CN107029114A - A kind of Chinese medicine compound prescription ointment of effective treatment chapped skin and preparation method thereof - Google Patents
A kind of Chinese medicine compound prescription ointment of effective treatment chapped skin and preparation method thereof Download PDFInfo
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Abstract
Description
技术领域technical field
本发明属于医药领域,具体涉及一种有效治疗皮肤皲裂的中药复方软膏及其制备方法。The invention belongs to the field of medicine, and in particular relates to a traditional Chinese medicine compound ointment for effectively treating chapped skin and a preparation method thereof.
背景技术Background technique
皮肤皲裂是一种常见的皮肤病变,多见于成人和老人。患处皮肤干燥、粗糙、增厚、变硬,变脆,弹性降低,局部活动或牵拉力较大时,即可将其拉破而产生皲裂,皲裂多沿皮纹方向走行,严重者裂口可深达皮下,有出血和自觉疼痛,活动更甚,细菌、病毒容易侵入,而发生外源性感染。皮损好发于手指、手掌、手缘、足跟及足跖、足缘等皮肤角质层较厚并经常摩擦部位。多发生于秋冬干燥季节,天暖渐愈,过程冗长徐缓,严重影响手足的功能。皲裂原因一是皮肤表面角化代谢异常,皮肤表面皮脂减少或皮脂分泌减少,致使皮肤保护性增厚和角质化,既有外部物理化学因素也有内部代谢因素;二是病理性,如某些皮肤病如鱼鳞病、手足癣、冻疮等。Cracked skin is a common skin lesion, more common in adults and the elderly. The skin of the affected area is dry, rough, thickened, hardened, brittle, and its elasticity is reduced. When the local movement or pulling force is large, it can be pulled apart and chapped. Deep into the subcutaneous area, there is bleeding and pain, and the activity is even worse. Bacteria and viruses are easy to invade, and exogenous infection occurs. Skin lesions are prone to occur in the thicker and often rubbing parts of the skin such as fingers, palms, hand margins, heels, soles of the feet, and margins of the feet. It mostly occurs in the dry season of autumn and winter, and the weather gradually warms up. The process is long and slow, which seriously affects the functions of the hands and feet. The first reason for chapped skin is abnormal keratinization metabolism on the skin surface, the reduction of sebum or sebum secretion on the skin surface, resulting in thickening and keratinization of the skin protection, both external physical and chemical factors and internal metabolic factors; the second is pathological, such as some skin Diseases such as ichthyosis, tinea pedis, frostbite, etc.
中医称手足皲裂为“破裂疮”,认为与阴血亏虚,气血失调,外感风邪,经络不畅,湿热内蕴入血,血热风燥,肌肤失养有关,以养血滋阴,活血通络,熄风润燥为治疗原则。一般轻症不需内服药,外用中药复方制剂可以直接作用病灶,达到内外兼治,可以获得良好效果。Traditional Chinese medicine calls chapped hands and feet "cracked sores". It is believed to be related to deficiency of yin and blood, imbalance of qi and blood, exogenous pathogenic factors, poor meridians, damp heat accumulated in the blood, blood heat and wind dryness, and skin loss of nourishment. Dredging the collaterals, expelling wind and moistening dryness are the principles of treatment. Generally, there is no need for internal medicine for mild cases, and compound preparations of traditional Chinese medicine for external use can directly act on the lesion, achieving both internal and external treatment, and good results can be obtained.
发明内容Contents of the invention
本发明的目的在于针对现有技术不足,提供一种有效治疗皮肤皲裂的中药复方软膏及其制备方法。本发明制得的中药复方软膏是一种能够根治皮肤皲裂且不易复发的纯中药制剂。The object of the present invention is to provide a traditional Chinese medicine compound ointment for effectively treating chapped skin and a preparation method thereof. The traditional Chinese medicine compound ointment prepared by the invention is a pure traditional Chinese medicinal preparation that can radically cure chapped skin and is not easy to relapse.
