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AR034124A1 - Forma cristalina alfa de la sal de terbutilamina de perindopril, procedimiento para su preparacion y composiciones farmaceuticas que la contienen - Google Patents

Forma cristalina alfa de la sal de terbutilamina de perindopril, procedimiento para su preparacion y composiciones farmaceuticas que la contienen

Info

Publication number
AR034124A1
AR034124A1 ARP010103226A ARP010103226A AR034124A1 AR 034124 A1 AR034124 A1 AR 034124A1 AR P010103226 A ARP010103226 A AR P010103226A AR P010103226 A ARP010103226 A AR P010103226A AR 034124 A1 AR034124 A1 AR 034124A1
Authority
AR
Argentina
Prior art keywords
perindopril
salt
procedure
pharmaceutical compositions
compositions containing
Prior art date
Application number
ARP010103226A
Other languages
English (en)
Inventor
Yves-Michel Ginot
Gerard Coquerel
Stephane Beilles
Bruno Pfeiffer
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8852172&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR034124(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Servier Lab filed Critical Servier Lab
Publication of AR034124A1 publication Critical patent/AR034124A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Forma cristalina alfa del compuesto de fórmula (1),cuyo diagrama de difracción de rayos X sobre polvo siguiente, medido en difractómetro (anticátodo de cobre) y expresado en términos de distancia interplanar d, de ángulo de Bragg 2 theta, de intensidad y de intensidad relativa (expresada en porcentaje con respecto al rayo más intenso) es el siguiente: Procedimiento de preparación de la forma cristalina alfa del compuesto de fórmula (1) en la cual se calienta a reflujo una solución de la sal de terbutilamina de perindopril en acetato de etilo, luego se enfría progresivamente hasta que se completa la cristalización. Composiciones farmacéuticas que contienen la forma cristalina alfa del compuesto de fórmula (1). Son útiles como inhibidores de la enzima de conversión de la angiotensina I y por lo tanto en el tratamiento de las enfermedades cardiovasculares.
ARP010103226A 2000-07-06 2001-07-06 Forma cristalina alfa de la sal de terbutilamina de perindopril, procedimiento para su preparacion y composiciones farmaceuticas que la contienen AR034124A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0008793A FR2811320B1 (fr) 2000-07-06 2000-07-06 Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent

Publications (1)

Publication Number Publication Date
AR034124A1 true AR034124A1 (es) 2004-02-04

Family

ID=8852172

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010103226A AR034124A1 (es) 2000-07-06 2001-07-06 Forma cristalina alfa de la sal de terbutilamina de perindopril, procedimiento para su preparacion y composiciones farmaceuticas que la contienen

Country Status (35)

