Meeting Abstracts

Cancer  remains  a  leading  cause  of  death,  despite  the  undeniable  progress  made  in  the  last  decades  in  the  diagnosis  and  therapeutic  treatments.  Further  improvements  are  only  possible  if  we  understand  more  in  depth  how  cancer  develops  and  metastasizes,  and  how  it  produces  its  damaging  effects  on  the  whole  organisms,  including  immune-suppression  and  cachexia,  that  eventually  lead  to  patient  death.  The  goal  of  the  International  Workshop  No-Cancer  2018  “understanding  cancer  cell  biology  to  improve  diagnosis  and  therapy”  held  in  28-30  Oct,  in  Novara  (Italy)  is  precisely  to  share  the  foremost  updated  knowledge  on  the  biology of cancer and the emerging technologies for early detection of cancer cells and the new “chemo-free” therapeutic options.This  is  the  third  international  Conference  on  Cancer  organized  under  the  auspices  of  the  Università  del  Piemonte  Orientale  and  other  Academic  and  Cultural  institutions,  and  ideally  follows  the  two  previous  ones “Basic to Translational Medicine 2016: focus on Cancer” and No-Cancer 2017 “From Cancerogenesis to Therapy: new paradigms, new opportunities”, held in Novara. As outlined in the title, the main objective of the present workshop No-Cancer 2018 is to discuss the current knowledge in Cancer Cell Biology with the aim of paving the design of more precise and non-invasive methods for early detection of cancer cells and of more effective and personalized therapeutic interventions. Twelve  internationally  renowned  speakers  coming  from  Belgium,  France,  Italy,  Germany,  Spain,  Portugal  and United States will present their recent research in a two-day scientific marathon. In addition, eight short communications  and  thirteen  flash  communications  have  been  selected  from  the  submitted  abstracts.  The  following topics are covered: Oncogenes, onco-suppressors and Non-Coding RNAs in Cancer development; Cancer Cell metabolism and Metabolic cross-talk between cancer cells and stromal cells; Role of diet and of microbiota in cancer progression and response to therapy; Novel non-invasive strategies for early detection of cancer, Genetic alterations predisposing to Cancer; Immune and Drug resistance; cachexia; Clinical trials with novel therapeutics. The invited lectures will focus particularly on ovary cancer, colon cancer, pancreatic cancer, breast cancer, prostate cancer, mesothelioma, and hemato-oncology.

An electrochemical kinetic model (EKM) is developed, describing the electrochemical hydrogen storage in hydride-forming materials under equilibrium conditions. This model is based on first principles of electrochemical reaction kinetics and statistical thermodynamics and describes the complex, multi-stage, electrochemical (de)hydrogenation process. A complete set of equations have been derived, describing the equilibrium hydrogen partial pressure and equilibrium electrode potential as a function of hydrogen content in both solid-solution and two-phase coexistence regions. The EKM has been applied to simulate the isotherms of thin film Pd electrodes of various thicknesses. Good agreement between experiment and theory is found in all cases. Relevant energy and kinetic parameters are obtained from the simulations.

Potentiometric electronic tongues have been proposed as versatile sensor arrays for chemical analysis of a wide variety of analytes without the need for high specificity of individual sensors[i]. The prospect of portable electronic tongues offers new approaches for distributed, decentralized chemical analysis for various applications such as traceability of goods in supply chains[ii] , [iii]. A challenge for electronic tongues, however, has often been the quantitative determination of concentrations of target analytes in the presence of multiple interferents due to the inherent cross-sensitivity of the sensors employed. In the present contribution, we extend our previously reported work[iv] on an all-solid-state electronic tongue based on an array of electrodeposited polymeric sensors to study the feasibility and accuracy of employing this class of sensors to the quantification of multiple analytes. The sensor array studied herein is entirely integrated on a conventional printed cir...

