- +13014057335
Peter Kofinas
University of Maryland, College Park, Bioengineering, Faculty Member
not Available.
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Solution blow spinning is a technique for depositing polymer fibers with promising potential use as a surgical sealant. This study assessed the feasibility and efficacy of solution blow spun polymer (BSP) for sealing bowel perforations in... more
Solution blow spinning is a technique for depositing polymer fibers with promising potential use as a surgical sealant. This study assessed the feasibility and efficacy of solution blow spun polymer (BSP) for sealing bowel perforations in a mouse model of partial cecal transection. We then evaluated its use for reinforcing a surgical anastomosis in a preclinical piglet model. Three commercially available surgical sealants (fibrin glue, polyethylene glycol (PEG) hydrogel, and cyanoacrylate) were compared to BSP in the ability to seal partially transected cecum in mice. For anastomosis feasibility testing in a piglet model, piglets were subjected to small bowel transection with sutured anastomosis reinforced with BSP application. Outcome measures included anastomotic burst pressure, anastomotic leak rate, 14-day survival, and complication rate. For the mouse model, the survival rates for the sealants were 30% for fibrin glue, 20% for PEG hydrogel, 78% for cyanoacrylate, and 67% for BS...
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Solution blow spinning (SBS) is a technique that can be used to deposit fibers in situ at low cost for a variety of applications, which include biomedical materials and flexible electronics. This review is intended to provide an overview... more
Solution blow spinning (SBS) is a technique that can be used to deposit fibers in situ at low cost for a variety of applications, which include biomedical materials and flexible electronics. This review is intended to provide an overview of the basic principles and applications of SBS. We first describe a method for creating a spinnable polymer solution and stable polymer solution jet by manipulating parameters such as polymer concentration and gas pressure. This method is based on fundamental insights, theoretical models, and empirical studies. We then discuss the unique bundled morphology and mechanical properties of fiber mats produced by SBS, and how they compare with electrospun fiber mats. Applications of SBS in biomedical engineering are highlighted, showing enhanced cell infiltration and proliferation versus electrospun fiber scaffolds and in situ deposition of biodegradable polymers. We also discuss the impact of SBS in applications involving textiles and electronics, inclu...
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The development of practical and efficient surgical sealants has the propensity to improve operational outcomes. A biodegradable polymer blend is fabricated as a nonwoven fiber mat in situ. After direct deposition onto the tissue of... more
The development of practical and efficient surgical sealants has the propensity to improve operational outcomes. A biodegradable polymer blend is fabricated as a nonwoven fiber mat in situ. After direct deposition onto the tissue of interest, the material transitions from a fiber mat to a film. This transition promotes polymer-substrate interfacial interaction leading to improved adhesion and surgical sealant performance.
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High-aspect-ratio cobalt-oxide-coated Tobacco mosaic virus (TMV-) assembled polytetrafluoroethylene (PTFE) nonstick surfaces were integrated with a solvent-free polymer electrolyte to create an anode-electrolyte interface for use in... more
High-aspect-ratio cobalt-oxide-coated Tobacco mosaic virus (TMV-) assembled polytetrafluoroethylene (PTFE) nonstick surfaces were integrated with a solvent-free polymer electrolyte to create an anode-electrolyte interface for use in lithium-ion batteries. The virus-assembled PTFE surfaces consisted primarily of cobalt oxide and were readily intercalated with a low-molecular-weight poly (ethylene oxide) (PEO) based diblock copolymer electrolyte to produce a solid anode-electrolyte system. The resulting polymer-coated virus-based system was then peeled from the PTFE backing to produce a flexible electrode-electrolyte component. Electrochemical studies indicated the virus-structured metal-oxide PEO-based interface was stable and displayed robust charge transfer kinetics. Combined, these studies demonstrate the development of a novel solid-state electrode architecture with a unique peelable and flexible processing attribute.
