[go: up one dir, main page]

IL143408A0 - Tricyclic farnesyl protein transferase inhibitors - Google Patents

Tricyclic farnesyl protein transferase inhibitors

Info

Publication number
IL143408A0
IL143408A0 IL14340899A IL14340899A IL143408A0 IL 143408 A0 IL143408 A0 IL 143408A0 IL 14340899 A IL14340899 A IL 14340899A IL 14340899 A IL14340899 A IL 14340899A IL 143408 A0 IL143408 A0 IL 143408A0
Authority
IL
Israel
Prior art keywords
protein transferase
transferase inhibitors
farnesyl protein
tricyclic farnesyl
tricyclic
Prior art date
Application number
IL14340899A
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of IL143408A0 publication Critical patent/IL143408A0/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Electroluminescent Light Sources (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL14340899A 1998-12-18 1999-12-16 Tricyclic farnesyl protein transferase inhibitors IL143408A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21639898A 1998-12-18 1998-12-18
PCT/US1999/027939 WO2000037459A1 (en) 1998-12-18 1999-12-16 Tricyclic farnesyl protein transferase inhibitors

Publications (1)

Publication Number Publication Date
IL143408A0 true IL143408A0 (en) 2002-04-21

Family

ID=22806914

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14340899A IL143408A0 (en) 1998-12-18 1999-12-16 Tricyclic farnesyl protein transferase inhibitors

Country Status (20)

Country Link
EP (1) EP1140902A1 (en)
JP (1) JP2002533336A (en)
KR (1) KR20010081116A (en)
CN (1) CN1326850C (en)
AR (1) AR021718A1 (en)
AU (1) AU776558B2 (en)
BR (1) BR9916314A (en)
CA (1) CA2354779A1 (en)
CO (1) CO5160350A1 (en)
CZ (1) CZ20011950A3 (en)
HU (1) HUP0202152A2 (en)
IL (1) IL143408A0 (en)
NO (1) NO20012961L (en)
NZ (1) NZ511878A (en)
PE (1) PE20001342A1 (en)
PL (1) PL348293A1 (en)
SK (1) SK7592001A3 (en)
TR (1) TR200101755T2 (en)
WO (1) WO2000037459A1 (en)
ZA (1) ZA200104233B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ20011950A3 (en) 1998-12-18 2001-12-12 Schering Corporation Compound according to general formula of a tricyclic compound; use thereof, method of treating tumor cells, inhibition method of farnesylprotein transferase and pharmaceutical preparation
US7342016B2 (en) 2000-08-30 2008-03-11 Schering Corporation Farnesyl protein transferase inhibitors as antitumor agents
US6645966B2 (en) 2001-01-22 2003-11-11 Schering Corporation Treatment of malaria with farnesyl protein transferase inhibitors
AU2002257114A1 (en) * 2001-04-06 2002-10-21 Schering Corporation Treatment of malaria with farsenyl protein transferase inhibitors
EP1838324A2 (en) * 2004-12-13 2007-10-03 Schering Corporation Novel farnesyl protein transferase inhibitors and their use to treat cancer
WO2006065794A1 (en) * 2004-12-14 2006-06-22 Schering Corporation Farnesyl protein transferase inhibitors and methods for treating proliferative diseases
JP2009523799A (en) * 2006-01-19 2009-06-25 シェーリング コーポレイション Piperazine derivatives as farnesyl protein transferase inhibitors
MX2016012060A (en) 2014-03-19 2017-01-19 Viamet Pharmaceuticals Inc 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-y l)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation.
MX371291B (en) 2014-03-19 2020-01-24 Viamet Pharmaceuticals Nc Inc 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-y l)-3-(1h-tetrazol-1-yl)propan-2-ols and proceses for their preparation.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL111235A (en) 1993-10-15 2001-03-19 Schering Plough Corp Pharmaceutical compositions for inhibition of g-protein function and for treatment of proliferative diseases containing tricyclic compounds some such compounds and process for preparing part of them
US5712280A (en) 1995-04-07 1998-01-27 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5801175A (en) 1995-04-07 1998-09-01 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases and pharmaceutical compositions comprising them
PE92098A1 (en) * 1996-07-31 1998-12-31 Schering Corp TRICYCLIC N-CYANOIMINES USEFUL AS PROTEIN TRANSFERASE INHIBITORS FARNESILO
KR100640672B1 (en) * 1997-06-17 2006-11-02 파마코페이아 드럭 디스커버리, 인크. Benzpyrido Cycloheptane Compounds Useful for Inhibiting Farnesyl Protein Transferase and Pharmaceutical Compositions Comprising the Same
CZ20011950A3 (en) 1998-12-18 2001-12-12 Schering Corporation Compound according to general formula of a tricyclic compound; use thereof, method of treating tumor cells, inhibition method of farnesylprotein transferase and pharmaceutical preparation

Also Published As

Publication number Publication date
SK7592001A3 (en) 2002-03-05
AU2030700A (en) 2000-07-12
KR20010081116A (en) 2001-08-27
BR9916314A (en) 2001-10-02
HUP0202152A2 (en) 2002-10-28
NZ511878A (en) 2003-10-31
CA2354779A1 (en) 2000-06-29
CO5160350A1 (en) 2002-05-30
TR200101755T2 (en) 2001-09-21
AU776558B2 (en) 2004-09-16
EP1140902A1 (en) 2001-10-10
CN1326850C (en) 2007-07-18
NO20012961D0 (en) 2001-06-15
JP2002533336A (en) 2002-10-08
PL348293A1 (en) 2002-05-20
CN1334811A (en) 2002-02-06
CZ20011950A3 (en) 2001-12-12
ZA200104233B (en) 2002-08-22
NO20012961L (en) 2001-08-16
PE20001342A1 (en) 2000-12-09
AR021718A1 (en) 2002-07-31
WO2000037459A1 (en) 2000-06-29

Similar Documents

Publication Publication Date Title
ZA985778B (en) Inhibitors of farnesyl protein transferase.
HUP9902016A3 (en) Inhibitors of farnesyl protein transferase
IL126833A0 (en) Inhibitors of protein farnesyl transferase
EP0918771A4 (en) Thiadioxobenzodiazepine inhibitors of farnesyl protein transferase
PL348294A1 (en) Farnesyl protein transferase inhibitors
PL347979A1 (en) Farnesyl protein transferase inhibitors with in vivo
EP1027042A4 (en) Inhibitors of farnesyl protein transferase
AU2001235496A1 (en) Farnesyl protein transferase inhibitor combinations with anti-tumor alkylating agents
HK1054548A1 (en) Tricyclic antitumor compounds being farnesyl protein transferase inhibitors
AU4020897A (en) 3-mercaptopyrrolidines as farnesyl protein transferase inhibitors
IL143408A0 (en) Tricyclic farnesyl protein transferase inhibitors
AU2435199A (en) Farnesyl transferase inhibitors
PL355887A1 (en) Farnesyl transferase inhibitors
IL130453A0 (en) Farnesyl transferase inhibitors
AU3514302A (en) 0ovel farnesyl protein transferase inhibitors
ZA985210B (en) Compounds for the inhibition of farnesyl protein transferase
IL141626A0 (en) Farnesyl transferase inhibitors
ZA971254B (en) Farnesyl transferase inhibitors
IL155594A0 (en) Farnesyl transferase inhibitors
SI0948483T1 (en) Farnesyl transferase inhibitors
IL149870A0 (en) Inhibitors of farnesyl protein transferase
HUP9903221A3 (en) Inhibitors of protein farnesyl transferase
ZA971621B (en) Inhibitors of farnesyl protein transferase