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MX2010009860A - Sintesis total de salinosporamida a y sus analogos. - Google Patents

Sintesis total de salinosporamida a y sus analogos.

Info

Publication number
MX2010009860A
MX2010009860A MX2010009860A MX2010009860A MX2010009860A MX 2010009860 A MX2010009860 A MX 2010009860A MX 2010009860 A MX2010009860 A MX 2010009860A MX 2010009860 A MX2010009860 A MX 2010009860A MX 2010009860 A MX2010009860 A MX 2010009860A
Authority
MX
Mexico
Prior art keywords
analogs
salinosporamide
methods
total synthesis
compounds
Prior art date
Application number
MX2010009860A
Other languages
English (en)
Inventor
Ling Taotao
Samuel Danishefsky
Original Assignee
Nereus Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nereus Pharmaceuticals Inc filed Critical Nereus Pharmaceuticals Inc
Publication of MX2010009860A publication Critical patent/MX2010009860A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

La presente solicitud se refiere a ciertos compuestos y a los métodos para la preparación de ciertos compuestos que pueden emplearse en los campos de química y medicina. Específicamente, aquí se describen métodos para la preparación de diversos compuestos e intermediarios y los compuestos e intermediarios mismos. Más específicamente, aquí se describen métodos para sintetizar Salinosporamida A y sus análogos, que incluyen formar un compuestos de la fórmula (VIII).
MX2010009860A 2008-03-07 2009-03-06 Sintesis total de salinosporamida a y sus analogos. MX2010009860A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3490008P 2008-03-07 2008-03-07
US7354508P 2008-06-18 2008-06-18
PCT/US2009/036376 WO2009134531A2 (en) 2008-03-07 2009-03-06 Total synthesis of salinosporamide a and analogs thereof

Publications (1)

Publication Number Publication Date
MX2010009860A true MX2010009860A (es) 2010-09-30

Family

ID=41063770

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010009860A MX2010009860A (es) 2008-03-07 2009-03-06 Sintesis total de salinosporamida a y sus analogos.

Country Status (13)

Country Link
US (3) US8003802B2 (es)
EP (1) EP2262812A2 (es)
JP (1) JP2011514352A (es)
KR (1) KR20100131475A (es)
CN (1) CN102015721A (es)
AU (1) AU2009241635A1 (es)
BR (1) BRPI0909661A2 (es)
CA (1) CA2717715A1 (es)
CO (1) CO6331341A2 (es)
IL (1) IL208035A0 (es)
MX (1) MX2010009860A (es)
NZ (1) NZ587985A (es)
WO (1) WO2009134531A2 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7176232B2 (en) 2002-06-24 2007-02-13 The Regents Of The University Of California Salinosporamides and methods for use thereof
US20050049294A1 (en) 2003-06-20 2005-03-03 Michael Palladino Methods of using [3.2.0] heterocyclic compounds and analogs thereof
ZA200600473B (en) * 2003-06-20 2007-04-25 Univ California Salinosporamides and methods for use thereof
BRPI0517135B1 (pt) 2004-12-03 2022-04-19 Triphase Research And Development I Corp Composições e métodos para tratar doenças neoplásticas
MX2008012847A (es) * 2006-04-06 2008-10-13 Nereus Pharmaceuticals Inc Sintesis total de salinosporamida a y analogos de la misma.
US8394816B2 (en) * 2007-12-07 2013-03-12 Irene Ghobrial Methods of using [3.2.0] heterocyclic compounds and analogs thereof in treating Waldenstrom's Macroglobulinemia
WO2009134531A2 (en) 2008-03-07 2009-11-05 Nereus Pharmaceuticals, Inc. Total synthesis of salinosporamide a and analogs thereof
WO2009140287A1 (en) * 2008-05-12 2009-11-19 Nereus Pharmaceuticals, Inc. Salinosporamide derivatives as proteasome inhibitors
US9272014B2 (en) * 2011-03-29 2016-03-01 Texas Tech University System Galectin-3C combination therapy for human cancer
ES2984487T3 (es) 2016-06-01 2024-10-29 Celgene Tri A Holdings Ltd Uso combinado de marizomib y bevacizumab para el tratamiento de cánceres del sistema nervioso central (SNC)
US10703760B2 (en) 2016-08-19 2020-07-07 Celgene International Ii Sàrl Morphic forms of marizomib and uses thereof
CN107383033A (zh) * 2017-06-29 2017-11-24 上海药明康德新药开发有限公司 顺式5‑叔丁氧羰基‑四氢呋喃并[3,4‑c]吡咯‑3A‑羧酸甲酯的合成方法

