IL128566A0 - Process for preparing pharmacologically acceptable salt of N-1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-amino acid - Google Patents

Process for preparing pharmacologically acceptable salt of N-1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-amino acid

Info

Publication number: IL128566A0
Authority: IL; Israel
Prior art keywords: phenylpropyl; ethoxycarbonyl; amino acid; alanyl; formula
Prior art date: 1997-07-22

Application number

IL12856698A

Other languages

English (en)

Original Assignee

Kaneka Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-07-22

Filing date

1998-07-21

Publication date

2000-01-31

1998-07-21 Application filed by Kaneka Corp filed Critical Kaneka Corp

2000-01-31 Publication of IL128566A0 publication Critical patent/IL128566A0/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Peptides Or Proteins (AREA)
Pyrrole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IL12856698A 1997-07-22 1998-07-21 Process for preparing pharmacologically acceptable salt of N-1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-amino acid IL128566A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP19586597		1997-07-22
PCT/JP1998/003240 WO1999005164A1 (fr)	1997-07-22	1998-07-21	Procede de preparation de sels pharmacocompatibles d'acides amines n-(1(s)-ethoxycarbonyl-3-phenylpropyl)-l-alanyl

Publications (1)

Publication Number	Publication Date
IL128566A0 true IL128566A0 (en)	2000-01-31

Family

ID=16348284

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
IL12856698A IL128566A0 (en)	1997-07-22	1998-07-21	Process for preparing pharmacologically acceptable salt of N-1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-amino acid
IL128566A IL128566A (en)	1997-07-22	1999-02-17	Process for the preparation of pharmacologically acceptable salt of N- (1 (S) - ethoxy carbonyl – 3 – phenylpropyl - L– alenyl – amino acid
IL164690A IL164690A (en)	1997-07-22	2004-10-19	Process for the preparation of pharmacologically acceptable salt of N - (1 (S) - ethoxy carbonyl - 3 - phenylpropyl - L - Alenyl - amino acid

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
IL128566A IL128566A (en)	1997-07-22	1999-02-17	Process for the preparation of pharmacologically acceptable salt of N- (1 (S) - ethoxy carbonyl – 3 – phenylpropyl - L– alenyl – amino acid
IL164690A IL164690A (en)	1997-07-22	2004-10-19	Process for the preparation of pharmacologically acceptable salt of N - (1 (S) - ethoxy carbonyl - 3 - phenylpropyl - L - Alenyl - amino acid

Country Status (14)

Country	Link
US (3)	US6335453B1 (no)
EP (1)	EP0967221B1 (no)
JP (1)	JP3996648B2 (no)
KR (1)	KR100557512B1 (no)
CN (1)	CN1139599C (no)
AT (1)	ATE296311T1 (no)
CA (1)	CA2266757C (no)
DE (1)	DE69830307T2 (no)
ES (1)	ES2241149T3 (no)
HU (1)	HU227816B1 (no)
IL (3)	IL128566A0 (no)
IN (1)	IN184759B (no)
SI (1)	SI9820007B (no)
WO (1)	WO1999005164A1 (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IN184759B (no) *	1997-07-22	2000-09-23	Kaneka Corp
PL339360A1 (en) *	1998-07-21	2000-12-18	Kaneka Corp	Method of crystallising n-(1(s)-ethoxycarbonyl-3-phenylpropyl)-l-alanyl-l-proline maleate
JP4149706B2 (ja) *	2000-05-15	2008-09-17	株式会社カネカ	Ｎ−（１（ｓ）−エトキシカルボニル−３−フェニルプロピル）−ｌ−アラニンｎ−カルボキシ無水物の晶析法
AR036187A1 (es)	2001-07-24	2004-08-18	Adir	Un proceso para la preparacion de perindopril, compuestos analogos y sus sales, compuesto intermediario 2,5-dioxo-oxazolidina y proceso para preparar un intermediario
AU2005327440A1 (en) *	2005-02-14	2006-08-17	Lupin Limited	Improved process for preparation of highly pure trandolapril
WO2014202659A1 (en)	2013-06-21	2014-12-24	Sanofi-Aventis Deutschland Gmbh	Process for the preparation of amides of n-[1-(s)-(ethoxycarbonyl)-3-phenylpropyl]-l-alanine
CN109734775A (zh) *	2018-12-31	2019-05-10	辰欣药业股份有限公司	一种马来酸依那普利的精制方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3435046A (en) *	1965-07-02	1969-03-25	Merck & Co Inc	Trialkyl-silyl ethers of n-carboxy anhydrides of monohydroxy alpha-amino acids and processes for preparing them
IL58849A (en)	1978-12-11	1983-03-31	Merck & Co Inc	Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
JPH0613550B2 (ja) *	1983-06-03	1994-02-23	味の素株式会社	α―Ｌ―アスパルチル―Ｌ―フェニルアラニン―低級アルキルエステルの製造法
JPS6248696A (ja) *	1985-08-27	1987-03-03	Kanegafuchi Chem Ind Co Ltd	Ｎ−〔１（ｓ）−エトキシカルボニル−３−フエニルプロピル〕−ｌ−アラニル−ｌ−プロリンの製造法
US4946942A (en) *	1988-03-11	1990-08-07	Bioresearch, Inc.	Urethane-protected amino acid-N-carboxyanhydrides
IN184759B (no) *	1997-07-22	2000-09-23	Kaneka Corp

