ATE431423T1 - Verfahren zum screening der leichten kette eines antikörpers - Google Patents
Verfahren zum screening der leichten kette eines antikörpersInfo
- Publication number
- ATE431423T1 ATE431423T1 AT04703920T AT04703920T ATE431423T1 AT E431423 T1 ATE431423 T1 AT E431423T1 AT 04703920 T AT04703920 T AT 04703920T AT 04703920 T AT04703920 T AT 04703920T AT E431423 T1 ATE431423 T1 AT E431423T1
- Authority
- AT
- Austria
- Prior art keywords
- antibody
- library
- desired antigen
- screening
- heavy chain
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000012216 screening Methods 0.000 title abstract 2
- 239000000427 antigen Substances 0.000 abstract 5
- 102000036639 antigens Human genes 0.000 abstract 5
- 108091007433 antigens Proteins 0.000 abstract 5
- 230000003248 secreting effect Effects 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pyrane Compounds (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003012648 | 2003-01-21 | ||
| PCT/JP2004/000496 WO2004065611A1 (ja) | 2003-01-21 | 2004-01-21 | 抗体の軽鎖スクリーニング方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE431423T1 true ATE431423T1 (de) | 2009-05-15 |
Family
ID=32767339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04703920T ATE431423T1 (de) | 2003-01-21 | 2004-01-21 | Verfahren zum screening der leichten kette eines antikörpers |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8337841B2 (de) |
| EP (1) | EP1605058B1 (de) |
| JP (1) | JP4477579B2 (de) |
| AT (1) | ATE431423T1 (de) |
| DE (1) | DE602004021095D1 (de) |
| WO (1) | WO2004065611A1 (de) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1500665B1 (de) * | 2002-04-15 | 2011-06-15 | Chugai Seiyaku Kabushiki Kaisha | VERFAHREN ZUR HERSTELLUNG VON scDb-BIBLIOTHEKEN |
| WO2004111233A1 (ja) * | 2003-06-11 | 2004-12-23 | Chugai Seiyaku Kabushiki Kaisha | 抗体の製造方法 |
| AU2003271174A1 (en) | 2003-10-10 | 2005-04-27 | Chugai Seiyaku Kabushiki Kaisha | Double specific antibodies substituting for functional protein |
| EP1693448A4 (de) * | 2003-10-14 | 2008-03-05 | Chugai Pharmaceutical Co Ltd | Doppelt spezifische antikörper als ersatz für funktionelles protein |
| TW200530269A (en) * | 2003-12-12 | 2005-09-16 | Chugai Pharmaceutical Co Ltd | Anti-Mpl antibodies |
| US20070281327A1 (en) * | 2003-12-12 | 2007-12-06 | Kiyotaka Nakano | Methods of Screening for Modified Antibodies With Agonistic Activities |
| US20080206229A1 (en) * | 2003-12-12 | 2008-08-28 | Koichiro Ono | Modified Antibodies Recognizing Receptor Trimers or Higher Multimers |
| EP1870458B1 (de) * | 2005-03-31 | 2018-05-09 | Chugai Seiyaku Kabushiki Kaisha | sc(Fv)2-STRUKTURISOMERE |
| TWI671403B (zh) * | 2005-03-31 | 2019-09-11 | 中外製藥股份有限公司 | 控制組裝之多肽的製造方法 |
| TW200714313A (en) * | 2005-04-08 | 2007-04-16 | Chugai Pharmaceutical Co Ltd | Antibodies that substitute for coagulation factor VIII |
| CA2610987C (en) * | 2005-06-10 | 2013-09-10 | Chugai Seiyaku Kabushiki Kaisha | Stabilizer for protein preparation comprising meglumine and use thereof |
