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AU8125694A - 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents - Google Patents

5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents

Info

Publication number
AU8125694A
AU8125694A AU81256/94A AU8125694A AU8125694A AU 8125694 A AU8125694 A AU 8125694A AU 81256/94 A AU81256/94 A AU 81256/94A AU 8125694 A AU8125694 A AU 8125694A AU 8125694 A AU8125694 A AU 8125694A
Authority
AU
Australia
Prior art keywords
dihydropyrone derivatives
protease inhibitors
antiviral agents
dihydropyrone
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU81256/94A
Other versions
AU689158B2 (en
Inventor
Edmund Lee Ellsworth
Elizabeth Lunney
Bradley Dean Tait
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Parke Davis and Co LLC
Original Assignee
Parke Davis and Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/319,820 external-priority patent/US5840751A/en
Application filed by Parke Davis and Co LLC filed Critical Parke Davis and Co LLC
Publication of AU8125694A publication Critical patent/AU8125694A/en
Application granted granted Critical
Publication of AU689158B2 publication Critical patent/AU689158B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

The present invention relates to novel 5,6-dihydropyrone derivatives and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The 5,6-dihydropyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized 5,6-dihydropyrones and of related structures.
AU81256/94A 1993-11-19 1994-10-26 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents Ceased AU689158B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US15544393A 1993-11-19 1993-11-19
US155443 1993-11-19
US08/319,820 US5840751A (en) 1993-11-19 1994-10-12 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents
US319820 1994-10-12
PCT/US1994/012269 WO1995014012A1 (en) 1993-11-19 1994-10-26 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents

Publications (2)

Publication Number Publication Date
AU8125694A true AU8125694A (en) 1995-06-06
AU689158B2 AU689158B2 (en) 1998-03-26

Family

ID=26852338

Family Applications (1)

Application Number Title Priority Date Filing Date
AU81256/94A Ceased AU689158B2 (en) 1993-11-19 1994-10-26 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents

Country Status (18)