1998
- 1998-07-20 IN IN1259CA1998 patent/IN184759B/en unknown
- 1998-07-21 HU HU0001145A patent/HU227816B1/hu not_active IP Right Cessation
- 1998-07-21 US US09/269,107 patent/US6335453B1/en not_active Expired - Lifetime
- 1998-07-21 CN CNB988010232A patent/CN1139599C/zh not_active Expired - Fee Related
- 1998-07-21 JP JP50965199A patent/JP3996648B2/ja not_active Expired - Lifetime
- 1998-07-21 DE DE69830307T patent/DE69830307T2/de not_active Expired - Lifetime
- 1998-07-21 ES ES98932585T patent/ES2241149T3/es not_active Expired - Lifetime
- 1998-07-21 AT AT98932585T patent/ATE296311T1/de active
- 1998-07-21 KR KR1019997002184A patent/KR100557512B1/ko not_active IP Right Cessation
- 1998-07-21 CA CA2266757A patent/CA2266757C/en not_active Expired - Fee Related
- 1998-07-21 WO PCT/JP1998/003240 patent/WO1999005164A1/ja active IP Right Grant
- 1998-07-21 SI SI9820007A patent/SI9820007B/sl not_active IP Right Cessation
- 1998-07-21 EP EP98932585A patent/EP0967221B1/en not_active Expired - Lifetime
- 1998-07-21 IL IL12856698A patent/IL128566A0/xx active IP Right Grant
1999
- 1999-02-17 IL IL128566A patent/IL128566A/en not_active IP Right Cessation
2001
- 2001-11-21 US US09/989,186 patent/US6518436B2/en not_active Expired - Fee Related
2002
- 2002-11-18 US US10/295,897 patent/US6713628B2/en not_active Expired - Fee Related
2004
- 2004-10-19 IL IL164690A patent/IL164690A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0967221B1 (en)	2005-05-25
DE69830307T2 (de)	2006-02-02
HUP0001145A2 (hu)	2000-11-28
ES2241149T3 (es)	2005-10-16
US6518436B2 (en)	2003-02-11
HUP0001145A3 (en)	2001-02-28
JP3996648B2 (ja)	2007-10-24
IL164690A (en)	2006-12-10
IN184759B (no)	2000-09-23
IL164690A0 (en)	2005-12-18
IL128566A (en)	2006-06-11
SI9820007B (sl)	2007-12-31
ATE296311T1 (de)	2005-06-15
US6713628B2 (en)	2004-03-30
US20020087007A1 (en)	2002-07-04
KR100557512B1 (ko)	2006-03-03
KR20000068566A (ko)	2000-11-25
EP0967221A4 (en)	2002-05-02
HU227816B1 (en)	2012-03-28
SI9820007A (sl)	1999-10-31
CA2266757C (en)	2010-10-19
CA2266757A1 (en)	1999-02-04
CN1234804A (zh)	1999-11-10
CN1139599C (zh)	2004-02-25
US6335453B1 (en)	2002-01-01
WO1999005164A1 (fr)	1999-02-04
EP0967221A1 (en)	1999-12-29
DE69830307D1 (de)	2005-06-30
US20030105327A1 (en)	2003-06-05

Publication	Publication Date	Title
HUT64842A (en)	1994-03-28	Method for producing pharmaceutical preparatives containing 2-[n-(2-amino-ethyl)-amino]-acetic acid derivatives
IL128566A0 (en)	2000-01-31	Process for preparing pharmacologically acceptable salt of N-1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-amino acid
MY106287A (en)	1995-04-29	Acid addition salts of amidated taurine or glycine, their preparation and use
NZ336793A (en)	2000-08-25	Method for stabilizing peptides by adding an organic acid and then lyophilizing the peptide mixture
EP1123935A3 (en)	2001-09-05	3'-Fluorinated guanosine derivatives for the treatment or prophylaxis of HBV or retroviral infections
EP0930292A4 (en)	2000-07-12	METHOD FOR PRODUCING BETA-AMINO-ALPHA-HYDROXYCARBONIC ACID DERIVATIVES
ATE150028T1 (de)	1997-03-15	Neue ganglioside-derivaten
CA2197304A1 (en)	1996-03-14	Acetic anhydride activation for c-terminal protein sequencing
IE890998L (en)	1989-09-28	Peptides
EP0343801A3 (en)	1991-05-02	N-(5,6,7,8-tetrahydropyrido(2,3-d)pyrimidin-6-yl-alkanoyl)-glutamic acid derivatives
ES2115543A1 (es)	1998-06-16	Procedimiento para la obtencion de carbetocina y sus sales de adicion de acido farmaceuticamente aceptables o complejos de la misma.
NO833071L (no)	1983-08-26	Fremgangsmaate for fremstilling av n-propanoldiamin-derivater
IL84195A (en)	1992-08-18	Peptide aminoalkylamides and peptide hydrazides,their preparation by the solid phase method and their use to prepare peptides
DE3886656D1 (de)	1994-02-10	Lösungssynthese eines Oktapeptids.
DE3665462D1 (en)	1989-10-12	Pharmacologically active peptides
DE3886655D1 (de)	1994-02-10	Verfahren zur Herstellung eines Oktapeptids.
EP1197489A4 (en)	2002-09-25	PYRIMIDINE DERIVATIVES AND THEIR PREPARATION PROCESS
ES2052447A1 (es)	1994-07-01	Peptidos hemorreguladores.
JPS5419967A (en)	1979-02-15	Preparation of phroglutamineglycilamino acid
EP0266006A3 (en)	1990-04-11	Novel hypotensive diuretic peptides

Legal Events

Date	Code	Title
2006-12-07	FF	Patent granted
2006-12-07	KB	Patent renewed
2008-11-03	KB	Patent renewed