CA1212665B - PREPARATION DE .beta.-LACTAM CONTENANT DES AGENTS ANTIBACTERIENS ET DES INHIBITEURS DE LA .beta.- LACTAMASE - Google Patents

PREPARATION DE .beta.-LACTAM CONTENANT DES AGENTS ANTIBACTERIENS ET DES INHIBITEURS DE LA .beta.- LACTAMASE

Info

Publication number: CA1212665B
Authority: CA; Canada
Prior art keywords: formula; resultant compound; compound; resultant; group
Prior art date: 1979-02-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA000499579A

Other languages

English (en)

Inventor

Giovanni Franceschi

Maurizio Foglio

Federico Arcamone

Cosimo Scarafile

Aurora Sanfilippo

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pfizer Italia SRL

Original Assignee

Farmitalia Carlo Erba SRL

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-02-24

Filing date

1986-01-14

Publication date

1986-10-14

1986-01-14 Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL

1986-10-14 Application granted granted Critical

1986-10-14 Publication of CA1212665B publication Critical patent/CA1212665B/fr

Status Expired legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/568—Four-membered rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Cephalosporin Compounds (AREA)

CA000499579A 1979-02-24 1986-01-14 PREPARATION DE .beta.-LACTAM CONTENANT DES AGENTS ANTIBACTERIENS ET DES INHIBITEURS DE LA .beta.- LACTAMASE Expired CA1212665B (fr)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB7906634		1979-02-24
GB7906634		1979-02-24
GB7932591		1979-09-20
GB7932591		1979-09-20

Publications (1)

Publication Number	Publication Date
CA1212665B true CA1212665B (fr)	1986-10-14

Family

ID=26270697

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
CA000346011A Expired CA1154010A (fr)	1979-02-24	1980-02-20	PREPARATION D'AGENTS ANTIBACTERIENS CONTENANT DU .beta.-LACTANE ET D'INHIBITEURS DE LA .beta.-LACTAMASE
CA000499579A Expired CA1212665B (fr)	1979-02-24	1986-01-14	PREPARATION DE .beta.-LACTAM CONTENANT DES AGENTS ANTIBACTERIENS ET DES INHIBITEURS DE LA .beta.- LACTAMASE

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
CA000346011A Expired CA1154010A (fr)	1979-02-24	1980-02-20	PREPARATION D'AGENTS ANTIBACTERIENS CONTENANT DU .beta.-LACTANE ET D'INHIBITEURS DE LA .beta.-LACTAMASE

Country Status (24)

