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AR074863A1 - Proceso y compuestos intermedios para preparar un inhibidor de proteasa macrociclico del vhc - Google Patents

Proceso y compuestos intermedios para preparar un inhibidor de proteasa macrociclico del vhc

Info

Publication number
AR074863A1
AR074863A1 ARP090105059A AR074863A1 AR 074863 A1 AR074863 A1 AR 074863A1 AR P090105059 A ARP090105059 A AR P090105059A AR 074863 A1 AR074863 A1 AR 074863A1
Authority
AR
Argentina
Prior art keywords
formula
macrociclic
hcv
prepare
protease inhibitor
Prior art date
Application number
Other languages
English (en)
Original Assignee
Ortho Mcneil Janssen Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Janssen Pharm filed Critical Ortho Mcneil Janssen Pharm
Publication of AR074863A1 publication Critical patent/AR074863A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/475—Preparation of carboxylic acid esters by splitting of carbon-to-carbon bonds and redistribution, e.g. disproportionation or migration of groups between different molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Furan Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente también se refiere a procesos que involucran esta sal. Reivindicación 1: Un proceso para preparar un compuesto de fórmula (4), comenzando a partir de una sal de cinconidina de fórmula (1), la cual se hace reaccionar con N-metil-hexenamina (NMHA) de fórmula (2) en una reacción de formación de amida para proporcionar la amida de lactona bicíclica de fórmula (3), en donde el grupo lactona se abre para proporcionar el producto deseado de fórmula (4), donde R1 es alquilo C1-4. Reivindicación 14: La sal de cinconidina de fórmula (1).
ARP090105059 2008-12-23 2009-12-22 Proceso y compuestos intermedios para preparar un inhibidor de proteasa macrociclico del vhc AR074863A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08172691 2008-12-23

Publications (1)

Publication Number Publication Date
AR074863A1 true AR074863A1 (es) 2011-02-16

Family

ID=40548041

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090105059 AR074863A1 (es) 2008-12-23 2009-12-22 Proceso y compuestos intermedios para preparar un inhibidor de proteasa macrociclico del vhc

Country Status (23)

Country Link
US (2) US8927722B2 (es)
EP (1) EP2382198B1 (es)
JP (1) JP5687631B2 (es)
KR (1) KR101734507B1 (es)
CN (1) CN102264715B (es)
AR (1) AR074863A1 (es)
AU (1) AU2009331530B2 (es)
BR (1) BRPI0923393B1 (es)
CA (1) CA2745565C (es)
CY (1) CY1114488T1 (es)
DK (1) DK2382198T3 (es)
ES (1) ES2429013T3 (es)
HK (1) HK1164839A1 (es)
HR (1) HRP20130906T1 (es)
IL (1) IL213246A (es)
MX (1) MX2011006764A (es)
PL (1) PL2382198T3 (es)
PT (1) PT2382198E (es)
RU (1) RU2016120007A (es)
SI (1) SI2382198T1 (es)
SM (1) SMT201300116B (es)
TW (1) TWI461424B (es)
WO (1) WO2010072742A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101734507B1 (ko) 2008-12-23 2017-05-11 얀센 파마슈티칼스 인코포레이티드 Ｈｃｖ의 마크로시클릭 프로테아제 억제제를 제조하기 위한 방법 및 중간체
AU2012311461B2 (en) * 2011-09-22 2017-07-06 Janssen Pharmaceuticals, Inc. Processes and intermediates for preparing a macrocyclic protease inhibitor of HCV
EA201490892A1 (ru) 2011-10-28 2014-08-29 Янссен Фармасьютикалз, Инк. Усовершенствованный способ получения промежуточного соединения макроциклического ингибитора tmc 435 протеазы
CN103387509B (zh) * 2012-05-11 2016-06-08 重庆博腾制药科技股份有限公司 一种hcv蛋白酶抑制剂中间体的制备方法
AR091279A1 (es) * 2012-06-08 2015-01-21 Gilead Sciences Inc Inhibidores macrociclicos de virus flaviviridae
SI2859009T1 (sl) 2012-06-08 2017-12-29 Gilead Sciences, Inc. Makrociklični inhibitorji flaviviridae virusov
EA026235B1 (ru) * 2012-06-08 2017-03-31 Джилид Сайэнс, Инк. Макроциклические ингибиторы вирусов flaviviridae
UA119315C2 (uk) 2012-07-03 2019-06-10 Гіліад Фармассет Елелсі Інгібітори вірусу гепатиту с
CN105073758B (zh) 2013-03-15 2017-08-11 吉利德科学公司 丙型肝炎病毒抑制剂
CN105308043B (zh) * 2014-05-29 2018-01-30 杭州普晒医药科技有限公司 丙型肝炎药物的晶型及其制备方法、其药物组合物和用途
MA41812A (fr) 2015-03-27 2018-01-30 Janssen Pharmaceuticals Inc Procédés et intermédiaires pour la préparation d'un inhibiteur de protéase macrocyclique du vhc

