is characterized in that: described thick paste is that to measure proportion under 50～60 ℃ of conditions be 1.25 thick paste.
- 10. the preparation method of described Chinese medicine composition according to claim 5, it is characterized in that: described steps d is specially described Matrii Sulfas Exsiccatus, Indigo Naturalis and the mixing of Rhizoma Atractylodis powder after 10 minutes, join again and mixed in the described thick paste 10～20 minutes, make its mix homogeneously, under 50～60 ℃ condition, be dried to moisture≤10%, after pulverizing was 10～40 purpose powder, sealing is preserved, and was for subsequent use.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105343662A (en) * | 2015-11-10 | 2016-02-24 | 张霞 | Externally-applied traditional Chinese medicine for treating skin eczema and preparation method of externally-applied traditional Chinese medicine |
| CN117159631A (en) * | 2023-04-07 | 2023-12-05 | 上海中医药大学附属曙光医院 | A kind of traditional Chinese medicine composition for treating psoriasis and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106309599A (en) * | 2016-11-16 | 2017-01-11 | 宋波 | Traditional Chinese medicine ointment for treating infantile eczema and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101804166A (en) * | 2010-05-05 | 2010-08-18 | 余静 | Traditional Chinese medicine composition for treating dermatitis and eczema of infants |
| CN102178877B (en) * | 2011-04-28 | 2012-09-05 | 尚德信 | External preparation for treating eczema of scrotum and preparation method thereof |
| CN102784340A (en) * | 2012-08-09 | 2012-11-21 | 陈俊梅 | Traditional Chinese medicine composition for treating children eczema |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101804166A (en) * | 2010-05-05 | 2010-08-18 | 余静 | Traditional Chinese medicine composition for treating dermatitis and eczema of infants |
| CN102178877B (en) * | 2011-04-28 | 2012-09-05 | 尚德信 | External preparation for treating eczema of scrotum and preparation method thereof |
| CN102784340A (en) * | 2012-08-09 | 2012-11-21 | 陈俊梅 | Traditional Chinese medicine composition for treating children eczema |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105343662A (en) * | 2015-11-10 | 2016-02-24 | 张霞 | Externally-applied traditional Chinese medicine for treating skin eczema and preparation method of externally-applied traditional Chinese medicine |
| CN117159631A (en) * | 2023-04-07 | 2023-12-05 | 上海中医药大学附属曙光医院 | A kind of traditional Chinese medicine composition for treating psoriasis and preparation method thereof |
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