CA2266757C - Process for preparing pharmacologically acceptable salts of n-(1(s)-ethoxycarbonyl-3-phenylpropyl)-l-alanyl-amino acids - Google Patents

Process for preparing pharmacologically acceptable salts of n-(1(s)-ethoxycarbonyl-3-phenylpropyl)-l-alanyl-amino acids Download PDF

Info

Publication number: CA2266757C
Authority: CA; Canada
Prior art keywords: phenylpropyl; ethoxycarbonyl; alanyl; amino acid; proline
Prior art date: 1997-07-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CA2266757A

Other languages

English (en)

French (fr)

Other versions

CA2266757A1 (en

Inventor

Yasuyoshi Ueda

Koichi Kinoshita

Tadashi Moroshima

Yoshifumi Yanagida

Yoshihide Fuse

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Kaneka Corp

Original Assignee

Kaneka Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-07-22

Filing date

1998-07-21

Publication date

2010-10-19

1998-07-21 Application filed by Kaneka Corp filed Critical Kaneka Corp

1999-02-04 Publication of CA2266757A1 publication Critical patent/CA2266757A1/en

2010-10-19 Application granted granted Critical

2010-10-19 Publication of CA2266757C publication Critical patent/CA2266757C/en

2018-07-21 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Peptides Or Proteins (AREA)
Pyrrole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CA2266757A 1997-07-22 1998-07-21 Process for preparing pharmacologically acceptable salts of n-(1(s)-ethoxycarbonyl-3-phenylpropyl)-l-alanyl-amino acids Expired - Fee Related CA2266757C (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP19586597		1997-07-22
JP9/195865		1997-07-22
PCT/JP1998/003240 WO1999005164A1 (fr)	1997-07-22	1998-07-21	Procede de preparation de sels pharmacocompatibles d'acides amines n-(1(s)-ethoxycarbonyl-3-phenylpropyl)-l-alanyl

Publications (2)

Publication Number	Publication Date
CA2266757A1 CA2266757A1 (en)	1999-02-04
CA2266757C true CA2266757C (en)	2010-10-19

Family

ID=16348284

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA2266757A Expired - Fee Related CA2266757C (en)	1997-07-22	1998-07-21	Process for preparing pharmacologically acceptable salts of n-(1(s)-ethoxycarbonyl-3-phenylpropyl)-l-alanyl-amino acids

Country Status (14)

Country	Link
US (3)	US6335453B1 (no)
EP (1)	EP0967221B1 (no)
JP (1)	JP3996648B2 (no)
KR (1)	KR100557512B1 (no)
CN (1)	CN1139599C (no)
AT (1)	ATE296311T1 (no)
CA (1)	CA2266757C (no)
DE (1)	DE69830307T2 (no)
ES (1)	ES2241149T3 (no)
HU (1)	HU227816B1 (no)
IL (3)	IL128566A0 (no)
IN (1)	IN184759B (no)
SI (1)	SI9820007B (no)
WO (1)	WO1999005164A1 (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IN184759B (no) *	1997-07-22	2000-09-23	Kaneka Corp
PL339360A1 (en) *	1998-07-21	2000-12-18	Kaneka Corp	Method of crystallising n-(1(s)-ethoxycarbonyl-3-phenylpropyl)-l-alanyl-l-proline maleate
JP4149706B2 (ja) *	2000-05-15	2008-09-17	株式会社カネカ	Ｎ−（１（ｓ）−エトキシカルボニル−３−フェニルプロピル）−ｌ−アラニンｎ−カルボキシ無水物の晶析法
AR036187A1 (es)	2001-07-24	2004-08-18	Adir	Un proceso para la preparacion de perindopril, compuestos analogos y sus sales, compuesto intermediario 2,5-dioxo-oxazolidina y proceso para preparar un intermediario
AU2005327440A1 (en) *	2005-02-14	2006-08-17	Lupin Limited	Improved process for preparation of highly pure trandolapril
WO2014202659A1 (en)	2013-06-21	2014-12-24	Sanofi-Aventis Deutschland Gmbh	Process for the preparation of amides of n-[1-(s)-(ethoxycarbonyl)-3-phenylpropyl]-l-alanine
CN109734775A (zh) *	2018-12-31	2019-05-10	辰欣药业股份有限公司	一种马来酸依那普利的精制方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3435046A (en) *	1965-07-02	1969-03-25	Merck & Co Inc	Trialkyl-silyl ethers of n-carboxy anhydrides of monohydroxy alpha-amino acids and processes for preparing them
IL58849A (en)	1978-12-11	1983-03-31	Merck & Co Inc	Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
JPH0613550B2 (ja) *	1983-06-03	1994-02-23	味の素株式会社	α―Ｌ―アスパルチル―Ｌ―フェニルアラニン―低級アルキルエステルの製造法
JPS6248696A (ja) *	1985-08-27	1987-03-03	Kanegafuchi Chem Ind Co Ltd	Ｎ−〔１（ｓ）−エトキシカルボニル−３−フエニルプロピル〕−ｌ−アラニル−ｌ−プロリンの製造法
US4946942A (en) *	1988-03-11	1990-08-07	Bioresearch, Inc.	Urethane-protected amino acid-N-carboxyanhydrides
IN184759B (no) *	1997-07-22	2000-09-23	Kaneka Corp

