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DE69125715D1 - Heterozyklische verbindungen - Google Patents

Heterozyklische verbindungen

Info

Publication number
DE69125715D1
DE69125715D1 DE69125715T DE69125715T DE69125715D1 DE 69125715 D1 DE69125715 D1 DE 69125715D1 DE 69125715 T DE69125715 T DE 69125715T DE 69125715 T DE69125715 T DE 69125715T DE 69125715 D1 DE69125715 D1 DE 69125715D1
Authority
DE
Germany
Prior art keywords
pharmaceutically acceptable
acceptable esters
heterocyclic
connections
heterocyclic connections
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69125715T
Other languages
English (en)
Other versions
DE69125715T2 (de
Inventor
Thomas Krenitsky
Devron Averett
Jeffrey Wilson
Allan Moorman
George KOSZALKA
Stanley Chamberlain
David Porter
Gerald Wolberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of DE69125715D1 publication Critical patent/DE69125715D1/de
Application granted granted Critical
Publication of DE69125715T2 publication Critical patent/DE69125715T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Earth Drilling (AREA)
  • Stereophonic System (AREA)
  • Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
DE69125715T 1990-07-19 1991-07-18 Heterozyklische verbindungen Expired - Lifetime DE69125715T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909015914A GB9015914D0 (en) 1990-07-19 1990-07-19 Heterocyclic compounds
PCT/GB1991/001196 WO1992001456A1 (en) 1990-07-19 1991-07-18 Heterocyclic compounds

Publications (2)

Publication Number Publication Date
DE69125715D1 true DE69125715D1 (de) 1997-05-22
DE69125715T2 DE69125715T2 (de) 1997-08-07

Family

ID=10679359

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69125715T Expired - Lifetime DE69125715T2 (de) 1990-07-19 1991-07-18 Heterozyklische verbindungen

Country Status (23)

Country Link
US (3) US5492897A (de)
EP (1) EP0539479B1 (de)
JP (1) JP2873086B2 (de)
KR (1) KR100187326B1 (de)
AT (1) ATE151637T1 (de)
CA (1) CA2087543C (de)
CY (1) CY2165B1 (de)
DE (1) DE69125715T2 (de)
DK (1) DK0539479T3 (de)
ES (1) ES2103311T3 (de)
GB (1) GB9015914D0 (de)
GR (1) GR3023776T3 (de)
HU (2) HUT62911A (de)
IE (1) IE912513A1 (de)
IL (1) IL98881A (de)
MC (1) MC2289A1 (de)
MY (1) MY111871A (de)
NZ (1) NZ239025A (de)
PT (1) PT98371B (de)
RU (1) RU2114860C1 (de)
TW (1) TW208655B (de)
WO (1) WO1992001456A1 (de)
ZA (1) ZA915656B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9015914D0 (en) * 1990-07-19 1990-09-05 Wellcome Found Heterocyclic compounds
AU6771198A (en) * 1997-03-24 1998-10-20 Glaxo Group Limited Method for treating b-cell tumors with ara-g nucleoside derivatives
DE69935718T2 (de) * 1998-07-02 2007-12-27 Kyowa Hakko Kogyo Co., Ltd. Antidiabetische medikamente
US6753322B2 (en) * 2000-06-06 2004-06-22 Pfizer Inc 2-aminocarbonyl-9H-purine derivatives
AU2002365412B2 (en) * 2001-11-27 2008-10-09 Anadys Pharmaceuticals, Inc. 3-Beta-D-ribofuranosylthiazolo[4,5-d]pyrimidine nucleosides and uses thereof
US7321033B2 (en) * 2001-11-27 2008-01-22 Anadys Pharmaceuticals, Inc. 3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof
WO2004012746A2 (en) * 2002-08-02 2004-02-12 The Regents Of The University Of California New uses for inhibitors of inosine monophosphate dehydrogenase
EA200600540A1 (ru) * 2003-09-05 2006-08-25 Анадис Фармасьютикалз, Инк. Введение лигандов tlr7 и их пролекарств для лечения инфекции вируса гепатита с
GB0321613D0 (en) * 2003-09-15 2003-10-15 Drug Discovery Lab As Compounds
WO2006030217A2 (en) * 2004-09-15 2006-03-23 Drug Discovery Laboratory As Drug conjugates of long chain fatty acid or ester moieties as protein binding prodrugs
EP1814390A4 (de) * 2004-11-12 2009-07-01 Univ Northwestern Verfahren zur behandlung von bösartigen blutkrankheiten mit nucleosid-analoga
EP2561872B1 (de) * 2004-12-17 2014-09-10 Anadys Pharmaceuticals, Inc. 3, 5-DISUBSTITUTIERTE UND 3,5,7-TRISUBSTITUIERTE 3H-OXAZOLO [4,5-d]PYRIMIDIN-2-ON VERBINDUNGEN UND PRODRUGS
US20060189543A1 (en) * 2005-02-23 2006-08-24 Rosenbloom Richard A Compositions and methods for the treatment of leukemia
TWI383987B (zh) 2005-11-21 2013-02-01 Anadys Pharmaceuticals Inc 製備５-胺基-３Ｈ-噻唑并〔４，５-ｄ〕嘧啶-２-酮之新穎方法
KR101461604B1 (ko) * 2006-06-22 2014-11-18 애나디스 파마슈티칼스, 인코포레이티드 5-아미노-3-(3''-데옥시-β-Ｄ-리보퓨라노실)-티아졸로［4,5-ｄ］파이리미딘-2,7-다이온의 프로드럭
ATE499940T1 (de) 2006-07-18 2011-03-15 Anadys Pharmaceuticals Inc Carbonat- und carbamat-prodrugs von thiazolo ä4,5-dü-pyrimidinen
CN101768197A (zh) * 2008-12-29 2010-07-07 北京德众万全药物技术开发有限公司 一种奈拉滨的制备方法
WO2012092484A2 (en) * 2010-12-29 2012-07-05 Inhibitex, Inc. Substituted purine nucleosides, phosphoroamidate and phosphorodiamidate derivatives for treatment of viral infections
WO2018230479A1 (ja) * 2017-06-13 2018-12-20 大原薬品工業株式会社 ヌクレオシド系抗がん剤又は抗ウィルス剤の５'位シリルエーテル誘導体
AU2021414592A1 (en) * 2020-12-30 2023-08-10 Southern University Of Science And Technology Methods and modified nucleosides for treating coronavirus infections

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2152486A1 (de) * 1970-11-20 1972-06-29 Akad Wissenschaften Ddr Verfahren zur Herstellung von 5'-Desoxy-5'-fluor-6-methyl-mercaptopurinribosid
US3872084A (en) * 1972-10-10 1975-03-18 Syntex Inc Purine nucleoside 3,5-cyclicphosphate compounds
US4081534A (en) * 1973-09-11 1978-03-28 Burroughs Wellcome Co. Amino purine nucleosides as autoimmune suppressant agents
GB1573777A (en) * 1977-11-03 1980-08-28 Wellcome Found 9-d-arabinonucleosides and an enzymatic process for their preparation
JPS61233696A (ja) * 1985-04-08 1986-10-17 Kanegafuchi Chem Ind Co Ltd ７−ヒドロキシグアニン誘導体及びその製造方法並びにそれを有効成分とする抗腫瘍剤
GB8712745D0 (en) * 1987-05-30 1987-07-01 Wellcome Found Antiviral compounds
CA1317291C (en) * 1987-12-14 1993-05-04 Naeem Botros Hanna Antitumor 6-sulfenamide, 6-sulfinamide and 6-sulfonamide purines, purine nucleosides, purine nucleotides and related compounds
US5352669A (en) * 1990-03-13 1994-10-04 The Of The United States Of America As Represented By The Department Of Health And Human Services O6 -benzylated guanine, guanosine and 2'-deoxyguanosine compounds possessing O6 -alkylguanine-DNA alkyltransferase depleting activity
GB9015914D0 (en) * 1990-07-19 1990-09-05 Wellcome Found Heterocyclic compounds

Also Published As

Publication number Publication date
NZ239025A (en) 1993-08-26
US5747472A (en) 1998-05-05
IL98881A0 (en) 1992-07-15
WO1992001456A1 (en) 1992-02-06
AU8196091A (en) 1992-02-18
JPH05508649A (ja) 1993-12-02
EP0539479A1 (de) 1993-05-05
RU2114860C1 (ru) 1998-07-10
HU9300115D0 (en) 1993-04-28
TW208655B (de) 1993-07-01
CY2165B1 (en) 2002-08-23
DE69125715T2 (de) 1997-08-07
PT98371A (pt) 1992-06-30
IL98881A (en) 1996-01-19
ZA915656B (en) 1993-03-31
GR3023776T3 (en) 1997-09-30
PT98371B (pt) 1999-01-29
HUT62911A (en) 1993-06-28
JP2873086B2 (ja) 1999-03-24
ES2103311T3 (es) 1997-09-16
US5821236A (en) 1998-10-13
KR100187326B1 (ko) 1999-05-01
US5492897A (en) 1996-02-20
CA2087543A1 (en) 1992-01-20
EP0539479B1 (de) 1997-04-16
MC2289A1 (fr) 1993-07-14
DK0539479T3 (da) 1997-08-25
CA2087543C (en) 1998-08-25
IE912513A1 (en) 1992-01-29
GB9015914D0 (en) 1990-09-05
ATE151637T1 (de) 1997-05-15
AU641533B2 (en) 1993-09-23
MY111871A (en) 2001-02-28

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