Country Link
US (2) US20030186896A1 (es)
EP (1) EP1296947B1 (es)
JP (2) JP3602826B2 (es)
KR (1) KR100513570B1 (es)
CN (1) CN1328259C (es)
AP (1) AP1537A (es)
AR (1) AR034124A1 (es)
AT (1) ATE258918T1 (es)
AU (2) AU2001276418B2 (es)
BG (1) BG64868B1 (es)
BR (1) BR0112367A (es)
CA (1) CA2415438C (es)
CZ (1) CZ297672B6 (es)
DE (1) DE60101968T2 (es)
DK (1) DK1296947T3 (es)
EA (1) EA005008B1 (es)
EE (1) EE05268B1 (es)
ES (1) ES2214434T3 (es)
FR (1) FR2811320B1 (es)
GE (1) GEP20043361B (es)
HK (1) HK1055425A1 (es)
HR (1) HRP20030077B1 (es)
ME (1) ME00443B (es)
MX (1) MXPA02012949A (es)
NO (1) NO323447B1 (es)
NZ (1) NZ523173A (es)
OA (1) OA12304A (es)
PL (1) PL206359B1 (es)
PT (1) PT1296947E (es)
RS (1) RS50915B (es)
SK (1) SK285714B6 (es)
TR (1) TR200400238T4 (es)
UA (1) UA57188C2 (es)
WO (1) WO2001087835A1 (es)
ZA (1) ZA200210092B (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2811319B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811318B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2838648B1 (fr) * 2002-04-18 2004-05-21 Servier Lab Nouveau sel de perindopril et les compositions pharmaceutiques qui le contiennent
GB2395195A (en) 2002-11-18 2004-05-19 Cipla Ltd Preparation of perindopril from carboxy-protected precursor, & perindopril monohydrates for use as angiotensin converting enzyme (ACE) inhibitors
PL1636185T3 (pl) 2003-06-24 2012-12-31 Servier Lab Nowe formy krystaliczne peryndoprylu erbuminy
WO2005037788A1 (en) 2003-10-21 2005-04-28 Lupin Ltd. Novel method for preparation of crystalline perindopril erbumine
SI21703A (en) 2004-01-14 2005-08-31 Lek Farmacevtska Druzba Dd Inclusion complexes of perindopril, procedure of their preparation, pharmaceutical compositions containing these complexes and their application in treatment of hypertensia
ES2603856T3 (es) * 2004-03-29 2017-03-01 Les Laboratoires Servier Procedimiento para preparar una composición farmacéutica sólida
WO2005108365A1 (en) * 2004-05-07 2005-11-17 Glenmark Pharmaceuticals Limited Processes for the preparation of alpha polymorph of perindopril erbumine
US20050250706A1 (en) * 2004-05-07 2005-11-10 Glenmark Pharmaceuticals Limited Processes for the preparation of alpha polymorph of perindopril erbumine
SI21800A (sl) * 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
SI21881A (sl) 2004-10-15 2006-04-30 Diagen, Smartno Pri Ljubljani, D.O.O. Nove kristalne oblike perindopril erbumin hidratov, postopek za njihovo pripravo in farmacevtske oblike, ki vsebujejo te spojine
SG125976A1 (en) * 2005-03-11 2006-10-30 Servier Lab New gama crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it
SG125975A1 (en) * 2005-03-11 2006-10-30 Servier Lab New alpha crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it
JP2006290825A (ja) * 2005-04-13 2006-10-26 Shiono Chemical Co Ltd アルファ型ペリンドプリルエルブミンの製造法
WO2007017894A2 (en) * 2005-05-05 2007-02-15 Arch Pharmalabs Limited PREPARATION OF NOVEL CRYSTALLINE η(ETA) FORM OF PERINDOPRIL ERBUMINE
US20070032661A1 (en) * 2005-08-03 2007-02-08 Glenmark Pharmaceuticals Limited Process for the preparation of intermediates of perindopril
MX2008002064A (es) * 2005-08-12 2008-04-17 Lek Pharmaceuticals Un proceso para la preparacion de perindopril-erbumina.
WO2007020009A1 (en) * 2005-08-12 2007-02-22 Sandoz Ag New crystalline form of perindopril erbumine
EP1815857A1 (en) 2006-02-02 2007-08-08 LEK Pharmaceuticals D.D. A pharmaceutical composition comprising perindopril
WO2007092758A2 (en) * 2006-02-03 2007-08-16 Dr. Reddy's Laboratories Ltd. Crystalline forms of perindopril erbumine
FR2897866B1 (fr) * 2006-02-28 2008-04-18 Servier Lab Forme cristalline alpha du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2897865B1 (fr) * 2006-02-28 2008-04-18 Servier Lab Forme cristalline beta du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
EA200600630A1 (ru) * 2006-04-20 2007-02-27 ИСМАГИЛОВ, Искандар Халиуллович ζ-ЗЕТА ФОРМА ПЕРИНДОПРИЛ ЭРБУМИНА
EP1964836A3 (en) * 2006-11-06 2008-11-19 IPCA Laboratories Limited A process for the preparation of perindopril erbumine in alpha crystalline form
GB0624084D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amino acid salts
GB0624087D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril combination salt
GB0624090D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amine salts
WO2008114270A1 (en) * 2007-03-22 2008-09-25 Aarti Healthcare Limited Process for the preparation of perindopril erbumine salt and novel polymorph (s) thereof
WO2008120241A2 (en) * 2007-03-29 2008-10-09 Ipca Laboratories Limited Novel alcohol solvates of perindopril erbumine
SI22543A (sl) 2007-06-27 2008-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nove soli perindoprila
AU2013201812B2 (en) * 2007-06-27 2015-04-02 Les Laboratoires Servier Salts of perindopril
SI23149A (sl) * 2009-09-21 2011-03-31 Silverstone Pharma Nove benzatinske soli ACE inhibitorjev, postopek za njihovo pripravo in njihova uporaba za zdravljenje kardiovaskularnih bolezni
PT105315B (pt) 2010-09-29 2013-01-16 Inst Superior Tecnico Uma nova forma cristalina hidratada de erbumina de perindopril, métodos para a sua preparação e sua utilização em preparações farmacêuticas
CN103822996A (zh) * 2014-03-20 2014-05-28 东英（江苏）药业有限公司 一种培哚普利叔丁胺盐含量的测定方法
CN105395497B (zh) * 2015-12-04 2019-06-18 杭州新诺华医药有限公司 一种稳定的α晶型培哚普利叔丁胺片及制备方法
EP3842035A1 (en) 2019-12-23 2021-06-30 KRKA, d.d., Novo mesto Composition for the preparation of perindopril arginine granules, a method for their preparation and pharmaceutical composition comprising the granules