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EP1341414B1 (en) 2000-11-16 2013-01-02 The Regents of The University of California Marine actinomycete taxon for drug and fermentation product discovery
US7176232B2 (en) 2002-06-24 2007-02-13 The Regents Of The University Of California Salinosporamides and methods for use thereof
US7179834B2 (en) 2002-06-24 2007-02-20 The Regents Of The University Of California Salinosporamides and methods for use thereof
US20060229353A1 (en) 2003-02-14 2006-10-12 Marc Stadler Substituted heterocycles
US20050049294A1 (en) 2003-06-20 2005-03-03 Michael Palladino Methods of using [3.2.0] heterocyclic compounds and analogs thereof
ZA200600473B (en) 2003-06-20 2007-04-25 Univ California Salinosporamides and methods for use thereof
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WO2005099687A2 (en) 2004-04-09 2005-10-27 President And Fellows Of Harvard College Analogs of salinosporamide a
US7183417B2 (en) 2004-04-09 2007-02-27 President And Fellows Of Harvard College Simple stereocontrolled synthesis of salinosporamide A
US20060264495A1 (en) 2004-04-30 2006-11-23 Michael Palladino Methods of using [3.2.0] heterocyclic compounds and analogs thereof
AU2005283141B2 (en) 2004-04-30 2012-05-10 Nereus Pharmaceuticals, Inc. (3.2.0) heterocyclic compounds and methods of using the same
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EP1771411A1 (en) 2004-07-12 2007-04-11 Bayer CropScience Aktiengesellschaft Substituted 2-pyrrolidone derivatives as fungicides and insecticides
BRPI0517135B1 (pt) 2004-12-03 2022-04-19 Triphase Research And Development I Corp Composições e métodos para tratar doenças neoplásticas
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US7691896B2 (en) 2005-08-10 2010-04-06 President And Fellows Of Harvard College Analogs of salinosporamide A
WO2007021897A1 (en) 2005-08-10 2007-02-22 President And Fellows Of Harvard College Analogs of salinosporamide a
US7465720B2 (en) 2005-09-12 2008-12-16 President And Fellows Of Harvard College Proteasome inhibiting β-lactam compounds
US20090148445A1 (en) 2005-11-04 2009-06-11 The Regents Of The University Of California Methods of sensitizing cancer to therapy-induced cytotoxicity
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US7759327B2 (en) 2006-01-06 2010-07-20 The Trustees Of Columbia University In The City Of New York Compositions containing zinc salts for coating medical articles
MX2008012847A (es) 2006-04-06 2008-10-13 Nereus Pharmaceuticals Inc Sintesis total de salinosporamida a y analogos de la misma.
US20080280968A1 (en) 2007-05-04 2008-11-13 Nereus Pharmaceuticals, Inc. Methods of using [3.2.0] heterocyclic compounds and analogs thereof for treating infectious diseases
US8394816B2 (en) 2007-12-07 2013-03-12 Irene Ghobrial Methods of using [3.2.0] heterocyclic compounds and analogs thereof in treating Waldenstrom's Macroglobulinemia
WO2009134531A2 (en) * 2008-03-07 2009-11-05 Nereus Pharmaceuticals, Inc. Total synthesis of salinosporamide a and analogs thereof
WO2009140287A1 (en) 2008-05-12 2009-11-19 Nereus Pharmaceuticals, Inc. Salinosporamide derivatives as proteasome inhibitors

Also Published As

Publication number Publication date
CA2717715A1 (en) 2009-11-05
US20130012720A1 (en) 2013-01-10
WO2009134531A2 (en) 2009-11-05
US20090234137A1 (en) 2009-09-17
IL208035A0 (en) 2010-12-30
KR20100131475A (ko) 2010-12-15
US8314251B2 (en) 2012-11-20
US8003802B2 (en) 2011-08-23
BRPI0909661A2 (pt) 2015-08-11
EP2262812A2 (en) 2010-12-22
NZ587985A (en) 2012-07-27
WO2009134531A3 (en) 2010-11-18
CO6331341A2 (es) 2011-10-20
US20110269969A1 (en) 2011-11-03
AU2009241635A1 (en) 2009-11-05
JP2011514352A (ja) 2011-05-06
CN102015721A (zh) 2011-04-13

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