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ATE468331T1 - Neue cyanopyridine-derivate zur behandlung von krebs und anderer erkrankungen - Google Patents

Neue cyanopyridine-derivate zur behandlung von krebs und anderer erkrankungen

Info

Publication number
ATE468331T1
ATE468331T1 AT04716144T AT04716144T ATE468331T1 AT E468331 T1 ATE468331 T1 AT E468331T1 AT 04716144 T AT04716144 T AT 04716144T AT 04716144 T AT04716144 T AT 04716144T AT E468331 T1 ATE468331 T1 AT E468331T1
Authority
AT
Austria
Prior art keywords
cancer
diseases
treatment
new
cyanopyridine derivatives
Prior art date
Application number
AT04716144T
Other languages
English (en)
Inventor
William Scott
Jacques Dumas
Stephen Boyer
Wendy Lee
Yuanwei Chen
Barton Phillips
Sharad Verma
Jianqing Chen
Zhi Chen
Jianmei Fan
Brian Raudenbush
Aniko Redman
Lin Yi
Qingming Zhu
Original Assignee
Bayer Healthcare Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Llc filed Critical Bayer Healthcare Llc
Application granted granted Critical
Publication of ATE468331T1 publication Critical patent/ATE468331T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT04716144T 2003-02-28 2004-03-01 Neue cyanopyridine-derivate zur behandlung von krebs und anderer erkrankungen ATE468331T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US45034803P 2003-02-28 2003-02-28
US45032403P 2003-02-28 2003-02-28
US45032303P 2003-02-28 2003-02-28
PCT/US2004/006286 WO2004078747A1 (en) 2003-02-28 2004-03-01 Novel cyanopyridine derivatives useful in the treatment of cancer and other disorders

Publications (1)

Publication Number Publication Date
ATE468331T1 true ATE468331T1 (de) 2010-06-15

Family

ID=32966445

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04716144T ATE468331T1 (de) 2003-02-28 2004-03-01 Neue cyanopyridine-derivate zur behandlung von krebs und anderer erkrankungen

Country Status (21)

Country Link
US (5) US7557129B2 (de)
EP (1) EP1599467B1 (de)
JP (1) JP4658037B2 (de)
KR (1) KR101109262B1 (de)
AR (1) AR043437A1 (de)
AT (1) ATE468331T1 (de)
AU (1) AU2004217977B2 (de)
BR (1) BRPI0407897A (de)
CA (1) CA2517361C (de)
CY (1) CY1111143T1 (de)
DE (1) DE602004027218D1 (de)
DK (1) DK1599467T3 (de)
ES (1) ES2344347T3 (de)
IL (1) IL170503A (de)
MX (1) MXPA05009067A (de)
PL (1) PL1599467T3 (de)
PT (1) PT1599467E (de)
SI (1) SI1599467T1 (de)
TW (1) TW200504053A (de)
UY (1) UY28213A1 (de)
WO (1) WO2004078747A1 (de)

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US20100075971A1 (en) 2010-03-25
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TW200504053A (en) 2005-02-01
HK1089155A1 (en) 2006-11-24
DK1599467T3 (da) 2010-09-06
SI1599467T1 (sl) 2010-09-30
WO2004078747A8 (en) 2004-11-04
KR20050106050A (ko) 2005-11-08
US20040229937A1 (en) 2004-11-18
US20050032798A1 (en) 2005-02-10
US7557129B2 (en) 2009-07-07
DE602004027218D1 (de) 2010-07-01
AU2004217977A1 (en) 2004-09-16
US8076488B2 (en) 2011-12-13
US20050038031A1 (en) 2005-02-17
EP1599467B1 (de) 2010-05-19
EP1599467A1 (de) 2005-11-30
PT1599467E (pt) 2010-07-15
US7928227B2 (en) 2011-04-19
IL170503A (en) 2012-02-29
JP2006519264A (ja) 2006-08-24
KR101109262B1 (ko) 2012-01-30
AU2004217977B2 (en) 2010-04-01
CY1111143T1 (el) 2015-06-11
ES2344347T3 (es) 2010-08-25
WO2004078747A1 (en) 2004-09-16
CA2517361A1 (en) 2004-09-16
US20040235829A1 (en) 2004-11-25
CA2517361C (en) 2012-05-15
MXPA05009067A (es) 2005-11-17
BRPI0407897A (pt) 2006-03-01
PL1599467T3 (pl) 2010-10-29

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