| KR101360671B1 (ko) | 2005-06-10 | 2014-02-07 | 추가이 세이야쿠 가부시키가이샤 | ｓｃ（Ｆｖ）２를 함유하는 의약조성물 |
| EP1900814A4 (de) * | 2005-06-10 | 2010-07-21 | Chugai Pharmaceutical Co Ltd | Stellengerichtete sc(fv)2-mutante |
| WO2007042809A2 (en) * | 2005-10-11 | 2007-04-19 | Domantis Limited | Antibody polypeptide library screening and selected antibody polypeptides |
| DK3056568T3 (da) | 2006-03-31 | 2021-11-01 | Chugai Pharmaceutical Co Ltd | Fremgangsmåder til kontrollering af antistoffers blodfarmakokinetik |
| DK2009101T3 (en) | 2006-03-31 | 2018-01-15 | Chugai Pharmaceutical Co Ltd | Antibody modification method for purification of a bispecific antibody |
| EP3689912A1 (de) | 2007-09-26 | 2020-08-05 | Chugai Seiyaku Kabushiki Kaisha | Verfahren zur modifizierung eines isoelektrischen punkts eines antikörpers über aminosäuresubstitution in cdr |
| CA2734340C (en) | 2008-08-28 | 2019-03-05 | Novartis Ag | Cell surface display of polypeptide isoforms by stop codon readthrough |
| NZ631363A (en) | 2010-02-08 | 2016-05-27 | Regeneron Pharma | Common light chain mouse |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| KR102318383B1 (ko) * | 2010-07-16 | 2021-10-27 | 아디맵 엘엘씨 | 항체 라이브러리 |
| CA2817964C (en) | 2010-11-17 | 2018-06-12 | Chugai Seiyaku Kabushiki Kaisha | Multi-specific antigen-binding molecule having alternative function to function of blood coagulation factor viii |
| FI3434767T3 (fi) | 2010-11-30 | 2026-02-12 | Chugai Seiyaku Kk | Sytotoksisuutta aiheuttava terapeuttinen aine |
| LT3572517T (lt) | 2011-08-05 | 2021-04-26 | Regeneron Pharmaceuticals, Inc. | Humanizuotos universalios lengvosios grandinės pelės |
| US20140013456A1 (en) | 2012-03-16 | 2014-01-09 | Regeneron Pharmaceuticals, Inc. | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
| HK1200271A1 (en) | 2012-03-16 | 2015-08-07 | 瑞泽恩制药公司 | Mice that produce antigen-binding proteins with ph-dependent binding characteristics |
| SMT201800229T1 (it) | 2012-03-16 | 2018-07-17 | Regeneron Pharma | Anticorpi a catena leggera ingegnerizzati con istidina e roditori modificati geneticamente per la generazione degli stessi |
| DK2825037T3 (da) | 2012-03-16 | 2019-07-29 | Regeneron Pharma | Gnavere, der udtrykker pH-sensitive immunoglobulinsekvenser |
| ES2749200T3 (es) | 2012-05-10 | 2020-03-19 | Bioatla Llc | Anticuerpos monoclonales multiespecíficos |
| EP3050896B1 (de) | 2013-09-27 | 2021-07-07 | Chugai Seiyaku Kabushiki Kaisha | Verfahren zur herstellung eines polypeptid-heteromultimers |
| BR112016006502A2 (pt) * | 2013-09-30 | 2017-09-19 | Chugai Pharmaceutical Co Ltd | Método para a produção de molécula de ligação de antígeno usando-se fago auxiliar modificado |
| EP3895528A1 (de) | 2014-03-21 | 2021-10-20 | Regeneron Pharmaceuticals, Inc. | Einzeldomänenbindende proteine produzierende nichtmenschliche tiere |
| EP3825326A1 (de) * | 2014-04-01 | 2021-05-26 | Adimab, LLC | Multispezifische antikörperanaloga mit einer gemeinsamen leichten kette sowie verfahren zu deren herstellung und verwendung |
