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BR9916314A - Inibidores tricìclicos da proteìna farnesil transferase - Google Patents

Inibidores tricìclicos da proteìna farnesil transferase

Info

Publication number
BR9916314A
BR9916314A BR9916314-4A BR9916314A BR9916314A BR 9916314 A BR9916314 A BR 9916314A BR 9916314 A BR9916314 A BR 9916314A BR 9916314 A BR9916314 A BR 9916314A
Authority
BR
Brazil
Prior art keywords
group
farnesyl transferase
compounds
protein inhibitors
transferase protein
Prior art date
Application number
BR9916314-4A
Other languages
English (en)
Inventor
Arthur G Taveras
Ronald J Doll
Alan B Cooper
Johan A Ferreira
Timothy Guzi
Alan K Mallams
Dinanath F Rane
Viyyoor M Girijavallabhan
Adriano Afonso
Cynthia J Aki
Jianping Chao
Carmen Alvarez
Joseph M Kelly
Tarik Lalwani
Jagdish A Desai
James J-S Wang
Jay Weinstein
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of BR9916314A publication Critical patent/BR9916314A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Electroluminescent Light Sources (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Patente de Invenção: <B>"INIBIDORES TRICìCLICOS DA PROTEìNA FARNESIL TRANSFERASE"<D>. Estão descritos compostos de fórmula (1.0) onde R^ 13^ representa um anel imidazol; R^ 14^ representa um grupo carbamato, uréia, amida ou sulfonamida; R^ 8^ representa H quando a cadeia alquila entre o grupo amida e o grupo imidazol R^ 13^ é substituída, ou R^ 8^ representa um substituinte tal como arilalquila, heteroarilalquila ou cicloalquila; e os outros substituintes são como definidos neste relatório. Também estão descritos compostos onde R^ 8^ é H, e a cadeia alquila entre o grupo amida e o grupo imidazol R^ 13^ é não-substituída. Também está descrito um método de tratamento de câncer e um método de inibição da proteína farnesil transferase usando os compostos descritos.
BR9916314-4A 1998-12-18 1999-12-16 Inibidores tricìclicos da proteìna farnesil transferase BR9916314A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21639898A 1998-12-18 1998-12-18
PCT/US1999/027939 WO2000037459A1 (en) 1998-12-18 1999-12-16 Tricyclic farnesyl protein transferase inhibitors

Publications (1)

Publication Number Publication Date
BR9916314A true BR9916314A (pt) 2001-10-02

Family

ID=22806914

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9916314-4A BR9916314A (pt) 1998-12-18 1999-12-16 Inibidores tricìclicos da proteìna farnesil transferase

Country Status (20)

Country Link
EP (1) EP1140902A1 (pt)
JP (1) JP2002533336A (pt)
KR (1) KR20010081116A (pt)
CN (1) CN1326850C (pt)
AR (1) AR021718A1 (pt)
AU (1) AU776558B2 (pt)
BR (1) BR9916314A (pt)
CA (1) CA2354779A1 (pt)
CO (1) CO5160350A1 (pt)
CZ (1) CZ20011950A3 (pt)
HU (1) HUP0202152A2 (pt)
IL (1) IL143408A0 (pt)
NO (1) NO20012961L (pt)
NZ (1) NZ511878A (pt)
PE (1) PE20001342A1 (pt)
PL (1) PL348293A1 (pt)
SK (1) SK7592001A3 (pt)
TR (1) TR200101755T2 (pt)
WO (1) WO2000037459A1 (pt)
ZA (1) ZA200104233B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ511878A (en) 1998-12-18 2003-10-31 Schering Corp Tricyclic farnesyl protein transferase inhibitors
US7342016B2 (en) 2000-08-30 2008-03-11 Schering Corporation Farnesyl protein transferase inhibitors as antitumor agents
US6645966B2 (en) 2001-01-22 2003-11-11 Schering Corporation Treatment of malaria with farnesyl protein transferase inhibitors
AU2002257114A1 (en) * 2001-04-06 2002-10-21 Schering Corporation Treatment of malaria with farsenyl protein transferase inhibitors
EP1838324A2 (en) 2004-12-13 2007-10-03 Schering Corporation Novel farnesyl protein transferase inhibitors and their use to treat cancer
CN101128202A (zh) * 2004-12-14 2008-02-20 先灵公司 法呢基蛋白质转移酶抑制剂和用于治疗增殖性疾病的方法
CN101400656A (zh) * 2006-01-19 2009-04-01 先灵公司 作为法呢基蛋白转移酶抑制剂的哌嗪衍生物
BR112016021257B1 (pt) * 2014-03-19 2021-03-02 Viamet Pharmaceuticals (NC), Inc. 2-(2,4- difluorofenil-1,1-diflúor-1-(5-substituído-piridin-2-il)-3- (1h-tetrazol-1-il)propan-2-óis e processos para preparação e uso dos mesmos
MX2016012060A (es) 2014-03-19 2017-01-19 Viamet Pharmaceuticals Inc 2-(2,4-difluorofenil)-1,1-difluoro-1-(5-sustituido-piridin-2-il)- 3-(1h-tetrazol-1-il)propan-2-oles y procesos para su preparacion.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
US5712280A (en) 1995-04-07 1998-01-27 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
US5801175A (en) * 1995-04-07 1998-09-01 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
PE92098A1 (es) * 1996-07-31 1998-12-31 Schering Corp N-cianoiminas triciclicas utiles como inhibidores de transferasa de proteina farnesilo
IL133386A0 (en) * 1997-06-17 2001-04-30 Schering Corp Benzpyrido cycloheptane compounds useful for inhibition of a farnesyl protein transferase
NZ511878A (en) 1998-12-18 2003-10-31 Schering Corp Tricyclic farnesyl protein transferase inhibitors

Also Published As

Publication number Publication date
KR20010081116A (ko) 2001-08-27
JP2002533336A (ja) 2002-10-08
WO2000037459A1 (en) 2000-06-29
PE20001342A1 (es) 2000-12-09
NO20012961D0 (no) 2001-06-15
CN1326850C (zh) 2007-07-18
CA2354779A1 (en) 2000-06-29
SK7592001A3 (en) 2002-03-05
ZA200104233B (en) 2002-08-22
NO20012961L (no) 2001-08-16
CO5160350A1 (es) 2002-05-30
TR200101755T2 (tr) 2001-09-21
IL143408A0 (en) 2002-04-21
AR021718A1 (es) 2002-07-31
CN1334811A (zh) 2002-02-06
AU776558B2 (en) 2004-09-16
PL348293A1 (en) 2002-05-20
NZ511878A (en) 2003-10-31
HUP0202152A2 (en) 2002-10-28
EP1140902A1 (en) 2001-10-10
CZ20011950A3 (cs) 2001-12-12
AU2030700A (en) 2000-07-12

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5O, 6O E 7O ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1913 DE 04/09/2007.