[go: up one dir, main page]

PL1636185T3 - Nowe formy krystaliczne peryndoprylu erbuminy - Google Patents

Nowe formy krystaliczne peryndoprylu erbuminy

Info

Publication number
PL1636185T3
PL1636185T3 PL04737029T PL04737029T PL1636185T3 PL 1636185 T3 PL1636185 T3 PL 1636185T3 PL 04737029 T PL04737029 T PL 04737029T PL 04737029 T PL04737029 T PL 04737029T PL 1636185 T3 PL1636185 T3 PL 1636185T3
Authority
PL
Poland
Prior art keywords
crystalline form
stirring
water
perindopril erbumine
tert
Prior art date
Application number
PL04737029T
Other languages
English (en)
Inventor
Christoph Strässler
Vit Lellek
Roger Fässler
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of PL1636185T3 publication Critical patent/PL1636185T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
PL04737029T 2003-06-24 2004-06-18 Nowe formy krystaliczne peryndoprylu erbuminy PL1636185T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH11092003 2003-06-24
EP04737029A EP1636185B1 (de) 2003-06-24 2004-06-18 Neue kristalline formen von perindopril erbumine
PCT/CH2004/000374 WO2004113293A1 (de) 2003-06-24 2004-06-18 Neue kristalline formen von perindopril erbumine

Publications (1)

Publication Number Publication Date
PL1636185T3 true PL1636185T3 (pl) 2012-12-31

Family

ID=33520350

Family Applications (1)

Application Number Title Priority Date Filing Date
PL04737029T PL1636185T3 (pl) 2003-06-24 2004-06-18 Nowe formy krystaliczne peryndoprylu erbuminy

Country Status (22)

Country Link
US (2) US7705046B2 (pl)
EP (1) EP1636185B1 (pl)
JP (1) JP2007507418A (pl)
KR (1) KR20060035636A (pl)
CN (2) CN101333181A (pl)
AT (1) ATE540924T1 (pl)
AU (1) AU2004249345B8 (pl)
BR (1) BRPI0411966A (pl)
CA (1) CA2530550C (pl)
CY (1) CY1112597T1 (pl)
DK (1) DK1636185T3 (pl)
EA (1) EA008603B1 (pl)
ES (1) ES2382171T3 (pl)
HK (1) HK1093984A1 (pl)
MX (1) MXPA05013811A (pl)
NO (1) NO333128B1 (pl)
NZ (1) NZ544160A (pl)
PL (1) PL1636185T3 (pl)
PT (1) PT1636185E (pl)
SI (1) SI1636185T1 (pl)
WO (1) WO2004113293A1 (pl)
ZA (1) ZA200600655B (pl)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG125976A1 (en) * 2005-03-11 2006-10-30 Servier Lab New gama crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it
SG125975A1 (en) * 2005-03-11 2006-10-30 Servier Lab New alpha crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it
WO2007017894A2 (en) * 2005-05-05 2007-02-15 Arch Pharmalabs Limited PREPARATION OF NOVEL CRYSTALLINE η(ETA) FORM OF PERINDOPRIL ERBUMINE
WO2007017893A2 (en) * 2005-05-05 2007-02-15 Arch Pharmalabs Limited Preparation of novel crystalline form of perindopril erbumine monohydrate
WO2007020009A1 (en) * 2005-08-12 2007-02-22 Sandoz Ag New crystalline form of perindopril erbumine
MX2008002064A (es) * 2005-08-12 2008-04-17 Lek Pharmaceuticals Un proceso para la preparacion de perindopril-erbumina.
EP1815857A1 (en) 2006-02-02 2007-08-08 LEK Pharmaceuticals D.D. A pharmaceutical composition comprising perindopril
WO2007092758A2 (en) * 2006-02-03 2007-08-16 Dr. Reddy's Laboratories Ltd. Crystalline forms of perindopril erbumine
EA200600630A1 (ru) * 2006-04-20 2007-02-27 ИСМАГИЛОВ, Искандар Халиуллович ζ-ЗЕТА ФОРМА ПЕРИНДОПРИЛ ЭРБУМИНА
WO2008050185A2 (en) * 2006-10-26 2008-05-02 Glenmark Pharmaceuticals Limited Novel polymorphs of perindopril erbumine
WO2008114270A1 (en) * 2007-03-22 2008-09-25 Aarti Healthcare Limited Process for the preparation of perindopril erbumine salt and novel polymorph (s) thereof
SI22543A (sl) 2007-06-27 2008-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nove soli perindoprila
PT105315B (pt) 2010-09-29 2013-01-16 Inst Superior Tecnico Uma nova forma cristalina hidratada de erbumina de perindopril, métodos para a sua preparação e sua utilização em preparações farmacêuticas

