A functional candidate gene approach was used to
search for genes affecting milk production trait... more A functional candidate gene approach was used to search for genes affecting milk production traits in Holstein dairy cattle. Signal transducer and activator of transcription 1 (STAT1) was chosen because of its involvement in the development of the mammary gland. Using the pooled genomic DNA sequencing approach, we identified a single nucleotide polymorphism. Genomic DNA was extracted from 1,292 sons obtained from the Cooperative Dairy DNA Repository and from 715 blood samples of daughters of 12 bulls obtained from the University of Wisconsin resource population. Daughter yield deviation data for the sons and yield deviation for the daughters were obtained for milk production traits from the USDA Animal Improvement Programs Laboratory. For the Repository population, allele C was associated with significant increases in milk fat and protein percentages. For the University of Wisconsin population, genotypes CC and CT were associated with significant increases in milk, fat, and protein yields. Results from this study are consistent with previous studies on the role of STAT1 in regulating the transcription of genes involved in milk protein synthesis and fat metabolism.
A functional candidate gene approach was used to
search for genes affecting milk production trait... more A functional candidate gene approach was used to search for genes affecting milk production traits in Holstein dairy cattle. Signal transducer and activator of transcription 1 (STAT1) was chosen because of its involvement in the development of the mammary gland. Using the pooled genomic DNA sequencing approach, we identified a single nucleotide polymorphism. Genomic DNA was extracted from 1,292 sons obtained from the Cooperative Dairy DNA Repository and from 715 blood samples of daughters of 12 bulls obtained from the University of Wisconsin resource population. Daughter yield deviation data for the sons and yield deviation for the daughters were obtained for milk production traits from the USDA Animal Improvement Programs Laboratory. For the Repository population, allele C was associated with significant increases in milk fat and protein percentages. For the University of Wisconsin population, genotypes CC and CT were associated with significant increases in milk, fat, and protein yields. Results from this study are consistent with previous studies on the role of STAT1 in regulating the transcription of genes involved in milk protein synthesis and fat metabolism.
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search for genes affecting milk production traits in Holstein
dairy cattle. Signal transducer and activator of
transcription 1 (STAT1) was chosen because of its
involvement in the development of the mammary gland.
Using the pooled genomic DNA sequencing approach,
we identified a single nucleotide polymorphism. Genomic
DNA was extracted from 1,292 sons obtained from the
Cooperative Dairy DNA Repository and from 715 blood
samples of daughters of 12 bulls obtained from the University
of Wisconsin resource population. Daughter yield
deviation data for the sons and yield deviation for the
daughters were obtained for milk production traits from
the USDA Animal Improvement Programs Laboratory.
For the Repository population, allele C was associated
with significant increases in milk fat and protein percentages.
For the University of Wisconsin population,
genotypes CC and CT were associated with significant
increases in milk, fat, and protein yields. Results from
this study are consistent with previous studies on the
role of STAT1 in regulating the transcription of genes
involved in milk protein synthesis and fat metabolism.
search for genes affecting milk production traits in Holstein
dairy cattle. Signal transducer and activator of
transcription 1 (STAT1) was chosen because of its
involvement in the development of the mammary gland.
Using the pooled genomic DNA sequencing approach,
we identified a single nucleotide polymorphism. Genomic
DNA was extracted from 1,292 sons obtained from the
Cooperative Dairy DNA Repository and from 715 blood
samples of daughters of 12 bulls obtained from the University
of Wisconsin resource population. Daughter yield
deviation data for the sons and yield deviation for the
daughters were obtained for milk production traits from
the USDA Animal Improvement Programs Laboratory.
For the Repository population, allele C was associated
with significant increases in milk fat and protein percentages.
For the University of Wisconsin population,
genotypes CC and CT were associated with significant
increases in milk, fat, and protein yields. Results from
this study are consistent with previous studies on the
role of STAT1 in regulating the transcription of genes
involved in milk protein synthesis and fat metabolism.