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BE1004486A3 - Formulations a liberation prolongee de peptides solubles dans l'eau. - Google Patents

Formulations a liberation prolongee de peptides solubles dans l'eau. Download PDF

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Publication number
BE1004486A3
BE1004486A3 BE9000693A BE9000693A BE1004486A3 BE 1004486 A3 BE1004486 A3 BE 1004486A3 BE 9000693 A BE9000693 A BE 9000693A BE 9000693 A BE9000693 A BE 9000693A BE 1004486 A3 BE1004486 A3 BE 1004486A3
Authority
BE
Belgium
Prior art keywords
microparticles
water
days
polymer
emulsion
Prior art date
Application number
BE9000693A
Other languages
English (en)
French (fr)
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Sa filed Critical Sandoz Sa
Application granted granted Critical
Publication of BE1004486A3 publication Critical patent/BE1004486A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/095—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BE9000693A 1989-07-07 1990-07-05 Formulations a liberation prolongee de peptides solubles dans l'eau. BE1004486A3 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37702389A 1989-07-07 1989-07-07
US41134789A 1989-09-22 1989-09-22

Publications (1)

Publication Number Publication Date
BE1004486A3 true BE1004486A3 (fr) 1992-12-01

Family

ID=27007654

Family Applications (1)

Application Number Title Priority Date Filing Date
BE9000693A BE1004486A3 (fr) 1989-07-07 1990-07-05 Formulations a liberation prolongee de peptides solubles dans l'eau.

Country Status (27)

Country Link
JP (5) JPH0832624B2 (sv)
KR (2) KR100303681B1 (sv)
AT (1) AT406225B (sv)
AU (2) AU641407B2 (sv)
BE (1) BE1004486A3 (sv)
CA (1) CA2020477C (sv)
CH (1) CH685230A5 (sv)
CY (1) CY1965A (sv)
DE (2) DE4021517B4 (sv)
DK (1) DK175849B1 (sv)
FI (3) FI108611B (sv)
FR (1) FR2649319A1 (sv)
GB (2) GB2234896B (sv)
GR (1) GR1001121B (sv)
HK (2) HK97695A (sv)
HU (2) HU221294B1 (sv)
IE (2) IE64411B1 (sv)
IL (3) IL131880A (sv)
IT (1) IT1241460B (sv)
LU (1) LU87764A1 (sv)
MY (1) MY106722A (sv)
NL (1) NL195027C (sv)
NO (2) NO302928B1 (sv)
NZ (1) NZ234384A (sv)
PT (1) PT94628B (sv)
SE (1) SE512992C2 (sv)
SG (1) SG26416G (sv)

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CH683149A5 (fr) * 1991-07-22 1994-01-31 Debio Rech Pharma Sa Procédé pour la préparation de microsphères en matériau polymère biodégradable.
US6013853A (en) * 1992-02-14 2000-01-11 The University Of Texas System Continuous release polymeric implant carrier
US5876452A (en) * 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
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PE20050285A1 (es) * 2003-06-24 2005-06-09 Novartis Ag Composicion farmaceutica que comprende analogos ciclicos de somatostatina
ES2600554T3 (es) * 2003-07-18 2017-02-09 Oakwood Laboratories L.L.C. Prevención de la reducción del peso molecular del polímero, de la formación de impurezas y de la gelificación en composiciones poliméricas
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JP5808413B2 (ja) * 2010-09-30 2015-11-10 エボニック コーポレイションＥｖｏｎｉｋ Ｃｏｒｐｏｒａｔｉｏｎ 微粒子から残留有機溶剤を除去する方法
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KR102464650B1 (ko) 2016-05-03 2022-11-10 엘에스일렉트릭(주) 배선용 차단기의 한류장치
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FR2400950A1 (fr) * 1977-08-25 1979-03-23 Sandoz Sa Procede de preparation de microspheres comportant un noyau solide et une matiere polymere
EP0142272A1 (en) * 1983-10-11 1985-05-22 The Administrators Of The Tulane University Educational Fund Peptides and their use in therapy
EP0145240A2 (en) * 1983-11-04 1985-06-19 Takeda Chemical Industries, Ltd. Method for producing Microcapsule
EP0190833A2 (en) * 1985-02-07 1986-08-13 Takeda Chemical Industries, Ltd. Method for producing microcapsule

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Publication number Priority date Publication date Assignee Title
FR2070153A1 (sv) * 1969-10-23 1971-09-10 Du Pont
FR2400950A1 (fr) * 1977-08-25 1979-03-23 Sandoz Sa Procede de preparation de microspheres comportant un noyau solide et une matiere polymere
EP0142272A1 (en) * 1983-10-11 1985-05-22 The Administrators Of The Tulane University Educational Fund Peptides and their use in therapy
EP0145240A2 (en) * 1983-11-04 1985-06-19 Takeda Chemical Industries, Ltd. Method for producing Microcapsule
EP0190833A2 (en) * 1985-02-07 1986-08-13 Takeda Chemical Industries, Ltd. Method for producing microcapsule

Also Published As

Publication number Publication date
HUT54037A (en) 1991-01-28
JP2931773B2 (ja) 1999-08-09
JPH08198771A (ja) 1996-08-06
FI903429A0 (fi) 1990-07-06
PT94628A (pt) 1991-03-20
PT94628B (pt) 1997-06-30
CA2020477C (en) 2000-11-21
HU221294B1 (en) 2002-09-28
GB2265311B (en) 1994-02-09
KR910002430A (ko) 1991-02-25
SE9002364L (sv) 1991-01-08
IT9048113A0 (it) 1990-07-05
GB9306204D0 (en) 1993-05-19
DK162590A (da) 1991-01-08
FI109334B (sv) 2002-07-15
IL94983A (en) 1999-08-17
CY1965A (en) 1997-07-04
IT9048113A1 (it) 1992-01-05
GR1001121B (el) 1993-04-28
DE4042752B4 (de) 2009-05-07
NZ234384A (en) 1994-05-26
IT1241460B (it) 1994-01-17
CH685230A5 (de) 1995-05-15
DE4021517B4 (de) 2009-04-09
FR2649319B1 (sv) 1994-12-09
NO320444B1 (no) 2005-12-05
LU87764A1 (fr) 1992-03-11
FI109543B (sv) 2002-08-30
GB9014704D0 (en) 1990-08-22
IL131880A (en) 2001-12-23
GB2234896B (en) 1994-01-19
SE9002364D0 (sv) 1990-07-05
AU5874690A (en) 1991-01-10
HK97695A (en) 1995-06-23
IE902435A1 (en) 1991-02-13
IE64216B1 (en) 1995-07-26
IL94983A0 (en) 1991-06-10
IL131881A (en) 2001-12-23
IE64411B1 (en) 1995-08-09
HU903974D0 (en) 1990-11-28
NO903001L (no) 1991-01-08
KR100303681B1 (ko) 2002-05-16
NL195027C (nl) 2003-12-02
DK162590D0 (da) 1990-07-05
GB2234896A (en) 1991-02-20
AU641407B2 (en) 1993-09-23
AU2332195A (en) 1995-09-07
FI20000059A (sv) 2000-01-12
CA2020477A1 (en) 1991-01-08
HK197496A (en) 1996-11-08
JP2001233897A (ja) 2001-08-28
FR2649319A1 (fr) 1991-01-11
JPH07285853A (ja) 1995-10-31
JPH0368511A (ja) 1991-03-25
NL9001537A (nl) 1991-02-01
DK175849B1 (da) 2005-03-29
JPH07309897A (ja) 1995-11-28
NO302928B1 (no) 1998-05-11
GR900100513A (en) 1991-12-10
AT406225B (de) 2000-03-27
DE4021517A1 (de) 1991-01-17
SE512992C2 (sv) 2000-06-12
FI108611B (sv) 2002-02-28
NO983923L (no) 1991-01-08
NL195027B (nl) 2003-08-01
ATA144090A (de) 1999-08-15
HU211602A9 (en) 1995-12-28
GB2265311A (en) 1993-09-29
SG26416G (en) 1995-09-01
KR100442931B1 (ko) 2004-08-02
MY106722A (en) 1995-07-31
JPH0832624B2 (ja) 1996-03-29
FI20000060A (sv) 2000-01-12
NO983923D0 (no) 1998-08-26
AU687553B2 (en) 1998-02-26
NO903001D0 (no) 1990-07-05

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