CH307883A - Process for the preparation of a bactericidal salicylanilide. - Google Patents
Process for the preparation of a bactericidal salicylanilide.Info
- Publication number
- CH307883A CH307883A CH307883DA CH307883A CH 307883 A CH307883 A CH 307883A CH 307883D A CH307883D A CH 307883DA CH 307883 A CH307883 A CH 307883A
- Authority
- CH
- Switzerland
- Prior art keywords
- bactericidal
- salicylanilide
- preparation
- chloro
- mol
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Herstellung eines bakteriziden Salieylanilides. Gegenstand vorliegenden Patentes ist ein Verfahren zur Herstellung eines bakteriziden Salicylanilides. Das Verfahren ist dadurch ge kennzeichnet, dass man 1 Mol 4-Chlor-salicyl- säure auf 1 Mol 2,4,5-Trichlor-anilin ein wirken lässt.
Die erhaltene neue Verbindung, das 4-Clilor-salicylsäure-2',4',5'- trichlor- anilid, sehmilzt bei 251-252 . Sie soll als Desinfek tionsmittel für nicht arzneiliche Zwecke Ver wendung finden.
<I>Beispiel:</I> 43 Teile 4-Chlor-salicylsäure und 50 Teile 2,4,5-Trielilor-anilin werden in 450 Teilen Chlorbenzol gelöst und ein Teil Aluminium- ehlorid und 15 Teile Phosphortriehlorid zuge geben. Diese Suspension -wird so lange zum Sieden erhitzt, bis kein Chlorwasserstoff mehr entweicht, was nach ungefähr 2-3 Stunden der Fall ist. Die ehlorbenzolische Lösung wird dann mit Wasser vermischt und mit Soda brillantalkalisch gestellt.
Das Chlorbenzol wird mit Wasserdampf abgeblasen und der Destillationsrüekstand, nach dem Abfiltrieren und Trocknen, aus Chlorbenzol umkristalli siert. Das erhaltene 4-Chlor-salicylsäure- 2',4',5'-triehlor-anilid schmilzt bei 251-252 .
Process for the preparation of a bactericidal salieylanilide. The present patent relates to a process for the preparation of a bactericidal salicylanilide. The method is characterized in that 1 mol of 4-chloro-salicylic acid is allowed to act on 1 mol of 2,4,5-trichloro-aniline.
The new compound obtained, 4-Clilor-salicylic acid-2 ', 4', 5'-trichloro-anilide, melts at 251-252. It should be used as a disinfectant for non-medicinal purposes.
<I> Example: </I> 43 parts of 4-chlorosalicylic acid and 50 parts of 2,4,5-trieliloro aniline are dissolved in 450 parts of chlorobenzene and one part of aluminum chloride and 15 parts of phosphorus trichloride are added. This suspension is heated to boiling until no more hydrogen chloride escapes, which is the case after about 2-3 hours. The chlorobenzene solution is then mixed with water and made brilliantly alkaline with soda.
The chlorobenzene is blown off with steam and the residue from the distillation, after filtering off and drying, is recrystallized from chlorobenzene. The 4-chloro-salicylic acid-2 ', 4', 5'-triehlor anilide obtained melts at 251-252.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH304558T | 1951-12-29 | ||
| CH307883T | 1951-12-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH307883A true CH307883A (en) | 1955-06-15 |
Family
ID=25734852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH307883D CH307883A (en) | 1951-12-29 | 1951-12-29 | Process for the preparation of a bactericidal salicylanilide. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH307883A (en) |
-
1951
- 1951-12-29 CH CH307883D patent/CH307883A/en unknown
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