Country	Link
AT (1)	AT368506B (fr)
AU (1)	AU535080B2 (fr)
CA (2)	CA1154010A (fr)
CH (2)	CH654831A5 (fr)
CS (1)	CS226010B2 (fr)
DE (1)	DE3006273A1 (fr)
DK (1)	DK159448C (fr)
ES (2)	ES8200685A1 (fr)
FI (1)	FI75163C (fr)
FR (1)	FR2449690B1 (fr)
GB (1)	GB2043639B (fr)
GR (1)	GR73623B (fr)
HK (1)	HK74487A (fr)
HU (1)	HU182664B (fr)
IE (1)	IE49407B1 (fr)
IT (1)	IT1193922B (fr)
LU (1)	LU82192A1 (fr)
NL (1)	NL192265C (fr)
NO (1)	NO161000C (fr)
NZ (1)	NZ192949A (fr)
PT (1)	PT70849A (fr)
SE (1)	SE449489B (fr)
UA (1)	UA6041A1 (fr)
YU (1)	YU42964B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5625110A (en) *	1978-12-18	1981-03-10	Bristol Myers Co	Antibacterial
DE3121510A1 (de) *	1980-07-04	1982-06-16	Farmitalia Carlo Erba S.p.A., 20159 Milano	6-alkyl-2-subst.-peneme und verfahren zu ihrer herstellung
JPS588084A (ja) *	1981-07-08	1983-01-18	Takeda Chem Ind Ltd	（６ｒ）−置換−（５ｒ）−ペネム−３−カルボン酸誘導体およびその製造法
EP0180252B1 (fr) *	1981-07-15	1989-04-26	Sumitomo Pharmaceuticals Company, Limited	Procédé de préparation de dérivés d'azétidinone
SU1389680A3 (ru) *	1981-12-11	1988-04-15	Фармиталия Карло Эрба С.П.А. (Фирма)	Способ получени оптически активных пенемов или их солей с щелочными металлами
NO831160L (no) *	1982-04-08	1983-10-10	Erba Farmitalia	Fremstilling av substituerte penem-derivater
PH21930A (en) *	1982-11-16	1988-04-08	Ciba Geigy Ag	6-hydroxy-lower alkylpenem compounds,pharmaceutical composition containing same and method of use thereof
EP0112283B1 (fr) *	1982-11-16	1987-08-12	Ciba-Geigy Ag	Dérivés hétérocyclylthio, procédé pour leur préparation, compositions pharmaceutiques les contenant et leur application
GB8300295D0 (en) *	1983-01-06	1983-02-09	Erba Farmitalia	Penem esters
JPS59152387A (ja) *	1983-02-10	1984-08-31	Shionogi & Co Ltd	新規ペネム化合物
GB8321677D0 (en) *	1983-08-11	1983-09-14	Erba Farmitalia	Preparation of penems
US4656165A (en) *	1983-09-02	1987-04-07	Ciba-Geigy Corporation	Aminomethyl penem compounds
US4711886A (en) *	1984-07-02	1987-12-08	Merck & Co., Inc.	β-lactam derivatives as anti-inflammatory and antidegenerative agents
US4761408A (en) *	1984-11-02	1988-08-02	Ciba-Geigy Corporation	Crystalline aminomethyl compound
DE3882730D1 (de) *	1987-02-11	1993-09-09	Ciba Geigy Ag	Bicyclische beta-lactam-carbonsaeuren.
US5364768A (en) *	1987-07-07	1994-11-15	Farmitalia Carlo Erba S.R.L.	Process for the preparation of penems
GB2206578B (en) *	1987-07-07	1991-07-03	Erba Carlo Spa	Process for the preparation of penems
IT1286558B1 (it) *	1996-02-27	1998-07-15	Menarini Farma Ind	Processo per la preparazione di 2-alogenometil-penems e loro uso per la preparazione di penems antibatterici
DE69805975T2 (de)	1997-12-29	2002-12-19	Research Corp. Technologies, Inc.	2-beta-substituierte-6-alkylidenpenizillansäure-derivate als beta-laktamase inhibitoren
US6407091B1 (en)	1999-04-15	2002-06-18	Research Corporation Technologies, Inc.	β-lactamase inhibiting compounds
US6720445B2 (en)	2000-12-21	2004-04-13	Beacon Laboratories, Inc.	Acetyloxymethyl esters and methods for using the same
DE60214740T2 (de)	2001-07-24	2007-10-04	Southern Methodist University Foundation for Research, Dallas	3-substituierte 7-alkylidene-3-cephem-4-carbonsäuren als beta-lactamase inhibitoren
US7022691B2 (en)	2002-04-04	2006-04-04	John D. Buynak	Inhibitors of serine and metallo-β-lactamases

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
LU77306A1 (fr) *	1977-05-09	1979-01-18
AU3796278A (en) *	1977-07-13	1980-01-17	Glaxo Group Ltd	Penams and azetidinones
US4168314A (en) *	1977-11-17	1979-09-18	Merck & Co., Inc.	6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
US4155912A (en) *	1977-12-14	1979-05-22	Bristol-Myers Company	2-Methylpenem-3-carboxylic acid antibiotics
EP0003415A3 (fr) *	1978-01-20	1979-08-22	Glaxo Group Limited	Composés bêta-lactames, procédés pour leur préparation, compositions pharmaceutiques les contenant et les intermédiaires pour leur préparation
EP0042026B1 (fr) *	1978-02-02	1986-01-08	Ciba-Geigy Ag	Dérivés d'azétidin-2-one 3,4-disubstitués et procédé de préparation
EP0010358A1 (fr) *	1978-09-20	1980-04-30	Glaxo Group Limited	Composés de bêta-lactame, procédés pour leur préparation, compositions les contenant, intermédiaires utilisables dans leur préparation et méthodes pour leur production
JPS5625110A (en) *	1978-12-18	1981-03-10	Bristol Myers Co	Antibacterial
EP0013067A1 (fr) *	1978-12-22	1980-07-09	Beecham Group Plc	Agents antibactériens à cycle bêta-lactame bicyclique, leur utilisation dans des compositions pharmaceutiques, procédés pour leur préparation et intermédiaires à utiliser dans de tels procédés

