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BR9807944A - Derivados antimitóticos dos alcalóides da vinca, compostos, processo para preparar os compostos, processo para preparar a 4'-desóki-20', 20'-difluorovinblastina, processo para preparar a 20', 20'-diflúoro-3', 4'-diidrovinorrelbina ou vinflunina, produtos medicinais, e, composição farmacêutica - Google Patents

Derivados antimitóticos dos alcalóides da vinca, compostos, processo para preparar os compostos, processo para preparar a 4'-desóki-20', 20'-difluorovinblastina, processo para preparar a 20', 20'-diflúoro-3', 4'-diidrovinorrelbina ou vinflunina, produtos medicinais, e, composição farmacêutica

Info

Publication number
BR9807944A
BR9807944A BR9807944-1A BR9807944A BR9807944A BR 9807944 A BR9807944 A BR 9807944A BR 9807944 A BR9807944 A BR 9807944A BR 9807944 A BR9807944 A BR 9807944A
Authority
BR
Brazil
Prior art keywords
preparing
compounds
derivatives
difluorovinblastine
dihydrovinorelbine
Prior art date
Application number
BR9807944-1A
Other languages
English (en)
Other versions
BR9807944B1 (pt
Inventor
Alain Duflos
Jacques Fahy
Valerie Thillaye Du Boulay
Jean-Marc Barret
Bridget Hill
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pf Medicament filed Critical Pf Medicament
Publication of BR9807944A publication Critical patent/BR9807944A/pt
Publication of BR9807944B1 publication Critical patent/BR9807944B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Saccharide Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"DERIVADOS ANTIMITóTICOS DOS ALCALóIDES DA VINCA, COMPOSTOS, PROCESSO PARA PREPARAR OS COMPOSTOS, PROCESSO PARA PREPARAR A 4'-DESóXI-20', 20'-DIFLUOROVINBLASTINA, PROCESSO PARA PREPARAR A 20', 20'-DIFLúORO-3',4'-DIIDROVINORRELBINA OU VINFLUNINA, PRODUTOS MEDICINAIS, E, COMPOSIçãO FARMACêUTICA". A invenção diz respeito a derivados halogenados da família da vinblastina e da vinorrelbina, que correpondem à fórmula geral (I): e seus sais terapeuticamente aceitáveis. A invenção também diz respeito a aplicação destes compostos em terapia e seus métodos de preparação. A invenção ainda diz respeito a um método para preparar a vinflunina ou a 20', 20-'difluoro-3-',4'-diidrovinorelbina, da fórmula (a).
BRPI9807944-1A 1997-04-10 1998-04-10 derivados antimitóticos dos alcalóides da vinca, processo para preparar os mesmos e uso dos derivados. BR9807944B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR97/04398 1997-04-10
FR9704398A FR2761990B1 (fr) 1997-04-10 1997-04-10 Derives halogenes antimitotiques d'alcaloides de vinca
PCT/FR1998/000730 WO1998045301A1 (fr) 1997-04-10 1998-04-10 Derives halogenes antimitotiques d'alcaloides de vinca

Publications (2)

Publication Number Publication Date
BR9807944A true BR9807944A (pt) 2000-03-08
BR9807944B1 BR9807944B1 (pt) 2011-02-08

Family

ID=9505731

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI9816177-6A BR9816177B1 (pt) 1997-04-10 1998-04-10 processo para preparar a 4'-desàxi-20', 20'-difluorovinblastina, e, processo para preparar a vinflunina.
BRPI9807944-1A BR9807944B1 (pt) 1997-04-10 1998-04-10 derivados antimitóticos dos alcalóides da vinca, processo para preparar os mesmos e uso dos derivados.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI9816177-6A BR9816177B1 (pt) 1997-04-10 1998-04-10 processo para preparar a 4'-desàxi-20', 20'-difluorovinblastina, e, processo para preparar a vinflunina.

Country Status (15)

Country Link
US (1) US6127377A (pt)
EP (3) EP1357125A3 (pt)
JP (3) JP4401440B2 (pt)
AT (2) ATE473987T1 (pt)
AU (1) AU737549C (pt)
BR (2) BR9816177B1 (pt)
CA (3) CA2455416C (pt)
CY (2) CY1111476T1 (pt)
DE (3) DE69841766D1 (pt)
DK (2) DK0975640T3 (pt)
ES (2) ES2222588T3 (pt)
FR (2) FR2761990B1 (pt)
LU (1) LU91769I2 (pt)
PT (2) PT1764368E (pt)
WO (1) WO1998045301A1 (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2761990B1 (fr) * 1997-04-10 1999-06-25 Pf Medicament Derives halogenes antimitotiques d'alcaloides de vinca
US6890558B2 (en) * 2002-05-31 2005-05-10 R.P. Scherer Technologies, Inc. Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment
WO2005055943A2 (en) * 2003-12-04 2005-06-23 Amr Technology, Inc. Vinorelbine derivatives
NZ547370A (en) * 2003-12-04 2010-09-30 Amr Technology Inc Vinca derivatives
FR2863891B1 (fr) * 2003-12-23 2006-03-24 Pf Medicament Composition pharmaceutique de vinflunine destinee a une administration parentale, procede de preparation et utilisation
US20110015221A1 (en) * 2003-12-23 2011-01-20 Pierre Fabre Medicament Pharmaceutical composition of vinflunine which is intended for parenteral administration preparation method thereof and use of same
WO2006122408A1 (en) 2005-05-18 2006-11-23 Aegera Therapeutics Inc. Bir domain binding compounds
FR2894966B1 (fr) * 2005-12-20 2008-03-14 Pierre Fabre Medicament Sa Nouvelle forme cristalline de la vinflunine
KR101506466B1 (ko) 2006-05-16 2015-03-27 파마사이언스 인크. Ｉａｐ ｂｉｒ 도메인 결합 화합물
US8039453B2 (en) * 2006-09-12 2011-10-18 Albany Molecular Research, Inc. Vinca derivatives
US20080125451A1 (en) * 2006-09-12 2008-05-29 Amr Technology, Inc. Vinorelbine derivatives
FR2905949B1 (fr) 2006-09-20 2008-11-21 Pierre Fabre Medicament Sa Derives fluores de catharanthine, leur preparation et leur utilisation comme precurseurs d'alcaloides dimeres de vinca
FR2910812B1 (fr) 2006-12-29 2009-03-20 Pierre Fabre Medicament Sa Compositions pharmaceutiques injectables lyophilisees de derives hemi-synthetiques d'alcaloide de vinca stables a temperature ambiante
FR2912406B1 (fr) 2007-02-13 2009-05-08 Pierre Fabre Medicament Sa Sels cristalins anhydres de vinflunine, procede de preparation et utilisation en tant que medicament et moyen de purification de la vinflunine.
FR2918566B1 (fr) * 2007-07-11 2009-10-09 Pierre Fabre Medicament Sa Composition pharmaceutique stable d'un sel hydrosoluble de vinflunine.
FR2918567B1 (fr) * 2007-07-11 2012-08-03 Pf Medicament Composition pharmaceutique stable d'un sel hydrosoluble de vinorelbine.
US20090076055A1 (en) * 2007-09-14 2009-03-19 Protia, Llc Deuterium-enriched vinflunine
DE102010020994B4 (de) * 2010-01-27 2022-01-27 Interpane Entwicklungs-Und Beratungsgesellschaft Mbh Verfahren zur Herstellung eines beschichteten Gegenstands mit Texturätzen
AU2011214057B2 (en) 2010-02-12 2016-11-17 Pharmascience Inc. IAP BIR domain binding compounds
AU2011218391B2 (en) * 2010-02-22 2015-01-22 The Scripps Research Institute 10'-fluorinated vinca alkaloids provide enhanced biological activity against MDR cancer cells

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2707988B1 (fr) * 1993-07-21 1995-10-13 Pf Medicament Nouveaux dérivés antimitotiques des alcaloïdes binaires du catharantus rosesus, leur procédé de préparation et les compositions pharmaceutiques les comprenant.
FR2761990B1 (fr) * 1997-04-10 1999-06-25 Pf Medicament Derives halogenes antimitotiques d'alcaloides de vinca

Also Published As

Publication number Publication date
FR2761990A1 (fr) 1998-10-16
JP2001518892A (ja) 2001-10-16
JP4307292B2 (ja) 2009-08-05
DE69824840D1 (de) 2004-08-05
CA2286560A1 (fr) 1998-10-15
ATE473987T1 (de) 2010-07-15
ES2347878T3 (es) 2010-11-22
WO1998045301A1 (fr) 1998-10-15
EP0975640B1 (fr) 2004-06-30
CA2665949A1 (fr) 1998-10-15
CY2010019I1 (el) 2012-01-25
CA2286560C (fr) 2009-09-08
DK1764368T3 (da) 2010-10-18
DE69824840T2 (de) 2005-07-21
FR10C0045I2 (fr) 2011-04-29
CA2455416C (fr) 2010-11-02
BR9807944B1 (pt) 2011-02-08
ATE270297T1 (de) 2004-07-15
AU737549B2 (en) 2001-08-23
EP0975640A1 (fr) 2000-02-02
EP1764368A1 (fr) 2007-03-21
EP1764368B1 (fr) 2010-07-14
JP2009167196A (ja) 2009-07-30
EP1357125A2 (fr) 2003-10-29
AU7340898A (en) 1998-10-30
DK0975640T3 (da) 2004-11-01
DE122010000054I1 (de) 2011-05-05
CA2665949C (fr) 2013-06-11
LU91769I2 (fr) 2011-02-22
CA2455416A1 (fr) 1998-10-15
JP2004277418A (ja) 2004-10-07
US6127377A (en) 2000-10-03
BR9816177B1 (pt) 2010-08-24
AU737549C (en) 2002-03-28
PT1764368E (pt) 2010-09-16
ES2222588T3 (es) 2005-02-01
FR10C0045I1 (pt) 2010-10-29
FR2761990B1 (fr) 1999-06-25
PT975640E (pt) 2004-11-30
CY1111476T1 (el) 2012-01-25
CY2010019I2 (el) 2012-01-25
DE69841766D1 (de) 2010-08-26
JP4401440B2 (ja) 2010-01-20
EP1357125A3 (fr) 2003-11-26

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 08/02/2011, OBSERVADAS AS CONDICOES LEGAIS.

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 08.02.2021