ATE263761T1 - 5,6-dihydropyronderivate als proteaseinhibitoren und antiviralmittel - Google Patents
5,6-dihydropyronderivate als proteaseinhibitoren und antiviralmittelInfo
- Publication number
- ATE263761T1 ATE263761T1 AT01114943T AT01114943T ATE263761T1 AT E263761 T1 ATE263761 T1 AT E263761T1 AT 01114943 T AT01114943 T AT 01114943T AT 01114943 T AT01114943 T AT 01114943T AT E263761 T1 ATE263761 T1 AT E263761T1
- Authority
- AT
- Austria
- Prior art keywords
- derivatives
- dihydropyron
- protease inhibitors
- antiviral agents
- present
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15544393A | 1993-11-19 | 1993-11-19 | |
| US08/319,820 US5840751A (en) | 1993-11-19 | 1994-10-12 | 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE263761T1 true ATE263761T1 (de) | 2004-04-15 |
Family
ID=26852338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01114943T ATE263761T1 (de) | 1993-11-19 | 1994-10-26 | 5,6-dihydropyronderivate als proteaseinhibitoren und antiviralmittel |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0729464A1 (no) |
| JP (1) | JP3684426B2 (no) |
| AT (1) | ATE263761T1 (no) |
| AU (1) | AU689158B2 (no) |
| CA (1) | CA2176043A1 (no) |
| DE (1) | DE69433705T2 (no) |
| DK (1) | DK1142887T3 (no) |
| ES (1) | ES2219457T3 (no) |
| FI (1) | FI962022L (no) |
| HR (1) | HRP940935B1 (no) |
| HU (1) | HUT77668A (no) |
| IL (1) | IL111674A0 (no) |
| NO (1) | NO316172B1 (no) |
| NZ (1) | NZ275961A (no) |
| PT (1) | PT1142887E (no) |
| RU (1) | RU2140917C1 (no) |
| SI (1) | SI1142887T1 (no) |
| WO (1) | WO1995014012A1 (no) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1252921T1 (de) * | 1995-08-11 | 2003-11-27 | Zenon Environmental Inc., Oakville | Vorrichtung zur Permeatentnahme aus einem flüssigen Substrat mit mehreren Bestandteilen |
| US5834506A (en) * | 1996-11-01 | 1998-11-10 | Warner-Lambert Company | Dihydropyrones with improved antiviral activity |
| RU2223958C2 (ru) | 1997-09-11 | 2004-02-20 | Фармация Энд Апджон Компани | Новый способ получения ингибитора протеазы |
| WO2000015634A2 (en) * | 1998-09-11 | 2000-03-23 | Warner-Lambert Company | Hiv protease inhibitors |
| US6288235B1 (en) | 1999-04-14 | 2001-09-11 | Ortho-Mcneil Pharmaceutical, Inc. | Methods for the synthesis of highly substituted 2,4-dioxopiperidine libraries |
| DE10030094A1 (de) * | 2000-06-19 | 2001-12-20 | Bayer Ag | Phenylsubstituierte 5,6-Dihydro-pyron-Derivate |
| US6710058B2 (en) | 2000-11-06 | 2004-03-23 | Bristol-Myers Squibb Pharma Company | Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors |
| DE10108470A1 (de) * | 2001-02-22 | 2002-09-05 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung optisch aktiver Dihydropyrone |
| US6500963B2 (en) | 2001-02-22 | 2002-12-31 | Boehringer Ingelheim Pharma Kg | Process for preparing optically active dihydropyrones |
| US7141681B2 (en) | 2001-02-22 | 2006-11-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Continuous process for preparing dihydropyrones |
| DE10108471C1 (de) | 2001-02-22 | 2002-11-21 | Boehringer Ingelheim Pharma | Kontinuierliches Verfahren zur Herstellung von 5,6-Dihydro-4-hydroxy-2-pyronen |
| TW200307667A (en) | 2002-05-06 | 2003-12-16 | Bristol Myers Squibb Co | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors |
| DOP2003000641A (es) | 2002-05-10 | 2003-11-15 | Pfizer | Inhibidores de las arn polimerasa dependiente de arn del virus de las hepatitis c y composiciones y tratamiento que los usan |
| US7148226B2 (en) | 2003-02-21 | 2006-12-12 | Agouron Pharmaceuticals, Inc. | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same |
| MX2007001527A (es) | 2004-08-18 | 2007-03-27 | Pfizer | Inhibidores de la arn polimerasa dependiente de arn del virus de la hepatitis c y composiciones y tratamientos que los usan. |
| DE102005059469A1 (de) | 2005-12-13 | 2007-06-14 | Bayer Cropscience Ag | Insektizide Zusammensetzungen mit verbesserter Wirkung |
| DE102006007882A1 (de) | 2006-02-21 | 2007-08-30 | Bayer Cropscience Ag | Cycloalkyl-phenylsubstituierte cyclische Ketoenole |
| US8324406B2 (en) * | 2006-06-16 | 2012-12-04 | Pharma Mar, S.A. | Antitumoral dihydropyran-2-one compounds |
| EP2406216B1 (de) | 2009-03-11 | 2017-04-19 | Bayer Intellectual Property GmbH | Halogenalkylmethylenoxy-phenyl-substituierte ketoenole |