为实现上述目的,本发明采用如下技术方案:To achieve the above object, the present invention adopts the following technical solutions:
一种有效治疗皮肤皲裂的中药复方软膏,按重量份数计,其原料组成为:红花提取物6~10份,当归提取物6~10份,荆芥提取物6~10份,防风提取物6~10份,白及提取物6~10份,苦楝子提取物6~10份,褐化香蕉皮提取物6~10份,冬青叶6~10份,大风子6~9份,甘油7~11份,老茶油10~20份,凡士林4~6份;所述老茶油为5年以上的茶油。A traditional Chinese medicine compound ointment for effectively treating chapped skin. The raw materials are composed of 6-10 parts of safflower extract, 6-10 parts of angelica extract, 6-10 parts of nepeta extract, and windproof extract in parts by weight. 6~10 parts of Chinese herbal medicine, 6~10 parts of white root extract, 6~10 parts of neem seed extract, 6~10 parts of browned banana peel extract, 6~10 parts of holly leaves, 6~9 parts of Dafengzi, glycerin 7 to 11 parts, 10 to 20 parts of old camellia oil, and 4 to 6 parts of vaseline; the old camellia oil is more than 5 years old.
优选地,一种有效治疗皮肤皲裂的中药复方软膏,按重量份数计,其原料组成为:红花提取物8份,当归提取物8份,荆芥提取物8份,防风提取物8份,白及提取物8份,苦楝子提取物8份,褐化香蕉皮提取物8份,冬青叶8份,大风子7份,甘油9份,老茶油15份,凡士林5份;所述老茶油为5年以上的茶油。Preferably, a traditional Chinese medicine compound ointment for effectively treating chapped skin is composed of raw materials in parts by weight: 8 parts of safflower extract, 8 parts of angelica extract, 8 parts of Nepeta extract, and 8 parts of windproof extract , 8 parts of white and extract, 8 parts of neem seed extract, 8 parts of browned banana peel extract, 8 parts of holly leaves, 7 parts of Dafengzi, 9 parts of glycerin, 15 parts of old tea oil, and 5 parts of vaseline; Old tea oil is tea oil that is more than 5 years old.
如上所述的一种有效治疗皮肤皲裂的中药复方软膏的制备方法,具体包括以下步骤:A kind of preparation method of the traditional Chinese medicine compound ointment for effectively treating chapped skin as described above, specifically comprises the following steps:
(1)分别取红花、当归、荆芥、防风、白及、苦楝子、褐化香蕉皮,以1.5-2.0倍体积95wt%酒精浸提24h,再于50-60℃水浴回流提取2-3h,回流2-3次,合并提取液,浓缩为浸膏,即分别制得红花提取物、当归提取物、荆芥提取物、防风提取物、白及提取物、苦楝子提取物和褐化香蕉皮提取物;(1) Safflower, Angelica, Nepeta, Fangfeng, Baiji, Neem, and browned banana peel were extracted with 1.5-2.0 times the volume of 95wt% alcohol for 24 hours, and then refluxed in a water bath at 50-60°C to extract 2- 3h, reflux 2-3 times, combine the extracts, and concentrate them into extracts to obtain safflower extracts, angelica extracts, nepeta extracts, windproof extracts, white and extracts, neem extracts and brown Chemicalized Banana Peel Extract;
(2)按重量配比分别取冬青叶和大风子,文火烧存性;(2) Take Holly Leaf and Dafengzi respectively according to the weight ratio, and simmer for preservation;
(3)取步骤(1)制得的红花提取物、当归提取物、荆芥提取物、防风提取物、白及提取物、苦楝子提取物和褐化香蕉皮提取物按重量配比混合,再加入步骤(2)处理后的冬青叶和大风子,最后再加入甘油、老茶油和凡士林,混合、匀质,紫外杀菌,装入带有螺旋口管状锡箔袋,加螺旋塑料管盖,制得所述有效治疗皮肤皲裂的中药复方软膏。(3) Take the safflower extract, angelica extract, nepeta extract, fangfeng extract, bletilla extract, neem extract and browned banana peel extract prepared in step (1) and mix them in proportion by weight , then add the holly leaves and Dafengzi treated in step (2), and finally add glycerin, old tea oil and vaseline, mix and homogenize, sterilize with ultraviolet light, put into a tubular tin foil bag with a screw mouth, and add a screw plastic tube cap , make the described traditional Chinese medicine compound ointment for effectively treating chapped skin.
