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MAPK1

S Wikipedije, slobodne enciklopedije
MAPK1
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

1PME, 1TVO, 1WZY, 2OJG, 2OJI, 2OJJ, 2Y9Q, 3D42, 3D44, 3I5Z, 3I60, 3SA0, 3TEI, 3W55, 4FMQ, 4FUX, 4FUY, 4FV0, 4FV1, 4FV2, 4FV3, 4FV4, 4FV5, 4FV6, 4FV7, 4FV8, 4FV9, 4G6N, 4G6O, 4H3P, 4H3Q, 4IZ5, 4IZ7, 4IZA, 4N0S, 4NIF, 4O6E, 4QTA, 4QTE, 4ZZM, 4ZZN, 4ZZO, 5BUE, 5BUI, 5BUJ, 4QP1, 4QP2, 4QP3, 4QP4, 4QP6, 4QP7, 4QP8, 4QP9, 4QPA, 4XJ0, 5BVD, 5BVE, 5BVF, 5AX3, 4ZXT, 5K4I

Identifikatori
AliasiMAPK1
Vanjski ID-jeviOMIM: 176948 MGI: 1346858 HomoloGene: 37670 GeneCards: MAPK1
Lokacija gena (čovjek)
Hromosom 22 (čovjek)
Hrom.Hromosom 22 (čovjek)[1]
Hromosom 22 (čovjek)
Genomska lokacija za MAPK1
Genomska lokacija za MAPK1
Bend22q11.22Početak21,759,657 bp[1]
Kraj21,867,680 bp[1]
Lokacija gena (miš)
Hromosom 16 (miš)
Hrom.Hromosom 16 (miš)[2]
Hromosom 16 (miš)
Genomska lokacija za MAPK1
Genomska lokacija za MAPK1
Bend16 A3|16 10.53 cMPočetak16,801,246 bp[2]
Kraj16,865,317 bp[2]
Obrazac RNK ekspresije


Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija• phosphatase binding
• ATP binding
• protein kinase activity
• transcription factor binding
• aktivnost sa transferazom
• mitogen-activated protein kinase kinase kinase binding
• phosphotyrosine residue binding
• GO:0001948, GO:0016582 vezivanje za proteine
• protein kinase binding
• vezivanje sa DNK
• nucleotide binding
• RNA polymerase II CTD heptapeptide repeat kinase activity
• protein serine/threonine kinase activity
• kinase activity
• vezivanje identičnih proteina
• MAP kinase activity
• double-stranded DNA binding
• MAP kinase kinase activity
Ćelijska komponenta• citoplazma
• citosol
• focal adhesion
• centar organizacije mikrotubula
• mitohondrija
• Kaveole
• dendrite cytoplasm
• citoskelet
• jedro
• Egzosom
• perikaryon
• late endosome
• Golđijev aparat
• Diobeno vreteno
• Akson
• early endosome
• mitotic spindle
• Pseudopodija
• extracellular region
• nukleoplazma
• azurophil granule lumen
• ficolin-1-rich granule lumen
• ćelijska membrana
• GO:0097483, GO:0097481 postsynaptic density
• membrana
• GO:0009327 makromolekulani kompleks
Biološki proces• caveolin-mediated endocytosis
• positive regulation of telomere capping
• response to exogenous dsRNA
• cardiac neural crest cell development involved in heart development
• positive regulation of translation
• cellular response to DNA damage stimulus
• platelet activation
• Fc-epsilon receptor signaling pathway
• protein phosphorylation
• face development
• cellular response to granulocyte macrophage colony-stimulating factor stimulus
• regulation of DNA-binding transcription factor activity
• animal organ morphogenesis
• ćelijski ciklus
• ERBB signaling pathway
• GO:0097285 apoptoza
• B cell receptor signaling pathway
• GO:0009373 regulation of transcription, DNA-templated
• regulation of protein stability
• Fc-gamma receptor signaling pathway involved in phagocytosis
• thymus development
• negative regulation of cell differentiation
• ERK1 and ERK2 cascade
• labyrinthine layer blood vessel development
• transcription, DNA-templated
• GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated
• heart development
• GO:0022415 viral process
• response to toxic substance
• regulation of stress-activated MAPK cascade
• chemical synaptic transmission
• growth hormone receptor signaling pathway via JAK-STAT
• cytosine metabolic process
• Fosforilacija
• outer ear morphogenesis
• response to estrogen
• Hemotaksija
• response to lipopolysaccharide
• thyroid gland development
• response to epidermal growth factor
• positive regulation of telomerase activity
• Nocicepcija
• peptidyl-threonine phosphorylation
• trachea formation
• lipopolysaccharide-mediated signaling pathway
• mammary gland epithelial cell proliferation
• GO:0007243 intracellular signal transduction
• lung morphogenesis
• neural crest cell development
• positive regulation of cell migration
• regulation of early endosome to late endosome transport
• response to stress
• positive regulation of telomere maintenance via telomerase
• MAPK cascade
• axon guidance
• fibroblast growth factor receptor signaling pathway
• positive regulation of peptidyl-threonine phosphorylation
• GO:0035404 peptidyl-serine phosphorylation
• positive regulation of cell population proliferation
• regulation of cellular response to heat
• Bergmann glial cell differentiation
• regulation of Golgi inheritance
• T cell receptor signaling pathway
• regulation of cytoskeleton organization
• GO:0072468 Transdukcija signala
• long-term potentiation
• regulation of ossification
• regulation of phosphatidylinositol 3-kinase signaling
• neutrophil degranulation
• Regulacija ekspresije gena
• cellular response to organic substance
• GO:0010260 starenje
• learning or memory
• GO:1901313 positive regulation of gene expression
• diadenosine tetraphosphate biosynthetic process
• regulation of cellular pH
• cellular response to amino acid starvation
• GO:0072353 cellular response to reactive oxygen species
• response to nicotine
• decidualization
• stress-activated MAPK cascade
• positive regulation of cardiac muscle cell proliferation
• cellular response to cadmium ion
• cellular response to tumor necrosis factor
• cellular response to dopamine
• positive regulation of protein import into nucleus
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