| DE102010008644A1 (de) | 2010-02-15 | 2011-08-18 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Zyklische Ketoenole zur Therapie |
| RU2461555C1 (ru) * | 2011-07-07 | 2012-09-20 | Государственное образовательное учреждение высшего профессионального образования "Пермский государственный университет" | Способ получения 5-арил-3-фенил-2-оксаспиро[5,6]додец-3-ен-1-онов, проявляющих анальгетическую активность |
| MY172133A (en) | 2012-01-26 | 2019-11-14 | Bayer Ip Gmbh | Phenyl-substituted ketoenols for controlling fish parasites |
| AU2013352998B2 (en) | 2012-11-28 | 2017-06-08 | Sumitomo Chemical Company, Limited | Dihydropyrone compounds and herbicides comprising the same |
| SE539512C2 (sv) | 2015-12-02 | 2017-10-03 | Ultupharma Ab | Compounds and methods of treating bacterial infections |
| US20230295108A1 (en) * | 2020-06-26 | 2023-09-21 | Nihon Nohyaku Co., Ltd. | Aryltetrahydropyridine derivative or salt thereof, insecticidal agent containing the compound, and method of use thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3818046A (en) * | 1972-12-18 | 1974-06-18 | Dow Chemical Co | Sulfur-containing hydroxy pyrones and alkali metal salts thereof |
| ZA938019B (en) * | 1992-11-13 | 1995-04-28 | Upjohn Co | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses |
-
1994
- 1994-10-26 PT PT01114943T patent/PT1142887E/pt unknown
- 1994-10-26 DE DE69433705T patent/DE69433705T2/de not_active Expired - Fee Related
- 1994-10-26 SI SI9430463T patent/SI1142887T1/xx unknown
- 1994-10-26 ES ES01114943T patent/ES2219457T3/es not_active Expired - Lifetime
- 1994-10-26 JP JP51445895A patent/JP3684426B2/ja not_active Expired - Fee Related
- 1994-10-26 WO PCT/US1994/012269 patent/WO1995014012A1/en not_active Application Discontinuation
- 1994-10-26 AU AU81256/94A patent/AU689158B2/en not_active Ceased
- 1994-10-26 DK DK01114943T patent/DK1142887T3/da active
- 1994-10-26 CA CA002176043A patent/CA2176043A1/en not_active Abandoned
- 1994-10-26 AT AT01114943T patent/ATE263761T1/de not_active IP Right Cessation
- 1994-10-26 HU HU9601348A patent/HUT77668A/hu not_active Application Discontinuation
- 1994-10-26 RU RU96113098/04A patent/RU2140917C1/ru not_active IP Right Cessation
- 1994-10-26 NZ NZ275961A patent/NZ275961A/en unknown
- 1994-10-26 EP EP95900429A patent/EP0729464A1/en not_active Withdrawn
- 1994-11-17 HR HR940935A patent/HRP940935B1/xx not_active IP Right Cessation
- 1994-11-17 IL IL11167494A patent/IL111674A0/xx unknown
-
1996
- 1996-05-13 FI FI962022A patent/FI962022L/fi unknown
- 1996-05-15 NO NO19962017A patent/NO316172B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SI1142887T1 (en) | 2004-08-31 |
| FI962022A0 (fi) | 1996-05-13 |
| FI962022L (fi) | 1996-07-12 |
| EP0729464A1 (en) | 1996-09-04 |
| NO962017D0 (no) | 1996-05-15 |
| HUT77668A (hu) | 1998-07-28 |
| HRP940935B1 (en) | 2004-08-31 |
| PT1142887E (pt) | 2004-08-31 |
| IL111674A0 (en) | 1995-01-24 |
| DK1142887T3 (da) | 2004-06-21 |
| RU2140917C1 (ru) | 1999-11-10 |
| DE69433705T2 (de) | 2005-03-10 |
| HRP940935A2 (en) | 1997-04-30 |
| JPH09505294A (ja) | 1997-05-27 |
| AU8125694A (en) | 1995-06-06 |
| WO1995014012A1 (en) | 1995-05-26 |
| AU689158B2 (en) | 1998-03-26 |
| ES2219457T3 (es) | 2004-12-01 |
| JP3684426B2 (ja) | 2005-08-17 |
| NO962017L (no) | 1996-07-08 |
| DE69433705D1 (de) | 2004-05-13 |
| NO316172B1 (no) | 2003-12-22 |
| HU9601348D0 (en) | 1996-07-29 |
| NZ275961A (en) | 2001-11-30 |
| CA2176043A1 (en) | 1995-05-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE263761T1 (de) | 5,6-dihydropyronderivate als proteaseinhibitoren und antiviralmittel | |
| PT729463E (pt) | Derivados de 5,6-dihidropirona como inibidores de protease e agentes antivirais | |
| MY138860A (en) | Hiv protease inhibitors. | |
| FI915819A0 (fi) | Hiv- proteas-inhibitorer. | |
| MD960171A (ro) | Derivaţi ai pironei folosiţi ca inhibitori ai proteazei şi agenţi antivirali | |
| HU9601350D0 (en) | Pyrone derivatives as protease inhibitors and antiviral agents | |
| WO1995014014A3 (en) | Pyrone derivatives as protease inhibitors and antiviral agents | |
| ATE238062T1 (de) | Hemmung von hiv-infektion |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1142887 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |