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BR9808588A - Ecteinascidinas e ecteinascidinas de n-óxido substituìdas por nucleófilo - Google Patents

Ecteinascidinas e ecteinascidinas de n-óxido substituìdas por nucleófilo

Info

Publication number
BR9808588A
BR9808588A BR9808588-3A BR9808588A BR9808588A BR 9808588 A BR9808588 A BR 9808588A BR 9808588 A BR9808588 A BR 9808588A BR 9808588 A BR9808588 A BR 9808588A
Authority
BR
Brazil
Prior art keywords
ecteinascidins
compounds
oxide
nucleophile
substituted
Prior art date
Application number
BR9808588-3A
Other languages
English (en)
Inventor
Kenneth L Rinehart
Tong Zhou
Original Assignee
Univ Illinois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Illinois filed Critical Univ Illinois
Publication of BR9808588A publication Critical patent/BR9808588A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/58—1,2-Diazines; Hydrogenated 1,2-diazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Agronomy & Crop Science (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Epoxy Compounds (AREA)

Abstract

Patente de Invenção: <B>"ECTEINASCIDINAS E ECTEINASCIDINAS DE N-óXIDO SUBSTITUìDAS POR NUCLEóFILO"<D>. Cinco novos compostos de ecteinascidina (Et) substituída por nucleófilo foram isolados de Ecteinascidia turbinata. Estes compostos foram purificados por técnicas cromatográficas e foram determinadas suas estruturas e bioatividades. Os cinco compostos de Et substituída por nucleófilo foram designados neste caso como Et 802 (1), Et 788 (2), Et 760 (3), Et 858 (4) e Et 815 (5). Também foram obtidos três novos compostos de ecteinascidinas de N-óxido, que foram designados neste caso como Et 717 (6), Et 775 (7) e Et 789 (8). Alguns destes compostos de Et recentemente verificados apresentam citotoxicidez excessivamente potente contra L1210.
BR9808588-3A 1997-04-15 1998-04-14 Ecteinascidinas e ecteinascidinas de n-óxido substituìdas por nucleófilo BR9808588A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4359697P 1997-04-15 1997-04-15
PCT/US1998/007340 WO1998046080A1 (en) 1997-04-15 1998-04-14 Nucleophile substituted ecteinascidins and n-oxide ecteinascidins

Publications (1)

Publication Number Publication Date
BR9808588A true BR9808588A (pt) 2000-05-23

Family

ID=21927969

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9808588-3A BR9808588A (pt) 1997-04-15 1998-04-14 Ecteinascidinas e ecteinascidinas de n-óxido substituìdas por nucleófilo

Country Status (20)

Country Link
US (1) US5985876A (pt)
EP (2) EP0975218A4 (pt)
JP (1) JP4382164B2 (pt)
KR (1) KR100513668B1 (pt)
CN (1) CN100343235C (pt)
AT (1) ATE420092T1 (pt)
AU (1) AU747303B2 (pt)
BR (1) BR9808588A (pt)
CA (1) CA2286796C (pt)
CY (1) CY1108958T1 (pt)
CZ (1) CZ298842B6 (pt)
DE (1) DE69840458D1 (pt)
DK (1) DK1668985T3 (pt)
ES (1) ES2321019T3 (pt)
HU (1) HUP0103590A3 (pt)
IL (1) IL132403A (pt)
NO (1) NO327455B1 (pt)
PL (2) PL197708B1 (pt)
PT (1) PT1668985E (pt)
WO (1) WO1998046080A1 (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040059112A1 (en) * 1994-02-18 2004-03-25 Rinehart Kenneth L. Ecteinascidins
DE69923965T2 (de) * 1998-05-11 2006-04-06 Pharma Mar, S.A., Tres Cantos Ecteinascidinderivate
MY164077A (en) * 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
MY130271A (en) * 1999-05-14 2007-06-29 Pharma Mar Sa Hemisynthetic method and new compounds
PL210703B1 (pl) * 2000-04-12 2012-02-29 Pharma Mar Związek ekteinascydynowy, kompozycja farmaceutyczna oraz zastosowanie związku ekteinascydynowego
US7919493B2 (en) * 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
MXPA02011319A (es) * 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
US7420051B2 (en) * 2000-05-15 2008-09-02 Pharma Mar, S.A. Synthetic process for the manufacture of an ecteinaschidin compound
IL155781A0 (en) * 2000-11-06 2003-12-23 Pharma Mar Sa Effective antitumor treatments
GB0117402D0 (en) * 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0119243D0 (en) * 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
JP2007511499A (ja) * 2003-11-13 2007-05-10 ファーマ・マール・エス・アー・ウー コンビネーション
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
CA2545054A1 (en) * 2003-11-14 2005-06-02 Pharma Mar, S.A. Combination therapy comprising the use of et-743 and paclitaxel for treating cancer
CA2573072A1 (en) * 2004-07-09 2006-01-19 Rafael Rosell Costa Use of ecteinascidin in the treatment of cancer in patients with low level of brca1
US20080242670A2 (en) * 2004-09-29 2008-10-02 Pharma Mar S.A., Sociedad Unipersonal Anti-Inflammatory Agents
ES2326825T3 (es) * 2004-10-26 2009-10-20 Pharma Mar S.A., Sociedad Unipersonal Doxorubicina liposomal pegilada en combinacion con ecteinascidina 743.
RS50510B (sr) 2004-10-29 2010-03-02 Pharma Mar S.A., Sociedad Unipersonal Formulacije koje sadrže ekteinascidin i disaharid
GB0522082D0 (en) 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
WO2009050303A1 (en) * 2007-10-19 2009-04-23 Pharma Mar, S.A. Prognostic molecular markers for et-743 treatment
EP2786753B1 (en) 2010-11-12 2019-01-09 Pharma Mar S.A. Combination therapy with an antitumor antibiotic
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4273773A (en) * 1979-09-24 1981-06-16 American Home Products Corporation Antihypertensive tricyclic isoindole derivatives
US5089273A (en) * 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
DK0574857T3 (da) * 1992-06-19 1998-05-04 Hoechst Ag Polycycliske 31668P- og 31668U-forbindelser, fremgangsmåder til deres fremstilling samt deres anvendelse som antibiotiske eller antitumorale lægemidler
US5426108A (en) * 1993-11-10 1995-06-20 American Cyanamid Company Antibiotic 31F508 ALPHA1, ALPHA2, BETA1 and BETA2
WO1999051238A1 (en) * 1998-04-06 1999-10-14 The Board Of Trustees Of The University Of Illinois Semi-synthetic ecteinascidins

Also Published As

Publication number Publication date
IL132403A0 (en) 2001-03-19
US5985876A (en) 1999-11-16
AU747303B2 (en) 2002-05-16
JP4382164B2 (ja) 2009-12-09
IL132403A (en) 2004-09-27
CZ367999A3 (cs) 2000-07-12
CZ298842B6 (cs) 2008-02-20
DK1668985T3 (da) 2009-05-04
HUP0103590A2 (hu) 2002-01-28
JP2001523228A (ja) 2001-11-20
DE69840458D1 (de) 2009-02-26
CA2286796C (en) 2008-08-05
EP0975218A4 (en) 2001-08-08
HUP0103590A3 (en) 2002-07-29
ES2321019T3 (es) 2009-06-01
CN100343235C (zh) 2007-10-17
WO1998046080A1 (en) 1998-10-22
EP1668985A3 (en) 2006-11-22
CY1108958T1 (el) 2012-05-23
ATE420092T1 (de) 2009-01-15
EP0975218A1 (en) 2000-02-02
PL197708B1 (pl) 2008-04-30
NO995016D0 (no) 1999-10-14
EP1668985A2 (en) 2006-06-14
AU7111498A (en) 1998-11-11
PL338508A1 (en) 2000-11-06
KR100513668B1 (ko) 2005-09-08
NO327455B1 (no) 2009-07-06
NO995016L (no) 1999-12-10
CN1261254A (zh) 2000-07-26
EP1668985B1 (en) 2009-01-07
CA2286796A1 (en) 1998-10-22
KR20010006402A (ko) 2001-01-26
PT1668985E (pt) 2009-04-09

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DE INT.CI: A61K 35/56; A61P 35/00; C07D 519/00

Ipc: A61K 35/56 (2008.04), A61P 35/00 (2008.04), C07D 5

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 37, INDEFIRO O PRESENTE PEDIDO, TENDO POR BASE OS ARTIGOS 8O E 13 DA LEI 9279 DE 14/05/1996.

B12B Appeal against refusal [chapter 12.2 patent gazette]
B08L Patent application lapsed because of non payment of annual fee [chapter 8.12 patent gazette]

Free format text: REFERENTE AO NAO RECOLHIMENTO DAS 14A, 15A E 16A ANUIDADES.

B08I Publication cancelled [chapter 8.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 8.12 NA RPI NO 2256 DE 01/04/2014 POR TER SIDO INDEVIDA.