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR2620703B1 (fr) * 1987-09-17 1991-10-04 Adir Procede de synthese industrielle de l'acide perhydroindole carboxylique - 2(2s, 3as, 7as). application a la synthese de carboxyalkyl dipeptides
FR2620744A1 (fr) * 1987-09-17 1989-03-24 Degremont Procede de traitement par l'ozone de materiaux ligno-cellulosiques, notamment de pates a papier et reacteur pour la mise en oeuvre de ce procede
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2771010B1 (fr) * 1997-11-19 2003-08-15 Adir Utilisation d'une combinaison d'un inhibiteur de l'enzyme de conversion de l'angiotensine et d'un diuretique pour le traitement des desordres microcirculatoires
FR2811318B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811319B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent

Also Published As

Publication number Publication date
EP1296947B1 (fr) 2004-02-04
HRP20030077B1 (en) 2011-07-31
YU100402A (sh) 2003-08-29
JP2005047902A (ja) 2005-02-24
US20030186896A1 (en) 2003-10-02
DE60101968T2 (de) 2004-12-23
GEP20043361B (en) 2004-06-10
TR200400238T4 (tr) 2004-03-22
ATE258918T1 (de) 2004-02-15
DE60101968D1 (de) 2004-03-11
EA005008B1 (ru) 2004-10-28
JP3602826B2 (ja) 2004-12-15
SK285714B6 (sk) 2007-06-07
JP5016185B2 (ja) 2012-09-05
US20050059609A1 (en) 2005-03-17
NO323447B1 (no) 2007-05-07
HRP20030077A2 (en) 2003-04-30
JP2003533507A (ja) 2003-11-11
CA2415438C (fr) 2009-01-20
PT1296947E (pt) 2004-05-31
CN1440387A (zh) 2003-09-03
FR2811320B1 (fr) 2002-08-23
AP1537A (en) 2006-01-10
CA2415438A1 (fr) 2001-11-22
MXPA02012949A (es) 2003-05-15
SK1492003A3 (en) 2003-06-03
PL348492A1 (en) 2002-01-14
FR2811320A1 (fr) 2002-01-11
BR0112367A (pt) 2003-05-13
BG64868B1 (bg) 2006-07-31
EA200300107A1 (ru) 2003-06-26
DK1296947T3 (da) 2004-06-01
EP1296947A1 (fr) 2003-04-02
EE05268B1 (et) 2010-02-15
KR100513570B1 (ko) 2005-09-09
NO20030024L (no) 2003-01-03
ZA200210092B (en) 2003-12-12
BG107532A (en) 2003-12-31
ME00443B (me) 2011-10-10
AP2002002691A0 (en) 2002-12-31
KR20030024773A (ko) 2003-03-26
WO2001087835A1 (fr) 2001-11-22
AU7641801A (en) 2001-11-26
UA57188C2 (uk) 2003-06-16
HK1055425A1 (en) 2004-01-09
CZ2003357A3 (cs) 2003-05-14
AU2001276418B2 (en) 2005-07-28
ES2214434T3 (es) 2004-09-16
OA12304A (en) 2003-12-29
EE200300001A (et) 2004-08-16
NO20030024D0 (no) 2003-01-03
RS50915B (sr) 2010-08-31
CN1328259C (zh) 2007-07-25
PL206359B1 (pl) 2010-07-30
CZ297672B6 (cs) 2007-02-28
NZ523173A (en) 2004-04-30

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