5594

26413

Ensembl

ENSG00000100030

ENSMUSG00000063358

UniProt

P28482

P63085

RefSeq (mRNK)

NM_138957
NM_002745

NM_001038663
NM_011949
NM_001357115
NM_028991

RefSeq (bjelančevina)

NP_002736
NP_620407

NP_001033752
NP_036079
NP_001344044

Lokacija (UCSC)Chr 22: 21.76 – 21.87 MbChr 16: 16.8 – 16.87 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Mitogen–aktivirana protein-kinaza 1, znana i kao MAPK1, p42MAPK i ERK2, jest enzim koji je kod ljudi kodiran genom sa MAPK1 hromosoma 22.[5]

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 360 aminokiselina, a molekulska težina 41.390 Da.

1020304050
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVR
VAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKD
VYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDL
KPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIML
NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQE
DLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEE
TARFQPGYRS

Funkcija

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Protein kodiran ovim genom član je porodice MAP-kinaza. MAP-kinaze, također poznate kao vanćelijske signalno regulirane kinaze (ERK), djeluju kao integracijska tačka za više biohemijskih signala i uključene su u širok spektar ćelijskih procesa, kao što je proliferacija, diferencijacija, regulacija i razvoj transkripcije. Aktivacija ove kinaze zahtijeva njenu fosforilaciju uzvodnim kinazama. Nakon aktivacije, ova kinaza translocira se u jedro stimuliranih ćelija, gdje fosforilira jedarne mete. Za ovaj gen prijavljene su dvije alternativno prerađene varijante transkripta koje kodiraju isti protein, ali se razlikuju u UTR-u.[6] MAPK1 contains multiple amino acid sites that are phosphorylated and ubiquitinated.[7]

Modelni organizmi

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U proučavanju funkcije MAPK1 korišteni su modelni organizmi. Uslovna linija nokaut-miša, zvana Mapk1tm1a(EUCOMM)Wtsi[8][9] generirana je kao dio programa Konzorcija za nokaut-miševe—projekta mutageneze visoke propusnosti za generiranje i distribuciju životinjskih modela bolesti zainteresiranim naučnicima.[10][11][12]

Fenotip Mapk1 nokaut-miševa
Svojstvo Fenotip
Vijabilnost homozigota Nenormalan
Studija recesivne letalnosti Nenormalan
Plodnost Normalan
Tjelesna težina Normalan
Anksioznost otvorenog polja| Normalan
Neurološka procjena Normalan
Snaga ugriza Normalan
Test vruće ploče Normalan
Dismorfologija Normalan [13]
Indirektna kalorimetrija Normalan
Test tolerancije glukoze Normalan
Slušni odgovor moždanog stabla Normalan
DEXA Normalan
Radiografija Normalan
Tjelesna temperatura Normalan
Morfologija OKA Normalan
klinička hemija Nenormalan[14]
Plazmatski imunoglobulini Normalan
Hematologija Normalan
Leukociti periferne krvi Normalan
Mikronukleus test Normalan
Težina srca Normalan
Cjelovitost repne epiderme Normalan
Histopatologija kože Normalan
Histopatologija mozga Normalan
Salmonella infekcija Normalan[15]
Citrobacter infekcija Normalan[16]
Svi testovi i analize su prema[17][18]

Mužjaci i ženke su podvrgnute standardiziranom fenotipskom pregledu, kako bi se utvrdili efekti deleciija.[17][19] Obavljeno je 27 testova na mutantnim miševima i uočene su tri značajne abnormalnosti.[17] Nijedan homozigotni mutantni embrion nije identifikovan tokom gestacije, pa stoga nijedan nije preživio do odbijanja. Preostali testovi su obavljeni na heterozigotnim mutantnim odraslim miševima, a mužjaci su imali smanjene razine amilaze u cirkulaciji.[17]

Uslovna delecija "Mapk1" u B-ćelijama pokazala je ulogu MAPK1 u proizvodnji antitijela zavisnih od T-ćelija.[20] Dominantni mutanti za dobijanje funkcije "Mapk1" kod transgenih miševa pokazao je ulogu MAPK1 u razvoju T-ćelija.[21] Uslovna inaktivacija "Mapk1" u nervnim progenitorskim ćelijama korteksa u razvoju dovodi do smanjenja debljine korteksa i smanjene proliferacije u nervnim progenitorskim ćelijama.[22]

Interakcije

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Pokazalo se da MAPK1 reaguje sa:

Klinički značaj

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Mutacije u MAPK1 su uključene u mnoge tipove kancera.[61]

Također pogledajte

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Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100030 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063358 - Ensembl, maj 2017
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