1980
- 1980-02-19 FI FI800493A patent/FI75163C/fi not_active IP Right Cessation
- 1980-02-19 GR GR61228A patent/GR73623B/el unknown
- 1980-02-19 GB GB8005476A patent/GB2043639B/en not_active Expired
- 1980-02-19 IT IT20021/80A patent/IT1193922B/it active
- 1980-02-19 AU AU55670/80A patent/AU535080B2/en not_active Ceased
- 1980-02-19 NL NL8001012A patent/NL192265C/nl not_active IP Right Cessation
- 1980-02-19 AT AT0091980A patent/AT368506B/de not_active IP Right Cessation
- 1980-02-20 DE DE19803006273 patent/DE3006273A1/de active Granted
- 1980-02-20 CA CA000346011A patent/CA1154010A/fr not_active Expired
- 1980-02-20 PT PT70849A patent/PT70849A/pt not_active IP Right Cessation
- 1980-02-20 IE IE338/80A patent/IE49407B1/en not_active IP Right Cessation
- 1980-02-20 YU YU461/80A patent/YU42964B/xx unknown
- 1980-02-21 CH CH2794/84A patent/CH654831A5/de not_active IP Right Cessation
- 1980-02-21 CH CH1400/80A patent/CH651570A5/de not_active IP Right Cessation
- 1980-02-22 SE SE8001424A patent/SE449489B/sv not_active IP Right Cessation
- 1980-02-22 CS CS801241A patent/CS226010B2/cs unknown
- 1980-02-22 LU LU82192A patent/LU82192A1/fr unknown
- 1980-02-22 NZ NZ192949A patent/NZ192949A/en unknown
- 1980-02-22 NO NO800501A patent/NO161000C/no unknown
- 1980-02-22 FR FR8003938A patent/FR2449690B1/fr not_active Expired
- 1980-02-22 DK DK077580A patent/DK159448C/da not_active IP Right Cessation
- 1980-02-22 HU HU80420A patent/HU182664B/hu not_active IP Right Cessation
- 1980-02-22 UA UA2886007A patent/UA6041A1/uk unknown
- 1980-02-23 ES ES488886A patent/ES8200685A1/es not_active Expired
- 1980-10-16 ES ES495977A patent/ES8107224A1/es not_active Expired
1986
- 1986-01-14 CA CA000499579A patent/CA1212665B/fr not_active Expired
1987
- 1987-10-15 HK HK744/87A patent/HK74487A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
FR2449690A1 (fr)	1980-09-19
CS226010B2 (en)	1984-03-19
ES495977A0 (es)	1981-10-01
IT1193922B (it)	1988-08-31
CH651570A5 (de)	1985-09-30
IT8020021A0 (it)	1980-02-19
DK159448C (da)	1991-03-04
NZ192949A (en)	1984-03-16
DE3006273A1 (de)	1980-09-04
AU535080B2 (en)	1984-03-01
IE800338L (en)	1980-08-24
ATA91980A (de)	1982-02-15
FI75163B (fi)	1988-01-29
SE449489B (sv)	1987-05-04
CH654831A5 (de)	1986-03-14
FI75163C (fi)	1988-05-09
GB2043639A (en)	1980-10-08
SE8001424L (sv)	1980-08-25
PT70849A (en)	1980-03-01
YU42964B (en)	1989-02-28
FI800493A (fi)	1980-08-25
ES8107224A1 (es)	1981-10-01
HU182664B (en)	1984-02-28
FR2449690B1 (fr)	1986-06-13
GB2043639B (en)	1983-07-20
AU5567080A (en)	1980-09-11
NL192265B (nl)	1996-12-02
IT8020021A1 (it)	1981-08-19
LU82192A1 (fr)	1980-06-06
DK77580A (da)	1980-08-25
AT368506B (de)	1982-10-25
NO161000B (no)	1989-03-13
HK74487A (en)	1987-10-23
NO161000C (no)	1989-06-21
ES488886A0 (es)	1981-11-16
IE49407B1 (en)	1985-10-02
NL192265C (nl)	1997-04-03
UA6041A1 (uk)	1994-12-29
NL8001012A (nl)	1980-08-26
GR73623B (fr)	1984-03-26
YU46180A (en)	1983-02-28
DK159448B (da)	1990-10-15
NO800501L (no)	1980-08-25
CA1154010A (fr)	1983-09-20
ES8200685A1 (es)	1981-11-16

