CH307878A - Process for the preparation of a bactericidal salicylanilide. - Google Patents
Process for the preparation of a bactericidal salicylanilide.Info
- Publication number
- CH307878A CH307878A CH307878DA CH307878A CH 307878 A CH307878 A CH 307878A CH 307878D A CH307878D A CH 307878DA CH 307878 A CH307878 A CH 307878A
- Authority
- CH
- Switzerland
- Prior art keywords
- salicylanilide
- bactericidal
- preparation
- dichloro
- mol
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
<B>Verfahren</B> zur <B>Herstellung eines</B> bakteriziden Salieylanilides. Gegenstand vorliegenden Patentes ist ein Verfahren zur Herstellung eines bakteriziden Salicylanilides. Das Verfahren ist dadurch ge- kennzeichnet, dass man 1 Mol 4,5-Dichlor- salicylsäure auf 1 Mol 3,4-Dichlor-anilin ein wirken lässt.
Die erhaltene neue Verbindung, das 4,5 - Dichlorsalicylsäure - 3',4'-dichlor - anilid, schmilzt bei 258-259 . Sie soll als Desinfek tionsmittel für nicht arzneiliche Zwecke Ver wendung finden.
Beispiel: 52 Teile 4,5-Dichlor-salicylsäure und 40 Teile 3,4-dichlor-anilin werden in 450 Teilen Chlorbenzol gelöst und ein Teil Aluminium- ehlorid und 15 Teile Phosphortrichlorid zuge geben. Diese Suspension wird so lange zum Sieden erhitzt, bis kein Chlorwasserstoff mehr entweicht, was nach ungefähr 2=3-ätunden der Fall ist. Die chlorbenzolische Lösung wird dann mit Wasser vermischt und mit Soda brillantalkalisch gestellt.
Das Chlorbenzol wird mit Wasserdampf abgeblasen und der Destillationsrückstand, nach dem Abfiltrieren und Trocknen, aus Chlorbenzol umkristalli- siert. Das erhaltene 4,5-Dichlor-salicylsäure- 3',4'-diehlor-anilid schmilzt bei 258-259 .
<B> Process </B> for the <B> production of </B> a bactericidal salieylanilide. The present patent relates to a process for the preparation of a bactericidal salicylanilide. The process is characterized in that 1 mol of 4,5-dichlorosalicylic acid is allowed to act on 1 mol of 3,4-dichloro-aniline.
The new compound obtained, 4,5 - dichlorosalicylic acid - 3 ', 4'-dichloro - anilide, melts at 258-259. It should be used as a disinfectant for non-medicinal purposes.
Example: 52 parts of 4,5-dichloro-salicylic acid and 40 parts of 3,4-dichloro-aniline are dissolved in 450 parts of chlorobenzene and one part of aluminum chloride and 15 parts of phosphorus trichloride are added. This suspension is heated to the boil until no more hydrogen chloride escapes, which is the case after about 2 = 3 hours. The chlorobenzene solution is then mixed with water and made brilliantly alkaline with soda.
The chlorobenzene is blown off with steam and the distillation residue is recrystallized from chlorobenzene after filtering off and drying. The 4,5-dichlorosalicylic acid-3 ', 4'-dichloro-anilide obtained melts at 258-259.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH304558T | 1951-12-29 | ||
| CH307878T | 1951-12-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH307878A true CH307878A (en) | 1955-06-15 |
Family
ID=25734847
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH307878D CH307878A (en) | 1951-12-29 | 1951-12-29 | Process for the preparation of a bactericidal salicylanilide. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH307878A (en) |
-
1951
- 1951-12-29 CH CH307878D patent/CH307878A/en unknown
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