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Research Interests: Biochemistry, Genetics, Biophysics, Materials Science, Inorganic Chemistry, and 14 moreHematology, Developmental Biology, Immunology, Molecular Biology, Biotechnology, Scanning Electron Microscopy, Electrospinning, Cell Biology, Tissue repair, Nanofiber, Spinning, Application, Weight Changes, and Cell Lines
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As technology evolves, leading to a constant miniaturization of electrical devices, the need for a compact, lighter, safer and versatile energy source has been a critical limiting factor. Owing to its highly reactive nature, lithium... more
As technology evolves, leading to a constant miniaturization of electrical devices, the need for a compact, lighter, safer and versatile energy source has been a critical limiting factor. Owing to its highly reactive nature, lithium batteries currently in use require thick and bulky ...
Abstract: Gas permeability coefficients P for several gases (He. CO2, CH4, 02, N2) were measured at 25 deg C in a series of semicrystalline diblock copolymers of poly (ethylene)/poly (ethylene-propylene)(E/EP). A simple model is presented... more
Abstract: Gas permeability coefficients P for several gases (He. CO2, CH4, 02, N2) were measured at 25 deg C in a series of semicrystalline diblock copolymers of poly (ethylene)/poly (ethylene-propylene)(E/EP). A simple model is presented describing the gas transport in these polymer systems. It predicts the permeability of a randomly oriented spherulitic diblock specimen from the permeabilities of the individual lamellar regions of the copolymer. Model predictions were in excellent agreement with the experimental data. ...
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Whenever effluents are discharged into natural waters there is a concern over the effect phosphorus will have on water quality in the receiving body of water. It is a well known fact that most natural waters are either phosphorus or... more
Whenever effluents are discharged into natural waters there is a concern over the effect phosphorus will have on water quality in the receiving body of water. It is a well known fact that most natural waters are either phosphorus or nitrogen limited. Discharge of phosphorus into these waters often leads to algae blooms that produce unsightly areas, lower oxygen concentrations in the water and may result in fish kills. Methods that will remove phosphorus even at extremely low concentration from aquacultural effluents is a major need in the ...
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The present application is drawn to a synthetic, polymer hydrogel-based material, which is able to actively induce the body's natural hemostatic coagulation process in blood or acellular plasma. The present invention provides the... more
The present application is drawn to a synthetic, polymer hydrogel-based material, which is able to actively induce the body's natural hemostatic coagulation process in blood or acellular plasma. The present invention provides the development of a primary amine containing polymer hydrogel capable of inducing blood coagulation and delivering therapeutics for hemostatic or wound care applications, and a method of forming such a primary amine containing polymer hydrogel capable of inducing the blood coagulation ...
Imprinted polymeric materials that selectively bind to a template article. Various types of template articles may be targeted by the imprinted polymeric materials, including microorganisms (eg, viruses or bacteria) or biologic... more
Imprinted polymeric materials that selectively bind to a template article. Various types of template articles may be targeted by the imprinted polymeric materials, including microorganisms (eg, viruses or bacteria) or biologic macromolecules (eg, proteins or DNA). The imprinted polymeric material may be formed by template-directed synthesis using monomer units that interact with the template article. The monomer units are used to form a polymer matrix around the template article. Subsequently, the template article is removed ...
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Abstract: Disclosed is a method of removing anionic pollutants from wastewater, comprising contacting said wastewater with an anion-binding polymer, whereby said anionic pollutants are absorbed to said polymer. Also disclosed is a method... more
Abstract: Disclosed is a method of removing anionic pollutants from wastewater, comprising contacting said wastewater with an anion-binding polymer, whereby said anionic pollutants are absorbed to said polymer. Also disclosed is a method of removing anionic pollutants from wastewater and providing an agricultural fertilizer, comprising contacting said wastewater with an anion-binding polymer, whereby said anionic pollutants are absorbed to said polymer, eluting the anionic pollutants from said polymer with a strongly alkaline ...