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4508729A (en) * 1979-12-07 1985-04-02 Adir Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
FR2503155A2 (fr) 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
US5519146A (en) * 1993-01-08 1996-05-21 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Process for crystallizing N2 - ((S) -1-ethoxycarbonyl-3-phenylpropyl)-N6 -trifluoroacetyl-L-lysyl-L-proline
FR2807431B1 (fr) 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2811320B1 (fr) 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811318B1 (fr) 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811319B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2827860B1 (fr) 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
GB2395195A (en) * 2002-11-18 2004-05-19 Cipla Ltd Preparation of perindopril from carboxy-protected precursor, & perindopril monohydrates for use as angiotensin converting enzyme (ACE) inhibitors
EP1973523A2 (en) * 2005-12-15 2008-10-01 Acusphere, Inc. Processes for making particle-based pharmaceutical formulations for pulmonary or nasal administration

Also Published As

Publication number Publication date
CA2530550A1 (en) 2004-12-08
ATE540924T1 (de) 2012-01-15
CN1812971A (zh) 2006-08-02
US20070135512A1 (en) 2007-06-14
CN100395235C (zh) 2008-06-18
EA200501859A1 (ru) 2006-06-30
NO333128B1 (no) 2013-03-11
AU2004249345B2 (en) 2009-02-26
EA008603B1 (ru) 2007-06-29
CN101333181A (zh) 2008-12-31
NZ544160A (en) 2008-07-31
DK1636185T3 (da) 2012-05-07
EP1636185B1 (de) 2012-01-11
ES2382171T3 (es) 2012-06-06
ZA200600655B (en) 2007-05-30
US20100160404A1 (en) 2010-06-24
AU2004249345A1 (en) 2004-12-29
PT1636185E (pt) 2012-04-16
SI1636185T1 (sl) 2012-06-29
AU2004249345B8 (en) 2009-06-25
WO2004113293A1 (de) 2004-12-29
EP1636185A1 (de) 2006-03-22
CY1112597T1 (el) 2016-02-10
NO20060256L (no) 2006-01-18
MXPA05013811A (es) 2006-06-27
KR20060035636A (ko) 2006-04-26
BRPI0411966A (pt) 2006-08-29
US7705046B2 (en) 2010-04-27
HK1093984A1 (en) 2007-03-16
CA2530550C (en) 2017-04-04
JP2007507418A (ja) 2007-03-29
US7981921B2 (en) 2011-07-19

Similar Documents

Publication Publication Date Title
HK1093984A1 (en) Novel crystalline forms of perindopril erbumine
AU2002359164A1 (en) Use of oxindole derivatives in the treatment of dementia related diseases, alzheimer's disease and conditions associated with glycogen synthase kinase-3
JPH05262659A (ja) ウコン植物調合剤及び医薬
GB2454615A (en) Antidiabetic azabicyclo (3.1.0) hexan compounds
WO2008035686A1 (fr) Agent pour améliorer la résistance à l'insuline
CN1284063A (zh) 新化合物
FI91156B (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten neplanosiinijohdannaisten valmistamiseksi
JPH02777A (ja) 新規化合物、その製法及びそれを含む医薬組成物
TW200634001A (en) Novel compounds
WO2008039087A3 (en) Indoline derivatives and uses thereof
JP2015030724A (ja) 子宮頸癌細胞増殖抑制剤
JP6178520B2 (ja) 新規な抗ｈｐｖ医薬製剤の用途
KR20000026053A (ko) 류코트리엔 생성 저해활성을 가지는 신이 추출물 및 신이로부터분리한 리그난 화합물
JP2022537518A (ja) 脳神経または心臓保護剤としてのアミノチオール系化合物の使用
WO1998056759A3 (de) Neue pentaerythritderivate, deren herstellung und verwendung sowie intermediate zur synthese derselben
FR2533566A1 (fr) Imino- et amino-acides acyloxycetone-substitues a action therapeutique
GEP20043408B (en) Process For Preparing 6-(4-Chlorophenyl)- 2,2-Dimethyl-7-Phenyl-2,3-Dihydro-1H-Pyrrolizin-5-YL-Acetic Acid, Pharmaceutical Composition Containing Them and Use Thereof for Treatment of Disorders of the Rheumatic Type
CN108929320A (zh) 3r-吲哚甲基-6r-恶唑烷酮修饰的哌嗪-2,5-二酮，其合成，活性和应用
NO173822B (no) Analogifremgangsmaate for fremstilling av den terapeutisk aktive forbindelse (4-amino-2,6-dimetylfenylsulfonyl)nitrometan og farmasoeytisk akseptable salter derav
CN108948137A (zh) 3s-吲哚乙基-6s-极性氨基酸修饰的哌嗪-2,5-二酮，其合成，活性和应用
Von Korff et al. A DIFFERENCE IN BOVINE AND HUMAN FIBRINO-PEPTIDES WITH RESPECT TO THE OCCURRENCE OF TYROSINE-O-SULFATE
CN101307080A (zh) 具有镇静活性的5-(4-β-D-吡喃阿洛糖苷-苯基)-3-芳基-4,5-二氢吡唑-1-硫代酰胺类化合物的制备
JPS62132878A (ja) 新生理活性物質モナコリンｍ及びその製造法
JPS61106564A (ja) 不飽和脂肪酸アミド誘導体およびこれを含有する血小板凝集抑制剤
JP2005053837A (ja) 吸収性骨疾患予防治療剤