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BR112019001179A2 - anticorpo biespecífico que exibe atividade alternativa aumentada de função de cofator fviii - Google Patents

anticorpo biespecífico que exibe atividade alternativa aumentada de função de cofator fviii

Info

Publication number
BR112019001179A2
BR112019001179A2 BR112019001179-0A BR112019001179A BR112019001179A2 BR 112019001179 A2 BR112019001179 A2 BR 112019001179A2 BR 112019001179 A BR112019001179 A BR 112019001179A BR 112019001179 A2 BR112019001179 A2 BR 112019001179A2
Authority
BR
Brazil
Prior art keywords
fviii
cofactor
bispecific antibody
activity
exhibiting increased
Prior art date
Application number
BR112019001179-0A
Other languages
English (en)
Inventor
Igawa Tomoyuki
Teranishi Yuri
Kato Kazuki
Koga Hikaru
Original Assignee
Chugai Seiyaku Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Seiyaku Kabushiki Kaisha filed Critical Chugai Seiyaku Kabushiki Kaisha
Publication of BR112019001179A2 publication Critical patent/BR112019001179A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Exposure Of Semiconductors, Excluding Electron Or Ion Beam Exposure (AREA)

Abstract

"anticorpo biespecífico que exibe atividade alternativa aumentada de função de cofator fviii". a presente invenção refere-se a substituições de aminoácidos de cadeia leve que aumentam a atividade de substituição de função de cofator fviii do ace910 (emicizumabe), novas cadeias leves que exibem atividade de substituição de função de cofator fviii e substituições de aminoácidos de cadeia pesada que aumentam a atividade de substituição de função de cofator fviii de novos anticorpos biespecíficos que contêm as cadeias leves.
BR112019001179-0A 2016-07-29 2017-07-27 anticorpo biespecífico que exibe atividade alternativa aumentada de função de cofator fviii BR112019001179A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2016-150769 2016-07-29
JP2016150769 2016-07-29
PCT/JP2017/027152 WO2018021450A1 (ja) 2016-07-29 2017-07-27 増強されたｆｖｉｉｉ補因子機能代替活性を有する二重特異性抗体

Publications (1)

Publication Number Publication Date
BR112019001179A2 true BR112019001179A2 (pt) 2019-04-30

Family

ID=61016987

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019001179-0A BR112019001179A2 (pt) 2016-07-29 2017-07-27 anticorpo biespecífico que exibe atividade alternativa aumentada de função de cofator fviii

Country Status (10)

Country Link
US (2) US20190185578A1 (pt)
EP (1) EP3492496A4 (pt)
JP (1) JP7050677B2 (pt)
KR (1) KR102591955B1 (pt)
CN (2) CN109415444B (pt)
AU (1) AU2017303205B2 (pt)
BR (1) BR112019001179A2 (pt)
CA (1) CA3027018A1 (pt)
MX (1) MX2018015721A (pt)
WO (1) WO2018021450A1 (pt)

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US20200270363A1 (en) 2015-12-25 2020-08-27 Chugai Seiyaku Kabushiki Kaisha Antibody having enhanced activity, and method for modifying same
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GB201709970D0 (en) 2017-06-22 2017-08-09 Kymab Ltd Bispecific antigen-binding molecules
EP3690050A4 (en) 2017-09-29 2021-06-16 Chugai Seiyaku Kabushiki Kaisha MULTISPECIFIC ANTIGENBINDING MOLECULE WITH BLOOD CLOG FACTOR VIII (FVIII) COFACTOR FUNCTION SUBSTITUATING ACTIVITY AND PHARMACEUTICAL FORMULATION WITH THIS MOLECULE AS THE ACTIVE SUBSTANCE
MA50893A (fr) 2017-11-15 2020-09-23 Novo Nordisk As Liants de facteur x renforçant l'activation fx
US11220554B2 (en) 2018-09-07 2022-01-11 Novo Nordisk A/S Procoagulant antibodies
BR112021012065A2 (pt) * 2018-12-21 2021-12-07 Kymab Ltd Anticorpo biespecífico que se liga a fixa e fx e catalisa a ativação de fx mediada por fixa; método; anticorpo anti-fixa; anticorpo anti-fx; ácido nucleico isolado; célula hospedeira in vitro; população de células hospedeiras in vitro; kit para produção de um anticorpo biespecífico; método de produção de um anticorpo biespecífico; composição; método para controlar o sangramento em um paciente com hemofilia a; uso de um anticorpo biespecífico; método, composição para uso ou uso; e método para reduzir o desenvolvimento de anticorpos antifármacos inibidores em um paciente com hemofilia a em tratamento com um polipeptídeo que substitui a atividade de fviiia
KR102520437B1 (ko) 2019-03-29 2023-04-12 재단법인 의약바이오컨버젼스연구단 항암활성을 갖는 신규한 화합물 및 이의 제조방법
KR20230130561A (ko) 2022-03-02 2023-09-12 노보 노르디스크 헬스 케어 악티엔게젤샤프트 Fviii 모방 이중특이적 항체를 2주마다 1회 투여하는 방법
KR20230130560A (ko) 2022-03-02 2023-09-12 노보 노르디스크 헬스 케어 악티엔게젤샤프트 Fviii 모방 이중특이적 항체의 주 1회 투여 방법
KR20230130558A (ko) 2022-03-02 2023-09-12 노보 노르디스크 헬스 케어 악티엔게젤샤프트 Fviii 모방 이중특이적 항체의 월 1회 투여 방법
JP2025003418A (ja) 2023-06-23 2025-01-09 ノヴォ・ノルディスク・ヘルス・ケア・アーゲー Ｆｖｉｉｉ模倣二重特異性抗体を２ヶ月に１回投与する方法

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Also Published As

Publication number Publication date
US20190185578A1 (en) 2019-06-20
KR20190037271A (ko) 2019-04-05
JPWO2018021450A1 (ja) 2019-05-23
RU2019104730A3 (pt) 2020-11-30
CN117986372A (zh) 2024-05-07
EP3492496A4 (en) 2020-07-29
MX2018015721A (es) 2019-05-27
KR102591955B1 (ko) 2023-10-19
JP7050677B2 (ja) 2022-04-08
WO2018021450A1 (ja) 2018-02-01
CN109415444B (zh) 2024-03-01
EP3492496A1 (en) 2019-06-05
RU2019104730A (ru) 2020-08-28
US20220073644A1 (en) 2022-03-10
AU2017303205A1 (en) 2019-01-17
AU2017303205B2 (en) 2024-08-01
CA3027018A1 (en) 2018-02-01
CN109415444A (zh) 2019-03-01

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