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8300536A (nl) * 1983-02-14 1984-09-03 Oce Andeno Bv Optisch actief alfa-azido-p-hydroxyfenylazijnzuur en zijn zouten alsmede de bereiding daarvan.
JPS6124539A (ja) * 1984-07-11 1986-02-03 Sagami Chem Res Center 光学活性（ｒ）−２，５，１２−トリヒドロキシ−１，２，３，４−テトラヒドロナフタセン−６，１１−ジオン−２−カルボン酸の取得方法
JP4218040B2 (ja) * 1997-12-26 2009-02-04 曽田香料株式会社 有機酸とアミンの複合塩の製造法
JP3844112B2 (ja) * 2000-08-23 2006-11-08 高砂香料工業株式会社 ３，５，６−トリヒドロキシヘキサン酸アンモニウム塩誘導体、及びその製造方法
DK1713823T3 (da) * 2004-01-30 2010-03-08 Medivir Ab HCV NS-3 serinproteaseinhibitorer
CN101146794A (zh) * 2005-01-21 2008-03-19 阿斯泰克斯治疗有限公司 用于抑制cdk和gsk的吡唑衍生物
PE20070211A1 (es) * 2005-07-29 2007-05-12 Medivir Ab Compuestos macrociclicos como inhibidores del virus de hepatitis c
EP1919904B1 (en) * 2005-07-29 2014-01-08 Janssen R&D Ireland Macrocyclic inhibitors of hepatitis c virus
PT2121674E (pt) * 2007-02-01 2010-09-03 Tibotec Pharm Ltd Processos e intermediários para a preparação de um inibidor macrocíclico da protease do hcv
JP5554570B2 (ja) * 2007-02-08 2014-07-23 ヤンセン・アールアンドデイ・アイルランド Ｈｃｖ阻害大環状フェニルカルバメート
KR101734507B1 (ko) 2008-12-23 2017-05-11 얀센 파마슈티칼스 인코포레이티드 Ｈｃｖ의 마크로시클릭 프로테아제 억제제를 제조하기 위한 방법 및 중간체

Also Published As

Publication number Publication date
AU2009331530B2 (en) 2015-04-09
IL213246A0 (en) 2011-07-31
AU2009331530A1 (en) 2011-06-23
SI2382198T1 (sl) 2013-11-29
HRP20130906T1 (hr) 2013-10-25
SMT201300116B (it) 2013-11-08
CN102264715A (zh) 2011-11-30
KR20110099048A (ko) 2011-09-05
PT2382198E (pt) 2013-10-01
DK2382198T3 (da) 2013-09-30
HK1164839A1 (zh) 2012-09-28
JP2012513381A (ja) 2012-06-14
ES2429013T3 (es) 2013-11-12
RU2016120007A (ru) 2018-11-13
TWI461424B (zh) 2014-11-21
US20110257403A1 (en) 2011-10-20
US9115077B2 (en) 2015-08-25
BRPI0923393B1 (pt) 2018-06-19
US20150080577A1 (en) 2015-03-19
RU2011130895A (ru) 2013-01-27
TW201033205A (en) 2010-09-16
BRPI0923393A2 (pt) 2015-07-28
CN102264715B (zh) 2015-12-02
CY1114488T1 (el) 2016-10-05
WO2010072742A1 (en) 2010-07-01
CA2745565C (en) 2017-03-07
MX2011006764A (es) 2011-08-03
JP5687631B2 (ja) 2015-03-18
KR101734507B1 (ko) 2017-05-11
PL2382198T3 (pl) 2013-11-29
IL213246A (en) 2017-10-31
US8927722B2 (en) 2015-01-06
EP2382198B1 (en) 2013-07-10
CA2745565A1 (en) 2010-07-01
EP2382198A1 (en) 2011-11-02

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