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CA2247151C - Gaz fluores micro-encapsules utilises en qualite d'agents d'imagerie - Google Patents

Gaz fluores micro-encapsules utilises en qualite d'agents d'imagerie Download PDF

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Publication number
CA2247151C
CA2247151C CA002247151A CA2247151A CA2247151C CA 2247151 C CA2247151 C CA 2247151C CA 002247151 A CA002247151 A CA 002247151A CA 2247151 A CA2247151 A CA 2247151A CA 2247151 C CA2247151 C CA 2247151C
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CA
Canada
Prior art keywords
microparticle
poly
polymer
composition
volatile salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002247151A
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English (en)
Other versions
CA2247151A1 (fr
Inventor
Howard Bernstein
Julie Ann Straub
Edith Mathiowitz
Henry T. Brush
Richard E. Wing
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Acusphere Inc
Original Assignee
Acusphere Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27086474&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2247151(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/611,248 external-priority patent/US5611344A/en
Application filed by Acusphere Inc filed Critical Acusphere Inc
Publication of CA2247151A1 publication Critical patent/CA2247151A1/fr
Application granted granted Critical
Publication of CA2247151C publication Critical patent/CA2247151C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/481—Diagnostic techniques involving the use of contrast agents, e.g. microbubbles introduced into the bloodstream
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Acoustics & Sound (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)

Abstract

Cette invention concerne l'incorporation de gaz fluorés, notamment d'un perfluorocarbone tel qu'un octafluoropropane, dans des microparticules polymères synthétiques, laquelle incorporation permet d'accroître sensiblement l'échogénicité par rapport aux particules dans lesquelles de l'air a été incorporé. Ces particules de perfluorocarbone micro-encapsulé sont fabriquées de manière à posséder un diamètre acceptable en ce qui concerne les tissus cibles devant être analysés par imagerie, par exemple, lors d'une administration intraveineuse ou orale. Un mode de réalisation consiste à produire des microparticules bio-adhésives permettant d'améliorer la qualité d'imagerie de surfaces de muqueuses.
CA002247151A 1996-03-05 1997-02-27 Gaz fluores micro-encapsules utilises en qualite d'agents d'imagerie Expired - Fee Related CA2247151C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/611,248 US5611344A (en) 1996-03-05 1996-03-05 Microencapsulated fluorinated gases for use as imaging agents
US745,676 1996-11-08
US08/745,676 US5853698A (en) 1996-03-05 1996-11-08 Method for making porous microparticles by spray drying
US611,248 1996-11-08
PCT/US1997/003117 WO1997032609A2 (fr) 1996-03-05 1997-02-27 Gaz fluores micro-encapsules utilises en qualite d'agents d'imagerie

Publications (2)

Publication Number Publication Date
CA2247151A1 CA2247151A1 (fr) 1997-09-12
CA2247151C true CA2247151C (fr) 2008-05-20

Family

ID=27086474

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002247151A Expired - Fee Related CA2247151C (fr) 1996-03-05 1997-02-27 Gaz fluores micro-encapsules utilises en qualite d'agents d'imagerie

Country Status (21)

Country Link
US (1) US6132699A (fr)
EP (1) EP0904113B1 (fr)
JP (1) JP3178724B2 (fr)
AT (1) ATE266426T1 (fr)
AU (1) AU721209B2 (fr)
BR (1) BR9707936B1 (fr)
CA (1) CA2247151C (fr)
CZ (1) CZ281298A3 (fr)
DE (1) DE69729088T2 (fr)
DK (1) DK0904113T3 (fr)
ES (1) ES2221687T3 (fr)
HK (1) HK1020428A1 (fr)
HU (1) HU226714B1 (fr)
ID (1) ID17753A (fr)
IL (1) IL126073A (fr)
MY (1) MY124549A (fr)
NO (1) NO312940B1 (fr)
NZ (1) NZ331460A (fr)
PT (1) PT904113E (fr)
TW (1) TWI246426B (fr)
WO (1) WO1997032609A2 (fr)

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US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6946117B1 (en) 1997-09-29 2005-09-20 Nektar Therapeutics Stabilized preparations for use in nebulizers
US6726650B2 (en) * 1997-12-04 2004-04-27 Bracco Research S.A. Automatic liquid injection system and method
US6223455B1 (en) † 1999-05-03 2001-05-01 Acusphere, Inc. Spray drying apparatus and methods of use
AU784936B2 (en) * 1999-12-10 2006-08-03 Iscience Corporation Treatment of ocular disease
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
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US6919068B2 (en) * 2002-05-17 2005-07-19 Point Biomedical Corporation Method of preparing gas-filled polymer matrix microparticles useful for echographic imaging
US6962006B2 (en) * 2002-12-19 2005-11-08 Acusphere, Inc. Methods and apparatus for making particles using spray dryer and in-line jet mill
US20040121003A1 (en) * 2002-12-19 2004-06-24 Acusphere, Inc. Methods for making pharmaceutical formulations comprising deagglomerated microparticles
US20050171425A1 (en) * 2004-01-16 2005-08-04 Phantoms-By-Design Medical devices having MRI-enhancing encapsulated fluids
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
CA2569134C (fr) * 2004-06-04 2010-11-23 Acusphere, Inc. Formulation de dosage d'agent de contraste ultrasonore
US20070178166A1 (en) * 2005-12-15 2007-08-02 Acusphere, Inc. Processes for making particle-based pharmaceutical formulations for pulmonary or nasal administration
US20070148211A1 (en) * 2005-12-15 2007-06-28 Acusphere, Inc. Processes for making particle-based pharmaceutical formulations for oral administration
DE102008045152A1 (de) * 2008-07-09 2010-01-14 Universität Duisburg-Essen Künstliche Sauerstoffträger und ihre Verwendung
KR101061224B1 (ko) * 2008-10-08 2011-08-31 포항공과대학교 산학협력단 Ｘ 선을 이용한 유동정보 측정용 캡슐
NL2003660C2 (en) * 2009-10-16 2011-04-19 Giskit B V Composition and method for medical imaging of body cavities.
JP2011140527A (ja) * 2011-04-20 2011-07-21 Acusphere Inc 超音波造影剤の投薬処方物

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Also Published As

Publication number Publication date
PT904113E (pt) 2004-09-30
AU721209B2 (en) 2000-06-29
TWI246426B (en) 2006-01-01
ATE266426T1 (de) 2004-05-15
NO984089L (no) 1998-09-04
CA2247151A1 (fr) 1997-09-12
MY124549A (en) 2006-06-30
AU2139297A (en) 1997-09-22
NO312940B1 (no) 2002-07-22
DK0904113T3 (da) 2004-08-30
DE69729088T2 (de) 2005-05-12
HK1020428A1 (en) 2000-04-20
CZ281298A3 (cs) 1999-01-13
DE69729088D1 (de) 2004-06-17
IL126073A0 (en) 1999-05-09
HU226714B1 (en) 2009-07-28
ID17753A (id) 1998-01-22
HUP9902897A2 (hu) 2000-01-28
EP0904113A2 (fr) 1999-03-31
BR9707936B1 (pt) 2010-12-14
ES2221687T3 (es) 2005-01-01
US6132699A (en) 2000-10-17
IL126073A (en) 2002-02-10
EP0904113B1 (fr) 2004-05-12
JP3178724B2 (ja) 2001-06-25
HUP9902897A3 (en) 2000-03-28
WO1997032609A3 (fr) 1998-01-29
NZ331460A (en) 1998-12-23
WO1997032609A2 (fr) 1997-09-12
JP2000501745A (ja) 2000-02-15
NO984089D0 (no) 1998-09-04
BR9707936A (pt) 2000-01-04

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