| KR102550926B1 (ko) | 2014-05-13 | 2023-07-05 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | 이중 항체 구축물을 발현하는 aav를 포함하는 조성물 및 이들의 용도 |
| TWI700300B (zh) * | 2014-09-26 | 2020-08-01 | 日商中外製藥股份有限公司 | 中和具有第ｖｉｉｉ凝血因子（ｆｖｉｉｉ）機能替代活性的物質之抗體 |
| MA40764A (fr) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
| TWI701435B (zh) | 2014-09-26 | 2020-08-11 | 日商中外製藥股份有限公司 | 測定ｆｖｉｉｉ的反應性之方法 |
| EP3271403A1 (de) | 2015-03-19 | 2018-01-24 | Regeneron Pharmaceuticals, Inc. | Nichtmenschliche tiere zur selektion von leichtkettigen variablen regionen zur antigenbindung |
| EP3279216A4 (de) | 2015-04-01 | 2019-06-19 | Chugai Seiyaku Kabushiki Kaisha | Verfahren zur herstellung von polypeptid-hetero-oligomer |
| JP6931329B2 (ja) | 2015-11-18 | 2021-09-01 | 中外製薬株式会社 | 免疫抑制機能を有する細胞に対するｔ細胞リダイレクト抗原結合分子を用いた併用療法 |
| WO2017086419A1 (ja) | 2015-11-18 | 2017-05-26 | 中外製薬株式会社 | 液性免疫応答の増強方法 |
| JP6954842B2 (ja) | 2015-12-25 | 2021-10-27 | 中外製薬株式会社 | 増強された活性を有する抗体及びその改変方法 |
| BR112018009312A8 (pt) | 2015-12-28 | 2019-02-26 | Chugai Pharmaceutical Co Ltd | método para promover eficiência de purificação de polipeptídeo contendo região de fc |
| BR112018068363A2 (pt) | 2016-03-14 | 2019-01-15 | Chugai Seiyaku Kabushiki Kaisha | fármaco terapêutico indutor de dano celular para uso em terapia de câncer |
| MX2018012648A (es) | 2016-04-28 | 2019-01-30 | Chugai Pharmaceutical Co Ltd | Preparaciones que contienen anticuerpos. |
| BR112019001179A2 (pt) | 2016-07-29 | 2019-04-30 | Chugai Seiyaku Kabushiki Kaisha | anticorpo biespecífico que exibe atividade alternativa aumentada de função de cofator fviii |
| WO2018047813A1 (en) | 2016-09-06 | 2018-03-15 | Chugai Seiyaku Kabushiki Kaisha | Methods of using a bispecific antibody that recognizes coagulation factor ix and/or activated coagulation factor ix and coagulation factor x and/or activated coagulation factor x |
| EP4088783A1 (de) * | 2017-08-01 | 2022-11-16 | Ab Studio Inc. | Spezifische antikörper und verwendungen davon |
| UA128389C2 (uk) | 2017-09-29 | 2024-07-03 | Чугаі Сейяку Кабусікі Кайся | Мультиспецифічна антигензв'язувальна молекула, яка має активність заміщувати кофакторну функцію фактора коагуляції крові viii (fviii), та фармацевтичний склад, який містить згадану молекулу як активний інгредієнт |
| MX2020003472A (es) | 2017-11-01 | 2020-08-03 | Chugai Pharmaceutical Co Ltd | Variante e isoforma de anticuerpos con actividad biologica reducida. |
| EP3732195A4 (de) | 2017-12-28 | 2022-02-09 | Chugai Seiyaku Kabushiki Kaisha | Zytotoxizitätsinduzierendes therapeutikum |
| EP3561703B1 (de) * | 2018-04-25 | 2021-01-20 | Bayer AG | Identifizieren der paarung von variablen domänen aus leichten und schweren ketten von antikörpern |
| CA3103414A1 (en) | 2018-06-14 | 2019-12-19 | Bioatla, Inc. | Multi-specific antibody constructs |
| JPWO2019244973A1 (ja) | 2018-06-20 | 2021-07-08 | 中外製薬株式会社 | 標的細胞に対する免疫反応を活性化する方法およびその組成物 |
| CN113660956B (zh) | 2019-01-28 | 2024-10-29 | Ab诊疗公司 | 双特异性抗体及其用途 |
| WO2020205504A1 (en) * | 2019-03-29 | 2020-10-08 | Compass Therapeutics Llc | Common light chains and methods of use |
