CH307890A - Process for the preparation of a bactericidal salicylanilide. - Google Patents
Process for the preparation of a bactericidal salicylanilide.Info
- Publication number
- CH307890A CH307890A CH307890DA CH307890A CH 307890 A CH307890 A CH 307890A CH 307890D A CH307890D A CH 307890DA CH 307890 A CH307890 A CH 307890A
- Authority
- CH
- Switzerland
- Prior art keywords
- salicylanilide
- bactericidal
- preparation
- dichloro
- methyl
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
<B>Verfahren zur Herstellung eines</B> hakteriziden Salicylanilides. Gegenstand vorliegenden Patentes ist ein Verfahren zur Herstellung eines bakteriziden Salicylanilides. Das Verfahren ist dadurch gekennzeichnet, dass man 1 Mol 4-Methyl-5- ehlor-salicylsäure auf 1 Mol 3,4-Dichlor-anilin einwirken lässt.
Die erhaltene neue Verbindung, das 4-.yletliyl -6 -chlor - sabicylsäure - 3',4'-dchlor- anilid, schmilzt bei 280-281 . Sie soll als Desinfektionsmittel für nicht arzneiliche Zwecke Verwendung finden.
<I>Beispiel:</I> 47 Teile 4-Methyl-5-chlor-salicylsäure und 40 Teile 3,4-Dichlor-anilin werden in 450 Teilen Chlorbenzol gelöst und ein Teil Alumi niumchlorid und 15 Teile Phosphortrichlorid zugegeben. Diese Suspension wird so lange zum Sieden erhitzt, bis kein Chlorwasserstoff mehr entweicht, was nach ungefähr 2-3 Std. der Fall ist. Die chlorbenzolische Lösung wird dann mit Wasser vermischt und mit Soda brillantalkalisch gestellt.
Das Chlor benzol wird mit Wasserdampf abgeblasen und der Destillationsrückstand, nach dem Abfil- trieren und Trocknen, aus Chlorbenzol um kristallisiert. Das erhaltene 4-Methyl-5-chlor- salicylsäure-3',4'-dichlor-anilid schmilzt bei 280-281 .
<B> Process for the production of a </B> bactericidal salicylanilide. The present patent relates to a process for the preparation of a bactericidal salicylanilide. The process is characterized in that 1 mol of 4-methyl-5-chlorosalicylic acid is allowed to act on 1 mol of 3,4-dichloro-aniline.
The new compound obtained, 4-ethylethyl-6-chloro-sabicylic acid-3 ', 4'-dchloro-anilide, melts at 280-281. It should be used as a disinfectant for non-medicinal purposes.
<I> Example: </I> 47 parts of 4-methyl-5-chloro-salicylic acid and 40 parts of 3,4-dichloro-aniline are dissolved in 450 parts of chlorobenzene and one part of aluminum chloride and 15 parts of phosphorus trichloride are added. This suspension is heated to boiling until no more hydrogen chloride escapes, which is the case after about 2-3 hours. The chlorobenzene solution is then mixed with water and made brilliantly alkaline with soda.
The chlorobenzene is blown off with steam and the distillation residue is recrystallized from chlorobenzene after it has been filtered off and dried. The 4-methyl-5-chlorosalicylic acid-3 ', 4'-dichloro-anilide obtained melts at 280-281.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH304558T | 1951-12-29 | ||
| CH307890T | 1951-12-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH307890A true CH307890A (en) | 1955-06-15 |
Family
ID=25734859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH307890D CH307890A (en) | 1951-12-29 | 1951-12-29 | Process for the preparation of a bactericidal salicylanilide. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH307890A (en) |
-
1951
- 1951-12-29 CH CH307890D patent/CH307890A/en unknown
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