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AR096203A1 - Dosificaciones y métodos para administrar moléculas de ácido nucleico formuladas en lípidos - Google Patents

Dosificaciones y métodos para administrar moléculas de ácido nucleico formuladas en lípidos

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Publication number
AR096203A1
AR096203A1 ARP140101844A ARP140101844A AR096203A1 AR 096203 A1 AR096203 A1 AR 096203A1 AR P140101844 A ARP140101844 A AR P140101844A AR P140101844 A ARP140101844 A AR P140101844A AR 096203 A1 AR096203 A1 AR 096203A1
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AR
Argentina
Prior art keywords
dose
composition
administered
nucleic acid
subject
Prior art date
Application number
ARP140101844A
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English (en)
Inventor
Kasperkovitz Pia
Gollob Jared
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of AR096203A1 publication Critical patent/AR096203A1/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
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    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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Abstract

Métodos, conjuntos de elementos y dispositivos de dosificación de un sujeto para reducir una respuesta de hipersensibilidad a una molécula de ácido nucleico (por ejemplo, ARN) formulada en lípidos. Reivindicación 1: Un método para reducir una respuesta relacionada con la infusión (IRR) y/o una reacción de hipersensibilidad, en un sujeto, a una composición que comprende una formulación de lípidos y una molécula de ácido nucleico, donde dicho método comprende administrar a un sujeto: una primera dosis de dicha composición; una segunda dosis de dicha composición; y en donde se cumple uno, dos, tres, cuatro o todas las siguientes condiciones de a) - e): a) la cantidad de dicha composición administrada en dicha primera dosis no es mas que 1/X, en donde X es 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 30, 40 ó 50, de la cantidad de dicha composición administrada en dicha segunda dosis; b) la cantidad de dicha composición administrada en dicha primera dosis no es mas que 1/X, en donde X es 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 30, 40 ó 50, de la cantidad total de dicha composición administrada; c) la primera dosis se administra sobre un período de tiempo que no es mayor que 1/X, en donde X es 2, 3, 4, 5, 6, 7, 8, 9 ó 10, del período de tiempo sobre el cual se administra la segunda dosis; d) la frecuencia de administración, por ejemplo, en mg/min o ml/min, de dicha primera dosis no es mayor que 1/X, en donde X es 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 30, 40 ó 50, de la frecuencia de administración de dicha segunda dosis; o e) las dosificaciones y los períodos de administración de dichas primera y segunda dosis se seleccionan de manera tal que no hay una IRR y/o una reacción de hipersensibilidad sustancial en dicho sujeto.
ARP140101844A 2013-05-06 2014-05-06 Dosificaciones y métodos para administrar moléculas de ácido nucleico formuladas en lípidos AR096203A1 (es)

Applications Claiming Priority (1)

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US201361820036P 2013-05-06 2013-05-06

Publications (1)

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AR096203A1 true AR096203A1 (es) 2015-12-16

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ID=51867849

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ARP140101844A AR096203A1 (es) 2013-05-06 2014-05-06 Dosificaciones y métodos para administrar moléculas de ácido nucleico formuladas en lípidos
ARP200100401A AR118087A2 (es) 2013-05-06 2020-02-14 Dosificaciones y métodos para administrar moléculas de ácido nucleico formuladas en lípidos

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ARP200100401A AR118087A2 (es) 2013-05-06 2020-02-14 Dosificaciones y métodos para administrar moléculas de ácido nucleico formuladas en lípidos

Country Status (5)

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US (4) US10246708B2 (es)
EP (1) EP2994167B1 (es)
AR (2) AR096203A1 (es)
TW (1) TW201515650A (es)
WO (1) WO2014182661A2 (es)

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