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BR0213562A - Benzimidazóis e análogos e seu uso como inibidores de cinases de proteìna - Google Patents

Benzimidazóis e análogos e seu uso como inibidores de cinases de proteìna

Info

Publication number
BR0213562A
BR0213562A BR0213562-0A BR0213562A BR0213562A BR 0213562 A BR0213562 A BR 0213562A BR 0213562 A BR0213562 A BR 0213562A BR 0213562 A BR0213562 A BR 0213562A
Authority
BR
Brazil
Prior art keywords
compounds
analogs
protein kinase
kinase inhibitors
benzimidazoles
Prior art date
Application number
BR0213562-0A
Other languages
English (en)
Inventor
Michael Louis Edwards
Paul Joseph Cox
Shelley Amendola
Stephanie Daniele Deprets
Timothy Alan Gillespy
Christopher David Edlin
Andrew David Morley
Charles J Gardner
Brian Pedgrift
Herve Bouchard
Didier Babin
Laurence Gauzy
Alain Brunet
Alain Le Brun
Tahir Nedeem Majid
John C Reader
Lloyd J Payne
Nawaz M Khan
Michael Cherry
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0113868A external-priority patent/FR2831537B1/fr
Priority claimed from GB0206893A external-priority patent/GB0206893D0/en
Priority claimed from GB0206895A external-priority patent/GB0206895D0/en
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of BR0213562A publication Critical patent/BR0213562A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
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    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
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  • Urology & Nephrology (AREA)
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Abstract

"BENZIMIDAZóIS E ANáLOGOS E SEU USO COMO INIBIDORES DE CINASES DE PROTEìNA". A invenção refere-se a compostos fisiologicamente ativos da fórmula geral (Ix) e composições contendo tais compostos, e suas pró-drogas, e sais e solvatos farmaceuticamente aceitáveis de tais compostos e suas pró-drogas, bem como a novos compostos dentro do escopo da fórmula (Ix), e a processos para sua preparação. Tais compostos e composições têm propriedades farmacêuticas valiosas, em particular a habilidade de inibir cinases.
BR0213562-0A 2001-10-26 2002-10-24 Benzimidazóis e análogos e seu uso como inibidores de cinases de proteìna BR0213562A (pt)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
FR0113868A FR2831537B1 (fr) 2001-10-26 2001-10-26 Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation
GB0206893A GB0206893D0 (en) 2002-03-22 2002-03-22 Chemical compounds
GB0206895A GB0206895D0 (en) 2002-03-22 2002-03-22 Chemical compounds
US39506002P 2002-07-11 2002-07-11
US39515102P 2002-07-11 2002-07-11
PCT/GB2002/004763 WO2003035065A1 (en) 2001-10-26 2002-10-24 Benzimidazoles and analogues and their use as protein kinases inhibitors

Publications (1)

Publication Number Publication Date
BR0213562A true BR0213562A (pt) 2004-08-31

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
BR0213562-0A BR0213562A (pt) 2001-10-26 2002-10-24 Benzimidazóis e análogos e seu uso como inibidores de cinases de proteìna

Country Status (9)

Country Link
EP (1) EP1441725A1 (pt)
JP (1) JP5039268B2 (pt)
AU (1) AU2002334217B2 (pt)
BR (1) BR0213562A (pt)
CA (1) CA2465247C (pt)
IL (1) IL161576A0 (pt)
MX (1) MXPA04003954A (pt)
UY (1) UY27516A1 (pt)
WO (1) WO2003035065A1 (pt)

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EP2322521B1 (en) * 2002-02-06 2013-09-04 Vertex Pharmaceuticals, Inc. Heteroaryl compounds useful as inhibitors of GSK-3
DE10227668A1 (de) * 2002-06-20 2004-01-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Arzneimittel zur Behandlung des systemic inflammatory response syndrome
JP2005538118A (ja) 2002-08-06 2005-12-15 アストラゼネカ アクチボラグ Ｔｉｅ２（ｔｅｋ）活性を持つ縮合したピリジン及びピリミジン
US7309701B2 (en) 2002-11-19 2007-12-18 Sanofi-Aventis Deutschland Gmbh Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them
US7462613B2 (en) 2002-11-19 2008-12-09 Sanofi-Aventis Deutschland Gmbh Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them
JP2004189738A (ja) * 2002-11-29 2004-07-08 Nippon Nohyaku Co Ltd 置換アニリド誘導体、その中間体及び農園芸用薬剤並びにその使用方法
KR101190964B1 (ko) * 2003-07-03 2012-10-12 아스텍스 테라퓨틱스 리미티드 벤즈이미다졸 유도체 및 단백질 키나제로서의 그의 용도
TWI372050B (en) 2003-07-03 2012-09-11 Astex Therapeutics Ltd (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles
GB0315657D0 (en) * 2003-07-03 2003-08-13 Astex Technology Ltd Pharmaceutical compounds
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EP1441725A1 (en) 2004-08-04
UY27516A1 (es) 2003-04-30
MXPA04003954A (es) 2004-11-29
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