New, higher-capacity materials are required in order to address the growing need for batteries with greater energy density and longer cycle life for modern applications. We present here a study of silicon-nanowire (SiNW) anodes, synthesized via a novel, catalysts free and scalable chemical vapor deposition (CVD) on stainless-steel mesh. This is a continuation to our previous paper (Harpak et al., Nano Lett. (2019) http://pubs.acs.org/doi/10.1021/acs.nanolett.8b05127) that describes the progress we recently made. The study is focused on the adaptation of the SiNW anode in various large-scale configurations. Our research efforts have resulted in the successful scale-up of the silicon anode from Si/Li half-cells with high areal capacity of 14 mAh cm−2, to coin cells with commercial cathodes, industrial 1/3AAA cells and proof-of-concept multilayered pouch cells. Testing of our anodes in cylindrical cells demonstrated the applicability of these anodes in commercial lithium-ion batteries ...

Introduction Lithium-ion batteries are attractive for applications, such as power sources for electric vehicles; high energy density and efficient power capability are needed for a positive electrode. Recently, surface coating of various materials, such as metal oxides, phosphates, fluorides and so on, has been reported to be effective for improving the capacity retention, rate capability and thermal stability[1,2]. Furthermore, as a coating technique, variety of technique has been proposed containing mechanical alloying technique, co-precipitation method and atomic layer deposition. In our previous works, we have demonstrated the electrochemical performances and structural properties of LiNi1/3Mn1/3Co1/3O2 (NMC) coated with Al oxides by using the evaporation to dryness technique[3] and mechanochemical coating technique with Al2O3 nanoparticles[4]. These results of treatment showed clearly enhanced electrochemical properties, and the surface modification by coating with Al oxide has...

The intermittent nature of renewable sources demands the utilization of resilient storage systems, which can smoothen their energy production and distribution to consumer utilities. Among the storge systems, rechargeable batteries offer easy maintenance, low cost, high round trip efficiency and durability. At present, sodium-ion batteries (SIBs) have garnered widespread interest for grid storage application due to inexpensive and earth abundant raw materials. Their practical realization is nested in successful exploration of suitable electrode and electrolyte materials. So far, various Na-ion cathodes have been discovered including layered oxides, polyanionic compounds and Prussian blue frameworks, whose energy densities are slightly inferiro to their Li-ion counterparts. Polyanionic frameworks consists of tetrahedral anions (XO4)n– (X= S, P) and MeOx (Me= 3d transition metal) polyhedral. In sulfate based polyanionic systems, the presence of SO4 2– anions will ensure rapid and bette...

We report on the characteristics of long channel (1 to 2 micron MoS2 thin film transistors) measured in the temperature range from 25 oC to 200 oC. Using the long channel allowed us minimizing the effect of the contact resistance for a more accurate extraction of the effective field effect mobility in the channel. The extracted field effect mobility, see Fig.1, (varying from 5 to 7 cm2/V-s in different samples) was only a very weak function of temperature. The on-to-off ratio was ~ 104 at room temperature decreasing to 103 at 220 oC. The devices had the threshold voltage varying from 80 V to 40 V when temperature increased from 25 oC to 220 oC, see Fig. 2. A very large subthreshold slope of nearly 11 V corresponded to the density of states in the energy gap of approximately 3x1013 cm-2 or approximately 3 x1012 1/(eVcm2) at the band edge. The low frequency noise measurements in the range from 1 Hz to 100 Hz revealed 1/f noise with no recombination-generation bulges. The density of tr...

Page 1. Structural behavior of layered cathode materials and first principles computations studies. JJ Saavedra-Arias, NK Karan, A. Kumar, R. Thomas, Y. Ishikawa*, and RS Katiyar Department of Physics, and Institute of Functional Nanomaterials, University of Puerto Rico ...

Results A polarization curve with a Pt/C MEA control and an HWV4-Pt/C modified MEA can be seen in Figure 1. The HWV4 modified electrode shows an improvement in performance when compared to the Pt/C control MEA. A similar performance increase was seen for the other HPAs tested.

Abstract We have fabricated proton conducting films using monomers based on vinyl substituted silicotungstic acid heteropoly acids (HPAs) and acrylate co-monomers. In this work we probe the limits of this system based on increasing the weight loading of the HPA to 85 wt%. Although impressive proton conductivities can be achieved with these films under hotter and drier operating conditions than in conventional proton exchange membranes, the materials have mechanical limitations. We show that very different film morphologies can ...