| KR20220017430A (ko) | 2019-06-05 | 2022-02-11 | 추가이 세이야쿠 가부시키가이샤 | 항체 절단 부위 결합 분자 |
| JP2023106635A (ja) | 2020-04-17 | 2023-08-02 | 中外製薬株式会社 | 二重特異性抗原結合分子ならびに、それに関連する組成物、組成物の製造のための使用、キット、および方法 |
| AU2021317974A1 (en) | 2020-07-31 | 2023-03-16 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical Composition comprising Cell Expressing Chimeric Receptor |
| WO2025154793A1 (ja) * | 2024-01-19 | 2025-07-24 | 株式会社ペルセウスプロテオミクス | 多重特異性抗体の製造に使用するための共通のｌ鎖を同定する方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9015198D0 (en) * | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| AU5509296A (en) | 1995-05-03 | 1996-11-21 | Colin Henry Self | Bispecific antibodies in which the binding capability is rev ersibly inhibited by a photocleavable moiety |
| ATE299938T1 (de) | 1997-05-02 | 2005-08-15 | Genentech Inc | Ein verfahren zur herstellung multispezifischer antikörper die heteromultimere und gemeinsame komponenten besitzen |
| DE19819846B4 (de) | 1998-05-05 | 2016-11-24 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Multivalente Antikörper-Konstrukte |
| US6897044B1 (en) | 1999-01-28 | 2005-05-24 | Biogen Idec, Inc. | Production of tetravalent antibodies |
| CA2390662A1 (en) | 1999-12-14 | 2001-06-21 | The Burnham Institute | Bcl-g polypeptides, encoding nucleic acids and methods of use |
| DK1265914T3 (da) | 2000-03-22 | 2008-03-10 | Curagen Corp | WNT-1-relaterede polypeptider og nukleinsyrer, der koder for samme |
| ATE352040T1 (de) * | 2000-11-17 | 2007-02-15 | Univ Rochester | In-vitro verfahren zur herstellung und identifizierung von immunglobulin moleküle in eukaryotischen zellen |
| ATE477280T1 (de) * | 2001-06-28 | 2010-08-15 | Domantis Ltd | Doppelspezifischer ligand und dessen verwendung |
| EP1500665B1 (de) * | 2002-04-15 | 2011-06-15 | Chugai Seiyaku Kabushiki Kaisha | VERFAHREN ZUR HERSTELLUNG VON scDb-BIBLIOTHEKEN |
| ES2442615T5 (es) * | 2002-07-18 | 2023-03-16 | Merus Nv | Producción recombinante de mezclas de anticuerpos |
| WO2004111233A1 (ja) * | 2003-06-11 | 2004-12-23 | Chugai Seiyaku Kabushiki Kaisha | 抗体の製造方法 |
-
2004
- 2004-01-21 AT AT04703920T patent/ATE431423T1/de not_active IP Right Cessation
- 2004-01-21 DE DE602004021095T patent/DE602004021095D1/de not_active Expired - Lifetime
- 2004-01-21 JP JP2005508106A patent/JP4477579B2/ja not_active Expired - Lifetime
- 2004-01-21 WO PCT/JP2004/000496 patent/WO2004065611A1/ja not_active Ceased
- 2004-01-21 EP EP04703920A patent/EP1605058B1/de not_active Expired - Lifetime
- 2004-01-21 US US10/542,839 patent/US8337841B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1605058B1 (de) | 2009-05-13 |
| EP1605058A1 (de) | 2005-12-14 |
| WO2004065611A1 (ja) | 2004-08-05 |
| US20060159673A1 (en) | 2006-07-20 |
| JPWO2004065611A1 (ja) | 2006-05-18 |
| DE602004021095D1 (de) | 2009-06-25 |
| US8337841B2 (en) | 2012-12-25 |
| JP4477579B2 (ja) | 2010-06-09 |
| EP1605058A4 (de) | 2006-04-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |