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IT1213033B - Esteri di n-alchil-nortropine eloro derivati ammonioquaternari aventi attivita'anti-broncospastica, procedimento per la loro preparazione e composizioni farmaceutiche che licontengono. - Google Patents

Esteri di n-alchil-nortropine eloro derivati ammonioquaternari aventi attivita'anti-broncospastica, procedimento per la loro preparazione e composizioni farmaceutiche che licontengono.

Info

Publication number
IT1213033B
IT1213033B IT8619371A IT1937186A IT1213033B IT 1213033 B IT1213033 B IT 1213033B IT 8619371 A IT8619371 A IT 8619371A IT 1937186 A IT1937186 A IT 1937186A IT 1213033 B IT1213033 B IT 1213033B
Authority
IT
Italy
Prior art keywords
ammonioquaternary
alchil
eloro
nortropine
bronchospastic
Prior art date
Application number
IT8619371A
Other languages
English (en)
Other versions
IT8619371A0 (it
Inventor
Luigi Turbanti
Guido Cerbai
Original Assignee
Guidotti & C Spa Labor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guidotti & C Spa Labor filed Critical Guidotti & C Spa Labor
Publication of IT8619371A0 publication Critical patent/IT8619371A0/it
Priority to IT8619371A priority Critical patent/IT1213033B/it
Priority to US07/012,476 priority patent/US4780467A/en
Priority to IN112/CAL/87A priority patent/IN165884B/en
Priority to EP87101817A priority patent/EP0234400B1/en
Priority to DK066587A priority patent/DK170254B1/da
Priority to JP62029447A priority patent/JPH0723374B2/ja
Priority to CA000529378A priority patent/CA1303043C/en
Priority to AT87101817T priority patent/ATE58734T1/de
Priority to NO870515A priority patent/NO166861C/no
Priority to DE8787101817T priority patent/DE3766377D1/de
Priority to IL81519A priority patent/IL81519A0/xx
Priority to KR1019870001130A priority patent/KR940009783B1/ko
Priority to PH34845A priority patent/PH25652A/en
Priority to ZA870983A priority patent/ZA87983B/xx
Priority to AR87306715A priority patent/AR244225A1/es
Application granted granted Critical
Publication of IT1213033B publication Critical patent/IT1213033B/it
Priority to GR90401043T priority patent/GR3001228T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IT8619371A 1986-02-11 1986-02-11 Esteri di n-alchil-nortropine eloro derivati ammonioquaternari aventi attivita'anti-broncospastica, procedimento per la loro preparazione e composizioni farmaceutiche che licontengono. IT1213033B (it)

Priority Applications (16)

Application Number Priority Date Filing Date Title
IT8619371A IT1213033B (it) 1986-02-11 1986-02-11 Esteri di n-alchil-nortropine eloro derivati ammonioquaternari aventi attivita'anti-broncospastica, procedimento per la loro preparazione e composizioni farmaceutiche che licontengono.
US07/012,476 US4780467A (en) 1986-02-11 1987-02-09 Esters of N-alkyl-nortropines and their quaternary derivatives having anti-bronchospastic activity, and pharmaceutical compositions containing them
IN112/CAL/87A IN165884B (it) 1986-02-11 1987-02-09
NO870515A NO166861C (no) 1986-02-11 1987-02-10 Analogifremgangsmaate for fremstilling av terapeutisk aktive n-alkyl-nortropinestere med fenylcykloheksenkarbonyl- og fenylcyklohekseneddiksyrer og kvaternaere ammoniumsalter derav.
IL81519A IL81519A0 (en) 1986-02-11 1987-02-10 Esters of n-alkyl-nortropines and their quaternary ammonium derivatives,their preparation and pharmaceutical compositions containing them
JP62029447A JPH0723374B2 (ja) 1986-02-11 1987-02-10 抗−気管支痙攣活性のｎ−アルキル−ノルトロピンエステル類およびその第四級誘導体類
CA000529378A CA1303043C (en) 1986-02-11 1987-02-10 Esters of n-alkyl-nortropines and their quaternary derivatives having anti-bronchospastic activity, process for their preparation and pharmaceutical compositions containing them
AT87101817T ATE58734T1 (de) 1986-02-11 1987-02-10 N-alkyl-nortropine ester und ihre quaternaeren derivate mit anti-bronchospastischer wirkung, verfahren zu deren herstellung und diese enthaltende arzneimittel.
EP87101817A EP0234400B1 (en) 1986-02-11 1987-02-10 Esters of n-alkyl-nortropines and their quaternary derivatives having anti-bronchospastic activity, process for their preparation and pharmaceutical compositions containing them
DE8787101817T DE3766377D1 (de) 1986-02-11 1987-02-10 N-alkyl-nortropine ester und ihre quaternaeren derivate mit anti-bronchospastischer wirkung, verfahren zu deren herstellung und diese enthaltende arzneimittel.
DK066587A DK170254B1 (da) 1986-02-11 1987-02-10 N-Alkyl-nortropinestere med phenyl-cyclohexen-carboxylsyre eller -eddikesyre og deres kvaternære ammoniumderivater, fremgangsmåde til deres fremstilling samt præparat indeholdende disse
KR1019870001130A KR940009783B1 (ko) 1986-02-11 1987-02-11 항-기관지경련성 활성이 있는 n-알킬-노르트로핀의 에스테르와 그의 제 4 급유도체의 제조방법
PH34845A PH25652A (en) 1986-02-11 1987-02-11 Esters of n-alkyl-nortropines, their quaternary derivatives having anti-bronchospatic activity, process for their preparation, pharmaceutical compositions containing them
ZA870983A ZA87983B (en) 1986-02-11 1987-02-11 Esters of n-alkyl-nortropines and their quaternary derivatives having anti-bronchospastic activity,process for their preparation and pharmaceutical compositions containing them
AR87306715A AR244225A1 (es) 1986-02-11 1987-02-11 Procedimiento para la preparacion de esteres de n-alquil-nortropina con los acidos fenil-ciclohexen-carboxilico y fenil-ciclohexen-acetico.
GR90401043T GR3001228T3 (en) 1986-02-11 1990-12-07 Esters of n-alkyl-nortropines and their quaternary derivatives having anti-bronchospastic activity, process for their preparation and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8619371A IT1213033B (it) 1986-02-11 1986-02-11 Esteri di n-alchil-nortropine eloro derivati ammonioquaternari aventi attivita'anti-broncospastica, procedimento per la loro preparazione e composizioni farmaceutiche che licontengono.

Publications (2)

Publication Number Publication Date
IT8619371A0 IT8619371A0 (it) 1986-02-11
IT1213033B true IT1213033B (it) 1989-12-07

Family

ID=11157123

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8619371A IT1213033B (it) 1986-02-11 1986-02-11 Esteri di n-alchil-nortropine eloro derivati ammonioquaternari aventi attivita'anti-broncospastica, procedimento per la loro preparazione e composizioni farmaceutiche che licontengono.

Country Status (16)

Country Link
US (1) US4780467A (it)
EP (1) EP0234400B1 (it)
JP (1) JPH0723374B2 (it)
KR (1) KR940009783B1 (it)
AR (1) AR244225A1 (it)
AT (1) ATE58734T1 (it)
CA (1) CA1303043C (it)
DE (1) DE3766377D1 (it)
DK (1) DK170254B1 (it)
GR (1) GR3001228T3 (it)
IL (1) IL81519A0 (it)
IN (1) IN165884B (it)
IT (1) IT1213033B (it)
NO (1) NO166861C (it)
PH (1) PH25652A (it)
ZA (1) ZA87983B (it)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2706198A (en) * 1952-03-29 1955-04-12 Merck & Co Inc Benzhydryl ethers of tropine and processes of preparation
FR1444661A (fr) * 1960-10-18 1966-07-08 Egyt Gyogyszervegyeszeti Gyar Procédé de préparation de dérivés de p-alkyl-benzyl-tropinium
DE1800974B2 (de) * 1967-10-07 1973-01-25 Laboratorio Guidotti E C. S.P.A., Pisa (Italien) Ester der 2-phenylcyclohexen-(1)3-carbonsaeure mit aminoalkoholen, deren salze mit anorganischen oder organischen saeuren und deren quaternaere ammoniumverbindungen mit alkylhalogeniden
FR2168881A1 (en) * 1972-01-25 1973-09-07 Synthelabo Tropanol 1-phenylcycloalkane carboxylic ester salts - spasmolytics and cholinergics

Also Published As

Publication number Publication date
IN165884B (it) 1990-02-03
AR244225A1 (es) 1993-10-29
EP0234400B1 (en) 1990-11-28
NO166861C (no) 1991-09-11
US4780467A (en) 1988-10-25
ATE58734T1 (de) 1990-12-15
ZA87983B (en) 1987-08-03
KR870007929A (ko) 1987-09-23
DK170254B1 (da) 1995-07-17
DK66587D0 (da) 1987-02-10
DK66587A (da) 1987-08-12
CA1303043C (en) 1992-06-09
IT8619371A0 (it) 1986-02-11
DE3766377D1 (de) 1991-01-10
KR940009783B1 (ko) 1994-10-17
EP0234400A1 (en) 1987-09-02
JPH0723374B2 (ja) 1995-03-15
IL81519A0 (en) 1987-09-16
PH25652A (en) 1991-08-21
JPS62246572A (ja) 1987-10-27
NO166861B (no) 1991-06-03
GR3001228T3 (en) 1992-07-30
NO870515L (no) 1987-08-12
NO870515D0 (no) 1987-02-10

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19950227