Country Link
EP (1) EP0729464A1 (en)
JP (1) JP3684426B2 (en)
AT (1) ATE263761T1 (en)
AU (1) AU689158B2 (en)
CA (1) CA2176043A1 (en)
DE (1) DE69433705T2 (en)
DK (1) DK1142887T3 (en)
ES (1) ES2219457T3 (en)
FI (1) FI962022A (en)
HR (1) HRP940935B1 (en)
HU (1) HUT77668A (en)
IL (1) IL111674A0 (en)
NO (1) NO316172B1 (en)
NZ (1) NZ275961A (en)
PT (1) PT1142887E (en)
RU (1) RU2140917C1 (en)
SI (1) SI1142887T1 (en)
WO (1) WO1995014012A1 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69633806T2 (en) * 1995-08-11 2005-05-12 Zenon Environmental Inc., Oakville Device for removing permeate from a liquid substrate with several components
US5834506A (en) * 1996-11-01 1998-11-10 Warner-Lambert Company Dihydropyrones with improved antiviral activity
PT1015441E (en) 1997-09-11 2004-08-31 Upjohn Co PROCESS FOR THE APPRODUCTION OF UTEIS 4-HYDROXY-2-OXO-PYRANO DERIVATIVES AS PROTEASE INHIBITORS
EP1112269A2 (en) * 1998-09-11 2001-07-04 Warner-Lambert Company Hiv protease inhibitors
US6288235B1 (en) 1999-04-14 2001-09-11 Ortho-Mcneil Pharmaceutical, Inc. Methods for the synthesis of highly substituted 2,4-dioxopiperidine libraries
DE10030094A1 (en) * 2000-06-19 2001-12-20 Bayer Ag New phenyl-substituted 5,6-dihydro-pyrone derivatives, useful as total or selective herbicides, insecticides, acaricides, nematocides, ectoparasiticides or antifouling agents
US6710058B2 (en) 2000-11-06 2004-03-23 Bristol-Myers Squibb Pharma Company Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
DE10108470A1 (en) * 2001-02-22 2002-09-05 Boehringer Ingelheim Pharma Process for the production of optically active dihydropyrones
US6500963B2 (en) 2001-02-22 2002-12-31 Boehringer Ingelheim Pharma Kg Process for preparing optically active dihydropyrones
DE10108471C1 (en) 2001-02-22 2002-11-21 Boehringer Ingelheim Pharma Continuous process for the preparation of 5,6-dihydro-4-hydroxy-2-pyrones
US7141681B2 (en) 2001-02-22 2006-11-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Continuous process for preparing dihydropyrones
TW200307667A (en) 2002-05-06 2003-12-16 Bristol Myers Squibb Co Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
DOP2003000641A (en) 2002-05-10 2003-11-15 Pfizer INHIBITORS OF RNA-DEPENDENT RNA POLYMERASE OF HEPATITIS C VIRUSES AND COMPOSITIONS AND TREATMENT USED
US7148226B2 (en) 2003-02-21 2006-12-12 Agouron Pharmaceuticals, Inc. Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same
UA88909C2 (en) 2004-08-18 2009-12-10 Пфайзер Инк. Inhibitors of hepatitis c virus rna-dependent rna polymerase, pharmaceutical composition based thereon and using the same
DE102005059469A1 (en) 2005-12-13 2007-06-14 Bayer Cropscience Ag Insecticidal compositions having improved activity
DE102006007882A1 (en) 2006-02-21 2007-08-30 Bayer Cropscience Ag New cyclic keto enol derivatives useful for controlling animal pests and/or unwanted plant growth
EP2404913A3 (en) * 2006-06-16 2012-06-06 Pharma Mar S.A. Process and intermediates for the preparation of antitumoral dihydropyran-2-one compounds
EP2406216B1 (en) 2009-03-11 2017-04-19 Bayer Intellectual Property GmbH Halogenalkylmethylenoxy-phenyl-substituted ketoenols
DE102010008644A1 (en) 2010-02-15 2011-08-18 Bayer Schering Pharma Aktiengesellschaft, 13353 Cyclic ketoenols for therapy
RU2461555C1 (en) * 2011-07-07 2012-09-20 Государственное образовательное учреждение высшего профессионального образования "Пермский государственный университет" Method of producing 5-aryl-3-phenyl-2-oxaspiro[5,6]dodec-3-en-1-ones, exhibiting analgesic activity
US9089137B2 (en) 2012-01-26 2015-07-28 Bayer Intellectual Property Gmbh Phenyl-substituted ketoenols for controlling fish parasites
DK2925736T3 (en) 2012-11-28 2017-03-13 Sumitomo Chemical Co DIHYDROPYRONE COMPOUNDS AND HERBICIDES COMPREHENSIVE THESE COMPOUNDS
SE539512C2 (en) * 2015-12-02 2017-10-03 Ultupharma Ab Compounds and methods of treating bacterial infections
EP4174056A4 (en) * 2020-06-26 2024-08-07 Nihon Nohyaku Co., Ltd. Aryl tetrahydropyridine derivative or salt thereof, insecticide containing same, and method for use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3818046A (en) * 1972-12-18 1974-06-18 Dow Chemical Co Sulfur-containing hydroxy pyrones and alkali metal salts thereof
ZA938019B (en) * 1992-11-13 1995-04-28 Upjohn Co Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses

Also Published As

Publication number Publication date
ES2219457T3 (en) 2004-12-01
NO962017D0 (en) 1996-05-15
SI1142887T1 (en) 2004-08-31
IL111674A0 (en) 1995-01-24
PT1142887E (en) 2004-08-31
WO1995014012A1 (en) 1995-05-26
NO962017L (en) 1996-07-08
NO316172B1 (en) 2003-12-22
DK1142887T3 (en) 2004-06-21
DE69433705T2 (en) 2005-03-10
HRP940935A2 (en) 1997-04-30
HU9601348D0 (en) 1996-07-29
RU2140917C1 (en) 1999-11-10
CA2176043A1 (en) 1995-05-26
HUT77668A (en) 1998-07-28
JP3684426B2 (en) 2005-08-17
EP0729464A1 (en) 1996-09-04
AU689158B2 (en) 1998-03-26
FI962022A0 (en) 1996-05-13
DE69433705D1 (en) 2004-05-13
HRP940935B1 (en) 2004-08-31
NZ275961A (en) 2001-11-30
ATE263761T1 (en) 2004-04-15
FI962022A (en) 1996-07-12
JPH09505294A (en) 1997-05-27

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