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PT98371A - Processo para a preparacao de derivados 6-alcoxi de arabinofuranosil-guanina e de composicoes farmaceuticas que os contem - Google Patents

Processo para a preparacao de derivados 6-alcoxi de arabinofuranosil-guanina e de composicoes farmaceuticas que os contem

Info

Publication number
PT98371A
PT98371A PT98371A PT9837191A PT98371A PT 98371 A PT98371 A PT 98371A PT 98371 A PT98371 A PT 98371A PT 9837191 A PT9837191 A PT 9837191A PT 98371 A PT98371 A PT 98371A
Authority
PT
Portugal
Prior art keywords
preparation
derivatives
arabinofuranosil
alcoxi
guanin
Prior art date
Application number
PT98371A
Other languages
English (en)
Other versions
PT98371B (pt
Inventor
Thomas Anthony Krenitsky
George Walter Koszalka
Deveron Randolph Averett
Jeffrey Douglas Wilson
Allan Ray Moorman
Stanley Dawes Chamberlain
David Porter
Gerald Wolberg
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of PT98371A publication Critical patent/PT98371A/pt
Publication of PT98371B publication Critical patent/PT98371B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Earth Drilling (AREA)
  • Stereophonic System (AREA)
  • Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
PT98371A 1990-07-19 1991-07-18 Processo para a preparacao de derivados 6-alcoxi de arabinofuranosil-guanina e de composicoes farmaceuticas que os contem PT98371B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909015914A GB9015914D0 (en) 1990-07-19 1990-07-19 Heterocyclic compounds

Publications (2)

Publication Number Publication Date
PT98371A true PT98371A (pt) 1992-06-30
PT98371B PT98371B (pt) 1999-01-29

Family

ID=10679359

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98371A PT98371B (pt) 1990-07-19 1991-07-18 Processo para a preparacao de derivados 6-alcoxi de arabinofuranosil-guanina e de composicoes farmaceuticas que os contem

Country Status (23)

Country Link
US (3) US5492897A (pt)
EP (1) EP0539479B1 (pt)
JP (1) JP2873086B2 (pt)
KR (1) KR100187326B1 (pt)
AT (1) ATE151637T1 (pt)
CA (1) CA2087543C (pt)
CY (1) CY2165B1 (pt)
DE (1) DE69125715T2 (pt)
DK (1) DK0539479T3 (pt)
ES (1) ES2103311T3 (pt)
GB (1) GB9015914D0 (pt)
GR (1) GR3023776T3 (pt)
HU (2) HUT62911A (pt)
IE (1) IE912513A1 (pt)
IL (1) IL98881A (pt)
MC (1) MC2289A1 (pt)
MY (1) MY111871A (pt)
NZ (1) NZ239025A (pt)
PT (1) PT98371B (pt)
RU (1) RU2114860C1 (pt)
TW (1) TW208655B (pt)
WO (1) WO1992001456A1 (pt)
ZA (1) ZA915656B (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9015914D0 (en) * 1990-07-19 1990-09-05 Wellcome Found Heterocyclic compounds
WO1998042352A1 (en) * 1997-03-24 1998-10-01 Glaxo Group Ltd. Method for treating b-cell tumors with ara-g nucleoside derivatives
DE69935718T2 (de) * 1998-07-02 2007-12-27 Kyowa Hakko Kogyo Co., Ltd. Antidiabetische medikamente
US6753322B2 (en) * 2000-06-06 2004-06-22 Pfizer Inc 2-aminocarbonyl-9H-purine derivatives
US7321033B2 (en) * 2001-11-27 2008-01-22 Anadys Pharmaceuticals, Inc. 3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof
BR0214407A (pt) 2001-11-27 2004-10-19 Anadys Pharmaceuticals Inc Compostos, composições farmacêuticas e método de modulação das imunoatividades da citocina
US20040127435A1 (en) * 2002-08-02 2004-07-01 Regents Of The University Of California Uses for inhibitors of inosine monophosphate dehydrogenase
AP2006003542A0 (en) * 2003-09-05 2006-04-30 Anadys Pharmaceuticals Inc Administration of TLR7 ligands and prodrugs for treatment of infection by hepatitis C virus.
GB0321613D0 (en) * 2003-09-15 2003-10-15 Drug Discovery Lab As Compounds
EP1804838A2 (en) * 2004-09-15 2007-07-11 Drug Discovery Laboratory AS Drug conjugates of long chain fatty acid or ester moieties as protein binding prodrugs
EP1814390A4 (en) * 2004-11-12 2009-07-01 Univ Northwestern METHOD FOR THE TREATMENT OF MOLECULAR BLOOD DISEASES WITH NUCLEOSIDE ANALOGUE
NZ555723A (en) 2004-12-17 2010-07-30 Anadys Pharmaceuticals Inc 3,5-disubstituted and 3,5,7-trisubstituted-3H-oxazolo and 3H-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof
US20060189543A1 (en) * 2005-02-23 2006-08-24 Rosenbloom Richard A Compositions and methods for the treatment of leukemia
CN101365705A (zh) 2005-11-21 2009-02-11 安那迪斯药品股份有限公司 制备5-氨基-3H-噻唑并[4,5-d]嘧啶-2-酮的方法
JP5345527B2 (ja) * 2006-06-22 2013-11-20 アナディス ファーマシューティカルズ インク プロドラッグである５−アミノ−３−（３’−デオキシ−β−Ｄ−リボフラノシル）−チアゾロ［４，５−ｄ］ピリミジン−２，７−ジオン
ATE499940T1 (de) 2006-07-18 2011-03-15 Anadys Pharmaceuticals Inc Carbonat- und carbamat-prodrugs von thiazolo ä4,5-dü-pyrimidinen
CN101768197A (zh) * 2008-12-29 2010-07-07 北京德众万全药物技术开发有限公司 一种奈拉滨的制备方法
WO2012092484A2 (en) * 2010-12-29 2012-07-05 Inhibitex, Inc. Substituted purine nucleosides, phosphoroamidate and phosphorodiamidate derivatives for treatment of viral infections
WO2018230479A1 (ja) * 2017-06-13 2018-12-20 大原薬品工業株式会社 ヌクレオシド系抗がん剤又は抗ウィルス剤の５'位シリルエーテル誘導体
CN113735862B (zh) * 2020-12-30 2024-02-02 南方科技大学 一种治疗病毒感染的核苷类化合物及其用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2152486A1 (de) * 1970-11-20 1972-06-29 Akad Wissenschaften Ddr Verfahren zur Herstellung von 5'-Desoxy-5'-fluor-6-methyl-mercaptopurinribosid
US3872084A (en) * 1972-10-10 1975-03-18 Syntex Inc Purine nucleoside 3,5-cyclicphosphate compounds
US4081534A (en) * 1973-09-11 1978-03-28 Burroughs Wellcome Co. Amino purine nucleosides as autoimmune suppressant agents
GB1573777A (en) * 1977-11-03 1980-08-28 Wellcome Found 9-d-arabinonucleosides and an enzymatic process for their preparation
JPS61233696A (ja) * 1985-04-08 1986-10-17 Kanegafuchi Chem Ind Co Ltd ７−ヒドロキシグアニン誘導体及びその製造方法並びにそれを有効成分とする抗腫瘍剤
GB8712745D0 (en) * 1987-05-30 1987-07-01 Wellcome Found Antiviral compounds
CA1317291C (en) * 1987-12-14 1993-05-04 Naeem Botros Hanna Antitumor 6-sulfenamide, 6-sulfinamide and 6-sulfonamide purines, purine nucleosides, purine nucleotides and related compounds
US5352669A (en) * 1990-03-13 1994-10-04 The Of The United States Of America As Represented By The Department Of Health And Human Services O6 -benzylated guanine, guanosine and 2'-deoxyguanosine compounds possessing O6 -alkylguanine-DNA alkyltransferase depleting activity
GB9015914D0 (en) * 1990-07-19 1990-09-05 Wellcome Found Heterocyclic compounds

Also Published As

Publication number Publication date
HUT62911A (en) 1993-06-28
NZ239025A (en) 1993-08-26
MC2289A1 (fr) 1993-07-14
JP2873086B2 (ja) 1999-03-24
ZA915656B (en) 1993-03-31
DK0539479T3 (da) 1997-08-25
WO1992001456A1 (en) 1992-02-06
DE69125715T2 (de) 1997-08-07
CA2087543C (en) 1998-08-25
EP0539479B1 (en) 1997-04-16
MY111871A (en) 2001-02-28
PT98371B (pt) 1999-01-29
US5821236A (en) 1998-10-13
IL98881A (en) 1996-01-19
GB9015914D0 (en) 1990-09-05
TW208655B (pt) 1993-07-01
CA2087543A1 (en) 1992-01-20
RU2114860C1 (ru) 1998-07-10
IL98881A0 (en) 1992-07-15
EP0539479A1 (en) 1993-05-05
GR3023776T3 (en) 1997-09-30
KR100187326B1 (ko) 1999-05-01
ES2103311T3 (es) 1997-09-16
IE912513A1 (en) 1992-01-29
HU9300115D0 (en) 1993-04-28
DE69125715D1 (de) 1997-05-22
US5747472A (en) 1998-05-05
ATE151637T1 (de) 1997-05-15
CY2165B1 (en) 2002-08-23
US5492897A (en) 1996-02-20
AU8196091A (en) 1992-02-18
JPH05508649A (ja) 1993-12-02
AU641533B2 (en) 1993-09-23

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Legal Events

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BB1A Laying open of patent application

Effective date: 19920122

FG3A Patent granted, date of granting

Effective date: 19981008

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20131008