1998
- 1998-07-20 IN IN1259CA1998 patent/IN184759B/en unknown
- 1998-07-21 HU HU0001145A patent/HU227816B1/hu not_active IP Right Cessation
- 1998-07-21 US US09/269,107 patent/US6335453B1/en not_active Expired - Lifetime
- 1998-07-21 CN CNB988010232A patent/CN1139599C/zh not_active Expired - Fee Related
- 1998-07-21 JP JP50965199A patent/JP3996648B2/ja not_active Expired - Lifetime
- 1998-07-21 DE DE69830307T patent/DE69830307T2/de not_active Expired - Lifetime
- 1998-07-21 ES ES98932585T patent/ES2241149T3/es not_active Expired - Lifetime
- 1998-07-21 AT AT98932585T patent/ATE296311T1/de active
- 1998-07-21 KR KR1019997002184A patent/KR100557512B1/ko not_active IP Right Cessation
- 1998-07-21 CA CA2266757A patent/CA2266757C/en not_active Expired - Fee Related
- 1998-07-21 WO PCT/JP1998/003240 patent/WO1999005164A1/ja active IP Right Grant
- 1998-07-21 SI SI9820007A patent/SI9820007B/sl not_active IP Right Cessation
- 1998-07-21 EP EP98932585A patent/EP0967221B1/en not_active Expired - Lifetime
- 1998-07-21 IL IL12856698A patent/IL128566A0/xx active IP Right Grant
1999
- 1999-02-17 IL IL128566A patent/IL128566A/en not_active IP Right Cessation
2001
- 2001-11-21 US US09/989,186 patent/US6518436B2/en not_active Expired - Fee Related
2002
- 2002-11-18 US US10/295,897 patent/US6713628B2/en not_active Expired - Fee Related
2004
- 2004-10-19 IL IL164690A patent/IL164690A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0967221B1 (en)	2005-05-25
DE69830307T2 (de)	2006-02-02
HUP0001145A2 (hu)	2000-11-28
ES2241149T3 (es)	2005-10-16
US6518436B2 (en)	2003-02-11
HUP0001145A3 (en)	2001-02-28
JP3996648B2 (ja)	2007-10-24
IL164690A (en)	2006-12-10
IN184759B (no)	2000-09-23
IL164690A0 (en)	2005-12-18
IL128566A (en)	2006-06-11
SI9820007B (sl)	2007-12-31
ATE296311T1 (de)	2005-06-15
US6713628B2 (en)	2004-03-30
US20020087007A1 (en)	2002-07-04
KR100557512B1 (ko)	2006-03-03
KR20000068566A (ko)	2000-11-25
EP0967221A4 (en)	2002-05-02
HU227816B1 (en)	2012-03-28
SI9820007A (sl)	1999-10-31
CA2266757A1 (en)	1999-02-04
IL128566A0 (en)	2000-01-31
CN1234804A (zh)	1999-11-10
CN1139599C (zh)	2004-02-25
US6335453B1 (en)	2002-01-01
WO1999005164A1 (fr)	1999-02-04
EP0967221A1 (en)	1999-12-29
DE69830307D1 (de)	2005-06-30
US20030105327A1 (en)	2003-06-05

Publication	Publication Date	Title
CA1329445C (en)	1994-05-10	Process for preparing n-[1(s)-ethoxycarbonyl-3- phenylpropyl]-l-alanyl-l-proline
US20040024180A1 (en)	2004-02-05	Process for the production of 2,5 -diketopiperazines,2,5-diketopiperazines , dipeptides and their use thereof
EP1279665B1 (en)	2008-02-20	A process for the preparation of perindopril, its analogous compounds and salts thereof using 2,5-dioxo-oxazolidine intermediate compounds
CA2266757C (en)	2010-10-19	Process for preparing pharmacologically acceptable salts of n-(1(s)-ethoxycarbonyl-3-phenylpropyl)-l-alanyl-amino acids
EP2627636A1 (en)	2013-08-21	Process for making bortezomib and intermediates for the process
AU2002328954A1 (en)	2003-05-29	A process for the preparation of perindopril, its analgous compounds and salts thereof using 2,5 -dioxo-oxazolidine intermediate compounds
JPH07304770A (ja)	1995-11-21	新規ベンゾアゼピノン誘導体
JP2752520B2 (ja)	1998-05-18	１−［Ｎ▲上２▼−（（Ｓ）−エトキシカルボニル）−３−フェニルプロピル）−Ｎ▲上６▼−トリフルオルアセチル］−Ｌ−リシル−Ｌ−プロリン（リシノプリル（Ｔｆａ）エチルエステルの精製法
WO2001002426A1 (en)	2001-01-11	A substantially crystalline form of melagatran
EP1076645B1 (en)	2004-03-03	Process for the preparation of methyl(2s)-2-[(3r)-3-(n-[tert-butyloxycarbonyl]-amino) -2-oxopyrr olidin-1-yl]propionate
JP4027092B2 (ja)	2007-12-26	２−アミノメチル−４−シアノ−チアゾールの製法
AU725683B2 (en)	2000-10-19	Process for the preparation of NMDA antagonists
JPH1192496A (ja)	1999-04-06	１−〔ｎ２−（（ｓ）−エトキシカルボニル）−３−フェニルプロピル）−ｎ６−トリフルオロアセチル〕−ｌ−リシル−ｌ−プロリンの単離方法およびその単離生成物
JPH0212238B2 (no)	1990-03-19
MXPA00010187A (en)	2001-11-21	Process for the preparation of methyl(2s)-2-[(3r)-3-(n-[tert -butyloxycarbonyl]- amino)-2-oxopyrrolidin-1-yl]propionate

Legal Events

Date	Code	Title	Description
2003-04-07	EEER	Examination request
2015-09-01	MKLA	Lapsed	Effective date: 20150721
2023-05-26	MKLA	Lapsed	Effective date: 20150721