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High-aspect-ratio cobalt-oxide-coated Tobacco mosaic virus (TMV-) assembled polytetrafluoroethylene (PTFE) nonstick surfaces were integrated with a solvent-free polymer electrolyte to create an anode-electrolyte interface for use in... more
High-aspect-ratio cobalt-oxide-coated Tobacco mosaic virus (TMV-) assembled polytetrafluoroethylene (PTFE) nonstick surfaces were integrated with a solvent-free polymer electrolyte to create an anode-electrolyte interface for use in lithium-ion batteries. The virus-assembled PTFE surfaces consisted primarily of cobalt oxide and were readily intercalated with a low-molecular-weight poly (ethylene oxide)(PEO) based diblock copolymer electrolyte to produce a solid anode-electrolyte system.
Abstract The formation of 10 nm self-assembled ZnO nanoparticles on Si and SiO 2/Si surfaces, using diblock copolymers, and wet chemical processing compatible with semiconductor manufacturing, is reported. The diblock copolymer,... more
Abstract The formation of 10 nm self-assembled ZnO nanoparticles on Si and SiO 2/Si surfaces, using diblock copolymers, and wet chemical processing compatible with semiconductor manufacturing, is reported. The diblock copolymer, consisting of norbornene and a norbornenedicarboxcylic acid blocks with a 400 to 50 repeat unit ratio, was synthesized by ring opening metathesis polymerization.
The formation of self-assembled ZnO nanoclusters using diblock copolymers, is reported. The diblock copolymers, consisting of a majority polymer (norbornene) and a minority polymer (norbornene-dicarboxcylic acid), were synthesized with a... more
The formation of self-assembled ZnO nanoclusters using diblock copolymers, is reported. The diblock copolymers, consisting of a majority polymer (norbornene) and a minority polymer (norbornene-dicarboxcylic acid), were synthesized with a block repeat unit ratio of 400/50, to obtain spherical microphase separation and hence a spherical morphology for the metal oxide nanoclusters.
Abstract Solid polymer electrolytes for lithium batteries possess increased safety over traditional carbonate electrolytes, but have not been shown effective at temperatures close to ambient. The inclusion of triethyl sulfonium based... more
Abstract Solid polymer electrolytes for lithium batteries possess increased safety over traditional carbonate electrolytes, but have not been shown effective at temperatures close to ambient. The inclusion of triethyl sulfonium based ionic liquids (IL) into poly (ethylene oxide)(PEO) homopolymers has demonstrated the ability to reach the necessary figures of merit for use in a lithium battery below physiological temperature.
Abstract Low loss core–shell iron–silica nanocomposites with improved magneto-dielectric properties at radio frequencies (1 MHz–1 GHz) were successfully fabricated. A new simple method was developed to synthesize metallic iron (Fe)... more
Abstract Low loss core–shell iron–silica nanocomposites with improved magneto-dielectric properties at radio frequencies (1 MHz–1 GHz) were successfully fabricated. A new simple method was developed to synthesize metallic iron (Fe) nanoparticles with uniform size distribution in an aqueous environment at room temperature. Citric acid and oleic acid served as surface-capping agents to control the particle size of the synthesized Fe nanoparticles.
Gas permeability coefficients were obtained for CO2 and He gases at room temperature in a semicrystalline ethylene/ethylene–propylene/ethylene (E/EP/E) triblock copolymer, and a blend of polyisoprene (PI) with an E/EP diblock copolymer.... more
Gas permeability coefficients were obtained for CO2 and He gases at room temperature in a semicrystalline ethylene/ethylene–propylene/ethylene (E/EP/E) triblock copolymer, and a blend of polyisoprene (PI) with an E/EP diblock copolymer. It was found that the gas transport properties of these polymer systems were influenced by changes in processing conditions and solvent treatments to create nanoporous membranes.