Publication	Publication Date	Title
CA1212665B (fr)	1986-10-14	PREPARATION DE .beta.-LACTAM CONTENANT DES AGENTS ANTIBACTERIENS ET DES INHIBITEURS DE LA .beta.- LACTAMASE
CA1279640C (fr)	1991-01-29	Procede de preparation de penems
US4482565A (en)	1984-11-13	β-Lactam-containing antibacterial agents and β-lactamase inhibitors
NO158540B (no)	1988-06-20	Analogifremgangsmaate ved fremstilling av terapeutisk aktive 2-penem-forbindelser.
US4778883A (en)	1988-10-18	3-(CHFCH3)-azetidinone intermediates
Yoshida et al.	1981	2-(Alkylthio) penem-3-carboxylic acids. IV. Synthesis of (hydroxyethyl)-azetidinone precursors to 1-thia analogs of thienamycin
EP0146730A1 (fr)	1985-07-03	Procédé de préparation de pénèmes
CA1215705A (fr)	1986-12-23	Procede de preparation de penems ayant une activite optique
US4713450A (en)	1987-12-15	2-thiacephems and (5R) penems derivatives
JPH03396B2 (fr)	1991-01-07
US4558042A (en)	1985-12-10	β-Lactam-containing antibacterial agents and β-lactamase inhibitors
HU196601B (en)	1988-12-28	New process for producing starting materials of penem derivatives
EP0131374A1 (fr)	1985-01-16	Procédé et intermédiaires pour la préparation de dérivés de pénème
IMUTA et al.	1985	Carbapenem and penem antibiotics. III. Synthesis and antibacterial activity of 2-functionalized-methyl penems related to asparenomycins
PL172378B1 (pl)	1997-09-30	Sposób wytwarzania nowych 4-podstawionych azetydynonów PL PL PL PL PL PL
CA1076125A (fr)	1980-04-22	Intermediaires d'analogues de cephalosporines
Osborne	1980	The chemistry of 4-mercaptoazetidin-2-ones. Part 2. Synthesis of bisnorpenicillins
US4554103A (en)	1985-11-19	Preparation of 4-acyloxyazetidinones from acyl nitrates and penams
KR100262240B1 (ko)	2000-07-15	3-치환된-7-옥소-1-아자비사이클로3,2,0 헵트-2-엔-2-카복실레이트 화합물 및 그의 제조방법
Iso et al.	1998	STEREOCONTROLLED SYNTHESIS OF 1s-AMINOALKYLCARBAPENEMS AND TRICYCLIC CARBAPENEMS (TRINEMS)
JPH0713058B2 (ja)	1995-02-15	４―置換アゼチジノン誘導体の製造方法
GB2116167A (en)	1983-09-21	Azetidinone derivatives
JPH0247995B2 (fr)	1990-10-23
CS226027B2 (cs)	1984-03-19	Způsob výroby nových derivátů penemkarboxylové kyseliny
GB2114132A (en)	1983-08-17	Azetidinone derivatives

Legal Events

Date	Code	Title	Description
1986-10-14	NARE	Reissued
2000-09-20	MKEX	Expiry