Ozden Cobanoglu
Uludag University, Department of Genetics, Faculty Member
- As a researcher, I am interested in studying the association between candidate genes and economically important traits in livestock species.edit
A functional candidate gene approach was used to search for genes affecting milk production traits in Holstein dairy cattle. Signal transducer and activator of transcription 1 (STAT1) was chosen because of its involvement in the... more
A functional candidate gene approach was used to
search for genes affecting milk production traits in Holstein
dairy cattle. Signal transducer and activator of
transcription 1 (STAT1) was chosen because of its
involvement in the development of the mammary gland.
Using the pooled genomic DNA sequencing approach,
we identified a single nucleotide polymorphism. Genomic
DNA was extracted from 1,292 sons obtained from the
Cooperative Dairy DNA Repository and from 715 blood
samples of daughters of 12 bulls obtained from the University
of Wisconsin resource population. Daughter yield
deviation data for the sons and yield deviation for the
daughters were obtained for milk production traits from
the USDA Animal Improvement Programs Laboratory.
For the Repository population, allele C was associated
with significant increases in milk fat and protein percentages.
For the University of Wisconsin population,
genotypes CC and CT were associated with significant
increases in milk, fat, and protein yields. Results from
this study are consistent with previous studies on the
role of STAT1 in regulating the transcription of genes
involved in milk protein synthesis and fat metabolism.
search for genes affecting milk production traits in Holstein
dairy cattle. Signal transducer and activator of
transcription 1 (STAT1) was chosen because of its
involvement in the development of the mammary gland.
Using the pooled genomic DNA sequencing approach,
we identified a single nucleotide polymorphism. Genomic
DNA was extracted from 1,292 sons obtained from the
Cooperative Dairy DNA Repository and from 715 blood
samples of daughters of 12 bulls obtained from the University
of Wisconsin resource population. Daughter yield
deviation data for the sons and yield deviation for the
daughters were obtained for milk production traits from
the USDA Animal Improvement Programs Laboratory.
For the Repository population, allele C was associated
with significant increases in milk fat and protein percentages.
For the University of Wisconsin population,
genotypes CC and CT were associated with significant
increases in milk, fat, and protein yields. Results from
this study are consistent with previous studies on the
role of STAT1 in regulating the transcription of genes
involved in milk protein synthesis and fat metabolism.
Research Interests:
Page 1. 73 Uludag Univ. J. Fac. Vet. Med. 30 (2011), 1: 73-82 Physiological Mechanisms of Multiple Ovulations and Factors Affecting Twin Calving Rates in Cattle ??zden ??OBANO??LU1 Geli?? Tarihi: 04.04.2011 Kabul Tarihi: 09.05.2011 ...
Research Interests:
Abstract: Main purpose of this study was to investigate genetic polymorphisms of Saanen (S), Maltese (M) and Turkish Hair (TH) goats based on erythrocyte potassium and glutathione types. It was also designed to detect the association... more
Abstract: Main purpose of this study was to investigate genetic polymorphisms of Saanen (S), Maltese (M) and Turkish Hair (TH) goats based on erythrocyte potassium and glutathione types. It was also designed to detect the association between these components and ...
Research Interests:
Abstract: The objectives of this study were to determine the body weight-age with different models and to choose the best fitted model. The study was designed to collect a total of 8 weekly body weight records from 142 quails from birth... more
Abstract: The objectives of this study were to determine the body weight-age with different models and to choose the best fitted model. The study was designed to collect a total of 8 weekly body weight records from 142 quails from birth up to 56 days of age in Tekirdag, ...
Research Interests:
This paper aims to search genetic structures of purebred Kivircik sheep raised in Turkey based on erythrocyte potassium and glutathione types and also to determine the relationship between these components and some blood parameters. The... more
This paper aims to search genetic structures of purebred Kivircik sheep raised in Turkey based on erythrocyte potassium and glutathione types and also to determine the relationship between these components and some blood parameters. The phenotypic frequencies were 68% ...
Research Interests:
The objective of this study was to identify twinning rate quantitative trait loci (QTL) by typing pooled samples in a preliminary screening followed by interval mapping to test QTL effects. Four elite North American Holstein half-sib sire... more
The objective of this study was to identify twinning rate quantitative trait loci (QTL) by typing pooled samples in a preliminary screening followed by interval mapping to test QTL effects. Four elite North American Holstein half-sib sire families with high twinning rate predicted transmitting abilities (PTA) were used in this study. Chromosomes 5, 7, 19 and 23 were not genotyped as these chromosomes were scanned for QTL in these families in a previous study. DNA was extracted from phenotypically extreme sons in each sire family. Two pools were prepared from sons of sires in each phenotypic tail, two each for high and low PTA levels for twinning rates. Each pool contained DNA from 4 to 15% of all sons of the sire depending on family. A total of 268 fluorescently labelled microsatellite markers were tested for heterozygosity in sires. About 135–170 informative markers per family were genotyped using pooled DNA samples. Based on the preliminary evidence for potential twinning rate QTL from pooled typing, interval mapping was performed subsequently on 12 chromosomal regions by family combinations. Evidence of QTL for twinning rate was found in one family on BTA21 and 29 at a chromosome-wide P < 0.05 and on BTA8, 10 and 14 with a chromosome-wide P < 0.01.