本发明的有益效果在于:本发明以红花、当归、荆芥、防风养血活血润肤,祛风止痒;以性寒冬青叶清热凉血解毒,祛风散湿;以苦楝子苦寒,理气通络,行气止痛,清热散湿,抗菌,大风子辛热祛风燥湿;白及苦寒收敛止血,消肿生肌;香蕉味甘、性寒清热解毒、养阴润燥,以甘油调匀润肤,附少量水杨酸消减角质透气,助药物透达肌理;全方内养血活血,行气通络,祛风清热散湿,养阴润燥,外敛伤止痒,内消肿生肌;冬青叶、苦楝子、大风子、白及、香蕉单品就是治疗皮肤皲裂的良药,配伍组合后更能起到内外兼修,标本兼治的效果。The beneficial effects of the present invention are as follows: the present invention uses safflower, angelica, nepeta, wind-proof, nourishes blood, activates blood and moisturizes the skin, dispels wind and relieves itching; Regulates qi and dredges collaterals, promotes qi and relieves pain, clears away heat and dampness, antibacterial, Dafengzi is pungent and hot, dispels wind and dampness; white and bitter cold astringes and stops bleeding, reduces swelling and promotes muscle growth; Mix well and moisturize the skin, add a small amount of salicylic acid to reduce cutin and breathe, and help the drug to penetrate the skin; the whole formula nourishes blood and activates blood, promotes qi and collaterals, dispels wind, clears heat and disperses dampness, nourishes yin and moistens dryness, restrains injuries externally, relieves itching, and eliminates internally Swelling and muscle growth; holly leaves, neem seeds, Dafengzi, baiji, and bananas are good medicines for treating chapped skin.
具体实施方式detailed description
以下结合具体实施例对本发明做进一步说明,但本发明不仅仅限于这些实施例。The present invention will be further described below in conjunction with specific examples, but the present invention is not limited to these examples.
实施例1Example 1
(1)分别取红花、当归、荆芥、防风、白及、苦楝子、褐化香蕉皮,以1.5倍体积95wt%酒精浸提24h,再于50℃水浴回流提取3h,回流3次,合并提取液,浓缩为浸膏,即分别制得红花提取物、当归提取物、荆芥提取物、防风提取物、白及提取物、苦楝子提取物和褐化香蕉皮提取物;(1) Safflower, Angelica, Nepeta, Fangfeng, Baiji, Neem, and browned banana peel were extracted with 1.5 times the volume of 95wt% alcohol for 24 hours, then refluxed in a water bath at 50°C for 3 hours, and refluxed 3 times. Combining the extracts and concentrating them into extracts to obtain safflower extracts, angelica extracts, nepeta extracts, fangfeng extracts, bletilla extracts, neem extracts and browned banana peel extracts;
(2)分别取冬青叶7份和大风子6份,文火烧存性;(2) Take 7 parts of holly leaves and 6 parts of Dafengzi respectively, and simmer for preservation;
(3)取步骤(1)制得的红花提取物6份、当归提取物6份、荆芥提取物6份、防风提取物6份、白及提取物6份、苦楝子提取物6份和褐化香蕉皮提取物6份混合,再加入步骤(2)处理后的冬青叶和大风子,最后再加入甘油7份、老茶油(5年以上)10份和凡士林4份,混合、匀质,紫外杀菌,装入带有螺旋口管状锡箔袋,加螺旋塑料管盖,制得所述有效治疗皮肤皲裂的中药复方软膏。(3) Take 6 parts of safflower extract, 6 parts of angelica extract, 6 parts of Nepeta extract, 6 parts of Fangfeng extract, 6 parts of Baiji extract and 6 parts of neem extract obtained in step (1) Mix with 6 parts of the browned banana peel extract, then add the treated holly leaves and Dafengzi after step (2), and finally add 7 parts of glycerin, 10 parts of old tea oil (more than 5 years old) and 4 parts of Vaseline, mix, Homogenize, sterilize by ultraviolet light, put into a tubular tin foil bag with a screw mouth, and add a screw plastic tube cover to prepare the traditional Chinese medicine compound ointment for effectively treating chapped skin.
