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CL2021000611A1 - Proceso para preparar n-(5-(3-(7-(3-fluorofenil)-3h-imidazo[4,5-c]piridin-2-il)-1h-indazol-5-il)piridin-3-il)-3-metilbutanamida por acoplamiento entre un indazol y una pirimidina; ciclación para formar un azabenzimidazol y desprotección del grupo indazol con tfa puro (divisional de la solicitud no. 201803423) - Google Patents

Proceso para preparar n-(5-(3-(7-(3-fluorofenil)-3h-imidazo[4,5-c]piridin-2-il)-1h-indazol-5-il)piridin-3-il)-3-metilbutanamida por acoplamiento entre un indazol y una pirimidina; ciclación para formar un azabenzimidazol y desprotección del grupo indazol con tfa puro (divisional de la solicitud no. 201803423)

Info

Publication number
CL2021000611A1
CL2021000611A1 CL2021000611A CL2021000611A CL2021000611A1 CL 2021000611 A1 CL2021000611 A1 CL 2021000611A1 CL 2021000611 A CL2021000611 A CL 2021000611A CL 2021000611 A CL2021000611 A CL 2021000611A CL 2021000611 A1 CL2021000611 A1 CL 2021000611A1
Authority
CL
Chile
Prior art keywords
pyridin
indazole
compound
formula
salt
Prior art date
Application number
CL2021000611A
Other languages
English (en)
Inventor
Sunil Kumar Kc
Original Assignee
Samumed Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samumed Llc filed Critical Samumed Llc
Publication of CL2021000611A1 publication Critical patent/CL2021000611A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un proceso para preparar un compuesto de Fórmula (1) o una sal del mismo, que comprende (a) hacer reaccionar un compuesto de Fórmula (8) o una sal del mismo, con bis(pinacolato)diboro y Pd(dppf)Cl2 para producir un compuesto de Fórmula (9) o una sal del mismo; (b) hacer reaccionar el compuesto de Fórmula (9), o la sal del mismo, con un compuesto de Fórmula (10) o una sal del mismo, con Pd(PPh3)4 y K3PO4 para preparar un compuesto de Fórmula (11) o una sal del mismo, (c) hacer reaccionar el compuesto de Fórmula (11), o la sal del mismo, con un compuesto de Fórmula (6) o una sal del mismo, para preparar un compuesto de Fórmula (12) o una sal del mismo; y (d) desproteger el compuesto de Fórmula (12), o la sal del mismo, para<br /> preparar el compuesto de Fórmula (1), o una sal del mismo, en donde la desprotección del compuesto de Fórmula (12) para preparar el compuesto de Fórmula (1) comprende hacer reaccionar el compuesto de Fórmula (12) con TFA puro.
CL2021000611A 2016-06-01 2021-03-12 Proceso para preparar n-(5-(3-(7-(3-fluorofenil)-3h-imidazo[4,5-c]piridin-2-il)-1h-indazol-5-il)piridin-3-il)-3-metilbutanamida por acoplamiento entre un indazol y una pirimidina; ciclación para formar un azabenzimidazol y desprotección del grupo indazol con tfa puro (divisional de la solicitud no. 201803423) CL2021000611A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662344170P 2016-06-01 2016-06-01
US201662418657P 2016-11-07 2016-11-07

Publications (1)

Publication Number Publication Date
CL2021000611A1 true CL2021000611A1 (es) 2021-10-01

Family

ID=59054292

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2018003423A CL2018003423A1 (es) 2016-06-01 2018-11-30 Proceso para preparar n-(5-(3-(7-(3-fluorofenil)-3h-imidazo[4,5-c]piridin-2-il)-1h-indazol-5-il)piridin-3-il)-3-metilbutanamida.
CL2021000611A CL2021000611A1 (es) 2016-06-01 2021-03-12 Proceso para preparar n-(5-(3-(7-(3-fluorofenil)-3h-imidazo[4,5-c]piridin-2-il)-1h-indazol-5-il)piridin-3-il)-3-metilbutanamida por acoplamiento entre un indazol y una pirimidina; ciclación para formar un azabenzimidazol y desprotección del grupo indazol con tfa puro (divisional de la solicitud no. 201803423)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CL2018003423A CL2018003423A1 (es) 2016-06-01 2018-11-30 Proceso para preparar n-(5-(3-(7-(3-fluorofenil)-3h-imidazo[4,5-c]piridin-2-il)-1h-indazol-5-il)piridin-3-il)-3-metilbutanamida.

Country Status (25)

Country Link
US (4) US10072004B2 (es)
EP (1) EP3464285B1 (es)
JP (1) JP7010851B2 (es)
KR (1) KR102477407B1 (es)
CN (1) CN109476660B (es)
AU (1) AU2017274350B2 (es)
CA (1) CA3026076A1 (es)
CL (2) CL2018003423A1 (es)
DK (1) DK3464285T3 (es)
ES (1) ES2933109T3 (es)
HR (1) HRP20221446T1 (es)
HU (1) HUE060797T2 (es)
IL (1) IL263362B (es)
LT (1) LT3464285T (es)
MD (1) MD3464285T2 (es)
MX (1) MX2018014871A (es)
MY (1) MY199242A (es)
NZ (1) NZ749580A (es)
PL (1) PL3464285T3 (es)
PT (1) PT3464285T (es)
RS (1) RS63813B1 (es)
SG (2) SG11201810683VA (es)
SI (1) SI3464285T1 (es)
SM (1) SMT202200486T1 (es)
WO (1) WO2017210407A1 (es)

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WO2016040193A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
WO2016040184A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
WO2016040190A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
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