实施例2Example 2
(1)分别取红花、当归、荆芥、防风、白及、苦楝子、褐化香蕉皮,以2.0倍体积95wt%酒精浸提24h,再于60℃水浴回流提取2h,回流2次,合并提取液,浓缩为浸膏,即分别制得红花提取物、当归提取物、荆芥提取物、防风提取物、白及提取物、苦楝子提取物和褐化香蕉皮提取物;(1) Safflower, Angelica, Nepeta, Fangfeng, Baiji, Neem, and browned banana peel were extracted with 2.0 times the volume of 95wt% alcohol for 24 hours, and then refluxed in a 60°C water bath for 2 hours, refluxed twice, Combining the extracts and concentrating them into extracts to obtain safflower extracts, angelica extracts, nepeta extracts, fangfeng extracts, bletilla extracts, neem extracts and browned banana peel extracts;
(2)分别取冬青叶10份和大风子9份,文火烧存性;(2) Take 10 parts of holly leaves and 9 parts of Dafengzi respectively, and simmer for preservation;
(3)取步骤(1)制得的红花提取物10份、当归提取物10份、荆芥提取物10份、防风提取物10份、白及提取物10份、苦楝子提取物10份和褐化香蕉皮提取物10份混合,再加入步骤(2)处理后的冬青叶和大风子,最后再加入甘油11份、老茶油(5年以上)20份和凡士林6份,混合、匀质,紫外杀菌,装入带有螺旋口管状锡箔袋,加螺旋塑料管盖,制得所述有效治疗皮肤皲裂的中药复方软膏。(3) Take 10 parts of safflower extract, 10 parts of angelica extract, 10 parts of Nepeta extract, 10 parts of Fangfeng extract, 10 parts of Baiji extract and 10 parts of neem extract obtained in step (1) Mix with 10 parts of the browned banana peel extract, then add the treated holly leaves and Dafengzi after step (2), and finally add 11 parts of glycerin, 20 parts of old tea oil (more than 5 years old) and 6 parts of Vaseline, mix, Homogenize, sterilize by ultraviolet light, put into a tubular tin foil bag with a screw mouth, and add a screw plastic tube cover to prepare the traditional Chinese medicine compound ointment for effectively treating chapped skin.
实施例3Example 3
(1)分别取红花、当归、荆芥、防风、白及、苦楝子、褐化香蕉皮,以1.5-2.0倍体积95wt%酒精浸提24h,再于55℃水浴回流提取2.5h,回流3次,合并提取液,浓缩为浸膏,即分别制得红花提取物、当归提取物、荆芥提取物、防风提取物、白及提取物、苦楝子提取物和褐化香蕉皮提取物;(1) Take safflower, angelica, Nepeta, Fangfeng, Baiji, neem seeds, and browned banana peel, extract them with 1.5-2.0 times the volume of 95wt% alcohol for 24 hours, then reflux in a water bath at 55°C for 2.5 hours, and reflux Three times, the extracts were combined and concentrated into extracts, that is, safflower extracts, angelica extracts, Nepeta extracts, Fangfeng extracts, white and extracts, neem extracts and browned banana peel extracts were prepared respectively. ;
(2)分别取冬青叶8份和大风子7份,文火烧存性;(2) Take 8 parts of holly leaves and 7 parts of Dafengzi respectively, and simmer for preservation;
(3)取步骤(1)制得的红花提取物8份、当归提取物8份、荆芥提取物8份、防风提取物8份、白及提取物8份、苦楝子提取物8份和褐化香蕉皮提取物8份混合,再加入步骤(2)处理后的冬青叶和大风子,最后再加入甘油9份、老茶油(5年以上)15份和凡士林5份,混合、匀质,紫外杀菌,装入带有螺旋口管状锡箔袋,加螺旋塑料管盖,制得所述有效治疗皮肤皲裂的中药复方软膏。(3) Take 8 parts of safflower extract, 8 parts of angelica extract, 8 parts of Nepeta extract, 8 parts of Fangfeng extract, 8 parts of Baiji extract and 8 parts of neem extract obtained in step (1) Mix with 8 parts of browned banana peel extract, then add the treated holly leaves and Semen chinensis in step (2), and finally add 9 parts of glycerin, 15 parts of old tea oil (more than 5 years old) and 5 parts of Vaseline, mix, Homogenize, sterilize by ultraviolet light, put into a tubular tin foil bag with a screw mouth, and add a screw plastic tube cover to prepare the traditional Chinese medicine compound ointment for effectively treating chapped skin.
将本发明复方软膏涂至皮肤皲裂处,2-3天皲裂皮肤裂口愈合,疼痛、瘙痒消失;连续涂抹5-7天,皮肤干燥,表皮角化、增厚显著改善;8-10天后皮肤皮脂分泌和代谢恢复正常,临床治愈率90%以上。Apply the compound ointment of the present invention to the chapped skin, and the chapped skin will heal within 2-3 days, and the pain and itching will disappear; after 5-7 days of continuous application, the skin will be dry, and the keratinization and thickening of the epidermis will be significantly improved; after 8-10 days, the skin sebum The secretion and metabolism returned to normal, and the clinical cure rate was over 90%.
以上所述仅为本发明的较佳实施例,凡依本发明申请专利范围所做的均等变化与修饰,皆应属本发明的涵盖范围。The above descriptions are only preferred embodiments of the present invention, and all equivalent changes and modifications made according to the scope of the patent application of the present invention shall fall within the scope of the present invention.
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